Ammasi Periasamy

Biography

Dr. Periasamy is an internationally recognized expert in the development of advanced microscopy techniques for single cellular imaging and analysis in living cells, tissue, and animal. A key area of Dr. Periasamy’s research is focused on the design and development of optical methodologies to investigate/monitor exogenous and endogenous molecular interactions. His group has recently developed a FLIRR (Fluorescence Lifetime Redox Ratio) to investigate metabolism and mitochondrial dysfunction in cancer cells and tissues. The main goal of the project is to monitor the early detection of prostate cancer (PCa) and correlate with PSA. The clinical sample tests were encouraging.
Dr. Periasamy is one of the pioneers in the development of fluorescence lifetime imaging microscopy (FLIM) for measuring the oscillations in cytosolic and nuclear free calcium in single intact living cells. His group has developed a 2- and 3-color steady state, confocal, multiphoton, and FLIM based Förster resonance energy transfer (FRET) imaging systems for protein localization in living specimens. He has published more than 185 articles in refereed journals, book chapters and proceedings. He has more than 200 invited lectures nationally and internationally. Dr. Periasamy has edited three books, series book editor on cellular and clinical imaging (11 books), Chairperson in organizing an annual international conference on Multiphoton Microscopy in the Biomedical Sciences through SPIE (since 2001) and runs a hands-on training annual workshop on FLIM, FRET and metabolic imaging Microscopy at the University of Virginia, Charlottesville, during March (since 2002). Dr. Periasamy was elected “Fellow” member of the SPIE Optical Society in 2012.