Personal information

Crystallographer, Structure-based drug design, Biochemical, Biophysical, and Structural Methods, cryo-EM, Receptor Tyrosine Kinases
United States

Activities

Employment (3)

Merck & Co., Inc., Rahway, NJ, USA (United States): Rahway, US

2025-01 to present | Senior Scientist (Protein and Structural Chemistry)
Employment
Source: Self-asserted source
Nicole Bertoletti

Yale School of Medicine: New Haven, CT, US

2022-10 to 2024-12 | Associate Research Scientist (Pharmacology)
Employment
Source: Self-asserted source
Nicole Bertoletti

Yale School of Medicine: New Haven, CT, US

2017-10 to 2022-10 | Postdoc Associate (Pharmacology)
Employment
Source: Self-asserted source
Nicole Bertoletti

Education and qualifications (2)

Philipps-Universität Marburg: Marburg, Hessen, DE

2014-01 to 2017-10 | Dr. rer. nat. (Pharmazeutische Chemie)
Education
Source: Self-asserted source
Nicole Bertoletti

University of Pisa: Pisa, Toscana, IT

2007-10 to 2013-04 | Master’s degree in Pharmaceutical Chemistry and Technologies (Pharmacy)
Education
Source: Self-asserted source
Nicole Bertoletti

Professional activities (4)

WISAY (Women in Science at Yale) Post-doctoral: New Haven, CT, US

Board Member
Service
Source: Self-asserted source
Nicole Bertoletti

YSM Safety & Security Committee: New Haven, CT, US

2022 to present | Nominated Member
Service
Source: Self-asserted source
Nicole Bertoletti

American Association For Cancer Research: Philadelphia, Pennsylvania, US

2018 to present
Membership
Source: Self-asserted source
Nicole Bertoletti

Deutsche Pharmazeutische Gesellschaft e.V.: Frankfurt, DE

2018 to 2019-12
Membership
Source: Self-asserted source
Nicole Bertoletti

Works (15)

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

Proceedings of the National Academy of Sciences
2023-03-28 | Journal article
Contributors: Stefan G. Krimmer; Nicole Bertoletti; Yoshihisa Suzuki; Luka Katic; Jyotidarsini Mohanty; Sheng Shu; Sangwon Lee; Irit Lax; Wei Mi; Joseph Schlessinger
Source: check_circle
Crossref

Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel “Achilles heel” for therapeutic intervention

2022-09-08 | Preprint
Contributors: Stefan G. Krimmer; Nicole Bertoletti; Yoshihisa Suzuki; Luka Katic; Jyotidarsini Mohanty; Sheng Shu; Sangwon Lee; Irit Lax; Wei Mi; Joseph Schlessinger
Source: check_circle
Crossref

Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase

Frontiers in Molecular Biosciences
2022-02-14 | Journal article
Part of ISSN: 2296-889X
Source: Self-asserted source
Nicole Bertoletti

Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead

ACS Medicinal Chemistry Letters
2021-02-11 | Journal article
Contributors: Joseph A. Ippolito; Haichan Niu; Nicole Bertoletti; Zachary J. Carter; Shengyan Jin; Krasimir A. Spasov; José A. Cisneros; Margarita Valhondo; Kara J. Cutrona; Karen S. Anderson et al.
Source: check_circle
Crossref

Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance

Molecules
2020-10-21 | Journal article
Contributors: Nicole Bertoletti; Albert H. Chan; Raymond F. Schinazi; Karen S. Anderson
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Structure-Guided Identification of DNMT3B Inhibitors

ACS Medicinal Chemistry Letters
2020-05-14 | Journal article
Contributors: Ana S. Newton; John C. Faver; Goran Micevic; Viswanathan Muthusamy; Shalley N. Kudalkar; Nicole Bertoletti; Karen S. Anderson; Marcus W. Bosenberg; William L. Jorgensen
Source: check_circle
Crossref

Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine

Protein Science
2019-09 | Journal article
Contributors: Nicole Bertoletti; Albert H. Chan; Raymond F. Schinazi; Y. Whitney Yin; Karen S. Anderson
Source: check_circle
Crossref

Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV

Antiviral Research
2019-07 | Journal article
Part of ISSN: 0166-3542
Source: Self-asserted source
Nicole Bertoletti

Mutational and structural studies uncover crucial amino acids determining activity and stability of 17β-HSD14

The Journal of Steroid Biochemistry and Molecular Biology
2019-05 | Journal article
Contributors: Mohammed J. Badran; Nicole Bertoletti; Aline Keils; Andreas Heine; Gerhard Klebe; Sandrine Marchais-Oberwinkler
Source: check_circle
Crossref

DRONE: Direct Tracking of DNA Cytidine Deamination and Other DNA Modifying Activities

Analytical Chemistry
2018-09 | Journal article
Part of ISSN: 0003-2700
Contributors: Tomoaki Sasaki; Shalley N. Kudalkar; Nicole Bertoletti; Karen S. Anderson
Source: Self-asserted source
Nicole Bertoletti via Crossref Metadata Search
grade
Preferred source (of 2)‎

Structure-based design and profiling of novel 17β-HSD14 inhibitors

European Journal of Medicinal Chemistry
2018-07 | Journal article
Part of ISSN: 0223-5234
Contributors: Florian Braun; Nicole Bertoletti; Gabriele Möller; Jerzy Adamski; Martin Frotscher; Nathalie Guragossian; Patrícia Alexandra Madeira Gírio; Marc Le Borgne; Laurent Ettouati; Pierre Falson et al.
Source: Self-asserted source
Nicole Bertoletti via Crossref Metadata Search
grade
Preferred source (of 2)‎

Validation of a 96-fragment library for crystallographic screening

Acta Crystallographica Section A Foundations and Advances
2017-12-01 | Journal article
Part of ISSN: 2053-2733
Source: Self-asserted source
Nicole Bertoletti

X-ray crystallography: essential tool for protein characterization and ligand optimization

Acta Crystallographica Section A Foundations and Advances
2017-12-01 | Journal article
Part of ISSN: 2053-2733
Source: Self-asserted source
Nicole Bertoletti

First Structure–Activity Relationship of 17β-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme

Journal of Medicinal Chemistry
2016-11 | Journal article
Part of ISSN: 0022-2623
Contributors: Florian Braun; Nicole Bertoletti; Gabriele Möller; Jerzy Adamski; Torsten Steinmetzer; Mohamed Salah; Ahmed S. Abdelsamie; Chris J. van Koppen; Andreas Heine; Gerhard Klebe et al.
Source: Self-asserted source
Nicole Bertoletti via Crossref Metadata Search

New Insights into Human 17β-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor

Journal of Medicinal Chemistry
2016-07 | Journal article
Part of ISSN: 0022-2623
Contributors: Nicole Bertoletti; Florian Braun; Mahalia Lepage; Gabriele Möller; Jerzy Adamski; Andreas Heine; Gerhard Klebe; Sandrine Marchais-Oberwinkler
Source: Self-asserted source
Nicole Bertoletti via Crossref Metadata Search

Peer review (4 reviews for 2 publications/grants)

Review activity for European journal of medicinal chemistry. (3)
Review activity for Nature communications (1)