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Biography

Dr. Carlos A. Barrero received his medical degree from Universidad de Caldas, Manizales, Colombia in 2001. From 2000 to 2006, he conducted advanced scientific research at the Fundacion Instituto de Inmunologia de Colombia, Bogota, D.C. Colombia and in 2006, he accepted a position as a postdoctoral fellow at Temple University School of Medicine in the laboratories of Dr. Salim Merali. In 2009, Dr. Barrero was appointed to the position of Associate Scientist in the department of biochemistry at Temple University School of Medicine, and 2013 he moved his research activities to Temple University School of Pharmacy. He is currently a Assistant Professor in the Pharmaceutical Sciences Department at Temple University School of Pharmacy and an active member of the Moulder Center for Drug Discovery Research. His research is focused on utilizing proteomics and metabolomics to develop a better understanding of the pathophysiology of disease like diabetes, COPD and HIV-1. my career as a Scientist, I have gained valuable experience conducting several projects in cell biology, biochemistry, confocal imaging analysis, proteomics, and metabolomics, mostly related to the characterization of proteins and small molecules, using different scientific approaches. All my recent experiences and my knowledge in molecular biology, immunology, and general medicine has primarily contributed to the advancement of my career as a Scientist, providing the ability to integrate cellular disease models and omics technologies to translational medicine. My research interests are focused on utilizing molecular cell biology, proteomics and metabolomics to develop a better understanding of the pathophysiology of diseases resulted from altered post-translational modifications (PTM). My work in proteomics and metabolomics has contributed to a better understanding of the pathophysiology of diabetes, neurodegenerative diseases, and chronic obstructive pulmonary disease (COPD). My research focuses on the identification of molecular transducers of chronic diseases with particular emphasis in COPD. My work in proteomics contributes to the understanding of the pathophysiology of COPD and the identification of biomarkers that can help in the early diagnostic and evaluation of treatment of this highly prevalent disease. Specifically, our proteomics results identified new possible plasma biomarkers for COPD and elucidated that histone H3.3 protein is increased in COPD and plays a critical role in the progression of the disease. My current interest is to explore the ability of H3.3 to be used as an early marker and as a therapeutic target for COPD progression. I am eager to apply my diverse proteomics expertise, and to develop genomics and translational skills, to characterize the molecular transducers triggered by cigarette smoke in lung cells that induce COPD.

Activities

Employment (7)

Temple University School of Pharmacy: Philadelphia, Pennsylvania, US

2017-09 to present | Assistant Professor in Tenure-Track (Pharmaceutical Sciences Department)
Employment
Source: Self-asserted source
Carlos Barrero

Temple University School of Pharmacy: Philadelphia, Pennsylvania, US

2016-07 to 2017-09 | Research Associate Professor (Pharmaceutical Sciences Department)
Employment
Source: Self-asserted source
Carlos Barrero

Temple University School of Pharmacy: Philadelphia, Pennsylvania, US

2014-06 to 2016-06 | Research Assistant Professor (Pharmaceutical Sciences Department)
Employment
Source: Self-asserted source
Carlos Barrero

Temple University School of Pharmacy: Philadelphia, Pennsylvania, US

2013-05 to 2014-05 | Associate Scientist (Pharmaceutical Sciences Department)
Employment
Source: Self-asserted source
Carlos Barrero

Temple University School of Medicine: Philadelphia, Pennsylvania, US

2009-05 to 2013-10 | Associate Scientist (Department of Biochemistry)
Employment
Source: Self-asserted source
Carlos Barrero

Temple University, School of Medicine: Philadelphia, Pennsylvania, US

2006-05 to 2009-04 | Postdoctoral Research Associate (Department of Biochemistry)
Employment
Source: Self-asserted source
Carlos Barrero

Fundación Instituto de Inmunología de Colombia: Bogota, CO

2002-01 to 2006-05 | Researcher
Employment
Source: Self-asserted source
Carlos Barrero

Education and qualifications (1)

Universidad de Caldas: Manizales, Caldas, CO

1995 to 2001 | Doctor of Medicine (Faculty of Health Science )
Education
Source: Self-asserted source
Carlos Barrero

Professional activities (3)

Washington University. St. Louis, Missouri: St. Louis, Missouri, US

2017 | Junior faculty Trainee of Programs to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE). (Cardiovascular Genetics and Epidemiology (CGE))
Distinction
Source: Self-asserted source
Carlos Barrero

Temple University : Philadelphia, Pennsylvania, US

2012 | Temple Excels Performance Bonus Award, Extraordinary achievement within the workplace, (School of Medicine)
Distinction
Source: Self-asserted source
Carlos Barrero

Colombian National Academy of Medicine : Bogota, Bogota D.C., CO

2005 | Honorary Distinction in Basic Research
Distinction
Source: Self-asserted source
Carlos Barrero

Funding (1)

Targeting Histone H3.3 Receptors as a Novel Approach to Prevent COPD Progression

2015-07 to 2020-06 | Award
Flight Attendant Medical Research Institute (Coral Gables, Florida, US)
GRANT_NUMBER:

256463

Source: Self-asserted source
Carlos Barrero

Works (50 of 72)

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Multi-Omics Analysis Identified Drug Repurposing Targets for Chronic Obstructive Pulmonary Disease

International Journal of Molecular Sciences
2024-10-16 | Journal article
Contributors: Fang Wang; Carlos A. Barrero
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Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction–associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

Science Translational Medicine
2023-09-27 | Journal article
Contributors: Connor Quinn; Mario C. Rico; Carmen Merali; Carlos A. Barrero; Oscar Perez-Leal; Victoria Mischley; John Karanicolas; Scott L. Friedman; Salim Merali
Source: check_circle
Crossref

Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage

Biomolecules
2023-08-31 | Journal article
Contributors: Mario C. Rico; Oscar Perez-Leal; Mary F. Barbe; Mamta Amin; Dennis J. Colussi; Magda L. Florez; Victor Olusajo; Dennise S. Rios; Carlos A. Barrero
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CRISPR/Cas9-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver Disease

Antioxidants
2023-06-29 | Journal article
Contributors: James Li; Sandra Arest; Bartlomiej Olszowy; John Gordon; Carlos A. Barrero; Oscar Perez-Leal
Source: check_circle
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Preferred source (of 2)‎

CRISPR-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver Disease

2023-06-06 | Preprint
Contributors: James Li; Sandra Arest; Bartlomiej Olszowy; John Gordon; Carlos A Barrero; Oscar Perez-Leal
Source: check_circle
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Preferred source (of 2)‎

Extracellular Histone 3.3 and Its Hyper-acetylated Isoform In-duce an Inflammatory Response and Damage Lung Tissue

2023-05-17 | Preprint
Contributors: Mario C. Rico; Oscar Perez-Leal; Mary F. Barbe; Mamta Amin; Dennis J. Colussi; Magda L. Florez; Victor Olusajo; Carlos A. Barrero
Source: check_circle
Crossref
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Preferred source (of 2)‎

Understanding Breast Cancer Aggressiveness and Its Implications in Diagnosis and Treatment

Journal of Clinical Medicine
2023-02-09 | Journal article
Contributors: Nader Afifi; Carlos A. Barrero
Source: check_circle
Crossref
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Preferred source (of 2)‎

Identification of Inhibitors of Tubulin Polymerization Using a CRISPR-Edited Cell Line with Endogenous Fluorescent Tagging of β-Tubulin and Histone H1

Biomolecules
2023-01-29 | Journal article
Contributors: Harutyun Khachatryan; Bartlomiej Olszowy; Carlos A. Barrero; John Gordon; Oscar Perez-Leal
Source: check_circle
Crossref
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Preferred source (of 2)‎

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

Pharmaceutics
2021-12-07 | Journal article
Contributors: Xu-Qiao Chen; Carlos A. Barrero; Rodrigo Vasquez-Del Carpio; E. Premkumar Reddy; Chiara Fecchio; Salim Merali; Alessia Deglincerti; Cheng Fang; Jack Rogers; Maria L. Maccecchini
Source: check_circle
Crossref
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Preferred source (of 2)‎

Back to Basic: Developing methods to determine intracellular drug concentrations for better PK predictions.

Temple University School of Pharmacy Research Day
2019-04 | Conference poster
Source: Self-asserted source
Carlos Barrero

Integrative Bioinformatics Analysis Revealed Novel Drug Repurposing Targets for COPD, Translating Genetics into Medicine

New York Academy of Sciences
2019-04 | Conference poster
Source: Self-asserted source
Carlos Barrero

Histone H3.3: A Novel Pharmaceutical Target for the Treatment of COPD

Translational Research Seminar at the Pulmonary Branch of the NIH-NHLBI Clinical Center.
2019-02-26 | Lecture
Source: Self-asserted source
Carlos Barrero

Cigarette Smoke Exposure Induces Acetylated Histone 3.3 (AcH3.3) Accumulation

American Society of Health-System Pharmacists (ASHP)
2018-12 | Conference poster
Source: Self-asserted source
Carlos Barrero

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.

Cell
2018-10-25 | Journal article
Part of PMID: 30454645
Source: Self-asserted source
Carlos Barrero

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.

Nature communications
2018-08-29 | Journal article
Part of PMC: PMC6115453
Source: Self-asserted source
Carlos Barrero

Histone 3.3 as a Biomarker for COPD Exacerbation

American Thoracic Society 2018 International Conference
2018-05-23 | Conference poster
Source: Self-asserted source
Carlos Barrero

Identifying Novel Disease Modifying Drugs for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

ATS 2018 BEAR Cage Competition (Building Education to Advance Research)
2018-05-21 | Lecture
Source: Self-asserted source
Carlos Barrero

Extracellular Histone H3.3 Damages Lung Tissue and Induce a Systemic Inflammatory Response.

American Thoracic Society 2018 International Conference
2018-05-20 | Conference poster
Source: Self-asserted source
Carlos Barrero

Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.

Molecular psychiatry
2018-05-04 | Journal article
Part of PMC: PMC6215750
Source: Self-asserted source
Carlos Barrero

Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses.

The Journal of biological chemistry
2017-07-06 | Journal article
Part of PMC: PMC5572918
Source: Self-asserted source
Carlos Barrero

Histone H3.3: A Novel Pharmaceutical Target for the Treatment of COPD.

Pharmaceutical Science Department, Temple University School of Pharmacy.
2017-05-30 | Lecture
Source: Self-asserted source
Carlos Barrero

Glucose Metabolism Profiles of Triple Negative and Hormone Sensitive Breast Cancer Cell Lines

Targeting Cancer Metabolism and Signaling
2017-05-25 | Conference poster
Source: Self-asserted source
Carlos Barrero

GLUT4 Carbonylations: A Major New Mechanism for overnutrition induced insulin Resistance.

Obesity Symposium University of Pennsylvania
2017-05-17 | Conference poster
Source: Self-asserted source
Carlos Barrero

Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers.

Respiratory research
2017-05-02 | Journal article
Part of PMC: PMC5414124
Source: Self-asserted source
Carlos Barrero

Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.

Human molecular genetics
2017-05-01 | Journal article
Part of PMC: PMC6075360
Source: Self-asserted source
Carlos Barrero

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.

Scientific reports
2017-04-06 | Journal article
Part of DOI: 10.1038/srep46002
Part of PMC: PMC5382538
Source: Self-asserted source
Carlos Barrero

Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.

Aging cell
2016-11-29 | Journal article
Part of PMC: PMC5334532
Source: Self-asserted source
Carlos Barrero

Mechanism of action of DFMO in neuroblastoma cells beyond inhibition of Polyamines: a Proteomics approach.

4th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives.
2016-09 | Lecture
Source: Self-asserted source
Carlos Barrero

Mechanism of action of DFMO in neuroblastoma cells beyond the inhibition of polyamines.

4th International Conference on Polyamines Biochemical Physiological and Clinical Perspectives
2016-09 | Conference poster
Source: Self-asserted source
Carlos Barrero

Altered glucose metabolism in specific tissues of aged mice.

Cell Symposium: Aging and Metabolism
2016-07-10 | Conference poster
Source: Self-asserted source
Carlos Barrero

Glutamate metabolism in HIV-1 infected macrophages: Role of HIV-1 Vpr.

Cell cycle (Georgetown, Tex.)
2016-05-31 | Journal article
Source: Self-asserted source
Carlos Barrero

Extracellular Histone 3.3 Damages Lung Tissue and Produces an Inflammatory Response at the Alveolar-Capillary Membrane

The Fifteen Scientific Symposium of the Flight Attendant Medical Research Institute (FAMRI)
2016-05-16 | Conference poster
Source: Self-asserted source
Carlos Barrero

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.

Cell reports
2016-05-12 | Journal article
Part of PMC: PMC4880542
Source: Self-asserted source
Carlos Barrero

Diagnosis and Treatment of COPD.

2016-03-22 | Patent
PAT:

9,291,626

Source: Self-asserted source
Carlos Barrero

Disruption of NAD(+) binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions.

World journal of biological chemistry
2015-11-01 | Journal article
Part of PMC: PMC4657119
Source: Self-asserted source
Carlos Barrero

The Dark Side of Histones.

Labroots – RocklandTM
2015-10-28 | Lecture
Source: Self-asserted source
Carlos Barrero

SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells.

PloS one
2015-09-09 | Journal article
Part of PMC: PMC4564160
Source: Self-asserted source
Carlos Barrero

Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men.

Science translational medicine
2015-09-01 | Journal article
Part of PMC: PMC5600191
Source: Self-asserted source
Carlos Barrero

Role of Histones In COPD

Temple University Lung Center
2015-06-12 | Lecture
Source: Self-asserted source
Carlos Barrero

Role of Histones In COPD.

Temple University Lung Center
2015-06-12 | Lecture
Source: Self-asserted source
Carlos Barrero

In vivo Model of Histone 3.3 Cytotoxicity: Implications in COPD Progression.

Fourteenth Scientific Symposium of the Flight Attendant Medical Research Institute (FAMRI)
2015-05-13 | Conference poster
Source: Self-asserted source
Carlos Barrero

Abstract 2889: Distinct microbiome in colorectal cancers with the CpG Island Methylator Phenotype

American Association for Cancer Research (AACR) Annual Meeting
2015-04-18 | Conference poster
Source: Self-asserted source
Carlos Barrero

Changes in protein expression in two cholangiocarcinoma cell lines undergoing formation of multicellular tumor spheroids in vitro.

PloS one
2015-03-10 | Journal article
Part of PMID: 25756965
Part of PMC: PMC4355290
Source: Self-asserted source
Carlos Barrero

A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.

The Journal of biological chemistry
2014-11-12 | Journal article
Part of PMC: PMC4276889
Source: Self-asserted source
Carlos Barrero

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.

Annals of neurology
2014-05-28 | Journal article
Part of DOI: 10.1002/ana.24145
Part of PMC: PMC4362695
Source: Self-asserted source
Carlos Barrero

Targeting the intranuclear functions of GAPDH: phosphoThr99-GAPDH is translocated into nucleus of A549 cells after genotoxic stress (739.6)

The FASEB Journal
2014-04 | Journal issue or edition
Source: Self-asserted source
Carlos Barrero

Response to comment on Boden et al. Insulin regulates the unfolded protein response in human adipose tissue. Diabetes 2014;63:912-922.

Diabetes
2014-04-01 | Journal article
Part of DOI: 10.2337/db13-1906
Part of PMC: PMC4876764
Source: Self-asserted source
Carlos Barrero

TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.

The Journal of biological chemistry
2014-02-03 | Journal article
Part of PMC: PMC3953274
Source: Self-asserted source
Carlos Barrero

Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders.

Journal of AIDS & clinical research
2014-01-01 | Journal article
Part of PMID: 25893137
Part of PMC: PMC4397651
Source: Self-asserted source
Carlos Barrero

Insulin regulates the unfolded protein response in human adipose tissue.

Diabetes
2013-10-15 | Journal article
Part of DOI: 10.2337/db13-0906
Part of PMC: PMC3931405
Source: Self-asserted source
Carlos Barrero
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Peer review (3 reviews for 2 publications/grants)

Review activity for Amino acids. (2)
Review activity for Molecular biology reports. (1)