Personal information

mass spectrometry, CNS protein metabolism, muscle physiology, cardio-metabolic complications

Biography

For 35+ years, Dr. Yarasheski's passion to conduct translational clinical research has focused on using various forms of chromatography-mass spectrometry to characterize and quantify biomolecules present in human biofluids and tissues, and that reveal underlying alterations in protein and amino acid metabolism that contribute to the pathogenesis of several conditions: unsuccessful aging, neurodegenerative disorders, infectious diseases, and cardiometabolic complications. For 29 of those years, Dr. Yarasheski was employed in the Department of Internal Medicine at Washington University School of Medicine where he rose to the rank of Full Professor, co-Directed the Biomedical Mass Spectrometry Research Facility, fully supported his independent mass spectrometry-based clinical research program, and collaborated with many investigators, institutions, and Foundations around the globe on their patient-oriented projects that required mass spectrometry analysis. In 2016, Dr. Yarasheski joined C2N Diagnostics as Senior Vice President where he directs and oversees all laboratory personnel and mass spectrometry research and discovery efforts focused on developing and validating fluid biomarkers for neurodegeneration and AD pathology. C2N Diagnostics' first commercially available mass spectrometry-based plasma diagnostic test for brain amyloid pathology was released in 2020; www.PrecivityAD.com.

Activities

Employment (6)

C2N Diagnostics (United States): St Louis, Missouri, US

2016-05-02 to present | Senior Vice President (Mass Spectrometry R & D)
Employment
Source: Self-asserted source
Kevin E Yarasheski

Washington University School of Medicine in St. Louis: Saint Louis, MO, US

2007-07-01 to 2016-05-01 | Full Professor (Internal Medicine)
Employment
Source: Self-asserted source
Kevin E Yarasheski

Washington University School of Medicine in St. Louis: Saint Louis, MO, US

1999-07-01 to 2007-06-30 | Associate Professor (Internal Medicine)
Employment
Source: Self-asserted source
Kevin E Yarasheski

Washington University School of Medicine in St. Louis: Saint Louis, MO, US

1995-07-01 to 1999-06-30 | Assistant Professor (Internal Medicine)
Employment
Source: Self-asserted source
Kevin E Yarasheski

Washington University School of Medicine in St. Louis: Saint Louis, MO, US

1993-07-01 to 1995-06-30 | Research Assistant Professor (Internal Medicine)
Employment
Source: Self-asserted source
Kevin E Yarasheski

Washington University School of Medicine in St. Louis: Saint Louis, MO, US

1989-07-01 to 1993-06-30 | Research Instructor in Medicine (Internal Medicine)
Employment
Source: Self-asserted source
Kevin E Yarasheski

Education and qualifications (1)

Washington University School of Medicine in St. Louis: Saint Louis, MO, US

1986-08-26 to 1989-06-30 | Post-Doctoral Research Fellow (Internal medicine)
Qualification
Source: Self-asserted source
Kevin E Yarasheski

Funding (8)

Characterizing the HIV-Muscle Mitochondrial Proteme

2005-09-30 to 2008-06-30 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: 5R21DK074345-02
Source: Self-asserted source
Kevin E Yarasheski via DimensionsWizard

Yoga for the Management of HIV-Metabolic Syndromes

2005-09-01 to 2009-06-30 | Grant
National Center for Complementary and Integrative Health (Bethesda, US)
GRANT_NUMBER: 5R21AT003083-03
Source: Self-asserted source
Kevin E Yarasheski via DimensionsWizard

Myocardial Function and FFA Metabolism in HIV Metabolic Syndrome

2000-09-15 to 2010-08-31 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: 5R01DK059531-09
Source: Self-asserted source
Kevin E Yarasheski via DimensionsWizard

MAGNETIC SECTOR GAS ISOTOPE RATIO MASS SPECTROMETER

1998-09-15 to 1999-09-14 | Grant
National Center for Research Resources (Bethesda, US)
GRANT_NUMBER: 1S10RR013063-01
Source: Self-asserted source
Kevin E Yarasheski via DimensionsWizard

MUSCLE AMINO ACID METABOLISM IN AIDS CACHEXIA

1998-05-15 to 2005-04-30 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: 5R01DK054163-05
Source: Self-asserted source
Kevin E Yarasheski via DimensionsWizard

EXERCISE AND PIOGLITAZONE FOR HIV CARDIOMETABOLIC SYNDROMES

1994-09-30 to 2012-06-30 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: 2R56DK049393-13A1
Source: Self-asserted source
Kevin E Yarasheski via DimensionsWizard

Exercise &Pioglitazone for HIV-Metabolic Syndromes

1994-09-30 to 2009-06-30 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: 5R01DK049393-12
Source: Self-asserted source
Kevin E Yarasheski via DimensionsWizard

ANABOLIC EFFECTS OF WEIGHT TRAINING AND GROWTH HORMONE

Source: Self-asserted source
Kevin E Yarasheski via DimensionsWizard

Works (50 of 276)

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Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam)

Plos One
2024 | Journal article
Contributors: Feldman, Howard H.; Luchsinger, Jose A.; Leger, Gabriel C.; Taylor, Curtis; Jacobs, Diane M.; Salmon, David P.; Edland, Steven D.; Messer, Karen; Revta, Carolyn; Flowers, Sarah A. et al.
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Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial

Alzheimer's & Dementia: The Journal of the Alzheimer's Association
2024 | Journal article
Contributors: Molina-Henry, Doris Patricia; Raman, Rema; Liu, Andy; Langford, Oliver; Johnson, Keith; Shum, Leona K.; Glover, Crystal M.; Dhadda, Shobha; Irizarry, Michael; Jimenez-Maggiora, Gustavo et al.
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The glymphatic system clears amyloid beta and tau from brain to plasma in humans

MedRxiv
2024 | Journal article
Contributors: Iliff, Jeffrey J.; Elbert, Donald L; Giovangrandi, Laurent; Singh, Tarandeep; Venkatesh, Venky V.; Corbellini, Alejandro; Kaplan, Robert M.; Ludington, Elizabeth; Yarasheski, Kevin; Lowenkron, Jeffrey et al.
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PrecivityAD2™ Blood Test: Analytical Validation of an LC-MS/MS Assay for Quantifying Plasma Phospho-tau217 and Non-Phospho-tau217 Peptide Concentrations That Are Used with Plasma Amyloid-β42/40 in a Multianalyte Assay with Algorithmic Analysis for Detecting Brain Amyloid Pathology

Diagnostics
2024-08-10 | Journal article
Contributors: Stephanie M. Eastwood; Matthew R. Meyer; Kristopher M. Kirmess; Traci L. Wente-Roth; Faith Irvin; Mary S. Holubasch; Philip B. Verghese; Tim West; Joel B. Braunstein; Kevin E. Yarasheski et al.
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PrecivityAD2™ Blood Test: Analytical Validation of an LC-MS/MS Assay for Quantifying Plasma Phospho-tau217 and Non-Phospho-tau217 Peptide Concentrations that are Used with Plasma Amyloid-β42/40 in a Multiple Analyte Assay with Algorithm for Detecting Brai

2024-06-20 | Preprint
Contributors: Stephanie M Eastwood; Matthew R Meyer; Kristopher M Kirmess; Tracie L Wente-Roth; Faith Irvin; Mary S Holubasch; Philip B Verghese; Tim West; Joel B Braunstein; Kevin E Yarasheski et al.
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Evaluation of Blood-Based Plasma Biomarkers as Potential Markers of Amyloid Burden in Preclinical Alzheimer's Disease

Journal of Alzheimer's Disease
2023 | Journal article
Contributors: Winston, Charisse N.; Langford, Oliver; Levin, Natalie; Raman, Rema; Yarasheski, Kevin; West, Tim; Abdel-Latif, Sara; Donohue, Michael; Nakamura, Akinori; Toba, Kenji et al.
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Independent study demonstrates amyloid probability score accurately indicates amyloid pathology

Annals of Clinical and Translational Neurology
2023 | Journal article
Contributors: Fogelman, Ilana; West, Tim; Braunstein, Joel B.; Verghese, Philip B.; Kirmess, Kristopher M.; Meyer, Matthew R.; Contois, John H.; Shobin, Eli; Ferber, Kyle L.; Gagnon, Jake et al.
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Plasma A<i>β</i>42/40 and cognitive variability are associated with cognitive function in Black Americans: Findings from the AA-FAIM cohort

Alzheimer's & Dementia: Translational Research & Clinical Interventions
2023 | Journal article
Contributors: Fischer, Barbara; Van Hulle, Carol Ann; Langhough, Rebecca; Norton, Derek; Zuelsdorff, Megan; Gooding, Diane Carol; Wyman, Mary F.; Johnson, Adrienne; Lambrou, Nickolas; James, Taryn et al.
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Plasma Aβ42/Aβ40 Ratios in Older People Living With Human Immunodeficiency Virus

Clinical Infectious Diseases
2023 | Journal article
Contributors: Cooley, Sarah A.; Nelson, Brittany; Boerwinkle, Anna; Yarasheski, Kevin E.; Kirmess, Kris M.; Meyer, Matthew R.; Schindler, Suzanne E.; Morris, John C.; Fagan, Anne; Ances, Beau M. et al.
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Sensitivity of the African Neuropsychology Battery Memory Subtests and Learning Slopes in Discriminating APOE 4 and Amyloid Pathology in Adult Individuals in the Democratic Republic of Congo

2023-10-05 | Preprint
Contributors: Jean Ikanga; Sarah D. Patrick; Megan Schwinne; Saranya Sundaram Patel; Emmanuel Epenge; Guy Gikelekele; Nathan Tshengele; Immaculee Kavugho; Samuel Mampunza; Kevin E. Yarasheski et al.
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Crossref

Exercise Training to Improve Brain Health in Older People Living With HIV: Study Protocol for a Randomized Controlled Trial

JMIR Research Protocols
2023-03-21 | Journal article
Contributors: Sarah Cooley; Brittany M Nelson; Alexander Rosenow; Elizabeth Westerhaus; W Todd Cade; Dominic N Reeds; Florin Vaida; Kevin E Yarasheski; Robert H Paul; Beau M Ances
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Assessment of a Plasma Amyloid Probability Score to Estimate Amyloid Positron Emission Tomography Findings Among Adults With Cognitive Impairment

JAMA Network Open
2022 | Journal article
Contributors: Hu, Yan; Kirmess, Kristopher M.; Meyer, Matthew R.; Rabinovici, Gil D.; Gatsonis, Constantine; Siegel, Barry A.; Whitmer, Rachel A.; Apgar, Charles; Hanna, Lucy; Kanekiyo, Michio et al.
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Exercise Training to Improve Brain Health in Older People Living With HIV: Study Protocol for a Randomized Controlled Trial (Preprint)

2022-08-02 | Preprint
Contributors: Sarah Cooley; Brittany M Nelson; Alexander Rosenow; Elizabeth Westerhaus; W Todd Cade; Dominic N Reeds; Florin Vaida; Kevin E Yarasheski; Robert H Paul; Beau M Ances
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Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light

Neurology
2022-07-19 | Journal article
Contributors: Suzanne E. Schindler; Thomas K. Karikari; Nicholas J. Ashton; Rachel L. Henson; Kevin E. Yarasheski; Tim West; Mathew R. Meyer; Kristopher M. Kirmess; Yan Li; Benjamin Saef et al.
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Socioeconomic status largely explains integrase inhibitors-related body composition differences in chronically infected men living with HIV

Antiviral Therapy
2022-06 | Journal article
Contributors: Julie K. Wisch; Sarah A. Cooley; Kevin E. Yarasheski; W. Todd Cade; Dominic N. Reeds; Brittany Nelson; Ruth Alemu; Tricia H. Burdo; Beau M. Ances
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A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis

Molecular Neurodegeneration
2021-12 | Journal article
Part of ISSN: 1750-1326
Source: Self-asserted source
Kevin E Yarasheski
grade
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The PrecivityAD™ test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis

Clinica Chimica Acta
2021-08 | Journal article
Part of ISSN: 0009-8981
Source: Self-asserted source
Kevin E Yarasheski
grade
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A Randomized, Double-blinded, Placebo-controlled Trial of Sitagliptin for Reducing Inflammation and Immune Activation in Treated and Suppressed Human Immunodeficiency Virus Infection

Clinical Infectious Diseases
2019 | Journal article
Contributors: Dube, Michael P.; Chan, Ellen S.; Lake, Jordan E.; Williams, Brett; Kinslow, Jennifer; Landay, Alan; Coombs, Robert W.; Floris-Moore, Michelle; Ribaudo, Heather J.; Yarasheski, Kevin E.
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Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss

Cell Metabolism
2019 | Journal article
Contributors: Colleluori, Georgia; Aguirre, Lina; Phadnis, Uma; Fowler, Kenneth; Armamento-Villarea, Reina; Sun, Zheng; Brunetti, Lorenzo; Park, Jun Hyoung; Kaipparettu, Benny Abraham; Putluri, Nagireddy et al.
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Dissemination and Implementation Program in Hypertension in Rwanda Report on Initial Training and Evaluation

Global Heart
2019 | Journal article
Contributors: Baumann, Ana A.; Mutabazi, Vincent; Brown, Angela L.; Hooley, Cole; Reeds, Dominic; Ingabire, Cecile; Ndahindwa, Vedaste; Nishimwe, Aurore; Cade, W. Todd; Fuentes, Lisa de las et al.
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Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness

Diabetology & Metabolic Syndrome
2019 | Journal article
Contributors: McGill, Janet B.; Johnson, Mariko; Hurst, Stacy; Cade, William T.; Yarasheski, Kevin E.; Ostlund, Richard E.; Schechtman, Kenneth B.; Razani, Babak; Kastan, Michael B.; McClain, Donald A. et al.
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Stable Isotope Labeling Kinetics in CNS Translational Medicine: Introduction to SILK Technology

Translational Medicine in CNS Drug Development
2019 | Book chapter
Part of ISBN: 9780128031612
Part of ISSN: 1569-7339
Source: Self-asserted source
Kevin E Yarasheski
grade
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SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases

Nature Reviews Neurology
2019-06-20 | Journal article
Part of ISSN: 1759-4758
Part of ISSN: 1759-4766
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Kevin E Yarasheski
grade
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Sitagliptin for reducing inflammation and immune activation in HIV: ACTG 5346-results of monocyte and lymphocyte activation markers and metabolic variables from a randomized, double-blind, placebo-controlled trial

Antiviral Therapy
2018 | Journal article
Contributors: Dube, M. P.; Chan, E. S.; Lake, J. E.; Williams, B.; Kinslow, J.; Landay, A.; Coombs, R. W.; Ribaudo, H. J.; Yarasheski, K. E.
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Tau Kinetics in Neurons and the Human Central Nervous System (vol 97, pg 1284, 2018)

Neuron
2018 | Journal article
Contributors: Sato, Chihiro; Barthelemy, Nicolas R.; Mawuenyega, Kwasi G.; Patterson, Bruce W.; Gordon, Brian A.; Jockel-Balsarotti, Jennifer; Sullivan, Melissa; Crisp, Matthew J.; Kasten, Tom; Kirmess, Kristopher M. et al.
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Tau Kinetics in Neurons and the Human Central Nervous System.

Neuron
2018-03-01 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
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HIV infection does not prevent the metabolic benefits of diet-induced weight loss in women with obesity.

Obesity (Silver Spring, Md.)
2017-02-28 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
grade
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Amino Acids as Fates of Anoxia-Induced Lactate Loads in the Painted Turtle

The FASEB Journal
2016 | Journal article
Contributors: Hill, Craig A.; Yarasheski, Kevin E.; Warren, Daniel E.
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SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.

Scientific reports
2016-12-06 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
grade
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Frailty in HIV: Epidemiology, Biology, Measurement, Interventions, and Research Needs.

Current HIV/AIDS reports
2016-12-01 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
grade
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Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide.

PloS one
2016-07-20 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
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Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.

Science signaling
2016-02-23 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
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How sweet is acute exercise after pure fructose ingestion?1

The American Journal of Clinical Nutrition
2016-02-01 | Journal article
Contributors: Kevin E Yarasheski; Elizabeth J Parks
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Sitagliptin increases the active form of stromal derived factor-1 alpha (SDF1 alpha (1-67)) and this correlates with an increase in endothelial progenitor cell number in HIV+ adults with impaired glucose tolerance

Antiviral Therapy
2015 | Journal article
Contributors: Yarasheski, K. E.; Wang, W.; He, H.; Struthers, H.; Laciny, E.; Best, C.; Mutimura, E.; Reeds, D.; Cohen, L. H.
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Tauroursodeoxycholic acid lowers intrahepatic triglyceride content and improves liver function tests and plasma lipid profile in insulin-resistant, HIV plus people receiving ritonavir

Antiviral Therapy
2015 | Journal article
Contributors: Reeds, D. N.; Chambers, K. T.; Dunn, R. J.; Yarasheski, K. E.; Finck, B. N.
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Age and amyloid effects on human central nervous system amyloid-beta kinetics.

Annals of neurology
2015-07-20 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
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In vivo kinetic approach reveals slow SOD1 turnover in the CNS.

The Journal of clinical investigation
2015-06-15 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
grade
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Sitagliptin Reduces Inflammation and Chronic Immune Cell Activation in HIV+ Adults With Impaired Glucose Tolerance.

The Journal of clinical endocrinology and metabolism
2015-05-04 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
grade
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DPP4 inhibition (sitagliptin) reduces inflammatory chemokine and immune activation markers in HIV plus adults with or without glucose intolerance

Antiviral Therapy
2014 | Journal article
Contributors: Yarasheski, K. E.; Reeds, D. N.; Best, C.; Laciny, E.; Struthers, H.; Royal, M.
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Effects of Acute Androgen Deprivation on Skeletal Muscle Protein Synthesis and Breakdown

Endocrine Reviews
2014 | Journal article
Contributors: He, Jiaxiu; Yarasheski, Kevin Edward; Bhasin, Shalender; Castaneda-Sceppa, Carmen; Binder, Ellen F.; Schroeder, E. Todd; Azen, Stanley P.; Sattler, Fred R.
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HIV serostatus and ART regimen influence the cardiometabolic effects of diet-induced weight loss in obese women

Antiviral Therapy
2014 | Journal article
Contributors: Reeds, D. N.; Cade, W. T.; Patterson, B. W.; Yarasheski, K. E.; Klein, S.
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Reply to comment on "An antidepressant decreases CSF Ab production in healthy individuals and in transgenic AD mice"

Science Translational Medicine
2014 | Journal article
Contributors: Sheline, Yvette I.; West, Tim; Yarasheski, Kevin; Jasielec, Mateusz S.; Hettinger, Jane C.; Tripoli, Danielle L.; Xiong, Chengjie; Frederiksen, Christine; Grzelak, Monica V.; Bateman, Randall J. et al.
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Stable Isotope Labeling Kinetics Reveal Tissue-Specific Differences in SOD1 Turnover in an ALS Animal Model

Annals of Neurology
2014 | Journal article
Contributors: Crisp, Matthew J.; Mawuenyega, Kwasi G.; Patterson, Bruce W.; Reddy, Naveen C.; Chott, Robert; Weihl, Conrad C.; Yarasheski, Kevin E.; Bateman, Randall J.; Miller, Timothy M.
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CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2014-06-01 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
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Testosterone Supplementation Improves Carbohydrate and Lipid Metabolism in Some Older Men with Abdominal Obesity.

Journal of gerontology & geriatric research
2014-06-01 | Journal article
Source: Self-asserted source
Kevin E Yarasheski

An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice.

Science translational medicine
2014-05-01 | Journal article
Source: Self-asserted source
Kevin E Yarasheski

Microbial community dynamics and stability during an ammonia-induced shift to syntrophic acetate oxidation.

Applied and environmental microbiology
2014-03-21 | Journal article
Source: Self-asserted source
Kevin E Yarasheski
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Age and sex affect protein metabolism at protein intakes that span the range of adequacy: Comparison of leucine kinetics and nitrogen balance data

Journal of Nutritional Biochemistry
2013 | Journal article
DOI:

10.1016/j.jnutbio.2012.03.021

Contributors: Conley, T.B.
Source: Self-asserted source
Kevin E Yarasheski via Scopus - Elsevier
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Age Attenuates Leucine Oxidation after Eccentric Exercise

International Journal of Sports Medicine
2013 | Journal article
DOI:

10.1055/s-0032-1327659

Contributors: Kullman, E.L.
Source: Self-asserted source
Kevin E Yarasheski via Scopus - Elsevier
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Cardiometabolic Risks During Anabolic Hormone Supplementation in Older Men

Obesity
2013 | Journal article
Contributors: He, J.; Bhasin, S.; Binder, E. F.; Yarasheski, K. E.; Castaneda-Sceppa, C.; Schroeder, E. T.; Roubenoff, R.; Chou, C. -P.; Azen, S. P.; Sattler, F. R.
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Peer review (1 review for 1 publication/grant)

Review activity for Alzheimer's research & therapy (1)