Personal information

Websites & social links

Hypertension in Africa Research Team (HART)
LinkedIn

Other IDs

Scopus Author ID: 55827039900
ResearcherID: G-8235-2015
ResearcherID: G-8235-2015
SciProfiles: 1707718

Keywords

higher education, research, physiology, inflammation, biomarkers, vascular disease

Countries

South Africa

Activities

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Employment (1)

North-West University: Potchefstroom, North West, ZA

2014-02-01 to present | Associate Professor (Physiology)
Employment
Source: Self-asserted source
Shani Botha-Le Roux

Education and qualifications (5)

University of Glasgow: Glasgow, Glasgow, GB

2016-04-18 to 2016-07-01 | Postdoctoral Research Fellow (BHF Glasgow Cardiovascular Research Centre)
Education
Source: Self-asserted source
Shani Botha-Le Roux

North-West University: Potchefstroom, North West, ZA

2012-01-01 to 2015-10-01 | PhD (Physiology)
Education
Source: Self-asserted source
Shani Botha-Le Roux

North-West University: Potchefstroom, North West, ZA

2011-01-01 to 2011-12-31 | MSc (Physiology)
Education
Source: Self-asserted source
Shani Botha-Le Roux

North-West University: Potchefstroom, North West, ZA

2010-01-01 to 2010-12-31 | BSc Hons (Phsyiology)
Education
Source: Self-asserted source
Shani Botha-Le Roux

North-West University: Potchefstroom, North West, ZA

2007-01-01 to 2009-12-31 | BSc (Physiology)
Education
Source: Self-asserted source
Shani Botha-Le Roux

Works (40)

Retinal Vessel Functional Responses in South Africans Living With and Without HIV: The EndoAfrica‐NWU Study

Microcirculation
2024-10 | Journal article
DOI: 10.1111/micc.12878
Contributors: Catharina Elizabeth Myburgh‐Jacobsz; Shani Botha‐Le Roux; Konstantin Kotliar; Annemarie Wentzel; Adriaan Jacobs; Patrick De Boever; Nandu Goswami; Hans Strijdom; Wayne Smith
Source: check_circle
Crossref

Perfusion and pulsatile pressure: their relationship with target organ damage in the African-PREDICT study

BMC Cardiovascular Disorders
2024-08-01 | Journal article
DOI: 10.1186/s12872-024-04071-y
Contributors: Donavan Rooi; Shani Botha-Le Roux; Yolandi Breet
Source: check_circle
Crossref

Determining Underlying Mechanisms of Early Vascular Ageing by Clustered Analysis: The African-PREDICT Study

Heart, Lung and Circulation
2022-10 | Journal article
DOI: 10.1016/j.hlc.2022.05.042
Contributors: Ashleigh Craig; Wayne Smith; Catharina M.C. Mels; Yolandi Breet; Shani Botha-le Roux; Adriaan Jacobs; Lebo F. Gafane-Matemane; Ruan Kruger
Source: check_circle
Crossref

Prognostic values of modifiable risk factors for cardiovascular events in South African health promotion

PLOS ONE
2022-08-10 | Journal article
DOI: 10.1371/journal.pone.0271169
Contributors: Jacobeth T. Kganakga; Mona Pathak; Petra Bester; Cristian Ricci; Shani Botha-Le Roux; Marike Cockeran; Minrie Greeff; Iolanthé M. Kruger
Source: check_circle
Crossref

Cardiovascular Profile of South African Adults with Low-Level Viremia during Antiretroviral Therapy

Journal of Clinical Medicine
2022-05-16 | Journal article
DOI: 10.3390/jcm11102812
Contributors: Shani Botha-Le Roux; Olof Elvstam; Patrick De Boever; Nandu Goswami; Martin Magnusson; Peter Nilsson; Hans Strijdom; Per Björkman; Carla Fourie
Source: check_circle
Crossref
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Homoarginine and blood pressure: a 10-year prospective relationship in normotensives

Journal of Human Hypertension
2022-02 | Journal article
DOI: 10.1038/s41371-020-00449-5
Contributors: Maserame Cleopatra Mokhaneli; Shani Botha-Le Roux; Carla Maria Theresia Fourie; Rainer Böger; Edzard Schwedhelm; Catharina Martha Cornelia Mels
Source: check_circle
Crossref

Age-related differences in the vascular function and structure of South Africans living with HIV

Southern African Journal of HIV Medicine
2022-02-24 | Journal article
DOI: 10.4102/sajhivmed.v23i1.1335
Contributors: Anisca Louwrens; Carla M.T. Fourie; Shani Botha-Le Roux; Yolandi Breet
Source: check_circle
Crossref

Cardiorespiratory Fitness, Blood Pressure and Ethnicity Are Related to Salivary Cortisol Responses after an Exercise Test in Children: The ExAMIN Youth SA Study

International Journal of Environmental Research and Public Health
2021-07-26 | Journal article
DOI: 10.3390/ijerph18157898
Contributors: Sabrina Köchli; Shani Botha-Le Roux; Aletta Sophia Uys; Ruan Kruger
Source: check_circle
Crossref
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Lifestyle factors associated with the transition from healthy to unhealthy adiposity among black South African adults over 10 years

Nutrition, Metabolism and Cardiovascular Diseases
2021-06 | Journal article
DOI: 10.1016/j.numecd.2021.03.017
Contributors: Herculina S. Kruger; Cristian Ricci; Marlien Pieters; Shani Botha-le Roux; Sarah J. Moss; Iolanthe M. Kruger; Tertia van Zyl; Aletta E. Schutte
Source: check_circle
Crossref

L‐homoarginine is associated with decreased cardiovascular‐ and all‐cause mortality

European Journal of Clinical Investigation
2021-05 | Journal article
DOI: 10.1111/eci.13472
Contributors: Maserame Cleopatra Mokhaneli; Shani Botha‐Le Roux; Carla Maria Theresia Fourie; Rainer Böger; Edzard Schwedhelm; Catharina Martha Cornelia Mels
Source: check_circle
Crossref

Potassium excretion and blood pressure are associated with heart rate variability in healthy black adults: The African-PREDICT study

Nutrition, Metabolism and Cardiovascular Diseases
2021-04 | Journal article
DOI: 10.1016/j.numecd.2020.12.021
Contributors: Sabrina Köchli; Aletta E. Schutte; Shani Botha-Le Roux; Lebo F. Gafane-Matemane; Wayne Smith; Johannes M. van Rooyen; Gontse G. Mokwatsi; Ruan Kruger
Source: check_circle
Crossref

Blood pressure and nitric oxide synthesis capacity in physically active and inactive groups: the SABPA study

Journal of Human Hypertension
2021-04-07 | Journal article
DOI: 10.1038/s41371-020-0344-2
Contributors: Elandi van Niekerk; Shani Botha Le Roux; Dorothee Atzler; Edzard Schwedhelm; Rainer H. Böger; Johannes M. van Rooyen; Sarah J. Moss; Catharina M. C. Mels
Source: check_circle
Crossref

Inflammation and salt in young adults: the African-PREDICT study

European Journal of Nutrition
2021-03-03 | Journal article
DOI: 10.1007/s00394-020-02292-3
Contributors: Simone H. Crouch; Shani Botha-Le Roux; Christian Delles; Lesley A. Graham; Aletta E. Schutte
Source: check_circle
Crossref

Inflammation and hypertension development: A longitudinal analysis of the African-PREDICT study

International Journal of Cardiology Hypertension
2020-12 | Journal article
DOI: 10.1016/j.ijchy.2020.100067
Contributors: Simone H. Crouch; Shani Botha-Le Roux; Christian Delles; Lesley A. Graham; Aletta E. Schutte
Source: check_circle
Crossref

Von Willebrand factor, its cleaving protease (ADAMTS13), and inflammation in young adults: The African-PREDICT study

Cytokine
2020-12 | Journal article
DOI: 10.1016/j.cyto.2020.155265
Contributors: Christine Möller; Aletta E. Schutte; Wayne Smith; Shani Botha-Le Roux
Source: check_circle
Crossref

Distinct inflammatory mediator patterns in young black and white adults: The African-predict study

Cytokine
2020-02 | Journal article
DOI: 10.1016/j.cyto.2019.154894
Contributors: Simone H. Crouch; Shani Botha-Le Roux; Christian Delles; Lesley A. Graham; Aletta E. Schutte
Source: check_circle
Crossref

Assessing tobacco use in an African population: Serum and urine cotinine cut-offs from South Africa.

Drug and alcohol dependence
2019 | Journal article
DOI: 10.1016/j.drugalcdep.2018.11.022
WOSUID:

MEDLINE:30593984
Contributors: Ware, Lisa J; Charlton, Karen; Kruger, Ruan; Breet, Yolandi; van Rooyen, Johannes; Huisman, Hugo; Botha, Shani; Uys, Aletta S; Rennie, Kirsten L; Naidoo, Nirmala et al.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination.

European journal of preventive cardiology
2019 | Journal article
DOI: 10.1177/2047487318822354
WOSUID:

MEDLINE:30681377
Contributors: Schutte, Aletta E; Gona, Philimon N; Delles, Christian; Uys, Aletta S; Burger, Adele; Mels, Catharina Mc; Kruger, Ruan; Smith, Wayne; Fourie, Carla Mt; Botha, Shani et al.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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Vascular Structure and Inflammation in a South African Population: The SABPA Study

Pulse
2019 | Journal article
DOI: 10.1159/000500899
Contributors: Carla Swart; Leandi Lammertyn; Paul I. Welsh; Shani Botha-Le Roux
Source: check_circle
Crossref

Iron loading, alcohol and mortality: A prospective study.

Clinical nutrition (Edinburgh, Scotland)
2018 | Journal article
DOI: 10.1016/j.clnu.2018.05.008
WOSUID:

MEDLINE:29803668
Contributors: Schutte, Rudolph; Huisman, Hugo; Mels, Catharina M C; Botha, Shani; Kruger, Ruan; Smith, Wayne; Kruger, Iolanthe M; Hawkins, Michelle; Smith, Lee; Breet, Yolandi et al.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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Bioavailable IGF-1 is beneficially associated with biomarkers of endothelial function in young healthy adults: The African-PREDICT study

Growth Hormone & IGF Research
2018-08 | Journal article
DOI: 10.1016/j.ghir.2018.06.002
Contributors: Sunelle A. Barnard; Wayne Smith; Catharina M.C. Mels; Shani Botha; Aletta E. Schutte
Source: check_circle
Crossref
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SuPAR Predicts 10-year Mortality in HIV Infected and Hypertensive Black South Africans

Atherosclerosis Supplements
2018-06 | Journal article
DOI: 10.1016/j.atherosclerosissup.2018.04.265
Part of ISSN: 1567-5688
Contributors: Shani. Botha; Yolandi Breet; Jesper Eugen-Olsen; Carla M. Fourie; Aletta E. Schutte
Source: Self-asserted source
Shani Botha-Le Roux via Crossref Metadata Search
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Effect of non-surgical weight management on weight and glycaemic control in people with type 2 diabetes: A comparison of interventional and non-interventional outcomes at 3 years

Diabetes, Obesity and Metabolism
2018-01-11 | Journal article
DOI: 10.1111/dom.13171
Part of ISSN: 1462-8902
Contributors: Shani Botha; Lorna Forde; Sheila MacNaughton; Ross Shearer; Robert Lindsay; Naveed Sattar; David Morrison; Paul Welsh; Jennifer Logue
Source: Self-asserted source
Shani Botha-Le Roux via Crossref Metadata Search
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Renin at different physical activity levels in a bi-ethnic population: The African-PREDICT study

Artery Research
2017 | Journal article
DOI: 10.1016/j.artres.2017.10.073
Part of ISSN: 1872-9312
Contributors: Johannes van Rooyen; Hugo Huisman; Leonè Malan; Catharina Mels; Ruan Kruger; Lebo Gafane-Matemane; Shani Botha; Alta Schutte
Source: Self-asserted source
Shani Botha-Le Roux via Crossref Metadata Search
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Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?

British Journal of Pharmacology
2017 | Journal article
DOI: 10.1111/bph.13818
EID:

2-s2.0-85020456946
Contributors: Welsh, P.; Grassia, G.; Botha, S.; Sattar, N.; Maffia, P.
Source: Self-asserted source
Shani Botha-Le Roux via Scopus - Elsevier
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Recent advances in understanding hypertension development in sub-Saharan Africa

Journal of Human Hypertension
2017-08 | Journal article
DOI: 10.1038/jhh.2017.18
Contributors: A E Schutte; S Botha; C M T Fourie; L F Gafane-Matemane; R Kruger; L Lammertyn; L Malan; C M C Mels; R Schutte; W Smith et al.
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Crossref
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ARTERIAL STIFFNESS IN A BLACK SOUTH AFRICAN COHORT INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS (HIV)

Atherosclerosis
2016 | Journal article
DOI: 10.1016/j.atherosclerosis.2016.07.806
WOSUID:

WOS:000388978400574
Contributors: Fourie, C. M.; van Rooyen, J. M.; Huisman, H. W.; Mels, C. M.; Smith, W.; Kruger, R.; Botha, S.; Lammertyn, L.; Gafane, L.; Schutte, A. E.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID

Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: A five-year prospective study

European Journal of Preventive Cardiology
2016 | Journal article
DOI: 10.1177/2047487316661436
WOSUID:

WOS:000385811000001
Contributors: Schutte, Aletta E.; Conti, Elena; Mels, Catharina M. C.; Smith, Wayne; Kruger, Ruan; Botha, Shani; Gnessi, Lucio; Volpe, Massimo; Huisman, Hugo W.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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OS 34-03 THE ASSOCIATION OF TETRAHYDROBIOPTERIN WITH A MARKER OF NITRIC OXIDE PRODUCTION IN A BLACK AND WHITE POPULATION: THE SABPA STUDY.

Journal of hypertension
2016 | Journal article
WOSUID:

MEDLINE:27754236
Contributors: Huisman, Hugo; Schutte, Aletta; Van Rooyen, Johannes; Fourie, Carla; Kruger, Ruan; Smith, Wayne; Lammertyn, Leandi; Malan, Leone; Botha, Shani; Mels, Carina
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID

Quantification of systemic renin-angiotensin system peptides of hypertensive black and white African men established from the RAS-Fingerprint.

Journal of the renin-angiotensin-aldosterone system : JRAAS
2016 | Journal article
WOSUID:

MEDLINE:27737932
Contributors: van Rooyen, J M; Poglitsch, M; Huisman, H W; Mels, Cmc; Kruger, R; Malan, L; Botha, S; Lammertyn, L; Gafane, L; Schutte, A E
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID

Quantification of systemic renin-angiotensin system peptides of hypertensive black and white African men established from the RAS-Fingerprint<sup>®</sup>

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
2016 | Journal article
DOI: 10.1177/1470320316669880
EID:

2-s2.0-84994791974
Contributors: Van Rooyen, J.M.; Poglitsch, M.; Huisman, H.W.; Mels, C.M.C.; Kruger, R.; Malan, L.; Botha, S.; Lammertyn, L.; Gafane, L.; Schutte, A.E.
Source: Self-asserted source
Shani Botha-Le Roux via Scopus - Elsevier
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The association of oxidative stress with arterial compliance and vascular resistance in a bi-ethnic population: the SABPA study

Free Radical Research
2016 | Journal article
DOI: 10.1080/10715762.2016.1201816
WOSUID:

WOS:000381036500012
Contributors: Mokhaneli, Maserame Cleopatra; Fourie, Carla Maria T.; Botha, Shani; Mels, Catharina Martha C.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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OS 34-03 THE ASSOCIATION OF TETRAHYDROBIOPTERIN WITH A MARKER OF NITRIC OXIDE PRODUCTION IN A BLACK AND WHITE POPULATION

Journal of Hypertension
2016-09 | Journal article
DOI: 10.1097/01.hjh.0000501016.84213.d7
Part of ISSN: 0263-6352
Contributors: Hugo Huisman; Aletta Schutte; Johannes Van Rooyen; Carla Fourie; Ruan Kruger; Wayne Smith; Leandi Lammertyn; Leone Malan; Shani Botha; Carina Mels
Source: Self-asserted source
Shani Botha-Le Roux via Crossref Metadata Search
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1C.01: SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR AS A PROGNOSTIC MARKER OF ALL-CAUSE AND CARDIOVASCULAR MORTALITY IN A BLACK POPULATION.

Journal of hypertension
2015 | Journal article
DOI: 10.1097/01.hjh.0000467375.80946.c1
WOSUID:

MEDLINE:26102960
Contributors: Botha, S; Fourie, C M T; Schutte, R; Eugen-Olsen, J; Pretorius, R; Schutte, A E
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID

Cornell product relates to albuminuria in hypertensive black adults independently of blood pressure: the SABPA study

Journal of the American Society of Hypertension
2015 | Journal article
DOI: 10.1016/j.jash.2014.12.003
WOSUID:

WOS:000351189000005
Contributors: Schutte, Rudolph; Huisman, Hugo W.; Ware, Lisa J.; Mels, Catherina M. C.; Smith, Wayne; Malan, Nicolaas T.; Malan, Leone; van Rooyen, Johannes M.; Fourie, Carla M. T.; Kruger, Ruan et al.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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Soluble urokinase plasminogen activator receptor and hypertension among black South Africans after 5 years

Hypertension Research
2015 | Journal article
DOI: 10.1038/hr.2015.22
WOSUID:

WOS:000355701800012
Contributors: Botha, Shani; Fourie, Carla M. T.; Schutte, Rudolph; Eugen-Olsen, Jesper; Schutte, Aletta E.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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Soluble urokinase plasminogen activator receptor as a prognostic marker of all-cause and cardiovascular mortality in a black population

International Journal of Cardiology
2015 | Journal article
DOI: 10.1016/j.ijcard.2015.03.041
WOSUID:

WOS:000353763800151
Contributors: Botha, Shani; Fourie, Carla M. T.; Schutte, Rudolph; Eugen-Olsen, Jesper; Pretorius, Ronel; Schutte, Aletta E.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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Associations of suPAR with lifestyle and cardiometabolic risk factors

European Journal of Clinical Investigation
2014 | Journal article
DOI: 10.1111/eci.12278
WOSUID:

WOS:000338011900002
Contributors: Botha, Shani; Fourie, Carla M. T.; Schutte, Rudolph; Kruger, Annamarie; Schutte, Aletta E.
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID
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Cardiometabolic Changes in Treated Versus Never Treated HIV-Infected Black South Africans: The PURE Study

Heart Lung and Circulation
2014 | Journal article
DOI: 10.1016/j.hlc.2013.07.019
EID:

2-s2.0-84894239664
Contributors: Botha, S.; Fourie, C.M.T.; van Rooyen, J.M.; Kruger, A.; Schutte, A.E.
Source: Self-asserted source
Shani Botha-Le Roux via Scopus - Elsevier
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Salt Intake, Blood Pressure and Renal Function in a Black Population: A 5-Year Prospective Study

Hypertension
2014 | Journal article
WOSUID:

WOS:000209790800466
Contributors: Schutte, Aletta E.; Van Rooyen, Johannes M.; Huisman, Hugo W.; Fourie, Carla M.; Wentzel-Viljoen, Edelweiss; Mels, Carina M.; Smith, Wayne; Botha, Shani; Kruger, Annamarie; Schutte, Rudolph
Source: Self-asserted source
Shani Botha-Le Roux via ResearcherID

Peer review (11 reviews for 5 publications/grants)

Review activity for British journal of nutrition. (1)
Review activity for European journal of applied physiology. (3)
Review activity for Journal of acquired immune deficiency syndromes : (1)
Review activity for Journal of human hypertension (4)
Review activity for PLoS medicine. (2)
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