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Works (27)

The faucet knob effect of DptE crotonylation on the initial flow of daptomycin biosynthesis

Metabolic Engineering
2025-01 | Journal article
DOI: 10.1016/j.ymben.2024.11.003
Contributors: Wen-Li Gao; Lie Ma; Meng-Han Li; Wei-Feng Xu; Chen-Fan Sun; Qing-Wei Zhao; Xin-Ai Chen; Zhong-Yuan Lyu; Yong-quan Li
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Stepwise increase of fidaxomicin in an engineered heterologous host Streptomyces albus through multi-level metabolic engineering

Synthetic and Systems Biotechnology
2024-12 | Journal article
DOI: 10.1016/j.synbio.2024.06.004
Contributors: Huang Xie; Yi-Ting Su; Qing-Ting Bu; Yue-Ping Li; Qing-Wei Zhao; Yi-Ling Du; Yong-Quan Li
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De Novo Biosynthesis of a Bioactive Meroterpene Bakuchiol in Yeast

ACS Synthetic Biology
2024-11-15 | Journal article
DOI: 10.1021/acssynbio.4c00416
Contributors: Yi-Lei Zheng; Ye Xu; Yan-Qiu Liu; Qing-Wei Zhao; Yong-Quan Li
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Transcriptional regulation of the fidaxomicin gene cluster and cellular development in Actinoplanes deccanensis YP-1 by the pleiotropic regulator MtrA

Microbiology Spectrum
2023-12-12 | Journal article
DOI: 10.1128/spectrum.02702-23
Contributors: Huang Xie; Jing-Yi Ruan; Qing-Ting Bu; Yue-Ping Li; Yi-Ting Su; Qing-Wei Zhao; Yi-Ling Du; Yong-Quan Li; Xiaoyu Tang
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A Novel Zn2Cys6 Transcription Factor, TopC, Positively Regulates Trichodin A and Asperpyridone A Biosynthesis in Tolypocladium ophioglossoides

Microorganisms
2023-10-17 | Journal article
DOI: 10.3390/microorganisms11102578
Contributors: Xiang Liu; Rui-Qi Li; Qing-Xin Zeng; Yong-Quan Li; Xin-Ai Chen
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Identification and Characterization of a New Regulator, TagR, for Environmental Stress Resistance Based on the DNA Methylome of Streptomyces roseosporus

Microbiology Spectrum
2023-06-15 | Journal article
DOI: 10.1128/spectrum.00380-23
Contributors: Wen-Li Gao; Jiao-Le Fang; Chen-Yang Zhu; Wei-Feng Xu; Zhong-Yuan Lyu; Xin-Ai Chan; Qing-Wei Zhao; Yong-Quan Li; Wenli Li
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Degradation mechanism of AtrA mediated by ClpXP and its application in daptomycin production in Streptomyces roseosporus

Protein Science
2023-04 | Journal article
DOI: 10.1002/pro.4617
Contributors: Wei‐Feng Xu; Chen‐Fan Sun; Wen‐Li Gao; Daniel H. Scharf; Chen‐Yang Zhu; Qing‐Ting Bu; Qing‐Wei Zhao; Yong‐Quan Li
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Chemoenzymatic Synthesis of Phenol Diarylamine Using Non-Heme Diiron N-Oxygenase

ACS Catalysis
2023-01-20 | Journal article
DOI: 10.1021/acscatal.2c05190
Contributors: Yuan-Yang Guo; Ze-Hua Tian; Luying Wang; Zheng-De Lai; Lingjun Li; Yong-Quan Li
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m4C DNA methylation regulates biosynthesis of daptomycin in Streptomyces roseosporus L30

Synthetic and Systems Biotechnology
2022-12 | Journal article
DOI: 10.1016/j.synbio.2022.06.001
Contributors: Jiao-Le Fang; Wen-Li Gao; Wei-Feng Xu; Zhong-Yuan Lyu; Lie Ma; Shuai Luo; Xin-Ai Chen; Xu-Ming Mao; Yong-Quan Li
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Salinomycin biosynthesis reversely regulates the β‐oxidation pathway in Streptomyces albus by carrying a 3‐hydroxyacyl‐CoA dehydrogenase gene in its biosynthetic gene cluster

Microbial Biotechnology
2022-12 | Journal article
DOI: 10.1111/1751-7915.14145
Contributors: Jiaxiu Wei; Binbin Chen; Jianxin Dong; Xueyu Wang; Yongquan Li; Yingchun Liu; Wenjun Guan
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Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism

Biomolecules
2022-12-10 | Journal article
DOI: 10.3390/biom12121848
Contributors: Weifeng Xu; Wenli Gao; Qingting Bu; Yongquan Li
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Chemoenzymatic Cascade Synthesis of Phenol Diarylamine Using Non-Heme Diiron N-Oxygenase

2022-08-29 | Preprint
DOI: 10.21203/rs.3.rs-1970030/v1
Contributors: Yuanyang Guo; Ze-Hua Tian; Luying Wang; Zheng-De Lai; Lingjun Li; Yong-Quan Li
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Redirection of acyl donor metabolic flux for lipopeptide A40926B0 biosynthesis

Microbial Biotechnology
2022-06 | Journal article
DOI: 10.1111/1751-7915.14021
Contributors: Tian‐Yu Xia; Xin‐Ai Chen; Yan‐Qiu Liu; Daniel H. Scharf; Qing‐Wei Zhao; Yong‐Quan Li
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Gram-Level Production of Balanol through Regulatory Pathway and Medium Optimization in Herb Fungus Tolypocladium ophioglossoides

Journal of Fungi
2022-05-16 | Journal article
DOI: 10.3390/jof8050510
Contributors: Rui-Qi Li; Xiang Liu; Min Zhang; Wei-Qun Xu; Yong-Quan Li; Xin-Ai Chen
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A novel strategy of gene screen based on multi-omics in Streptomyces roseosporus

Applied Microbiology and Biotechnology
2022-04 | Journal article
DOI: 10.1007/s00253-022-11904-3
Contributors: Wei-Feng Xu; Jiao-Le Fang; Qing-Ting Bu; Zhong-Yuan Lyu; Chen-Yang Zhu; Chen-Fan Sun; Qing-Wei Zhao; Yong-Quan Li
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Directed Evolution of a Nonheme Diiron N-oxygenase AzoC for Improving Its Catalytic Efficiency toward Nitrogen Heterocycle Substrates

Molecules
2022-01-27 | Journal article
DOI: 10.3390/molecules27030868
Contributors: Ye Xu; Xiao-Fang Liu; Xin-Ai Chen; Yong-Quan Li
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Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis

Microbial Cell Factories
2021-12 | Journal article
DOI: 10.1186/s12934-021-01660-w
Contributors: Qing-Bin Wu; Xiao-Ying Zhang; Xin-Ai Chen; Yong-Quan Li
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Discovery of Semi-Pinacolases from the Epoxide Hydrolase Family during Efficient Assembly of a Fungal Polyketide

ACS Catalysis
2021-12-17 | Journal article
DOI: 10.1021/acscatal.1c03899
Contributors: Fei Cao; Wen-Tao Tao; Qian Yu; Chu-Xuan Xu; Jin-Tao Cheng; Ruo-Xi Liu; Qing-Wei Zhao; Xin-Hang Jiang; Yu Liu; Yong-Quan Li et al.
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Strategy for Producing the High-Quality Glycopeptide Antibiotic A82846B in Amycolatopsis orientalis Based on the CRISPR-Cas12a System

ACS Synthetic Biology
2021-11-19 | Journal article
DOI: 10.1021/acssynbio.1c00317
Contributors: Hui Qian; Wei Wei; Xin-Ai Chen; Xiao-Ting Mo; Mei Ge; Qing-Wei Zhao; Yong-Quan Li
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Activation and discovery of tsukubarubicin from Streptomyces tsukubaensis through overexpressing SARPs

Applied Microbiology and Biotechnology
2021-06-22 | Journal article
DOI: 10.1007/s00253-021-11344-5
Contributors: Qing-Bin Wu; Xin-Ai Chen; Zhong-Yuan Lv; Xiao-Ying Zhang; Yu Liu; Yong-Quan Li
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A Cell Factory of a Fungicolous Fungus Calcarisporium arbuscula for Efficient Production of Natural Products

ACS Synthetic Biology
2021-04-16 | Journal article
DOI: 10.1021/acssynbio.0c00371
Contributors: Jin-Tao Cheng; Jia-Hui Yu; Chen-Fan Sun; Fei Cao; You-Min Ying; Zha-Jun Zhan; Wen-Ju Li; Xin-Ai Chen; Qing-Wei Zhao; Yong-Quan Li et al.
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Comprehensive dissection of dispensable genomic regions in Streptomyces based on comparative analysis approach

Microbial Cell Factories
2020-12 | Journal article
DOI: 10.1186/s12934-020-01359-4
Contributors: Qing-Ting Bu; Yue-Ping Li; Huang Xie; Jue Wang; Zi-Yue Li; Xin-Ai Chen; Xu-Ming Mao; Yong-Quan Li
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Activation of anthrachamycin biosynthesis in Streptomyces chattanoogensis L10 by site-directed mutagenesis of rpoB

Journal of Zhejiang University-SCIENCE B
2019-12 | Journal article
DOI: 10.1631/jzus.B1900344
Contributors: Zi-yue Li; Qing-ting Bu; Jue Wang; Yu Liu; Xin-ai Chen; Xu-ming Mao; Yong-Quan Li
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Rational construction of genome-reduced and high-efficient industrial Streptomyces chassis based on multiple comparative genomic approaches

Microbial Cell Factories
2019-12 | Journal article
DOI: 10.1186/s12934-019-1055-7
Contributors: Qing-Ting Bu; Pin Yu; Jue Wang; Zi-Yue Li; Xin-Ai Chen; Xu-Ming Mao; Yong-Quan Li
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Molecular mechanism of azoxy bond formation for azoxymycins biosynthesis

Nature Communications
2019-10-08 | Journal article
DOI: 10.1038/s41467-019-12250-1
Contributors: Yuan-Yang Guo; Zhen-Hua Li; Tian-Yu Xia; Yi-Ling Du; Xu-Ming Mao; Yong-Quan Li
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FadR1, a pathway-specific activator of fidaxomicin biosynthesis in Actinoplanes deccanensis Yp-1

Applied Microbiology and Biotechnology
2019-09 | Journal article
DOI: 10.1007/s00253-019-09949-y
Contributors: Yue-Ping Li; Pin Yu; Ji-Feng Li; Yi-Li Tang; Qing-Ting Bu; Xu-Ming Mao; Yong-Quan Li
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Revelation of the Balanol Biosynthetic Pathway in Tolypocladium ophioglossoides

Organic Letters
2018-10-19 | Journal article
DOI: 10.1021/acs.orglett.8b01543
Contributors: Xian He; Min Zhang; Yuan-Yang Guo; Xu-Ming Mao; Xin-Ai Chen; Yong-Quan Li
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Peer review (1 review for 1 publication/grant)

Review activity for Organic letters. (1)
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