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Employment (2)

University of Washington: Seattle, WA, US

2014-09 to present | Senior Fellow (Department of Biochemistry)
Employment
Source: Self-asserted source
Eric Lynch

McGill University: Montreal, QC, CA

2014-05 to 2014-08 | Postdoctoral Fellow (Department of Anatomy and Cell Biology)
Employment
Source: Self-asserted source
Eric Lynch

Education and qualifications (1)

University of Edinburgh: Edinburgh, GB

2008 to 2013 | PhD
Education
Source: Self-asserted source
Eric Lynch

Works (22)

Structural basis for allosteric regulation of human phosphofructokinase-1

Nature Communications
2024-08-25 | Journal article
DOI: 10.1038/s41467-024-51808-6
Contributors: Eric M. Lynch; Heather Hansen; Lauren Salay; Madison Cooper; Stepan Timr; Justin M. Kollman; Bradley A. Webb
Source: check_circle
Crossref

De novo design of pH-responsive self-assembling helical protein filaments

Nature Nanotechnology
2024-07 | Journal article
DOI: 10.1038/s41565-024-01641-1
Contributors: Hao Shen; Eric M. Lynch; Susrut Akkineni; Joseph L. Watson; Justin Decarreau; Neville P. Bethel; Issa Benna; William Sheffler; Daniel Farrell; Frank DiMaio et al.
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Crossref

Evolutionarily divergentMycobacterium tuberculosisCTP synthase filaments are under selective pressure

2024-07-25 | Preprint
DOI: 10.1101/2024.07.25.605180
Contributors: Eric M. Lynch; Yao Lu; Jin Ho Park; Lin Shao; Justin Kollman; E. Hesper Rego
Source: check_circle
Crossref

Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation

eLife
2021-11-04 | Journal article
DOI: 10.7554/eLife.73368
Contributors: Jesse M Hansen; Avital Horowitz; Eric M Lynch; Daniel P Farrell; Joel Quispe; Frank DiMaio; Justin M Kollman
Source: check_circle
Crossref

Structural basis for isoform-specific inhibition of human CTPS1

Proceedings of the National Academy of Sciences
2021-10-05 | Journal article
DOI: 10.1073/pnas.2107968118
Contributors: Eric M. Lynch; Michael A. DiMattia; Steven Albanese; Gydo C. P. van Zundert; Jesse M. Hansen; Joel D. Quispe; Madison A. Kennedy; Andreas Verras; Kenneth Borrelli; Angela V. Toms et al.
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Crossref

Selective activation of PFKL suppresses the phagocytic oxidative burst

Cell
2021-07 | Journal article
DOI: 10.1016/j.cell.2021.07.004
Part of ISSN: 0092-8674
Source: Self-asserted source
Eric Lynch

Multimeric antibodies from antigen-specific human IgM+ memory B cells restrict Plasmodium parasites

Journal of Experimental Medicine
2021-04-05 | Journal article
DOI: 10.1084/jem.20200942
Contributors: Christopher D. Thouvenel; Mary F. Fontana; Jason Netland; Akshay T. Krishnamurty; Kennidy K. Takehara; Yu Chen; Suruchi Singh; Kazutoyo Miura; Gladys J. Keitany; Eric M. Lynch et al.
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Crossref

Computational design of transmembrane pores

Nature
2020-09-03 | Journal article
DOI: 10.1038/s41586-020-2646-5
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Eric Lynch

CTP synthase polymerization in germline cells of the developing Drosophila egg supports egg production

Biology Open
2020-07-15 | Journal article
DOI: 10.1242/bio.050328
Part of ISSN: 2046-6390
Source: Self-asserted source
Eric Lynch

Filament formation by metabolic enzymes—A new twist on regulation

Current Opinion in Cell Biology
2020-05-14 | Journal article
DOI: 10.1016/j.ceb.2020.04.006
Part of ISSN: 0955-0674
Source: Self-asserted source
Eric Lynch

Polymerization in the actin ATPase clan regulates hexokinase activity in yeast

Science
2020-02-28 | Journal article
DOI: 10.1126/science.aay5359
Contributors: Patrick R. Stoddard; Eric M. Lynch; Daniel P. Farrell; Annie M. Dosey; Frank DiMaio; Tom A. Williams; Justin M. Kollman; Andrew W. Murray; Ethan C. Garner
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Crossref

Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments

Nature Structural & Molecular Biology
2020-01 | Journal article
DOI: 10.1038/s41594-019-0352-5
Contributors: Eric M. Lynch; Justin M. Kollman
Source: check_circle
Crossref

Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments

2019-09-16 | Other
DOI: 10.1101/770594
Contributors: Eric M. Lynch; Justin M. Kollman
Source: check_circle
Crossref

Architecture of the Mto1/2 microtubule nucleation complex

2019-08-31 | Other
DOI: 10.1101/754457
Contributors: Harish C. Thakur; Eric M. Lynch; Weronika E. Borek; Xun X. Bao; Sanju Ashraf; Juan Zou; Juri Rappsilber; Atlanta G. Cook; Kenneth E. Sawin
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Crossref

Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1

Current Biology
2019-07 | Journal article
DOI: 10.1016/j.cub.2019.05.058
Part of ISSN: 0960-9822
Source: Self-asserted source
Eric Lynch

Independent evolution of polymerization in the Actin ATPase clan regulates hexokinase activity

2019-07-02 | Other
DOI: 10.1101/686915
Contributors: Patrick R Stoddard; Eric M. Lynch; Daniel P. Farrell; Quincey A. Justman; Annie M. Dosey; Frank DiMaio; Tom A. Williams; Justin M. Kollman; Andrew W. Murray; Ethan C. Garner
Source: check_circle
Crossref

De novo design of self-assembling helical protein filaments

Science
2018-11-09 | Journal article
DOI: 10.1126/science.aau3775
Contributors: Hao Shen; Jorge A. Fallas; Eric Lynch; William Sheffler; Bradley Parry; Nicholas Jannetty; Justin Decarreau; Michael Wagenbach; Juan Jesus Vicente; Jiajun Chen et al.
Source: check_circle
Crossref

Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

eLife
2018-05-29 | Journal article
DOI: 10.7554/eLife.33465
Contributors: Xun X Bao; Christos Spanos; Tomoko Kojidani; Eric M Lynch; Juri Rappsilber; Yasushi Hiraoka; Tokuko Haraguchi; Kenneth E Sawin
Source: check_circle
Crossref

Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

2017-11-09 | Other
DOI: 10.1101/216838
Contributors: Xun X. Bao; Christos Spanos; Tomoko Kojidani; Eric M. Lynch; Juri Rappsilber; Yasushi Hiraoka; Tokuko Haraguchi; Kenneth E. Sawin
Source: check_circle
Crossref

Human CTP synthase filament structure reveals the active enzyme conformation.

Nature structural & molecular biology
2017-06 | Journal article
DOI: 10.1038/nsmb.3407
PMID: 28459447
Source: Self-asserted source
Eric Lynch via Europe PubMed Central

The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.

Nature cell biology
2017-04 | Journal article
DOI: 10.1038/ncb3486
PMID: 28263957
PMC: PMC5376238
Source: Self-asserted source
Eric Lynch via Europe PubMed Central

Activation of the γ-tubulin complex by the Mto1/2 complex.

Current biology : CB
2014-04 | Journal article
DOI: 10.1016/j.cub.2014.03.006
PMID: 24704079
PMC: PMC3989768
Source: Self-asserted source
Eric Lynch via Europe PubMed Central
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