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John Innes Centre profile

Keywords

Biosynthesis, Natural Products, Streptomyces

Countries

United Kingdom

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Employment (3)

John Innes Centre: Norwich, Norfolk, GB

2013-10-01 to present | Project Leader (Department of Molecular Microbiology)
Employment
Source: Self-asserted source
Andrew Truman

University of Cambridge Saint John's College: Cambridge, Cambridgeshire, GB

2009-10 to 2013-09 | Title A Research Fellow
Employment
Source: Self-asserted source
Andrew Truman

University of Cambridge: Cambridge, Cambridgeshire, GB

2008-05 to 2009-09 | Postdoctoral Research Associate (Chemistry)
Employment
Source: Self-asserted source
Andrew Truman

Education and qualifications (2)

University of Cambridge: Cambridge, Cambridgeshire, GB

2004-10 to 2008-05 | PhD (Chemistry)
Education
Source: Self-asserted source
Andrew Truman

Imperial College London: London, London, GB

2000-10 to 2004-06 | MSci (Chemistry)
Education
Source: Self-asserted source
Andrew Truman

Funding (4)

Harnessing the biosynthetic potential of bacteria to produce ribosomally synthesised natural products

2021-09-30 to 2024-09-29 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.9698881
GRANT_NUMBER: BB/V016024/1
Source: Self-asserted source
Andrew Truman via DimensionsWizard

Extending bicyclomycin treatment of multi-drug resistant Gram-negative pathogens

Source: Self-asserted source
Andrew Truman via DimensionsWizard

Elucidating and engineering bottromycin biosynthesis

2015-03-01 to 2018-02-28 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
GRANT_NUMBER: BB/M003140/1
GRANT_NUMBER: BB/M003140/1
Source: Self-asserted source
Andrew Truman via DimensionsWizard

Investigating the Biosynthesis of Unusual Peptide Natural Products

2013-10-01 to 2018-09-01 | Grant
The Royal Society (London, GB)
GRANT_NUMBER: uf120457
GRANT_NUMBER: uf120457
Source: Self-asserted source
Andrew Truman via DimensionsWizard

Works (36)

Bottromycins - biosynthesis, synthesis and activity

Natural Product Reports
2021 | Journal article
DOI: 10.1039/D0NP00097C
Contributors: Laura Franz; Uli Kazmaier; Andrew W. Truman; Jesko Koehnke
Source: check_circle
Crossref

Discovery and characterisation of an amidine-containing ribosomally-synthesised peptide that is widely distributed in nature

Chemical Science
2021 | Journal article
DOI: 10.1039/D1SC01456K
Contributors: Alicia H. Russell; Natalia M. Vior; Edward S. Hems; Rodney Lacret; Andrew W. Truman
Source: check_circle
Crossref

Understanding thioamitide biosynthesis using pathway engineering and untargeted metabolomics

Chemical Science
2021 | Journal article
DOI: 10.1039/D0SC06835G
Contributors: Tom H. Eyles; Natalia M. Vior; Rodney Lacret; Andrew W. Truman
Source: check_circle
Crossref

Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by Nonomuraea coxensis DSM 45129

ACS Chemical Biology
2021-05-21 | Journal article
DOI: 10.1021/acschembio.1c00170
Contributors: Oleksandr Yushchuk; Natalia M. Vior; Andres Andreo-Vidal; Francesca Berini; Christian Rückert; Tobias Busche; Elisa Binda; Jörn Kalinowski; Andrew W. Truman; Flavia Marinelli
Source: check_circle
Crossref

A biofoundry workflow for the identification of genetic determinants of microbial growth inhibition

Synthetic Biology
2021-02-17 | Journal article
DOI: 10.1093/synbio/ysab004
Contributors: Alaster D Moffat; Adam Elliston; Nicola J Patron; Andrew W Truman; Jose A Carrasco Lopez
Source: check_circle
Crossref

The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes

Nature Chemical Biology
2020-09-01 | Journal article
DOI: 10.1038/s41589-020-0569-y
Contributors: Asfandyar Sikandar; Laura Franz; Sebastian Adam; Javier Santos-Aberturas; Liliya Horbal; Andriy Luzhetskyy; Andrew W. Truman; Olga V. Kalinina; Jesko Koehnke
Source: check_circle
Crossref

Reproducible molecular networking of untargeted mass spectrometry data using GNPS.

Nature protocols
2020-05 | Journal article
DOI: 10.1038/s41596-020-0317-5
PMID: 32405051
Contributors: Aron AT; Gentry EC; McPhail KL; Nothias LF; Nothias-Esposito M; Bouslimani A; Petras D; Gauglitz JM; Sikora N; Vargas F et al.
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Discovery and characterisation of an amidine-containing ribosomally-synthesised peptide that is widely distributed in nature

2020-05-04 | Preprint
DOI: 10.1101/2020.05.04.076059
Contributors: Alicia H. Russell; Natalia M. Vior; Edward S. Hems; Rodney Lacret; Andrew W. Truman
Source: check_circle
Crossref

Regulation of Bottromycin Biosynthesis Involves an Internal Transcriptional Start Site and a Cluster-Situated Modulator

Frontiers in Microbiology
2020-03 | Journal article
DOI: 10.3389/fmicb.2020.00495
Part of ISSN: 1664-302X
Contributors: Natalia M. Vior; Eva Cea-Torrescassana; Tom H. Eyles; Govind Chandra; Andrew W. Truman
Source: Self-asserted source
Andrew Truman via Crossref Metadata Search

Teicoplanin biosynthesis: unraveling the interplay of structural, regulatory, and resistance genes

Applied Microbiology and Biotechnology
2020-02 | Journal article
DOI: 10.1007/s00253-020-10436-y
Part of ISSN: 0175-7598
Contributors: Oleksandr Yushchuk; Bohdan Ostash; Andrew W. Truman; Flavia Marinelli; Victor Fedorenko
Source: Self-asserted source
Andrew Truman via Crossref Metadata Search

Thioalbamide, A Thioamidated Peptide from Amycolatopsis alba, Affects Tumor Growth and Stemness by Inducing Metabolic Dysfunction and Oxidative Stress

Cells
2019-11-08 | Journal article
DOI: 10.3390/cells8111408
Contributors: Luca Frattaruolo; Marco Fiorillo; Matteo Brindisi; Rosita Curcio; Vincenza Dolce; Rodney Lacret; Andrew W. Truman; Federica Sotgia; Michael P. Lisanti; Anna Rita Cappello
Source: check_circle
Crossref
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Preferred source (of 2)‎

Antibiotics: past, present and future.

Current Opinion in Microbiology
2019-10-01 | Journal article
DOI: 10.1016/j.mib.2019.10.008
PMID: 31733401
Source: Self-asserted source
Andrew Truman

Editorial overview: Antimicrobials: Tackling AMR in the 21st century.

Current Opinion in Microbiology
2019-10-01 | Journal article
DOI: 10.1016/j.mib.2019.11.004
PMID: 31818391
Source: Self-asserted source
Andrew Truman

Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool

Nucleic Acids Research
2019-05-21 | Journal article
DOI: 10.1093/nar/gkz192
Contributors: Javier Santos-Aberturas; Govind Chandra; Luca Frattaruolo; Rodney Lacret; Thu H Pham; Natalia M Vior; Tom H Eyles; Andrew W Truman
Source: check_circle
Crossref

Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis

Frontiers in Microbiology
2019-03 | Journal article
DOI: 10.3389/fmicb.2019.00580
Part of ISSN: 1664-302X
Contributors: Yolanda Martínez-Burgo; Javier Santos-Aberturas; Antonio Rodríguez-García; Eva G. Barreales; José Rubén Tormo; Andrew W. Truman; Fernando Reyes; Jesús F. Aparicio; Paloma Liras
Source: Self-asserted source
Andrew Truman via Crossref Metadata Search

Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool

2018-12-13 | Other
DOI: 10.1101/494286
Contributors: Javier Santos-Aberturas; Govind Chandra; Luca Frattaruolo; Rodney Lacret; Thu H. Pham; Natalia M. Vior; Tom H. Eyles; Andrew W. Truman
Source: check_circle
Crossref

Rapid and Robust Yeast-Mediated Pathway Refactoring Generates Multiple New Bottromycin-Related Metabolites

ACS Synthetic Biology
2018-05-18 | Journal article
DOI: 10.1021/acssynbio.8b00038
Contributors: Tom H. Eyles; Natalia M. Vior; Andrew W. Truman
Source: check_circle
Crossref

Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes

Applied and Environmental Microbiology
2018-03-02 | Journal article
DOI: 10.1128/aem.02828-17
Part of ISSN: 0099-2240
Contributors: Natalia M. Vior; Rodney Lacret; Govind Chandra; Siobhán Dorai-Raj; Martin Trick; Andrew W. Truman
Source: Self-asserted source
Andrew Truman via Crossref Metadata Search

Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors.

Nature communications
2017-12 | Journal article
DOI: 10.1038/s41467-017-01975-6
PMID: 29213087
PMC: PMC5719088
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes

2017-12-21 | Other
DOI: 10.1101/236828
Contributors: Natalia M. Vior; Rodney Lacret; Govind Chandra; Siobhán Dorai-Raj; Martin Trick; Andrew W. Truman
Source: check_circle
Crossref

Macroamidine Formation in Bottromycins Is Catalyzed by a Divergent YcaO Enzyme

Journal of the American Chemical Society
2017-12-20 | Journal article
DOI: 10.1021/jacs.7b09898
Contributors: Laura Franz; Sebastian Adam; Javier Santos-Aberturas; Andrew W. Truman; Jesko Koehnke
Source: check_circle
Crossref

A Genomics-Based Approach Identifies a Thioviridamide-Like Compound with Selective Anticancer Activity

ACS Chemical Biology
2017-11-17 | Journal article
DOI: 10.1021/acschembio.7b00677
Contributors: Luca Frattaruolo; Rodney Lacret; Anna Rita Cappello; Andrew W. Truman
Source: check_circle
Crossref

The frontline antibiotic vancomycin induces a zinc starvation response in bacteria by binding to Zn(II).

2016 | Journal article
DOI: 10.1038/srep19602
PMID: 26797186
PMC: PMC4726154
Contributors: Zarkan A; Macklyne HR; Truman AW; Hesketh AR; Hong HJ
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics

Angewandte Chemie
2016-08-08 | Journal article
DOI: 10.1002/ange.201604304
Contributors: William J. K. Crone; Natalia M. Vior; Javier Santos‐Aberturas; Lukas G. Schmitz; Finian J. Leeper; Andrew W. Truman
Source: check_circle
Crossref

Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics

Angewandte Chemie International Edition
2016-08-08 | Journal article
DOI: 10.1002/anie.201604304
Contributors: William J. K. Crone; Natalia M. Vior; Javier Santos‐Aberturas; Lukas G. Schmitz; Finian J. Leeper; Andrew W. Truman
Source: check_circle
Crossref

Characterization of the post-assembly line tailoring processes in teicoplanin biosynthesis.

2016-06 | Journal article
PMID: 27285718
Contributors: Yushchuk O; Ostash B; Pham TH; Luzhetskyy A; Fedorenko V; Truman AW; Horbal L
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides

Beilstein J. Org. Chem.
2016-06 | Journal article
DOI: 10.3762/bjoc.12.120
Contributors: Andrew W Truman
Source: Self-asserted source
Andrew Truman via Crossref Metadata Search

Minimum Information about a Biosynthetic Gene cluster.

2015-09 | Journal article
DOI: 10.1038/nchembio.1890
PMID: 26284661
Contributors: Medema MH; Kottmann R; Yilmaz P; Cummings M; Biggins JB; Blin K; de Bruijn I; Chooi YH; Claesen J; Coates RC et al.
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

The pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in Actinoplanes teichomyceticus.

2014-11 | Journal article
DOI: 10.1007/s00253-014-5969-z
PMID: 25104028
Contributors: Horbal L; Kobylyanskyy A; Truman AW; Zaburranyi N; Ostash B; Luzhetskyy A; Marinelli F; Fedorenko V
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Antibiotic resistance mechanisms inform discovery: identification and characterization of a novel amycolatopsis strain producing ristocetin.

2014-10 | Journal article
DOI: 10.1128/AAC.03349-14
PMID: 25022591
PMC: PMC4187901
Contributors: Truman AW; Kwun MJ; Cheng J; Yang SH; Suh JW; Hong HJ
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

2013-01 | Journal article
DOI: 10.1039/c2np20085f
PMID: 23165928
PMC: PMC3954855
Contributors: Arnison PG; Bibb MJ; Bierbaum G; Bowers AA; Bugni TS; Bulaj G; Camarero JA; Campopiano DJ; Challis GL; Clardy J et al.
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Identification and characterisation of the gene cluster for the anti-MRSA antibiotic bottromycin: expanding the biosynthetic diversity of ribosomal peptides

Chem. Sci.
2012 | Journal article
DOI: 10.1039/c2sc21190d
Contributors: William J. K. Crone; Finian J. Leeper; Andrew W. Truman
Source: Self-asserted source
Andrew Truman via Crossref Metadata Search

Chimeric glycosyltransferases for the generation of hybrid glycopeptides.

2009-06 | Journal article
DOI: 10.1016/j.chembiol.2009.04.013
PMID: 19549605
Contributors: Truman AW; Dias MV; Wu S; Blundell TL; Huang F; Spencer JB
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function.

2008-05 | Journal article
DOI: 10.1016/j.chembiol.2008.03.019
PMID: 18482700
Contributors: Truman AW; Fan Q; Röttgen M; Stegmann E; Leadlay PF; Spencer JB
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin.

2007 | Journal article
DOI: 10.1002/anie.200604194
PMID: 17226887
Contributors: Truman AW; Huang F; Llewellyn NM; Spencer JB
Source: Self-asserted source
Andrew Truman via Europe PubMed Central

Identification of a deacetylase involved in the maturation of teicoplanin.

2006-11 | Journal article
DOI: 10.1002/cbic.200600308
PMID: 17009278
Contributors: Truman AW; Robinson L; Spencer JB
Source: Self-asserted source
Andrew Truman via Europe PubMed Central
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