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Biography

James joined KEMRI-Wellcome Trust Research Program (KWTRP) in 2018 as a joint fellow between KWTRP and the Pirbright Institute, UK. At the Pirbright Institute, his research was focused on setting up a platform for foot and mouth disease, capsid specific single bovine B-cell sorting, B- cell sequencing, antibody expression and functionality assays in Prof. John Hammonds lab. In 2019 he came back to Prof. George Warimwe’s group and focussed on studying arboviruses including Rift Valley fever, Chikungunya and dengue, designing constructs for vaccine development and serological assays development to study these viruses. He is also the biosafety officer in the Programme. James studied BSc Biochemistry degree from Kenyatta University, Kenya. He then went to Wageningen University and Research centre (WUR), the Netherlands where he studied a MSc in Molecular life science (Biomedical research). His PhD research conducted at the International Livestock Research Institute (ILRI), Kenya and WUR focused on identification of novel Theileria parva antigens for development of a subunit vaccine for control of East Coast fever in Africa.
James is interested in developing serological tools to improve infectious diseases diagnosis and surveillance and constructs for vaccine development.

Activities

Employment (1)

Centre for Geographic Medicine Research Coast: Kilifi, KE

2018-01-03 to present | Mid-career researcher (Bioscience)
Employment
Source: Self-asserted source
James Nyagwange

Education and qualifications (2)

Wageningen University & Research: Wageningen, NL

2014-05-01 to 2019-05-14 | PhD (CBI)
Qualification
Source: Self-asserted source
James Nyagwange

International Livestock Research Institute: Nairobi, Nairobi, KE

2014-05-01 to 2017-12-31 | PhD (AHH)
Qualification
Source: Self-asserted source
James Nyagwange

Funding (3)

G2P – Global Knowledge Exchange to Enable In Country Risk Assessment of SARS CoV-2 Variants

2023-02 to 2026-01 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
James Nyagwange

Platform for rapid immunological characterization of SARS CoV-2 variants in Kenya and the Eastern Africa Region

2023-01 to 2026-01 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
James Nyagwange

Kenya multi-site serosurveillance for SARS-CoV-2 and other pathogens

2021-12 to 2023-11 | Grant
Bill & Melinda Gates Foundation (Seattle, Washington, US)
Source: Self-asserted source
James Nyagwange

Works (24)

Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study

Wellcome Open Research
2024-12-02 | Journal article
Contributors: John Kimotho; Yiakon Sein; Shahin Sayed; Reena Shah; Kennedy Mwai; Mansoor Saleh; Perpetual Wanjiku; Jedidah Mwacharo; James Nyagwange; Henry Karanja et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Comparative performance of the InBios SCoV-2 DetectTM IgG ELISA and the in-house KWTRP ELISA in detecting SARS-CoV-2 spike IgG antibodies in Kenyan populations [version 1; peer review: 2 approved with reservations]

2024-06-28 | Journal article
Part of ISSN: 2398-502X
Funded by GRANT_NUMBER:

203077

Funded by GRANT_NUMBER:

214320

Funded by GRANT_NUMBER:

220991

Funded by GRANT_NUMBER: INV-039626
Contributors: Bernadette Kutima; Eunice Wageci Kagucia; Kennedy Mwai; Makobu Kimani; Antipa Sigilai; Daisy Mugo; Henry Karanja; John N Gitonga; Angela Karani; Donald Akech et al.
Source: check_circle
Wellcome Open Research

Emergence and predominance of novel influenza A (H3N2) subclade (3C.2a1b.2a.2a.3a.1) in Kenya and globally in 2023

2023-12-17 | Preprint
Contributors: John Mwita Morobe; Edidah Moraa; Arnold W. Lambisia; Martin Mutunga; Brenda Kiage; Esther Nyadzua Katama; Timothy Makori; Joyce Nyiro; Leonard Ndwiga; James Nyagwange et al.
Source: check_circle
Crossref

Safety and immunogenicity of ChAdOx1 nCoV-19 (AZD1222) vaccine in adults in Kenya: a phase 1/2 single-blind, randomised controlled trial [version 2; peer review: 3 approved]

2023-11-27 | Journal article
Part of ISSN: 2398-502X
Funded by GRANT_NUMBER: 203077
Funded by GRANT_NUMBER: 220991
Funded by GRANT_NUMBER: 971614
Contributors: Mainga Hamaluba; Samuel Sang; Benedict Orindi; Irene Njau; Henry Karanja; Naomi Kamau; John N. Gitonga; Daisy Mugo; Daniel Wright; James Nyagwange et al.
Source: check_circle
Wellcome Open Research
grade
Preferred source (of 2)‎

Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study

Wellcome Open Research
2023-08-17 | Journal article
Contributors: John Kimotho; Yiakon Sein; Shahin Sayed; Reena Shah; Kennedy Mwai; Mansoor Saleh; Perpetual Wanjiku; Jedidah Mwacharo; James Nyagwange; Henry Karanja et al.
Source: check_circle
Crossref

Metagenomic analysis of coastal Kenya female Aedes aegypti mosquito RNA metaviromes reveal presence of diverse insect specific viruses [version 2; peer review: 1 approved, 1 approved with reservations]

2023-08-16 | Journal article
Part of ISSN: 2398-502X
Funded by GRANT_NUMBER: 203077_Z_16_Z
Funded by GRANT_NUMBER:

MC_PC_15092

Contributors: Donwilliams O. Omuoyo; Doris K. Nyamwaya; Everlyn Kamau; James N. Nyagwange; Henry K. Karanja; John N. Gitonga; Zaydah de Laurent; Jonathan C. Ngala; Johnson Kinyua; Martin K. Rono et al.
Source: check_circle
Wellcome Open Research
grade
Preferred source (of 2)‎

A Customizable Suite of Methods to Sequence and Annotate Cattle Antibodies

Vaccines
2023-06-14 | Journal article
Contributors: Kristel Ramirez Valdez; Benjamin Nzau; Daniel Dorey-Robinson; Michael Jarman; James Nyagwange; John C. Schwartz; Graham Freimanis; Angela W. Steyn; George M. Warimwe; Liam J. Morrison et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Safety and immunogenicity of ChAdOx1 nCoV-19 (AZD1222) vaccine in adults in Kenya: a phase 1/2 single-blind, randomised controlled trial

Wellcome Open Research
2023-04-24 | Journal article
Contributors: Mainga Hamaluba; Samuel Sang; Benedict Orindi; Irene Njau; Henry Karanja; Naomi Kamau; John N. Gitonga; Daisy Mugo; Daniel Wright; James Nyagwange et al.
Source: check_circle
Crossref

Metagenomic analysis of coastal Kenya female Aedes aegypti mosquito RNA metaviromes reveal presence of diverse insect specific viruses

Wellcome Open Research
2023-03-23 | Journal article
Contributors: Donwilliams O. Omuoyo; Doris K. Nyamwaya; Everlyn Kamau; James N. Nyagwange; Henry K. Karanja; John N. Gitonga; Zaydah de Laurent; Jonathan C. Ngala; Johnson Kinyua; Martin K. Rono et al.
Source: check_circle
Crossref

Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2022-12-05 | Journal article
Contributors: Nyagwange J; Kutima B; Kennedy Mwai; 0000-0002-8249-6833; Gitonga JN; Mugo D; Yiakon Sein; Wright D; Omuoyo DO; Nyiro JU et al.
Source: Self-asserted source
James Nyagwange
grade
Preferred source (of 2)‎

Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020-21.

PloS one
2022-10-14 | Journal article
Contributors: Ruth K Lucinde; Mugo D; Christian Bottomley; Karani A; Gardiner E; Rabia AZIZA; Gitonga JN; Karanja H; Nyagwange J; Tuju J et al.
Source: Self-asserted source
James Nyagwange

SARS-CoV-2 seroprevalence in three Kenyan health and demographic surveillance sites, December 2020-May 2021.

PLOS global public health
2022-08-18 | Journal article | Author
Contributors: Anthony Etyang; Ifedayo Adetifa; Richard Omore; Misore T; Abdhalah Ziraba; Maurine Ng'oda; Evelyn Gitau; Gitonga J; Mugo D; Bernadette Ataku et al.
Source: Self-asserted source
James Nyagwange

Epidemiology of COVID-19 infections on routine polymerase chain reaction (PCR) and serology testing in Coastal Kenya.

Wellcome open research
2022-02-23 | Journal article | Author
Contributors: James Nyagwange; Leonard Ndwiga; Kelvin Muteru Kimenyi; Kevin Wamae; Tuju J; Testing Team C; Kutima B; John Gitonga; 0000-0002-8249-6833; Mugo D et al.
Source: Self-asserted source
James Nyagwange
grade
Preferred source (of 2)‎

Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2022-01-01 | Journal article
Contributors: Anthony Etyang; Ruth K Lucinde; Karanja H; Kalu C; Mugo D; Nyagwange J; Gitonga J; Tuju J; Wanjiku P; Karani A et al.
Source: Self-asserted source
James Nyagwange

Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
2021-12-27 | Journal article
Contributors: Nyagwange J; Kutima B; Kennedy Mwai; Karanja HK; Gitonga JN; Mugo D; Uyoga S; Tuju J; Lynette Ochola-Oyier; Ndungu F et al.
Source: Self-asserted source
James Nyagwange

Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels.

Nature communications
2021-10-26 | Journal article
Contributors: Christian Bottomley; Mark Otiende; Sophie Uyoga; Katherine Gallagher; Wangeci Kagucia; Etyang AO; Mugo D; Gitonga J; Karanja H; Nyagwange J et al.
Source: Self-asserted source
James Nyagwange

COVID-19 transmission dynamics underlying epidemic waves in Kenya.

Science (New York, N.Y.)
2021-10-07 | Journal article | Author
Contributors: Samuel Brand; John Ojal; Rabia AZIZA; Vincent Were; Emelda Okiro; Ivy Kombe; Caroline Mburu; morris ogero; Ambrose Agweyu; George Warimwe et al.
Source: Self-asserted source
James Nyagwange

Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya.

Nature communications
2021-06-25 | Journal article
Contributors: Ifedayo Adetifa; Sophie Uyoga; Gitonga JN; Mugo D; Mark Otiende; Nyagwange J; Karanja HK; Tuju J; Wanjiku P; Aman R et al.
Source: Self-asserted source
James Nyagwange

Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immunoglobulin G Antibody Seroprevalence Among Truck Drivers and Assistants in Kenya.

Open forum infectious diseases
2021-06-12 | Journal article
Contributors: Wangeci Kagucia; Gitonga JN; Kalu C; Ochomo E; Ochieng B; Kuya N; Karani A; Nyagwange J; Karia B; Mugo D et al.
Source: Self-asserted source
James Nyagwange

Synergistic Effect of Two Nanotechnologies Enhances the Protective Capacity of the <i>Theileria parva</i> Sporozoite p67C Antigen in Cattle.

Journal of immunology (Baltimore, Md. : 1950)
2021-01-08 | Journal article | Author
Contributors: Anna Lacasta; Karishma Mody; De Goeyse I; Chengzhong Yu; Zhang J; James Nyagwange; Mwalimu S; Elias Awino; Saya R; Njoroge T et al.
Source: Self-asserted source
James Nyagwange
grade
Preferred source (of 2)‎

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors.

Science (New York, N.Y.)
2020-11-11 | Journal article | Author
Contributors: Sophie Uyoga; Ifedayo Adetifa; 0000-0002-8249-6833; James Nyagwange; James Tuju; perpetual Wanjiku; Aman R; Mwangangi M; Amoth P; George Kasera et al.
Source: Self-asserted source
James Nyagwange
grade
Preferred source (of 2)‎

Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever.

International journal for parasitology. Drugs and drug resistance
2019-01-25 | Journal article
Contributors: Nyagwange J; Awino E; Edwin Tijhaar; Nicholas Svitek; Pelle R; Vishvanath Nene
Source: Self-asserted source
James Nyagwange

Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro.

Veterinary immunology and immunopathology
2018-03-12 | Journal article
Contributors: Nyagwange J; Vishvanath Nene; Mwalimu S; Sonal P Henson; Lucilla Steinaa; Nzau B; Tijhaar E; Pelle R
Source: Self-asserted source
James Nyagwange

Characterization of the Theileria parva sporozoite proteome.

International journal for parasitology
2017-12-16 | Journal article
Contributors: Nyagwange J; Tijhaar E; Nicola Ternette; Fredrick M Mobegi; Tretina K; Silva JC; Pelle R; Vishvanath Nene
Source: Self-asserted source
James Nyagwange