Personal information

Websites & social links

The Slade Lab at Virginia Tech
Twitter

Other IDs

ResearcherID: E-1329-2015
Loop profile: 73935

Keywords

Host-pathogen, Fusobacterium, Microbiology, Biochemistry, Intracellular

Countries

United States

Activities

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Employment (4)

Virginia Polytechnic Institute and State University: Blacksburg, VA, US

2014-08-10 to present | Assistant Professor (Biochemistry)
Employment
Source: Self-asserted source
Daniel Slade

Scripps Florida: Jupiter, FL, US

2011-08-01 to 2014-07-01 | Research Associate (Chemistry)
Employment
Source: Self-asserted source
Daniel Slade

Massachusetts General Hospital: Boston, MA, US

2008-07-01 to 2011-07-01 | NIH Postdoctoral Fellow (Infectious Diseases)
Employment
Source: Self-asserted source
Daniel Slade

Harvard Medical School: Boston, MA, US

2008-07-01 to 2011-07-01 | NIH Postdoctoral Fellow (Micobiology & Molecular Genetics)
Employment
Source: Self-asserted source
Daniel Slade

Education and qualifications (2)

University of South Carolina: Columbia, SC, US

2002-08-01 to 2007-06-27 | PhD (Chemistry & Biochemistry)
Education
Source: Self-asserted source
Daniel Slade

Wofford College: Spartanburg, SC, US

1998-09-01 to 2002-05-01 | BS (Chemistry)
Education
Source: Self-asserted source
Daniel Slade

Funding (3)

A Tissue Engineering Approach to Analyzing Host-Microbe Interactions in Cancer

2019-08-01 to 2021-07-31 | Grant
National Cancer Institute (Rockville, US)
URL: https://app.dimensions.ai/details/grant/grant.8553881
GRANT_NUMBER: R21CA238630
Source: Self-asserted source
Daniel Slade via DimensionsWizard

Structure- and ligand-based design of new IspD-targeting antimalarials

2016-12-16 to 2018-11-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://grants.uberresearch.com/100000060/R21AI128362/Structure-and-ligand-based-design-of-new-IspD-targeting-antimalarials
GRANT_NUMBER: R21AI128362
Source: Self-asserted source
Daniel Slade via DimensionsWizard

Conserved Effectors Required for Protein Localization and Shigella Virulence

2009-08-01 to 2011-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2370676
GRANT_NUMBER: F32AI082911
Source: Self-asserted source
Daniel Slade via DimensionsWizard

Works (43)

Type IV pili facilitated natural competence in Fusobacterium nucleatum

Anaerobe
2023-08 | Journal article
DOI: 10.1016/j.anaerobe.2023.102760
Contributors: Blake E. Sanders; Ariana Umaña; Tam T.D. Nguyen; Kevin J. Williams; Christopher C. Yoo; Michael A. Casasanta; Bryce Wozniak; Daniel J. Slade
Source: check_circle
Crossref

Type 4 pili mediated natural competence inFusobacterium nucleatum

2023-06-09 | Preprint
DOI: 10.1101/2023.06.09.544391
Contributors: Blake E. Sanders; Ariana Umana; Tam T.D. Nguyen; Kevin J. Williams; Christopher C. Yoo; Michael A. Casasanta; Bryce Wozniak; Daniel J. Slade
Source: check_circle
Crossref

Enhanced Fusobacterium nucleatum Genetics Using Host DNA Methyltransferases To Bypass Restriction-Modification Systems

Journal of Bacteriology
2022-12-20 | Journal article
DOI: 10.1128/jb.00279-22
Contributors: Ariana Umaña; Tam T. D. Nguyen; Blake E. Sanders; Kevin J. Williams; Bryce Wozniak; Daniel J. Slade; Joseph Bondy-Denomy
Source: check_circle
Crossref

Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling

Science Signaling
2022-10-18 | Journal article
DOI: 10.1126/scisignal.abn4948
Contributors: Barath Udayasuryan; Raffae N. Ahmad; Tam T. D. Nguyen; Ariana Umaña; LaDeidra Monét Roberts; Polina Sobol; Stephen D. Jones; Jennifer M. Munson; Daniel J. Slade; Scott S. Verbridge
Source: check_circle
Crossref

DNA methyltransferase enhanced Fusobacterium nucleatum genetics

2022-07-20 | Preprint
DOI: 10.1101/2022.07.20.500824
Contributors: Ariana Umaña; Tam T.D. Nguyen; Blake E. Sanders; Kevin J. Williams; Bryce Wozniak; Daniel J. Slade
Source: check_circle
Crossref

The Shigella Spp. Type III Effector Protein OspB Is a Cysteine Protease

mBio
2022-06-28 | Journal article
DOI: 10.1128/mbio.01270-22
Contributors: Thomas E. Wood; Kathleen A. Westervelt; Jessica M. Yoon; Heather D. Eshleman; Roie Levy; Henry Burnes; Daniel J. Slade; Cammie F. Lesser; Marcia B. Goldberg; M. Sloan Siegrist
Source: check_circle
Crossref

CRISPR-Cas systems in Fusobacterium: An untapped genetic frontier

2022-01-21 | Preprint
DOI: 10.1101/2022.01.21.477265
Contributors: Ariana Umaña; Daniel J. Slade
Source: check_circle
Crossref

Fusobacterium nucleatum induces pancreatic cancer cell proliferation and migration by regulating host autocrine and paracrine signaling

2021-11-19 | Preprint
DOI: 10.1101/2021.11.19.469245
Contributors: Barath Udayasuryan; Tam T. D. Nguyen; Ariana Umaña; Raffae N. Ahmad; LaDeidra Monét Roberts; Polina Sobol; Stephen D. Jones; Jennifer M. Munson; Daniel J. Slade; Scott S. Verbridge
Source: check_circle
Crossref

The Shigella type III effector protein OspB is a cysteine protease

2021-09-01 | Preprint
DOI: 10.1101/2021.09.01.458261
Contributors: Thomas E. Wood; Kathleen A. Westervelt; Jessica M. Yoon; Heather D. Eshleman; Roie Levy; Henry Burnes; Daniel J. Slade; Cammie F. Lesser; Marcia B. Goldberg
Source: check_circle
Crossref

New Roles for Fusobacterium nucleatum in Cancer: Target the Bacteria, Host, or Both?

Trends in Cancer
2021-03 | Journal article
DOI: 10.1016/j.trecan.2020.11.006
Contributors: Daniel J. Slade
Source: check_circle
Crossref

Genome Sequences for Two Acinetobacter baumannii Strains Obtained Using the Unicycler Hybrid Assembly Pipeline

Microbiology Resource Announcements
2021-03-11 | Journal article
DOI: 10.1128/MRA.00017-21
Contributors: John M. Farrow, III; Everett C. Pesci; Daniel J. Slade; Irene L. G. Newton
Source: check_circle
Crossref

Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer

iScience
2020-12 | Journal article
DOI: 10.1016/j.isci.2020.101878
Contributors: Barath Udayasuryan; Tam T.D. Nguyen; Daniel J. Slade; Scott S. Verbridge
Source: check_circle
Crossref

Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration.

Science signaling
2020-07-21 | Journal article
DOI: 10.1126/scisignal.aba9157
PMID: 32694172
PMC: PMC7454160
Source: Self-asserted source
Daniel Slade

The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View.

Trends in cancer
2020-02-07 | Journal article
DOI: 10.1016/j.trecan.2020.01.004
PMID: 32101723
Source: Self-asserted source
Daniel Slade

Utilizing Whole Fusobacterium Genomes To Identify, Correct, and Characterize Potential Virulence Protein Families

Journal of Bacteriology
2019-12-09 | Journal article
DOI: 10.1128/JB.00273-19
Contributors: Ariana Umaña; Blake E. Sanders; Christopher C. Yoo; Michael A. Casasanta; Barath Udayasuryan; Scott S. Verbridge; Daniel J. Slade; Victor J. DiRita
Source: check_circle
Crossref

Comparison of type 5d autotransporter phospholipases demonstrates a correlation between high activity and intracellular pathogenic lifestyle.

The Biochemical journal
2019-09-24 | Journal article
DOI: 10.1042/bcj20190136
PMID: 31492736
Source: Self-asserted source
Daniel Slade

Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2

Biochemistry
2019-07-09 | Journal article
DOI: 10.1021/acs.biochem.9b00225
Contributors: Li Zheng; Mitesh Nagar; Aaron J. Maurais; Daniel J. Slade; Sangram S. Parelkar; Scott A. Coonrod; Eranthie Weerapana; Paul R. Thompson
Source: check_circle
Crossref

Complete Genome Sequence of Fusobacterium necrophorum subsp. necrophorum ATCC 25286

Microbiology Resource Announcements
2019-02-21 | Journal article
DOI: 10.1128/MRA.00025-19
Contributors: Ariana Umaña; Justin A. Lemkul; Daniel J. Slade; David A. Baltrus
Source: check_circle
Crossref

Reevaluating the Fusobacterium Virulence Factor Landscape

2019-01-29 | Other
DOI: 10.1101/534297
Contributors: Ariana Umana; Blake E. Sanders; Chris C. Yoo; Michael A. Casasanta; Barath Udayasuryan; Scott S. Verbridge; Daniel J. Slade
Source: check_circle
Crossref

Erratum for Sanders et al., “FusoPortal: an Interactive Repository of Hybrid MinION-Sequenced Fusobacterium Genomes Improves Gene Identification and Characterization”

mSphere
2018-08-29 | Journal article
DOI: 10.1128/mSphere.00379-18
Contributors: Blake E. Sanders; Ariana Umana; Justin A. Lemkul; Daniel J. Slade
Source: check_circle
Crossref

Fusobacterium Genomics Using MinION and Illumina Sequencing Enables Genome Completion and Correction

mSphere
2018-08-29 | Journal article
DOI: 10.1128/mSphere.00269-18
Contributors: S. Michelle Todd; Robert E. Settlage; Kevin K. Lahmers; Daniel J. Slade; Sarah E. F. D'Orazio
Source: check_circle
Crossref

FusoPortal: an Interactive Repository of Hybrid MinION-Sequenced Fusobacterium Genomes Improves Gene Identification and Characterization

mSphere
2018-08-29 | Journal article
DOI: 10.1128/mSphere.00228-18
Contributors: Blake E. Sanders; Ariana Umana; Justin A. Lemkul; Daniel J. Slade; Sarah E. F. D'Orazio
Source: check_circle
Crossref

FusoPortal: An interactive repository of hybrid MinION-sequenced Fusobacterium genomes improves gene identification and characterization

2018-04-22 | Other
DOI: 10.1101/305607
Contributors: Blake E. Sanders; Ariana Umana; Justin A. Lemkul; Daniel J. Slade
Source: check_circle
Crossref

Fusobacterium genomics using MinION and Illumina sequencing enables genome completion and correction

2018-04-20 | Other
DOI: 10.1101/305573
Contributors: S. Michelle Todd; Robert E. Settlage; Kevin K. Lahmers; Daniel J. Slade
Source: check_circle
Crossref

A chemical and biological toolbox for Type Vd secretion: Characterization of the phospholipase A1 autotransporter FplA from Fusobacterium nucleatum

Journal of Biological Chemistry
2017-12 | Journal article
DOI: 10.1074/jbc.M117.819144
Contributors: Michael A. Casasanta; Christopher C. Yoo; Hans B. Smith; Alison J. Duncan; Kyla Cochrane; Ann C. Varano; Emma Allen-Vercoe; Daniel J. Slade
Source: check_circle
Crossref

Biological Studies and Target Engagement of the 2-C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1R,3S)-MMV008138 and Analogs

ACS Infectious Diseases
2017-11-07 | Journal article
DOI: 10.1021/acsinfecdis.7b00159
Contributors: Maryam Ghavami; Emilio F. Merino; Zhong-Ke Yao; Rubayet Elahi; Morgan E. Simpson; Maria L. Fernández-Murga; Joshua H. Butler; Michael A. Casasanta; Priscilla M. Krai; Maxim M. Totrov et al.
Source: check_circle
Crossref

N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro

PLOS ONE
2017-07-10 | Journal article
DOI: 10.1371/journal.pone.0180372
Contributors: Brittany N. Balhouse; Logan Patterson; Eva M. Schmelz; Daniel J. Slade; Scott S. Verbridge; Pankaj K. Singh
Source: Self-asserted source
Daniel Slade via Crossref Metadata Search

FplA FromFusobacterium nucleatumis a Type Vd autotransporter phospholipase with a proposed role in altered host signaling and evasion of autophagy

2017-05-10 | Preprint
DOI: 10.1101/136598
Contributors: Michael A. Casasanta; Christopher C. Yoo; Hans B. Smith; A. Jane Duncan; Kyla Cochrane; Ann C. Varano; Emma Allen-Vercoe; Daniel J. Slade
Source: check_circle
Crossref

N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: implications for breast cancer viability and proliferationin vitro

2017-04-28 | Preprint
DOI: 10.1101/132092
Contributors: Brittany N. Balhouse; Logan Patterson; Eva M. Schmelz; Daniel J. Slade; Scott S. Verbridge
Source: check_circle
Crossref

Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M

EBioMedicine
2016-12-03 | Journal article
DOI: 10.1016/j.ebiom.2016.11.039
Source: Self-asserted source
Daniel Slade

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Nat Chem Biol
2015 | Journal article
DOI:

10.1038/nchembio.1735
Contributors: Lewis, H. D.; Liddle, J.; Coote, J. E.; Atkinson, S. J.; Barker, M. D.; Bax, B. D.; Bicker, K. L.; Bingham, R. P.; Campbell, M.; Chen, Y. H. et al.
Source: Self-asserted source
Daniel Slade via ResearcherID

Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design

ACS Chem Biol
2015 | Journal article
DOI:

10.1021/cb500933j
Contributors: Slade, D. J.; Fang, P.; Dreyton, C. J.; Zhang, Y.; Fuhrmann, J.; Rempel, D.; Bax, B. D.; Coonrod, S. A.; Lewis, H. D.; Guo, M. et al.
Source: Self-asserted source
Daniel Slade via ResearcherID

Chemical proteomic platform to identify citrullinated proteins

ACS chemical biology
2015-11-10 | Journal article
DOI: 10.1021/acschembio.5b00438
Source: Self-asserted source
Daniel Slade

A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming

Bioessays
2014 | Journal article
DOI:

10.1002/bies.201400057
Contributors: Slade, D. J.; Horibata, S.; Coonrod, S. A.; Thompson, P. R.
Source: Self-asserted source
Daniel Slade via ResearcherID

Chemical and biological methods to detect post-translational modifications of arginine

Biopolymers
2014 | Journal article
DOI:

10.1002/bip.22256
Contributors: Slade, D. J.; Subramanian, V.; Fuhrmann, J.; Thompson, P. R.
Source: Self-asserted source
Daniel Slade via ResearcherID

Pluripotency: citrullination unravels stem cells

Nat Chem Biol
2014 | Journal article
DOI:

10.1038/nchembio.1504
Contributors: Slade, D. J.; Subramanian, V.; Thompson, P. R.
Source: Self-asserted source
Daniel Slade via ResearcherID

Activation of PAD4 in NET formation

Front Immunol
2012 | Journal article
DOI:

10.3389/fimmu.2012.00360
Contributors: Rohrbach, A. S.; Slade, D. J.; Thompson, P. R.; Mowen, K. A.
Source: Self-asserted source
Daniel Slade via ResearcherID

Genetic reporter system for positioning of proteins at the bacterial pole

MBio
2012 | Journal article
DOI:

10.1128/mBio.00251-11
Contributors: Fixen, K. R.; Janakiraman, A.; Garrity, S.; Slade, D. J.; Gray, A. N.; Karahan, N.; Hochschild, A.; Goldberg, M. B.
Source: Self-asserted source
Daniel Slade via ResearcherID

Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor alpha target gene activation

Proc Natl Acad Sci U S A
2012 | Journal article
DOI:

10.1073/pnas.1203280109
Contributors: Zhang, X.; Bolt, M.; Guertin, M. J.; Chen, W.; Zhang, S.; Cherrington, B. D.; Slade, D. J.; Dreyton, C. J.; Subramanian, V.; Bicker, K. L. et al.
Source: Self-asserted source
Daniel Slade via ResearcherID

Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding

Mol Immunol
2008 | Journal article
DOI:

10.1016/j.molimm.2007.06.359
Contributors: Lovelace, L. L.; Chiswell, B.; Slade, D. J.; Sodetz, J. M.; Lebioda, L.
Source: Self-asserted source
Daniel Slade via ResearcherID

Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit

J Mol Biol
2008 | Journal article
DOI:

10.1016/j.jmb.2008.03.061
Contributors: Slade, D. J.; Lovelace, L. L.; Chruszcz, M.; Minor, W.; Lebioda, L.; Sodetz, J. M.
Source: Self-asserted source
Daniel Slade via ResearcherID

Binding of the lipocalin C8gamma to human complement protein C8alpha is mediated by loops located at the entrance to the C8gamma ligand binding site

Biochim Biophys Acta
2006 | Journal article
DOI:

10.1016/j.bbapap.2006.07.003
Contributors: Chiswell, B.; Slade, D. J.; Sodetz, J. M.
Source: Self-asserted source
Daniel Slade via ResearcherID

Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9

Biochemistry
2006 | Journal article
DOI:

10.1021/bi0601860
Contributors: Slade, D. J.; Chiswell, B.; Sodetz, J. M.
Source: Self-asserted source
Daniel Slade via ResearcherID
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