Personal information

Activities

Employment (2)

National Institute of Environmental Health Sciences: Durham, NC, US

2007-01 to present | Principal Investigator (Signal Transduction Laboratory)
Employment
Source: Self-asserted source
Xiaoling Li

Massachusetts Institute of Technology: Cambridge, MA, US

2003-01 to 2006-12 | Postdoctoral Fellow (Biology)
Employment
Source: Self-asserted source
Xiaoling Li

Education and qualifications (3)

Johns Hopkins School of Medicine: Baltimore, MD, US

1997-09 to 2002-12 | Ph. D. (Biological Chemistry)
Education
Source: Self-asserted source
Xiaoling Li

Institute of Biophysics Chinese Academy of Sciences: Chaoyang District, Beijing, CN

1994-09 to 1997-07 | M. S. (Molecular Biology)
Education
Source: Self-asserted source
Xiaoling Li

Peking University: Beijing, Beijing, CN

1989-10 to 1994-07 | B.S. (Biochemistry)
Education
Source: Self-asserted source
Xiaoling Li

Funding (2)

Sirtuins and nuclear receptors in aging and age-associated diseases

2006-12 to present | Grant
National Institute of Environmental Health Sciences (NC, NC, US)
GRANT_NUMBER:

ZIA ES102205

Source: Self-asserted source
Xiaoling Li

SIRT1 mediated gene silencing in leukemia

2004-07 to 2007-06 | Award
Leukemia and Lymphoma Society (NY, NY, US)
GRANT_NUMBER:

5318-05

Source: Self-asserted source
Xiaoling Li

Works (48)

Melatonin Prevents Thioacetamide–Induced Gut Leakiness and Liver Fibrosis Through the Gut–Liver Axis via Modulating Sirt1‐Related Deacetylation of Gut Junctional Complex and Hepatic Proteins

Journal of Pineal Research
2024-09 | Journal article
Contributors: Wiramon Rungratanawanich; Karli Rae LeFort; Young‐Eun Cho; Xiaoling Li; Byoung‐Joon Song
Source: check_circle
Crossref

Dietary methionine restriction in cancer development and antitumor immunity

Trends in Endocrinology & Metabolism
2024-05 | Journal article
Contributors: Ming Ji; Qing Xu; Xiaoling Li
Source: check_circle
Crossref

Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice

Molecular Human Reproduction
2022-06-30 | Journal article
Contributors: Magdalina J Cummings; Hongyao Yu; Sudikshya Paudel; Guang Hu; Xiaoling Li; Myriam Hemberger; Xiaoqiu Wang
Source: check_circle
Crossref

SIRT1 regulates cardiomyocyte alignment during maturation

Journal of Cell Science
2022-04-01 | Journal article
Contributors: Yi Fang; Wei Fan; Xiaojiang Xu; Agnes K. Janoshazi; David C. Fargo; Xiaoling Li
Source: check_circle
Crossref

Metabolic and epigenetic regulation of endoderm differentiation

Trends in Cell Biology
2022-02 | Journal article
Contributors: Yi Fang; Xiaoling Li
Source: check_circle
Crossref

SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

eLife
2021-05-27 | Journal article
Contributors: Wei Fan; Shuang Tang; Xiaojuan Fan; Yi Fang; Xiaojiang Xu; Leping Li; Jian Xu; Jian-Liang Li; Zefeng Wang; Xiaoling Li
Source: check_circle
Crossref

SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc- SMPDL3B

2021-02-25 | Other
Contributors: Xiaoling Li; Wei Fan; Shuang Tang; Xiaojuan Fan; Yi Fang; Xiaojiang Xu; Leping Li; Jian Xu; Jian-Liang Li; Zefeng Wang
Source: check_circle
Crossref

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

Molecular Cell
2018-05 | Journal article
Part of ISSN: 1097-2765
Contributors: He Huang; Shuang Tang; Ming Ji; Zhanyun Tang; Miho Shimada; Xiaojing Liu; Shankang Qi; Jason W. Locasale; Robert G. Roeder; Yingming Zhao et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis

Theranostics
2017 | Journal article
Part of ISSN: 1838-7640
Contributors: Yang Jiang; Yuan Cao; Yongbin Wang; Wei Li; Xinyi Liu; Yixuan Lv; Xiaoling Li; Jun Mi
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Methionine metabolism is essential for SIRT1‐regulated mouse embryonic stem cell maintenance and embryonic development

The EMBO Journal
2017-11-02 | Journal article
Contributors: Shuang Tang; Yi Fang; Gang Huang; Xiaojiang Xu; Elizabeth Padilla‐Banks; Wei Fan; Qing Xu; Sydney M Sanderson; Julie F Foley; Scotty Dowdy et al.
Source: check_circle
Crossref

Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota

Gastroenterology
2017-09 | Journal article
Part of ISSN: 0016-5085
Contributors: Alicia S. Wellman; Mallikarjuna R. Metukuri; Nevzat Kazgan; Xiaojiang Xu; Qing Xu; Natalie S.X. Ren; Agnieszka Czopik; Michael T. Shanahan; Ashley Kang; Willa Chen et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3

Journal of Biological Chemistry
2017-08 | Journal article
Part of ISSN: 0021-9258
Contributors: Sanghoon Kwon; Sunmi Seok; Peter Yau; Xiaoling Li; Byron Kemper; Jongsook Kim Kemper
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver

Molecular and Cellular Biology
2017-05 | Journal article
Part of ISSN: 0270-7306
Contributors: Sung E. Choi; Sanghoon Kwon; Sunmi Seok; Zhen Xiao; Kwan-Woo Lee; Yup Kang; Xiaoling Li; Kosaku Shinoda; Shingo Kajimura; Byron Kemper et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

The phosphorylation status of T522 modulates tissue‐specific functions of SIRT 1 in energy metabolism in mice

EMBO reports
2017-05 | Journal article
Contributors: Jing Lu; Qing Xu; Ming Ji; Xiumei Guo; Xiaojiang Xu; David C Fargo; Xiaoling Li
Source: check_circle
Crossref

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy

EBioMedicine
2017-03 | Journal article
Part of ISSN: 2352-3964
Contributors: Yongbin Wang; Guifang Gan; Bocheng Wang; Jinliang Wu; Yuan Cao; Dan Zhu; Yan Xu; Xiaona Wang; Hongxiu Han; Xiaoling Li et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development

Current Biology
2017-02 | Journal article
Part of ISSN: 0960-9822
Contributors: Natalie S.X. Ren; Ming Ji; Erik J. Tokar; Evan L. Busch; Xiaojiang Xu; DeAsia Lewis; Xiangchun Li; Aiwen Jin; Yanping Zhang; William K.K. Wu et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis

PLOS Pathogens
2015-03-04 | Journal article
Part of ISSN: 1553-7374
Contributors: Diana Moreira; Vasco Rodrigues; Maria Abengozar; Luis Rivas; Eduardo Rial; Mireille Laforge; Xiaoling Li; Marc Foretz; Benoit Viollet; Jérôme Estaquier et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

SIRT1-Mediated Deacetylation of CRABPII Regulates Cellular Retinoic Acid Signaling and Modulates Embryonic Stem Cell Differentiation

Molecular Cell
2014-09 | Journal article
Part of ISSN: 1097-2765
Contributors: Shuang Tang; Gang Huang; Wei Fan; Yue Chen; James M. Ward; Xiaojiang Xu; Qing Xu; Ashley Kang; Michael W. McBurney; David C. Fargo et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Intestine-Specific Deletion of SIRT1 in Mice Impairs DCoH2–HNF-1α–FXR Signaling and Alters Systemic Bile Acid Homeostasis

Gastroenterology
2014-04 | Journal article
Part of ISSN: 0016-5085
Contributors: Nevzat Kazgan; Mallikarjuna R. Metukuri; Aparna Purushotham; Jing Lu; Anuradha Rao; Sangkyu Lee; Matthew Pratt–Hyatt; Andrew Lickteig; Iván L. Csanaky; Yingming Zhao et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver

Gastroenterology
2014-03 | Journal article
Part of ISSN: 0016-5085
Contributors: Huquan Yin; Ming Hu; Xiaomei Liang; Joanne M. Ajmo; Xiaoling Li; Ramon Bataller; Gemma Odena; Stanley M. Stevens; Min You
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Dual role of SIRT1 in UVB-induced skin tumorigenesis

Oncogene
2014-01 | Journal article
Part of ISSN: 0950-9232
Contributors: M Ming; K Soltani; C R Shea; X Li; Y Y He
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette TransportersviaProtein Kinase A and Sirtuin-1 in Mouse and Human

Antioxidants & Redox Signaling
2014-01 | Journal article
Part of ISSN: 1523-0864
Contributors: Supriya R. Kulkarni; Ajay C. Donepudi; Jialin Xu; Wei Wei; Qiuqiong C. Cheng; Maureen V. Driscoll; Delinda A. Johnson; Jeffrey A. Johnson; Xiaoling Li; Angela L. Slitt
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation

Molecular and Cellular Biology
2013-09 | Journal article
Part of ISSN: 0270-7306
Contributors: Gaëlle Laurent; Vincent C. J. de Boer; Lydia W. S. Finley; Meredith Sweeney; Hong Lu; Thaddeus T. Schug; Yana Cen; Seung Min Jeong; Xiaoling Li; Anthony A. Sauve et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Elevated microRNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT

Aging Cell
2013-08-11 | Journal article
Part of ISSN: 1474-9718
Contributors: Sung-E Choi; Ting Fu; Sunmi Seok; Dong-Hyun Kim; Eunkyung Yu; Kwan-Woo Lee; Yup Kang; Xiaoling Li; Byron Kemper; Jongsook K. Kemper
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

The ways and means that fine tune Sirt1 activity

Trends in Biochemical Sciences
2013-03 | Journal article
Part of ISSN: 0968-0004
Contributors: Javier R. Revollo; Xiaoling Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

SIRT1 and energy metabolism

Acta Biochimica et Biophysica Sinica
2012 | Journal article
Part of ISSN: 1672-9145
Contributors: X. Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status

Scientific Reports
2012-09-07 | Journal article
Part of ISSN: 2045-2322
Contributors: Xiumei Guo; Mehmet Kesimer; Gökhan Tolun; Xunhai Zheng; Qing Xu; Jing Lu; John K. Sheehan; Jack D. Griffith; Xiaoling Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1 /Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice

Molecular and Cellular Biology
2012-01 | Journal article
Part of ISSN: 0270-7306
Contributors: A. Purushotham; Q. Xu; J. Lu; J. F. Foley; X. Yan; D.-H. Kim; J. K. Kemper; X. Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Mammalian Sirtuins and Energy Metabolism

International Journal of Biological Sciences
2011 | Journal article
Part of ISSN: 1449-2288
Contributors: Xiaoling Li; Nevzat Kazgan
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage

British Journal of Pharmacology
2011 | Journal article
Part of ISSN: 0007-1188
Contributors: SH Chen; HM Wu; B Ossola; N Schendzielorz; BC Wilson; CH Chu; SL Chen; Q Wang; D Zhang; L Qian et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding

The FASEB Journal
2011-10 | Journal article
Part of ISSN: 0892-6638
Contributors: A. Purushotham; Q. Xu; X. Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Sirtuin 1 in lipid metabolism and obesity

Annals of Medicine
2011-02 | Journal article
Part of ISSN: 0785-3890
Contributors: Thaddeus T. Schug; Xiaoling Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

Proceedings of the National Academy of Sciences
2010 | Journal article
Part of ISSN: 0027-8424
Contributors: M. Ming; C. R. Shea; X. Guo; X. Li; K. Soltani; W. Han; Y.-Y. He
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

Molecular and Cellular Biology
2010-07 | Journal article
Part of ISSN: 0270-7306
Contributors: T. T. Schug; Q. Xu; H. Gao; A. Peres-da-Silva; D. W. Draper; M. B. Fessler; A. Purushotham; X. Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

Genes & Development
2010-07-01 | Journal article
Part of ISSN: 0890-9369
Contributors: A. K. Walker; F. Yang; K. Jiang; J.-Y. Ji; J. L. Watts; A. Purushotham; O. Boss; M. L. Hirsch; S. Ribich; J. J. Smith et al.
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Surprising sirtuin crosstalk in the heart

Aging
2010-03 | Journal article
Part of ISSN: 1945-4589
Contributors: Thaddeus T. Schug; Xiaoling Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

Journal of Biological Chemistry
2010-02 | Journal article
Part of ISSN: 0021-9258
Contributors: Xiumei Guo; Jason G. Williams; Thaddeus T. Schug; Xiaoling Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

SIRT1 performs a balancing act on the tight-rope toward longevity

Aging
2009-07 | Journal article
Part of ISSN: 1945-4589
Contributors: Aparna Purushotham; Thaddeus T. Schug; Xiaoling Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

Cell Metabolism
2009-04 | Journal article
Part of ISSN: 1550-4131
Contributors: Aparna Purushotham; Thaddeus T. Schug; Qing Xu; Sailesh Surapureddi; Xiumei Guo; Xiaoling Li
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

Molecular Cell
2007-10 | Journal article
Part of ISSN: 1097-2765
Contributors: Xiaoling Li; Songwen Zhang; Gil Blander; Jeanette G. Tse; Monty Krieger; Leonard Guarente
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

The Dynamin-like GTPase DLP1 Is Essential for Peroxisome Division and Is Recruited to Peroxisomes in Part by PEX11

Journal of Biological Chemistry
2003-03-04 | Journal article
Part of ISSN: 0021-9258
Contributors: Xiaoling Li; Stephen J. Gould
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

PEX11  Is Required for Peroxisome Proliferation in Response to 4-Phenylbutyrate but Is Dispensable for Peroxisome Proliferator-Activated Receptor Alpha-Mediated Peroxisome Proliferation

Molecular and Cellular Biology
2002 | Journal article
Part of ISSN: 0270-7306
Contributors: X. Li; E. Baumgart; G.-X. Dong; J. C. Morrell; G. Jimenez-Sanchez; D. Valle; K. D. Smith; S. J. Gould
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

PEX11  Deficiency Is Lethal and Impairs Neuronal Migration but Does Not Abrogate Peroxisome Function

Molecular and Cellular Biology
2002-06 | Journal article
Part of ISSN: 0270-7306
Contributors: X. Li; E. Baumgart; J. C. Morrell; G. Jimenez-Sanchez; D. Valle; S. J. Gould
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

PEX11 promotes peroxisome division independently of peroxisome metabolism

The Journal of Cell Biology
2002-02-11 | Journal article
Part of ISSN: 0021-9525
Contributors: Xiaoling Li; Stephen J. Gould
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Inhibitors of Copi and Copii Do Not BlockPEX3-Mediated Peroxisome Synthesis

The Journal of Cell Biology
2000-06 | Journal article
Part of ISSN: 0021-9525
Contributors: Sarah T. South; Katherine A. Sacksteder; Xiaoling Li; Yifei Liu; Stephen J. Gould
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis

The Journal of Cell Biology
2000-03-06 | Journal article
Part of ISSN: 0021-9525
Contributors: Katherine A. Sacksteder; Jacob M. Jones; Sarah T. South; Xiaoling Li; Yifei Liu; Stephen J. Gould
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins

The Journal of Cell Biology
1998-07 | Journal article
Part of ISSN: 0021-9525
Contributors: Xian-Zhong Shawn Xu; Atish Choudhury; Xiaoling Li; Craig Montell
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Binding of a burst-phase intermediate formed in the folding of denatured D-glyceraldehyde-3-phosphate dehydrogenase by chaperonin 60 and 8-anilino-1-naphthalenesulphonic acid

Biochemical Journal
1998-04 | Journal article
Part of ISSN: 0264-6021
Contributors: Xiao-Ling LI; Xiang-Dong LEI; Hui CAI; Jian LI; Sheng-Li YANG; Chih-Chen WANG; Chen-Lu TSOU
Source: Self-asserted source
Xiaoling Li via Crossref Metadata Search

Peer review (36 reviews for 19 publications/grants)

Review activity for Cancer gene therapy. (1)
Review activity for Cell death and disease. (1)
Review activity for Cell discovery. (3)
Review activity for Cell metabolism. (4)
Review activity for Cell reports medicine. (1)
Review activity for Cell reports. (3)
Review activity for Cell stem cell. (1)
Review activity for Communications biology. (1)
Review activity for Developmental cell. (1)
Review activity for EMBO reports. (3)
Review activity for Epigenetics & chromatin. (1)
Review activity for Gut (1)
Review activity for Heliyon. (1)
Review activity for iScience. (1)
Review activity for Mechanisms of ageing and development. (2)
Review activity for Molecular cell. (1)
Review activity for Nature communications (7)
Review activity for Nature metabolism. (2)
Review activity for Oncogene. (1)