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Dr. Carlos A. Barrero received his medical degree from Universidad de Caldas, Manizales, Colombia in 2001. From 2000 to 2006, he conducted advanced scientific research at the Fundacion Instituto de Inmunologia de Colombia, Bogota, D.C. Colombia and in 2006, he accepted a position as a postdoctoral fellow at Temple University School of Medicine in the laboratories of Dr. Salim Merali. In 2009, Dr. Barrero was appointed to the position of Associate Scientist in the department of biochemistry at Temple University School of Medicine, and 2013 he moved his research activities to Temple University School of Pharmacy. He is currently a Assistant Professor in the Pharmaceutical Sciences Department at Temple University School of Pharmacy and an active member of the Moulder Center for Drug Discovery Research. His research is focused on utilizing proteomics and metabolomics to develop a better understanding of the pathophysiology of disease like diabetes, COPD and HIV-1. my career as a Scientist, I have gained valuable experience conducting several projects in cell biology, biochemistry, confocal imaging analysis, proteomics, and metabolomics, mostly related to the characterization of proteins and small molecules, using different scientific approaches. All my recent experiences and my knowledge in molecular biology, immunology, and general medicine has primarily contributed to the advancement of my career as a Scientist, providing the ability to integrate cellular disease models and omics technologies to translational medicine. My research interests are focused on utilizing molecular cell biology, proteomics and metabolomics to develop a better understanding of the pathophysiology of diseases resulted from altered post-translational modifications (PTM). My work in proteomics and metabolomics has contributed to a better understanding of the pathophysiology of diabetes, neurodegenerative diseases, and chronic obstructive pulmonary disease (COPD). My research focuses on the identification of molecular transducers of chronic diseases with particular emphasis in COPD. My work in proteomics contributes to the understanding of the pathophysiology of COPD and the identification of biomarkers that can help in the early diagnostic and evaluation of treatment of this highly prevalent disease. Specifically, our proteomics results identified new possible plasma biomarkers for COPD and elucidated that histone H3.3 protein is increased in COPD and plays a critical role in the progression of the disease. My current interest is to explore the ability of H3.3 to be used as an early marker and as a therapeutic target for COPD progression. I am eager to apply my diverse proteomics expertise, and to develop genomics and translational skills, to characterize the molecular transducers triggered by cigarette smoke in lung cells that induce COPD.
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