Personal information

Genetics, Genomics, behavioral genetics, genetic architecture
United States

Activities

Employment (2)

Vanderbilt University: Nashville, TN, US

2015-09-01 to present | Assistant Professor (Vanderbilt Genetics Institute, Department of Medicine, Division of Genetic Medicine)
Employment
Source: Self-asserted source
Lea K Davis

University of Chicago: Chicago, IL, US

2013-01-01 to 2015-08-31 | Research Associate (Assistant Professor) (Genetic Medicine)
Employment
Source: Self-asserted source
Lea K Davis

Education and qualifications (3)

University of Chicago: Chicago, IL, US

2010-06-01 to 2013-01-01 | Post-doctoral fellow (Genetic Medicine)
Education
Source: Self-asserted source
Lea K Davis

University of Illinois at Chicago: Chicago, IL, US

2009-06-10 to 2011-01-20 | post-doctoral fellow (Psychiatry)
Education
Source: Self-asserted source
Lea K Davis

University of Iowa: Iowa City, IA, US

2004-08-20 to 2009-05-15 | PhD (Psychiatry)
Education
Source: Self-asserted source
Lea K Davis

Funding (1)

Discovering the biological linkages between depression and cardiovascular disease

2025-04-01 to 2026-03-31 | Grant
American Heart Association (Dallas, US)
GRANT_NUMBER:

25IVPHA1476244

Source: check_circle
American Heart Association

Works (36)

Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex

Nature Genetics
2025-03 | Journal article
Contributors: Ted Schwaba; Travis T. Mallard; Adam X. Maihofer; Mijke Rhemtulla; Phil H. Lee; Jordan W. Smoller; Lea K. Davis; Michel G. Nivard; Andrew D. Grotzinger; Elliot M. Tucker-Drob
Source: check_circle
Crossref

Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases

Circulation: Genomic and Precision Medicine
2024-12 | Journal article
Contributors: Jiayue-Clara Jiang; Kritika Singh; Rachana Nitin; Lea K. Davis; Naomi R. Wray; Sonia Shah
Source: check_circle
Crossref

Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics

Biological Psychiatry
2024-10 | Journal article
Contributors: Alysa E. Doyle; Carrie E. Bearden; Raquel E. Gur; David H. Ledbetter; Christa L. Martin; Thomas H. McCoy, Jr.; Bogdan Pasaniuc; Roy H. Perlis; Jordan W. Smoller; Lea K. Davis
Source: check_circle
Crossref

Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

Neuropsychopharmacology
2024-10 | Journal article
Contributors: Emma C. Johnson; Isabelle Austin-Zimmerman; Hayley H. A. Thorpe; Daniel F. Levey; David A. A. Baranger; Sarah M. C. Colbert; Ditte Demontis; Jibran Y. Khokhar; Lea K. Davis; Howard J. Edenberg et al.
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Crossref

Genome-wide association studies of lifetime and frequency cannabis use in 131,895 individuals

2024-06-16 | Preprint
Contributors: Hayley H A Thorpe; Pierre Fontanillas; John J Meredith; Mariela V Jennings; Renata B Cupertino; Shreya Pakala; Sarah L Elson; Jibran Y Khokhar; Lea K Davis; Emma C Johnson et al.
Source: check_circle
Crossref

Phenomewide Association Study of Health Outcomes Associated With the Genetic Correlates of 25 Hydroxyvitamin D Concentration and Vitamin D Binding Protein Concentration

Twin Research and Human Genetics
2024-04 | Journal article
Contributors: Hailey A. Kresge; Freida Blostein; Slavina Goleva; Clara Albiñana; Joana A. Revez; Naomi R. Wray; Bjarni J. Vilhjálmsson; Zhihong Zhu; John J. McGrath; Lea K. Davis
Source: check_circle
Crossref

Genes associated with depression and coronary artery disease are enriched for cardiomyopathy and inflammatory phenotypes

Nature Mental Health
2024-04-05 | Journal article
Contributors: Kritika Singh; Hyunjoon Lee; Julia M. Sealock; Tyne Miller-Fleming; Peter Straub; Nancy J. Cox; Quinn S. Wells; Jordan W. Smoller; Emily C. Hodges; Lea K. Davis
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Crossref

Anti-Inflammatory Action of Antidepressants: Investigating the Longitudinal Effect of Antidepressants on White Blood Cell Count

Complex Psychiatry
2023 | Journal article
Contributors: Julia M. Sealock; Guanhua Chen; Lea K. Davis
Source: check_circle
Crossref

Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models

2023-11-02 | Preprint
Contributors: Theodore J. Morley; Drew Willimitis; Michael Ripperger; Hyunjoon Lee; Lide Han; Yu Zhou; Jooeun Kang; Lea K. Davis; Jordan W. Smoller; Karmel W. Choi et al.
Source: check_circle
Crossref

Quality control and analytic best practices for testing genetic models of sex differences in large populations

Cell
2023-05 | Journal article
Contributors: Ekaterina A. Khramtsova; Melissa A. Wilson; Joanna Martin; Stacey J. Winham; Karen Y. He; Lea K. Davis; Barbara E. Stranger
Source: check_circle
Crossref

Toward a deeper understanding of gene-by-sex interaction models

Cell Genomics
2023-05 | Journal article
Contributors: Ekaterina A. Khramtsova; Stacey J. Winham; Lea K. Davis; Barbara E. Stranger; Melissa A. Wilson
Source: check_circle
Crossref

Sex modifies the effect of genetic risk scores for polycystic ovary syndrome on metabolic phenotypes

PLOS Genetics
2023-05-31 | Journal article
Contributors: Ky’Era V. Actkins; Geoffrey Hayes; Genevieve Jean-Pierre; Melinda C. Aldrich; Digna R. Velez Edwards; Lea K. Davis
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Crossref

Sex Differences in Health Conditions Associated with Sexual Assault in a Large Hospital Population

Complex Psychiatry
2022 | Journal article
Contributors: Allison M. Lake; Slavina B. Goleva; Lauren R. Samuels; Laura M. Carpenter; Lea K. Davis
Source: check_circle
Crossref

Improving the computation efficiency of polygenic risk score modeling: faster in Julia

Life Science Alliance
2022-12 | Journal article
Contributors: Annika Faucon; Julian Samaroo; Tian Ge; Lea K Davis; Nancy J Cox; Ran Tao; Megan M Shuey
Source: check_circle
Crossref

Weldon, Bateson, and the origins of genetics: Reflections on the unraveling and rebuilding of a scientific community

PLOS Genetics
2022-10-27 | Journal article
Contributors: Lea K. Davis; Jonathan Flint
Source: check_circle
Crossref

Genes associated with depression and coronary artery disease are enriched for inflammation and cardiomyopathy-associated pathways

2022-10-26 | Preprint
Contributors: Kritika Singh; Hyunjoon Lee; Julia M Sealock; Tyne Miller-Flemming; Peter Straub; Nancy J. Cox; Quinn S. Wells; Jordan W. Smoller; Emily C. Hodges; Lea K. Davis
Source: check_circle
Crossref

Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases

2022-10-10 | Preprint
Contributors: Jiayue-Clara Jiang; Kritika Singh; Lea K. Davis; Naomi R. Wray; Sonia Shah
Source: check_circle
Crossref

Confronting ethical and social issues related to the genetics of musicality

2022-05-13 | Preprint
Contributors: Reyna L Gordon; Maria Niarchou; Daphne Martschenko; Matthew D. Morrison; Eamonn Bell; Nori Jacoby; Lea Davis
Source: check_circle
Crossref

Health conditions associated with sexual assault in a large hospital population

2022-04-05 | Preprint
Contributors: Allison M. Lake; Slavina B. Goleva; Lauren R. Samuels; Laura M. Carpenter; Lea K. Davis
Source: check_circle
Crossref

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose

Journal of Biological Chemistry
2022-02 | Journal article
Contributors: Emily M. Overway; Karin J. Bosma; Derek P. Claxton; James K. Oeser; Kritika Singh; Lindsay B. Breidenbach; Hassane S. Mchaourab; Lea K. Davis; Richard M. O'Brien
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Crossref

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry

Molecular Psychiatry
2021-11 | Journal article
Contributors: Sandra Sanchez-Roige; Pierre Fontanillas; Mariela V. Jennings; Sevim B. Bianchi; Yuye Huang; Alexander S. Hatoum; Julia Sealock; Lea K. Davis; Sarah L. Elson; Michelle Agee et al.
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Crossref

Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders Along the Impulsivity-Compulsivity Spectrum

Biological Psychiatry
2021-09 | Journal article
Contributors: Zhiyu Yang; Hanrui Wu; Phil H. Lee; Fotis Tsetsos; Lea K. Davis; Dongmei Yu; Sang Hong Lee; Søren Dalsgaard; Jan Haavik; Csaba Barta et al.
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Crossref

A dimensional perspective on the genetics of obsessive-compulsive disorder

Translational Psychiatry
2021-07-21 | Journal article
Contributors: Nora I. Strom; Takahiro Soda; Carol A. Mathews; Lea K. Davis
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Crossref

Contextualizing genetic risk score for disease screening and rare variant discovery

Nature Communications
2021-07-20 | Journal article
Contributors: Dan Zhou; Dongmei Yu; Jeremiah M. Scharf; Carol A. Mathews; Lauren McGrath; Edwin Cook; S. Hong Lee; Lea K. Davis; Eric R. Gamazon
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Crossref

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry

2021-06-03 | Other
Contributors: Sandra Sanchez-Roige; Pierre Fontanillas; Mariela V Jennings; Sevim Bianchi; Yuye Huang; Alex Hatoum; Julia Sealock; Lea K Davis; Sarah L Elson; Abraham A Palmer
Source: check_circle
Crossref

Calcium-Sensing Receptor Polymorphisms at rs1801725 are Associated with Increased Risk of Secondary Malignancies

2021-02-26 | Other
Contributors: Ky’Era V. Actkins; Heather K. Beasley; Annika B. Faucon; Lea K. Davis; Amos M. Sakwe
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Crossref

Automated Phenotyping Tool for Identifying Developmental Language Disorder Cases in Health Systems Data (APT-DLD): A New Research Algorithm for Deployment in Large-Scale Electronic Health Record Systems

Journal of Speech, Language, and Hearing Research
2020-09-15 | Journal article
Contributors: Courtney E. Walters, Jr.; Rachana Nitin; Katherine Margulis; Olivia Boorom; Daniel E. Gustavson; Catherine T. Bush; Lea K. Davis; Jennifer E. Below; Nancy J. Cox; Stephen M. Camarata et al.
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Crossref

A phenome-wide association study identifying risk factors for pediatric post-concussion syndrome

2020-07-17 | Other
Contributors: Aaron M. Yengo-Kahn; Natalie Hibshman; Christopher M. Bonfield; Eric S. Torstenson; Katherine A. Gifford; Daniil Belikau; Lea K. Davis; Scott L. Zuckerman; Jessica K. Dennis
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Crossref

Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

Nature Communications
2019-12-03 | Journal article
Contributors: Gengjie Jia; Yu Li; Hanxin Zhang; Ishanu Chattopadhyay; Anders Boeck Jensen; David R. Blair; Lea Davis; Peter N. Robinson; Torsten Dahlén; Søren Brunak et al.
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Crossref

Genome-wide analyses indirectly implicate miRNA regulatory mechanisms in Obsessive-compulsive Disorder psychopathology

2019-04-07 | Other
Contributors: NW McGregor; KS O’Connell; L Davis; CA Mathews; C Lochner; DJ Stein
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Crossref

Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

Nature Neuroscience
2019-03-08 | Journal article
Contributors: Sandra Sanchez-Roige; Pierre Fontanillas; Sarah L. Elson; Anita Pandit; Ellen M. Schmidt; Johanna R. Foerster; Gonçalo R. Abecasis; Joshua C. Gray; Harriet de Wit; Lea K. Davis et al.
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Crossref

A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers

Nature Communications
2018-08-30 | Journal article
Contributors: Jonathan D. Mosley; QiPing Feng; Quinn S. Wells; Sara L. Van Driest; Christian M. Shaffer; Todd L. Edwards; Lisa Bastarache; Wei-Qi Wei; Lea K. Davis; Catherine A. McCarty et al.
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Crossref

Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

Nature Neuroscience
2018-07-11 | Journal article
Contributors: Sandra Sanchez-Roige; Pierre Fontanillas; Sarah L. Elson; Anita Pandit; Ellen M. Schmidt; Johanna R. Foerster; Gonçalo R. Abecasis; Joshua C. Gray; Harriet de Wit; Lea K. Davis et al.
Source: check_circle
Crossref

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

Nature Neuroscience
2018-01-11 | Journal article
Contributors: Sandra Sanchez-Roige; Pierre Fontanillas; Sarah L. Elson; Anita Pandit; Ellen M. Schmidt; Johanna R. Foerster; Gonçalo R. Abecasis; Joshua C. Gray; Harriet de Wit; Lea K. Davis et al.
Source: check_circle
Crossref

Sex differences in the genetic architecture of obsessive-compulsive disorder

2017-11-21 | Other
Contributors: Ekaterina A. Khramtsova; Raphael Heldman; Eske M. Derks; Dongmei Yu; Lea K. Davis; Barbara E. Stranger
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Crossref

Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry

2017-06-15 | Preprint
Contributors: Sandra Sanchez-Roige; Pierre Fontanillas; Sarah L. Elson; Joshua C. Gray; Harriet de Wit; Lea K. Davis; James MacKillop; Abraham A. Palmer
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Crossref

Peer review (2 reviews for 2 publications/grants)

Review activity for Human Genetics and Genomics advances. (1)
Review activity for Nature (1)