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Employment (1)

Dana-Farber Cancer Institute: Boston, MA, US

2018-06-18 to 2020-07-24
Employment
Source: Self-asserted source
Stephen Tang

Education and qualifications (2)

Columbia University: New York, NY, US

2020-08-10 to 2027-05 | M.D., Ph.D.
Education
Source: Self-asserted source
Stephen Tang

Yale University: New Haven, CT, US

2014-08-27 to 2018-05-21 | B.S. (Molecular Biophysics and Biochemistry)
Education
Source: Self-asserted source
Stephen Tang

Works (14)

Protein-primed DNA homopolymer synthesis by an antiviral reverse transcriptase

2025-03-25 | Preprint
DOI: 10.1101/2025.03.24.645077
Contributors: Stephen Tang; Rimantė Žedaveinytė; Nathaniel Burman; Shishir Pandey; Josephine L. Ramirez; Louie M. Kulber; Tanner Wiegand; Royce A. Wilkinson; Yanzhe Ma; Dennis J. Zhang et al.
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Crossref

De novo gene synthesis by an antiviral reverse transcriptase

Science
2024-10-04 | Journal article
DOI: 10.1126/science.adq0876
Contributors: Stephen Tang; Valentin Conte; Dennis J. Zhang; Rimantė Žedaveinytė; George D. Lampe; Tanner Wiegand; Lauren C. Tang; Megan Wang; Matt W. G. Walker; Jerrin Thomas George et al.
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Crossref

Antagonistic conflict between transposon-encoded introns and guide RNAs

Science
2024-07-12 | Journal article
DOI: 10.1126/science.adm8189
Contributors: Rimantė Žedaveinytė; Chance Meers; Hoang C. Le; Edan E. Mortman; Stephen Tang; George D. Lampe; Sanjana R. Pesari; Diego R. Gelsinger; Tanner Wiegand; Samuel H. Sternberg
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Crossref

TnpB homologues exapted from transposons are RNA-guided transcription factors

Nature
2024-07-11 | Journal article
DOI: 10.1038/s41586-024-07598-4
Contributors: Tanner Wiegand; Florian T. Hoffmann; Matt W. G. Walker; Stephen Tang; Egill Richard; Hoang C. Le; Chance Meers; Samuel H. Sternberg
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Crossref

De novo gene synthesis by an antiviral reverse transcriptase

2024-05-08 | Preprint
DOI: 10.1101/2024.05.08.593200
Contributors: Stephen Tang; Valentin Conte; Dennis J. Zhang; Rimantė Žedaveinytė; George D. Lampe; Tanner Wiegand; Lauren C. Tang; Megan Wang; Matt W.G. Walker; Jerrin Thomas George et al.
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Crossref

Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases

Nature Biotechnology
2024-01 | Journal article
DOI: 10.1038/s41587-023-01748-1
Contributors: George D. Lampe; Rebeca T. King; Tyler S. Halpin-Healy; Sanne E. Klompe; Marcus I. Hogan; Phuc Leo H. Vo; Stephen Tang; Alejandro Chavez; Samuel H. Sternberg
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Crossref

Emergence of RNA-guided transcription factors via domestication of transposon-encoded TnpB nucleases

2023-11-30 | Preprint
DOI: 10.1101/2023.11.30.569447
Contributors: Tanner Wiegand; Florian T. Hoffmann; Matt W.G. Walker; Stephen Tang; Egill Richard; Hoang C. Le; Chance Meers; Samuel H. Sternberg
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Crossref

Antagonistic conflict between transposon-encoded introns and guide RNAs

2023-11-20 | Preprint
DOI: 10.1101/2023.11.20.567912
Contributors: Rimantė Žedaveinytė; Chance Meers; Hoang C. Le; Edan E. Mortman; Stephen Tang; George D. Lampe; Sanjana R. Pesari; Diego R. Gelsinger; Tanner Wiegand; Samuel H. Sternberg
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Crossref

Transposon-encoded nucleases use guide RNAs to promote their selfish spread

Nature
2023-10-26 | Journal article
DOI: 10.1038/s41586-023-06597-1
Contributors: Chance Meers; Hoang C. Le; Sanjana R. Pesari; Florian T. Hoffmann; Matt W. G. Walker; Jeanine Gezelle; Stephen Tang; Samuel H. Sternberg
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Crossref

Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases

2023-03-18 | Preprint
DOI: 10.1101/2023.03.17.533036
Contributors: George D. Lampe; Rebeca T. King; Tyler S. Halpin-Healy; Sanne E. Klompe; Marcus I. Hogan; Phuc Leo H. Vo; Stephen Tang; Alejandro Chavez; Samuel H. Sternberg
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Crossref

A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

Cell Reports
2022-02 | Journal article
DOI: 10.1016/j.celrep.2022.110417
Contributors: Stephen Tang; Vidyalakshmi Sethunath; Nebiyou Y. Metaferia; Marina F. Nogueira; Daniel S. Gallant; Emma R. Garner; Lauren A. Lairson; Christopher M. Penney; Jiao Li; Maya K. Gelbard et al.
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Crossref

Integrative clinical and molecular characterization of translocation renal cell carcinoma

Cell Reports
2022-01 | Journal article
DOI: 10.1016/j.celrep.2021.110190
Contributors: Ziad Bakouny; Ananthan Sadagopan; Praful Ravi; Nebiyou Y. Metaferia; Jiao Li; Shatha AbuHammad; Stephen Tang; Thomas Denize; Emma R. Garner; Xin Gao et al.
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Crossref

Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma

Nature Communications
2021-02-05 | Journal article
DOI: 10.1038/s41467-021-21068-9
Contributors: Ziad Bakouny; David A. Braun; Sachet A. Shukla; Wenting Pan; Xin Gao; Yue Hou; Abdallah Flaifel; Stephen Tang; Alice Bosma-Moody; Meng Xiao He et al.
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Crossref

A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

2020-06-17 | Preprint
DOI: 10.1101/2020.06.17.156034
Contributors: Stephen Tang; Nebiyou Y. Metaferia; Marina F. Nogueira; Maya K. Gelbard; Sarah Abou Alaiwi; Ji-Heui Seo; Justin H. Hwang; Craig A. Strathdee; Sylvan C. Baca; Jiao Li et al.
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