Personal information

Websites & social links

https://www.conicet.gov.ar/

Other IDs

Scopus Author ID: 7003936797

Keywords

Liver diseases, MASLD, MASH, Genetics, OMICS

Countries

Argentina

Activities

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Employment (1)

Consejo Nacional de Investigaciones Científicas y Técnicas: Buenos Aires, AR

2005-01-01 to present | Department Head (Clinical and Molecular Hepatology)
Employment
Source: Self-asserted source
Silvia Sookoian

Works (50 of 53)

Items per page:
Page 1 of 2

Global Burden of Major Chronic Liver Diseases in 2021

Liver International
2025-04 | Journal article
DOI: 10.1111/liv.70058
Contributors: Gong Feng; Yusuf Yilmaz; Luca Valenti; Wai‐Kay Seto; Calvin Q. Pan; Nahum Méndez‐Sánchez; Feng Ye; Silvia Sookoian; Giovanni Targher; Christopher D. Byrne et al.
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Crossref

Global Epidemiological Impact of PNPLA3 I148M on Liver Disease

Liver International
2025-03 | Journal article
DOI: 10.1111/liv.16123
Contributors: Julia Kozlitina; Silvia Sookoian
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Crossref

MASLD as a non-communicable disease

Nature Reviews Gastroenterology & Hepatology
2025-03 | Journal article
DOI: 10.1038/s41575-025-01039-x
Contributors: Silvia Sookoian; Carlos J. Pirola; Arun J. Sanyal
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Crossref

The Proteomics of MASLD Progression: Insights From Functional Analysis to Drive the Development of New Therapeutic Solutions

Alimentary Pharmacology & Therapeutics
2025-02 | Journal article
DOI: 10.1111/apt.18468
Contributors: Carlos José Pirola; Tomas Fernández Gianotti; Silvia Sookoian
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Crossref

Corrigendum to “Cross talk between the liver microbiome and epigenome in patients with metabolic dysfunction-associated steatotic liver disease”

eBioMedicine
2025-01 | Journal article
DOI: 10.1016/j.ebiom.2024.105525
Contributors: Carlos Jose Pirola; Adrian Salatino; Tomas Fernández Gianotti; Gustavo Osvaldo Castaño; Martin Garaycoechea; Silvia Sookoian
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Global, Regional, and National Burden of Primary Liver Cancer Attributable to Metabolic Risks: An Analysis of the Global Burden of Disease Study 1990–2021

American Journal of Gastroenterology
2025-01-03 | Journal article
DOI: 10.14309/ajg.0000000000003288
Contributors: Chutian Wu; Giovanni Targher; Christopher D. Byrne; Yilei Mao; Tan To Cheung; Yusuf Yilmaz; Luca Valenti; Nahum Méndez-Sánchez; Silvia Sookoian; Wah-Kheong Chan et al.
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Metabolic dysfunction-associated steatotic liver disease exhibits sex-specific microbial heterogeneity within intestinal compartments

Clinical and Molecular Hepatology
2025-01-01 | Journal article
DOI: 10.3350/cmh.2024.0359
Contributors: Carlos Jose Pirola; Maria Silvina Landa; Mariano Schuman; Silvia Inés García; Adrian Salatino; Silvia Sookoian
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Drug repurposing in MASLD and MASH-cirrhosis: Targets and treatment approaches based on pathways analysis

2024 | Book chapter
DOI: 10.1016/bs.pmbts.2024.01.006
Contributors: Carlos J. Pirola; Silvia Sookoian
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Crossref

Genetics of Metabolic Dysfunction-associated Steatotic Liver Disease: The State of the Art Update

Clinical Gastroenterology and Hepatology
2024-11 | Journal article
DOI: 10.1016/j.cgh.2024.05.052
Contributors: Silvia Sookoian; Yaron Rotman; Luca Valenti
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Crossref

Organ damage proteomic signature identifies patients with MASLD at-risk of systemic complications

2024-11-01 | Preprint
DOI: 10.1101/2024.10.28.24316149
Contributors: Carlos José Pirola; Luis Diambra; Tomas Fernández Gianotti; Gustavo Osvaldo Castaño; Julio San Martino; Martin Garaycoechea; Silvia Sookoian
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The gene expression signature of metabolic dysfunction- associated steatotic liver disease from a multiomics perspective

Clinical and Molecular Hepatology
2024-04-01 | Journal article
DOI: 10.3350/cmh.2024.0082
Contributors: Carlos Jose Pirola; Silvia Sookoian
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Crossref

Cross talk between the liver microbiome and epigenome in patients with metabolic dysfunction-associated steatotic liver disease

eBioMedicine
2024-03 | Journal article
DOI: 10.1016/j.ebiom.2024.104996
Contributors: Carlos Jose Pirola; Adrian Salatino; Tomas Fernández Gianotti; Gustavo Osvaldo Castaño; Martin Garaycoechea; Silvia Sookoian
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Crossref

From NAFLD to MASLD: updated naming and diagnosis criteria for fatty liver disease

Journal of Lipid Research
2024-01 | Journal article
DOI: 10.1016/j.jlr.2023.100485
Contributors: Mary E. Rinella; Silvia Sookoian
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The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease in the general population

Journal of Physiology and Biochemistry
2023-11 | Journal article
DOI: 10.1007/s13105-022-00893-6
Contributors: Silvia Sookoian; Carlos J. Pirola
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Non‐alcoholic fatty liver disease mediates the effect of obesity on arterial hypertension

Liver International
2023-10 | Journal article
DOI: 10.1111/liv.15643
Contributors: Carlos J. Pirola; Silvia Sookoian
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Crossref

SARS-CoV-2 targets the liver and manipulates glucose metabolism

Trends in Molecular Medicine
2023-09 | Journal article
DOI: 10.1016/j.molmed.2023.06.001
Contributors: Carlos J. Pirola; Silvia Sookoian
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Editorial: NAFLD, chronic kidney disease, and pleiotropy—Why is PNPLA3 omnipresent?

Alimentary Pharmacology & Therapeutics
2023-05 | Journal article
DOI: 10.1111/apt.17491
Contributors: Carlos J. Pirola; Silvia Sookoian
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Geographical similarity and differences in the burden and genetic predisposition of NAFLD

Hepatology
2023-04 | Journal article
DOI: 10.1002/hep.32774
Contributors: Terry Cheuk‐Fung Yip; Eduardo Vilar‐Gomez; Salvatore Petta; Yusuf Yilmaz; Grace Lai‐Hung Wong; Leon A. Adams; Victor de Lédinghen; Silvia Sookoian; Vincent Wai‐Sun Wong
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Advances in our understanding of the molecular heterogeneity of fatty liver disease: toward informed treatment decision making

Expert Review of Gastroenterology & Hepatology
2023-04-03 | Journal article
DOI: 10.1080/17474124.2023.2191190
Contributors: Carlos J Pirola; Silvia Sookoian
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Crossref

COVID‐19 and non‐alcoholic fatty liver disease: Biological insights from multi‐omics data

Liver International
2023-03 | Journal article
DOI: 10.1111/liv.15509
Contributors: Carlos J. Pirola; Silvia Sookoian
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Crossref

Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response

Clinical and Molecular Hepatology
2023-02-28 | Journal article
DOI: 10.3350/cmh.2022.0318
Contributors: Silvia Sookoian; Carlos J. Pirola
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Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease

Journal of Hepatology
2023-01 | Journal article
DOI: 10.1016/j.jhep.2022.08.030
Contributors: Fredrik Åberg; Christopher D. Byrne; Carlos J. Pirola; Ville Männistö; Silvia Sookoian
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Computational Pipeline for Next-Generation Sequencing (NGS) Studies in Genetics of NASH

2022 | Book chapter
DOI: 10.1007/978-1-0716-2128-8_16
Contributors: Adrian Salatino; Silvia Sookoian; Carlos J. Pirola
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PNPLA3 rs738409 and risk of fibrosis in NAFLD: Exploring mediation pathways through intermediate histological features

Hepatology
2022-11 | Journal article
DOI: 10.1002/hep.32491
Contributors: Eduardo Vilar‐Gomez; Carlos J. Pirola; Silvia Sookoian; Laura A. Wilson; Tiebing Liang; Naga Chalasani
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Personalized medicine in nonalcoholic fatty liver disease

Clinical and Molecular Hepatology
2022-10-01 | Journal article
DOI: 10.3350/cmh.2022.0175
Contributors: Carlos J. Pirola; Silvia Sookoian
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Repurposing drugs to target nonalcoholic steatohepatitis: Auranofin, a gold-organic molecule complex for the treatment of a specifc complex trait

Clinical and Molecular Hepatology
2022-10-01 | Journal article
DOI: 10.3350/cmh.2022.0208
Contributors: Carlos J. Pirola; Silvia Sookoian
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Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19

Computers in Biology and Medicine
2022-09 | Journal article
DOI: 10.1016/j.compbiomed.2022.105895
Contributors: Luis Diambra; Andres M. Alonso; Silvia Sookoian; Carlos J. Pirola
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Epigenetics factors in nonalcoholic fatty liver disease

Expert Review of Gastroenterology & Hepatology
2022-06-03 | Journal article
DOI: 10.1080/17474124.2020.1765772
Contributors: Carlos Jose Pirola; Silvia Sookoian
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Crossref

MicroRNAs as messengers of liver diseases: has the message finally been decrypted?

Clinical Science
2022-03-18 | Journal article
DOI: 10.1042/CS20211177
Contributors: Carlos J. Pirola; Silvia Sookoian
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Crossref

The influence of host genetics on liver microbiome composition in patients with NAFLD

eBioMedicine
2022-02 | Journal article
DOI: 10.1016/j.ebiom.2022.103858
Contributors: Carlos Jose Pirola; Adrian Salatino; Maria Florencia Quintanilla; Gustavo Osvaldo Castaño; Martin Garaycoechea; Silvia Sookoian
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Crossref

The lipidome in nonalcoholic fatty liver disease: actionable targets

Journal of Lipid Research
2021 | Journal article
DOI: 10.1016/j.jlr.2021.100073
Contributors: Carlos J. Pirola; Silvia Sookoian
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Genome‐wide Association Study of Liver‐related Enzymes Suggests Putative Pleiotropic Effects on Diverse Traits and Diseases

Hepatology
2021-12 | Journal article
DOI: 10.1002/hep.32175
Contributors: Hyun‐Seok Kim; Silvia Sookoian; Ruben Hernaez
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Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19

2021-12-09 | Preprint
DOI: 10.1101/2021.12.08.21267478
Contributors: Luis Diambra; Andres M Alonso; Silvia Sookoian; Carlos J Pirola
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Crossref

PNPLA3 and COVID‐19 outcomes: Thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system

Liver International
2021-11 | Journal article
DOI: 10.1111/liv.15043
Contributors: Carlos J. Pirola; Silvia Sookoian
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Crossref

Editorial: bariatric surgery to reduce the risk of liver cancer

Alimentary Pharmacology & Therapeutics
2021-05 | Journal article
DOI: 10.1111/apt.16357
Contributors: Carlos J. Pirola; Silvia Sookoian
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Crossref

NAFLD and Cardiometabolic Risk Factors: The Liver Fibrosis Trajectory Through the Lens of Biological Interactions

Hepatology
2021-02 | Journal article
DOI: 10.1002/hep.31672
Contributors: Carlos J. Pirola; Silvia Sookoian
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Liver mitochondrial DNA damage and genetic variability of Cytochrome b – a key component of the respirasome – drive the severity of fatty liver disease

Journal of Internal Medicine
2021-01 | Journal article
DOI: 10.1111/joim.13147
Contributors: C. J. Pirola; M. Garaycoechea; D. Flichman; G. O. Castaño; S. Sookoian
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COVID-19 and ACE2 in the Liver and Gastrointestinal Tract: Putative Biological Explanations of Sexual Dimorphism

Gastroenterology
2020-10 | Journal article
DOI: 10.1053/j.gastro.2020.04.050
Contributors: Carlos J. Pirola; Silvia Sookoian
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ADH1B∗2 Is Associated With Reduced Severity of Nonalcoholic Fatty Liver Disease in Adults, Independent of Alcohol Consumption

Gastroenterology
2020-09 | Journal article
DOI: 10.1053/j.gastro.2020.05.054
Contributors: Eduardo Vilar-Gomez; Silvia Sookoian; Carlos Jose Pirola; Tiebing Liang; Samer Gawrieh; Oscar Cummings; Wanqing Liu; Naga P. Chalasani
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Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

Gut
2020-08 | Journal article
DOI: 10.1136/gutjnl-2019-318811
Contributors: Silvia Sookoian; Adrian Salatino; Gustavo Osvaldo Castaño; Maria Silvia Landa; Cinthia Fijalkowky; Martin Garaycoechea; Carlos Jose Pirola
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SARS‐CoV‐2 virus and liver expression of host receptors: Putative mechanisms of liver involvement in COVID‐19

Liver International
2020-08 | Journal article
DOI: 10.1111/liv.14500
Contributors: Carlos J. Pirola; Silvia Sookoian
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Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology

Hepatology
2020-07 | Journal article
DOI: 10.1002/hep.31229
Contributors: Silvia Sookoian; Carlos J. Pirola; Luca Valenti; Nicholas O. Davidson
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Review article: shared disease mechanisms between non‐alcoholic fatty liver disease and metabolic syndrome – translating knowledge from systems biology to the bedside

Alimentary Pharmacology & Therapeutics
2019-03 | Journal article
DOI: 10.1111/apt.15163
Contributors: Silvia Sookoian; Carlos J. Pirola
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Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease

Journal of Lipid Research
2019-01-15 | Journal article
DOI: 10.1194/jlr.P089953
Contributors: Carlos J. Pirola; Martin Garaycoechea; Diego Flichman; Marco Arrese; Julio San Martino; Carla Gazzi; Gustavo O. Castaño; Silvia Sookoian
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Editorial: surviving your genes—the role of PNPLA3 variation in end‐stage liver disease

Alimentary Pharmacology & Therapeutics
2018-10 | Journal article
DOI: 10.1111/apt.14901
Contributors: C. J. Pirola; S. Sookoian
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A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic Steatohepatitis

Hepatology Communications
2018-09 | Journal article
DOI: 10.1002/hep4.1235
Contributors: Carlos J. Pirola; Diego Flichman; Hernán Dopazo; Tomas Fernández Gianotti; Julio San Martino; Cristian Rohr; Martin Garaycoechea; Carla Gazzi; Gustavo O. Castaño; Silvia Sookoian
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Metastasis‐associated lung adenocarcinoma transcript 1 as a common molecular driver in the pathogenesis of nonalcoholic steatohepatitis and chronic immune‐mediated liver damage

Hepatology Communications
2018-06 | Journal article
DOI: 10.1002/hep4.1184
Contributors: Silvia Sookoian; Diego Flichman; Martin E. Garaycoechea; Julio San Martino; Gustavo O. Castaño; Carlos J. Pirola
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The nonalcoholic steatohepatitis metabotype: Imbalance of circulating amino acids and transamination reactions reflect impaired mitochondrial function

Hepatology
2018-03 | Journal article
DOI: 10.1002/hep.29705
Contributors: Silvia Sookoian; Carlos J. Pirola
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Lack of evidence supporting a role of TMC4-rs641738 missense variant—MBOAT7- intergenic downstream variant—in the Susceptibility to Nonalcoholic Fatty Liver Disease

Scientific Reports
2018-03-23 | Journal article
DOI: 10.1038/s41598-018-23453-9
Contributors: Silvia Sookoian; Diego Flichman; Martin E. Garaycoechea; Carla Gazzi; Julio San Martino; Gustavo O. Castaño; Carlos J. Pirola
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Systematic review with meta‐analysis: the significance of histological disease severity in lean patients with nonalcoholic fatty liver disease

Alimentary Pharmacology & Therapeutics
2018-01 | Journal article
DOI: 10.1111/apt.14401
Contributors: S. Sookoian; C. J. Pirola
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Peer review (6 reviews for 4 publications/grants)

Review activity for Cell reports medicine. (1)
Review activity for Nature medicine. (3)
Review activity for The Lancet regional health. (1)
Review activity for Trends in molecular medicine. (1)
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