Robin Teufel (0000-0001-5863-7248)

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Biography

01/2022: Associate Professor of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel (Basel, Switzerland)

10/2020: Habilitation and Venia Legendi in Microbiology at the Faculty of Biology, University of Freiburg (Freiburg, Germany).

Since 04/2020: DFG-Heisenberg Research Group Leader at the Faculty of Biology, University of Freiburg (Freiburg, Germany).

02/2015 – 02/2020: DFG-Emmy Noether Research Group Leader at the Center for Biological Systems Analysis (ZBSA), University of Freiburg (Freiburg, Germany).

01/2014 – 01/2015: NIH-Postdoctoral Research Fellow at the Scripps Institution of Oceanography, Center for Marine Biotechnology & Biomedicine, University of California San Diego (La Jolla, USA) with Prof. Dr. Bradley S. Moore.

01/2012 – 12/2013: DFG-Postdoctoral Research Fellow at the Scripps Institution of Oceanography, Center for Marine Biotechnology & Biomedicine, University of California San Diego (La Jolla, USA) with Prof. Dr. Bradley S. Moore.

05/2008 – 10/2011: Doctorate (Dr. rer. nat., summa cum laude) “Aerobic Phenylacetate Catabolism – A novel Principle of Aromatic Degradation” at the University of Freiburg with Prof. Dr. Georg Fuchs.

10/2001 – 02/2008. Diploma in Biology “Die 3-Hydroxypropionyl-CoA Dehydratase des 3-Hydroxypropionat/4-Hydroxybutyrat-Zyklus der Crenarchaeota“ at the University of Freiburg with Prof. Dr. Georg Fuchs.

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University of Basel: Basel, Basel-Stadt, CH

2021-12-31 to present | Associate Professor, Head of Division Pharmaceutical Biology (Pharmaceutical Sciences)

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Robin Teufel

https://orcid.org/0000-0001-5863-7248

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Employment (5)

University of Basel: Basel, Basel-Stadt, CH

University of Freiburg: Freiburg, Baden-Württemberg, DE

University of Freiburg: Freiburg, Baden-Württemberg, DE

University of California, San Diego: San Diego, California, US

University of California, San Diego: San Diego, California, US

Education and qualifications (4)

University of Freiburg: Freiburg, Baden-Württemberg, DE

University of Freiburg: Freiburg, Baden-Württemberg, DE

University of Freiburg: Freiburg, Baden-Württemberg, DE

University of Freiburg: Freiburg, Baden-Württemberg, DE

Professional activities (2)

German Association of University Professors and Lecturers: Bonn, DE

Vereinigung für Allgemeine und Angewandte Mikrobiologie: Frankfurt, Hessen, DE

Funding (6)

Structural and mechanistic enzymology underlying the generation of complex bacterial natural products

The biosynthesis and enzymology of complex rubromycin and tropone marine bacterial natural products

Functional Diversity of Cofactors in Enzymes

Identification and Investigation of the Tetrodotoxin Biosynthetic Pathway

Novel Enzymology in Bacterial Secondary Metabolic Pathways

Biosynthesis of merochlorins - A novel class of highly active halogenated polyketide antibiotics from marine Streptomyces sp.

Works (42)

Vernonia sesquiterpene lactones: a review of their chemical and pharmacological aspects

Highly oxygenated antiplasmodial and non-hemolytic Δ7,9(11) stigmastane-type steroids from the twigs of Vernonia amygdalina Delile

Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin

Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin

Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Understanding the biosynthesis, metabolic regulation, and anti-phytopathogen activity of 3,7-dihydroxytropolone in Pseudomonas spp.

Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must

Understanding the biosynthesis, metabolic regulation, and anti-phytopathogen activity of 3,7-dihydroxytropolone inPseudomonasspp

Steroids from the Meliaceae family and their biological activities.

Correction to “The Antibacterial Synnepyrroles from Human-associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane”

Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus naudinianus

Bacterial Dehydrogenases Facilitate Oxidative Inactivation and Bioremediation of Chloramphenicol

An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct modulation of redox tailoring enzymes

Antibacterial Synnepyrroles from Human-Associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane

Bacterial flavoprotein monooxygenase YxeK salvages toxic S‐(2‐succino)‐adducts via oxygenolytic C–S bond cleavage

Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products

Catalytic Control of Spiroketal Formation in Rubromycin Polyketide Biosynthesis

Catalytic Control of Spiroketal Formation in Rubromycin Polyketide Biosynthesis

A Flavoprotein Dioxygenase Steers Bacterial Tropone Biosynthesis via Coenzyme A-Ester Oxygenolysis and Ring Epoxidation

Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides

The devil is in the details: The chemical basis and mechanistic versatility of flavoprotein monooxygenases

Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases

Bacterial tropone natural products and derivatives: Overview on the biosynthesis, bioactivities, ecological role and biotechnological potential.

Oxidative Carbon Backbone Rearrangement in Rishirilide Biosynthesis.

Structural and Mechanistic Basis of an Oxepin-CoA Forming Isomerase in Bacterial Primary and Secondary Metabolism

Structural methods for probing the interaction of flavoenzymes with dioxygen and its surrogates.

Insights into the enzymatic formation, chemical features, and biological role of the flavin-N5-oxide.

Enzymatic control of dioxygen binding and functionalization of the flavin cofactor.

Unusual "Head-to-Torso" Coupling of Terpene Precursors as a New Strategy for the Structural Diversification of Natural Products.

Preparation and Characterization of the Favorskiiase Flavoprotein EncM and Its Distinctive Flavin-N5-Oxide Cofactor.

Flavin-catalyzed redox tailoring reactions in natural product biosynthesis.

Unusual flavoenzyme catalysis in marine bacteria.

Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor.

Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin.

A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins.

One-pot enzymatic synthesis of merochlorin A and B.

Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement.

An oxygenase that forms and deoxygenates toxic epoxide.

Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point.

Bacterial phenylalanine and phenylacetate catabolic pathway revealed.

3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.

Peer review (43 reviews for 13 publications/grants)