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Asthma, Allergy, Birth cohort
United Kingdom

Biography

Adnan Custovic leads the Paediatric Allergy Group within the Centre for Paediatrics and Child Health at Imperial College London and is Honorary Consultant in Paediatric Allergy at St. Mary’s Hospital and Royal Brompton Hospital.

His professional training consisted of Specialist training in Paediatrics (University Children’s Hospital Sarajevo, 1987-91) and successive appointments as Clinical Research Fellow and Specialist Registrar in Allergy (University Hospital of South Manchester, 1992-98). This period saw him awarded M.Sc. (1991), M.D. with Gold Medal (1996) and Ph.D. (2000). Subsequent to completing his clinical specialist training, he obtained the Asthma UK Senior Research Fellowship. He was promoted to a position of Reader at the University of Manchester in 2000, which was followed by a professorship in 2002. He was a Professor of Allergy at the University of Manchester until September 2015, where he served as a Centre Lead for Respiratory Medicine in the Institute of Translational Medicine.

His research has focused upon the origins and natural history of asthma and allergy across the life-course, with an emphasis on prevention and translation for patient benefit. His research findings are of great practical significance, and have informed and changed national and international guidelines on asthma prevention and management. His studies in food allergy substantially impacted clinical practice. His discovery that IgE-response to peanut allergen Ara h 2 is much more predictive of true peanut allergy than standard tests using whole allergen extract marked the start of the component-resolved diagnostics as the new gold standard in clinical practice.

He pioneered the use of data-driven methodologies in the analysis of complex data, including the first use of machine learning in respiratory medicine/allergy. To gain more from birth cohorts across the UK, he led a multidisciplinary MRC-funded STELAR consortium, combining the world-leading expertise in birth cohorts with statistical machine learning and health informatics. This effort enabled the discovery of latent subtypes of childhood asthma, allergies, and developmental patterns of lung function from pre-school age to early adulthood. He currently leads MRC UNICORN programme which integrates birth cohorts with patient cohorts and randomised controlled trials for joint analyses, offering opportunity for a step change in understanding mechanisms underlying different asthma endotypes.

In 2020, he was elected to the Fellowship of the UK Academy of Medical Sciences. In 2019, he was granted membership of the Academy of Sciences and Arts of Bosnia and Herzegovina (ANUBiH). In 2015, he received a highly prestigious European Respiratory Society Gold Medal in Asthma, which is awarded to a researcher who has made an outstanding contribution in the field of asthma research. In 2013 he received the BSACI William Frankland Medal for outstanding contributions to clinical allergy in the UK.

He serves as the Associate Editor of the American Journal of Respiratory and Critical Care Medicine, and on the International Advisory Board of the Lancet Child and Adolescent Health. He has served as a Secretary of the British Society of Allergy and Clinical Immunology for two terms, and as President of Asthma section of the European Academy of Allergy and Clinical Immunology. He is a member of the UKRI Future Leaders Fellowships PRC and the MRC PSMB.

Professor Custovic has supervised 18 PhD/MD students to completion. He has delivered numerous prestigious named lectures. He holds honorary professorships, both home (Manchester) and abroad (Cape Town, Singapore, Zagreb).

Activities

Employment (9)

Royal Brompton & Harefield NHS Foundation Trust: London, GB

2017-12-01 to present | Honorary Consultant Paediatric Allergist
Employment
Source: Self-asserted source
Adnan Custovic

Imperial College London: London, London, GB

2015-09-15 to present | Professor of Paediatric Allergy (National Heart and Lung Institute)
Employment
Source: Self-asserted source
Adnan Custovic

Imperial College Healthcare NHS Trust: London, GB

2015-09-15 to present | Honorary Consultant Paediatric Allergist
Employment
Source: Self-asserted source
Adnan Custovic

University of Manchester: Manchester, Manchester, GB

2002-06-01 to 2015-09-14 | Professor of Allergy (Respiratory Medicine and |Allergy)
Employment
Source: Self-asserted source
Adnan Custovic

University Hospital of South Manchester NHS Foundation Trust: Manchester, Manchester, GB

1998-06-01 to 2015-09-14 | Honorary Consultant Allergist (Respiratory Medicine)
Employment
Source: Self-asserted source
Adnan Custovic

University of Manchester: Manchester, Manchester, GB

2000-01-01 to 2002-05-31 | Reader in Respiratory Medicine and Allergy (Respiraroty Medicine and Allergy)
Employment
Source: Self-asserted source
Adnan Custovic

Wythenshawe Hospital: Manchester, Manchester, GB

1995-05-31 to 1998 | Specialist registrar in Allergy (Respiratory Medicine)
Employment
Source: Self-asserted source
Adnan Custovic

Wythenshawe Hospital: Manchester, Manchester, GB

1992-01-15 to 1994-12-31 | Research registrar (Paediatrics/Respiratory)
Employment
Source: Self-asserted source
Adnan Custovic

University Children's Hospital: Sarajevo, BA

1988-01-01 to 1991-12-31 | Specialist training in paediatrics
Employment
Source: Self-asserted source
Adnan Custovic

Education and qualifications (4)

University of Manchester: Manchester, Manchester, GB

1996 to 2000 | PhD
Education
Source: Self-asserted source
Adnan Custovic

University of Manchester: Manchester, Manchester, GB

1992 to 1995 | MD
Education
Source: Self-asserted source
Adnan Custovic

University of Sarajevo: Sarajevo, BA

1988 to 1991 | MSc
Education
Source: Self-asserted source
Adnan Custovic

University of Sarajevo: Sarajevo, BA

1979 to 1985 | Dr Med
Education
Source: Self-asserted source
Adnan Custovic

Professional activities (4)

University of Cape Town: Rondebosch, Western Cape, ZA

2018-01-01 to present | Honorary Professor (Department of Paediatrics and Child Health)
Invited position
Source: Self-asserted source
Adnan Custovic

University of Manchester: Manchester, Greater Manchester, GB

2015-09-15 to present | Honorary Professor (Division of Informatics, Imaging and Data Sciences)
Invited position
Source: Self-asserted source
Adnan Custovic

University of Zagreb: Zagreb, Grad Zagreb, HR

2008-09-01 to present | Visiting Professor (School of Medicine)
Invited position
Source: Self-asserted source
Adnan Custovic

National University of Singapore: Singapore, SG

2018-08-01 to 2018-08-31 | Visiting Wong Hock Boon Professor in Paediatrics (Department of Paediatrics and Child Health)
Invited position
Source: Self-asserted source
Adnan Custovic

Funding (8)

Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?.

2019-03-19 to 2021-09-19 | Grant
Wellcome Trust (London, GB)
GRANT_NUMBER:

108818/Z/15/B

Source: Self-asserted source
Adnan Custovic via DimensionsWizard

Lung function trajectories from birth to school age in African children, and their early life determinants

2018-09-30 to 2021-09-29 | Grant
Medical Research Council (London, GB)
GRANT_NUMBER: MR/S002359/1
Source: Self-asserted source
Adnan Custovic via DimensionsWizard

Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?.

2016-09-19 to 2021-09-19 | Grant
Wellcome Trust (London, GB)
GRANT_NUMBER:

108818/Z/15/Z

Source: Self-asserted source
Adnan Custovic via DimensionsWizard

Asthma UK Centre for Applied Research

2013-10 to 2017-10 | Award
Asthma UK (London, GB)
Source: Self-asserted source
Adnan Custovic

Integrated Approaches to Food Allergen and Allergy Risk Management (iFAM)

2013-03 to 2017-03 | Grant
European Commission Directorate-General for Research and Innovation (Brussels, BE)
Source: Self-asserted source
Adnan Custovic

The Asthma UK Manchester Asthma and Allergy Study: Risk Factors for the Development of Asthma and Primary Prevention by Environmental Control

2004-10-01 to 2007-09-30 | Grant
Asthma UK (London, GB)
GRANT_NUMBER:

ASTHMA04/014

Source: Self-asserted source
Adnan Custovic via DimensionsWizard

The Asthma UK Manchester Asthma and Allergy Study: Primary prevention of asthma by allergen avoidance in high risk infants

2001-10-01 to 2004-09-30 | Grant
Asthma UK (London, GB)
GRANT_NUMBER:

ASTHMA01/012

Source: Self-asserted source
Adnan Custovic via DimensionsWizard

Gene-environment interaction in the development of atopy, asthma and other allergic diseases

2000-01-01 to 2004-12-31 | Grant
Asthma UK (London, GB)
GRANT_NUMBER:

ASTHMARF01C

Source: Self-asserted source
Adnan Custovic via DimensionsWizard

Peer review (30 reviews for 9 publications/grants)

Review activity for Allergy. (2)
Review activity for British journal of dermatology (1)
Review activity for Clinical and experimental allergy. (4)
Review activity for European respiratory journal. (1)
Review activity for Journal of allergy and clinical immunology. (2)
Review activity for Pediatric allergy and immunology. (14)
Review activity for The journal of allergy and clinical immunology (3)
Review activity for The Lancet. (1)
Review activity for Thorax (2)