Personal information

No personal information available

Activities

Works (31)

Structure-Based Discovery of MolPort-137: A Novel Autotaxin Inhibitor That Improves Paclitaxel Efficacy

International Journal of Molecular Sciences
2025-01-12 | Journal article
Contributors: Prateek Rai; Christopher J. Clark; Vandana Kardam; Carl B. Womack; Joshua Thammathong; Derek D. Norman; Gábor J. Tigyi; Kevin Bicker; April M. Weissmiller; Kshatresh Dutta Dubey et al.
Source: check_circle
Crossref

Novel Autotaxin Inhibitor ATX-1d Significantly Enhances Potency of Paclitaxel—An In Silico and In Vitro Study

Molecules
2024-09-10 | Journal article
Contributors: Prateek Rai; Christopher J. Clark; Carl B. Womack; Curtis Dearing; Joshua Thammathong; Derek D. Norman; Gábor J. Tigyi; Subhabrata Sen; Kevin Bicker; April M. Weissmiller et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Establishing Three-Dimensional Explant Culture of Human Dental Pulp Tissue

International Journal of Stem Cells
2024-08-30 | Journal article
Contributors: Eun Jin Seo; Soyoung Park; Eungyung Lee; Yang Hoon Huh; Ye Eun Ha; Gabor J. Tigyi; Taesung Jeong; Il Ho Jang; Jonghyun Shin
Source: check_circle
Crossref

LPA-Induced Thromboxane A2-Mediated Vasoconstriction Is Limited to Poly-Unsaturated Molecular Species in Mouse Aortas

International Journal of Molecular Sciences
2024-06-22 | Journal article
Contributors: Krisztina Vén; Balázs Besztercei; Anna Janovicz; Noémi Karsai; Jerold Chun; Gábor Tigyi; Zoltán Benyó; Éva Ruisanchez
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling.

Experimental biology and medicine (Maywood, N.J.)
2023-10-14 | Journal article
Contributors: A Janovicz; A Majer; M Kosztelnik; M Geiszt; S Ishii; Z Benyó; É Ruisanchez
Source: check_circle
UTHSC - Digital Measures
grade
Preferred source (of 2)‎

E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas

The FASEB Journal
2023-07 | Journal article
Contributors: Kuan‐Hung Lin; Sue Chin Lee; Mélanie A. Dacheux; Derek D. Norman; Andrea Balogh; Mitul Bavaria; Hsinyu Lee; Gabor Tigyi
Source: check_circle
Crossref

Lysophosphatidic acid induces proliferation and osteogenic differentiation of human dental pulp stem cell through lysophosphatidic acid receptor 3/extracellular signal-regulated kinase signaling axis.

Journal of dental sciences
2023-07-01 | Journal article
Contributors: S Heo; B Keum; E Seo; J Yoon; S Jeong; D Norman; I Jang; H Kim
Source: check_circle
UTHSC - Digital Measures

Enhancement of Sphingomyelinase-Induced Endothelial Nitric Oxide Synthase-Mediated Vasorelaxation in a Murine Model of Type 2 Diabetes

International Journal of Molecular Sciences
2023-05-06 | Journal article
Contributors: Éva Ruisanchez; Anna Janovicz; Rita Cecília Panta; Levente Kiss; Adrienn Párkányi; Zsuzsa Straky; Dávid Korda; Károly Liliom; Gábor Tigyi; Zoltán Benyó
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer.

Pharmacology & therapeutics
2023-05-01 | Journal article
Contributors: M Dacheux; D Norman
Source: check_circle
UTHSC - Digital Measures

Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis

Molecules
2022-08 | Journal article
Contributors: Gabor Tigyi
Source: check_circle
UTHSC - Digital Measures
grade
Preferred source (of 3)‎

Prometastatic Effect of ATX Derived from Alveolar Type II Pneumocytes and B16-F10 Melanoma Cells

Cancers
2022-03 | Journal article
Contributors: Gabor Tigyi
Source: check_circle
UTHSC - Digital Measures
grade
Preferred source (of 3)‎

Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors

Bioorg.Chem.
2021-10 | Journal article
Contributors: Gabor Tigyi
Source: check_circle
UTHSC - Digital Measures

A Luminacin D Analog HL142 Inhibits Ovarian Tumor Growth and Metastasis by Reversing EMT and Attenuating the TGFβ and FAK Pathways.

Journal of Cancer
2021-07-25 | Journal article
Contributors: B Wang; H Li ; X Zhao; G Zhao; P Dong; H Watari; W Li
Source: check_circle
UTHSC - Digital Measures

Luminacin D Analog HL142 Inhibits Ovarian Tumor Growth and Metastasis by Reversing EMT and Attenuating the TGFβ and FAK Pathways

J Cancer
2021-07-25 | Journal article
Contributors: Gabor Tigyi
Source: check_circle
UTHSC - Digital Measures
grade
Preferred source (of 2)‎

Correction to: Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?

Cancer metastasis reviews
2021-04-16 | Other
Contributors: M Dacheux; K Lin; D Norman; Z Benyó
Source: check_circle
UTHSC - Digital Measures

EIF5A2 controls ovarian tumor growth and metastasis by promoting epithelial to mesenchymal transition via the TGFβ pathway.

Cell & bioscience
2021-04-07 | Journal article
Contributors: G Zhao; P Dong; H Watari
Source: check_circle
UTHSC - Digital Measures

Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?

Cancer metastasis reviews
2021-03-01 | Other
Contributors: M Dacheux; K Lin; D Norman; Z Benyó
Source: check_circle
UTHSC - Digital Measures

Evaluation of In-cage Filter Paper as a Replacement for Sentinel Mice in the Detection of Murine Pathogens.

Journal of the American Association for Laboratory Animal Science : JAALAS
2021-03-01 | Journal article
Contributors: K O'Connell; R Livingston; D Johnson
Source: check_circle
UTHSC - Digital Measures

Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment.

Cellular signalling
2021-02-01 | Journal article
Contributors: K Lin; A Balogh; D Norman; M Bavaria; B Kuo; L Balázs; Z Benyó
Source: check_circle
UTHSC - Digital Measures

Opposing Roles of S1P3 Receptors in Myocardial Function

Cells
2020-07-24 | Journal article
Contributors: Dina Wafa; Nóra Koch; Janka Kovács; Margit Kerék; Richard L. Proia; Gábor J. Tigyi; Zoltán Benyó; Zsuzsanna Miklós
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Regulation of Tumor Immunity by Lysophosphatidic Acid

Cancers
2020-05-10 | Journal article
Contributors: Sue Chin Lee; Mélanie A. Dacheux; Derek D. Norman; Louisa Balázs; Raul M. Torres; Corinne E. Augelli-Szafran; Gábor J. Tigyi
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Osteoclast-Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss

Arthritis and Rheumatology
2019-11-01 | Journal article
Contributors: Sacha Flammier; Olivier Peyruchaud; Fanny Bourguillault; François Duboeuf; Jean Davignon; Derek Norman; Sylvie Isaac; Hubert Marotte; Irma Machuca-Gayet; Fabienne Coury
Source: check_circle
UTHSC - Digital Measures

Optical control of sphingosine-1-phosphate formation and function

Nature Chemical Biology
2019-06-01 | Journal article
Contributors: Johannes Morstein; Rose Hill; Alexander Novak; Suihan Feng; Derek Norman; Prashant Donthamsetti; James Frank; Takeshi Harayama; Benjamin Williams; Abby Parrill et al.
Source: check_circle
UTHSC - Digital Measures

LPA<inf>5</inf> is an inhibitory receptor that suppresses CD8 T-cell cytotoxic function via disruption of early TCR signaling

Frontiers in Immunology
2019-01-01 | Journal article
Contributors: Divij Mathew; Kimberly Kremer; Pamela Strauch; Roberta Pelanda; Raul Torres
Source: check_circle
UTHSC - Digital Measures

Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential

Journal of Lipid Research
2019-01-01 | Other
Contributors: Derek Norman; Erzsebet Szabo; Andrea Balogh; Karin Thompson; Alyssa Boler; W. Shannon McCool
Source: check_circle
UTHSC - Digital Measures

Regulation of tumor cell – Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis

2019-01-01 | Other
Contributors: Derek Norman; Erzsebet Szabo; Andrea Balogh; Guannan Zhao
Source: check_circle
UTHSC - Digital Measures

The LPA<inf>2</inf> receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids

Cellular Signalling
2018-11-01 | Journal article
Contributors: Bryan Kuo; Erzsébet Szabó; Andrea Balogh; Derek Norman; Asuka Inoue; Yuki Ono; Junken Aoki; Gábor Tigyi
Source: check_circle
UTHSC - Digital Measures
grade
Preferred source (of 2)‎

Prevention and treatment of secretory diarrhea by the lysophosphatidic acid analog Rx100

Experimental Biology and Medicine
2018-09-01 | Journal article
Contributors: Karin Thompson; Ramesh Ray; Shanta Alli; Wenbo Ge; Alyssa Boler; W. Shannon McCool; Pradeep Shukla; Radakrishna Rao
Source: check_circle
UTHSC - Digital Measures

Role of autotaxin in cancer stem cells

Cancer and Metastasis Reviews
2018-09-01 | Journal article
Contributors: Dongjun Lee; Dong Suh; Jae Kim
Source: check_circle
UTHSC - Digital Measures

Lysophospholipid Receptors

Reference Module in Biomedical Research,
2018-01 | Book chapter
DOI:

https://doi.org/10. 1016/ B9780128012383. 111365

Contributors: Gabor Tigyi
Source: check_circle
UTHSC - Digital Measures

Adipose-Derived Stem Cells Facilitate Ovarian Tumor Growth and Metastasis by Promoting Epithelial to Mesenchymal Transition Through Activating the TGF-β Pathway.

Front Oncol.
Journal article
Contributors: Gabor Tigyi
Source: check_circle
UTHSC - Digital Measures

Peer review (4 reviews for 3 publications/grants)

Review activity for Biochimica and biophysica acta. (1)
Review activity for Biochimica et biophysica acta. (2)
Review activity for Journal of affective disorders. (1)