Personal information

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Other IDs

Scopus Author ID: 57202609768

Keywords

Genomics, molecular genetics, bioinformatics, computational biology

Countries

New Zealand

Biography

A dedicated researcher with extensive experience in molecular genetics, genomics, bioinformatics, and computational biology.
Demonstrated expertise in developing data analysis pipelines and implementing bioinformatics tools for in-depth genomic
data interpretation. Proficient at leading bioinformatics projects, having effectively coordinated collaborations in both New
Zealand and Australia. Published researcher with expertise in translating complex scientific data into comprehensible insights
for diverse audiences. Possesses a unique blend of hands-on laboratory experience, data analytics proficiency, and robust
project management skills, making a notable impact in the field of biomedical sciences.

Activities

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Employment (2)

University of Auckland: Auckland, NZ

2023-10-02 to present | Research Fellow (Liggins Institute)
Employment
Source: Self-asserted source
Denis M Nyaga

University of Otago: Wellington, NZ

2021-08-15 to 2023-08-15 | Postdoctoral Fellow (Paediatrics and Child Health)
Employment
Source: Self-asserted source
Denis M Nyaga

Education and qualifications (3)

University of Auckland: Auckland, NZ

2017-05-01 to 2020-10-30 | PhD Biomedical Sciences (Liggins Insitute)
Education
Source: Self-asserted source
Denis M Nyaga

University of Hull: Hull, Kingston upon Hull, GB

2014-08-25 to 2015-08-15 | MSc Translational Oncology (Biomedical Sciences)
Education
Source: Self-asserted source
Denis M Nyaga

Kenyatta University: Nairobi, Nairobi, KE

2009-09-04 to 2013-04-05 | BSc Molecular and Cellular Biology (Biochemistry and Biotechnology )
Education
Source: Self-asserted source
Denis M Nyaga

Works (17)

From blood vessels to brain cells: Connecting the circulatory system and Parkinson's disease

Journal of Parkinson’s Disease
2025-03 | Journal article
DOI: 10.1177/1877718X241308168
Contributors: Oyedele J Olaoye; Sophie L Farrow; Denis M Nyaga; Antony A Cooper; Justin M O’Sullivan
Source: check_circle
Crossref

Benchmarking nanopore sequencing and rapid genomics feasibility: validation at a quaternary hospital in New Zealand

npj Genomic Medicine
2024-11-08 | Journal article
DOI: 10.1038/s41525-024-00445-5
Contributors: Denis M. Nyaga; Peter Tsai; Clare Gebbie; Hui Hui Phua; Patrick Yap; Polona Le Quesne Stabej; Sophie Farrow; Jing Rong; Gergely Toldi; Eric Thorstensen et al.
Source: check_circle
Crossref

Code error in Wang H, Avillach P. “Diagnostic Classification and Prognostic Prediction Using Common Genetic Variants in Autism Spectrum Disorder: Genotype-Based Deep Learning.” (Preprint)

2024-09-21 | Preprint
DOI: 10.2196/preprints.66556
Contributors: Catriona Miller; Theo Portlock; Denis M Nyaga; Greg D Gamble; Justin M O'Sullivan
Source: check_circle
Crossref

A review of model evaluation metrics for machine learning in genetics and genomics

Frontiers in Bioinformatics
2024-09-10 | Journal article
DOI: 10.3389/fbinf.2024.1457619
Part of ISSN: 2673-7647
Contributors: Catriona Miller; Theo Portlock; Denis M. Nyaga; Justin M. O’Sullivan
Source: Self-asserted source
Denis M Nyaga

SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?

Epilepsia
2024-08 | Journal article
DOI: 10.1111/epi.18016
Contributors: Emma Young; Rebekah Harris; Nico Lieffering; Guillem de Valles‐Ibáñez; Denis Nyaga; Mark F. Bennett; Michael S. Hildebrand; Ingrid E. Scheffer; Lynette G. Sadleir
Source: check_circle
Crossref

Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy

Nature Communications
2024-08-22 | Journal article
DOI: 10.1038/s41467-024-51310-z
Part of ISSN: 2041-1723
Contributors: Emily Banks; Vincent Francis; Sheng-Jia Lin; Fares Kharfallah; Vladimir S. FONOV; Maxime Lévesque; Chanshuai Han; Gopinath Kulasekaran; Marius Tuznik; Armin Bayati et al.
Source: Self-asserted source
Denis M Nyaga

Diagnostic utility of DNA methylation analysis in genetically unsolved pediatric epilepsies and CHD2 episignature refinement

Nature Communications
2024-08-06 | Journal article | Author
DOI: 10.1038/s41467-024-50159-6
Part of ISSN: 2041-1723
Contributors: Christy W. LaFlamme; Cassandra Rastin; Soham Sengupta; Helen Pennington; Sophie Russ-Hall; Amy Schneider; Emily S. Bonkowski; Edith P. Almanza Fuerte; Talia Judith Allan; Miranda PG Zalusky et al.
Source: Self-asserted source
Denis M Nyaga

Benchmarking and quality control for nanopore sequencing and feasibility of rapid genomics in New Zealand: validation phase at a single quaternary hospital

2024-06-15 | Preprint
DOI: 10.1101/2024.06.13.24307636
Contributors: Denis M. Nyaga; Peter Tsai; Clare Gebbie; Hui Hui Phua; Patrick Yap; Polona Le Quesne Stabej; Sophie Farrow; Jing Rong; Gergely Toldi; Eric Thorstensen et al.
Source: check_circle
Crossref

Leveraging multiple approaches for the detection of pathogenic deep intronic variants in developmental and epileptic encephalopathies: A case report

Epilepsia Open
2024-04 | Journal article
DOI: 10.1002/epi4.12887
Contributors: Denis M. Nyaga; Michael S. Hildebrand; Guillem de Valles‐Ibáñez; Ngaire F. Keenan; Zimeng Ye; Christy W. LaFlamme; Heather C. Mefford; Mark F. Bennett; Melanie Bahlo; Lynette G. Sadleir
Source: check_circle
Crossref

A de novo ACTB gene pathogenic variant in identical twins with phenotypic variation for hydrops and jejunal atresia

American Journal of Medical Genetics Part A
2022-04 | Journal article
DOI: 10.1002/ajmg.a.62631
Part of ISSN: 1552-4825
Part of ISSN: 1552-4833
Contributors: Kristina Sibbin; Patrick Yap; Denis Nyaga; Raoul Heller; Stephen Evans; Kate Strachan; Salam Alburaiky; Han M. (Alex) Nguyen; Sylvie Hermann‐Le Denmat; Austen R. D. Ganley et al.
Source: Self-asserted source
Denis M Nyaga

Assigning function to SNPs: Considerations when interpreting genetic variation

Seminars in Cell & Developmental Biology
2022-01 | Journal article
DOI: 10.1016/j.semcdb.2021.08.008
Part of ISSN: 1084-9521
Contributors: Tayaza Fadason; Sophie Farrow; Sreemol Gokuladhas; Evgeniia Golovina; Denis Nyaga; Justin M. O’Sullivan; William Schierding
Source: Self-asserted source
Denis M Nyaga

Identifying the lungs as a susceptible site for allele-specific regulatory changes associated with type 1 diabetes risk

Communications Biology
2021-09-14 | Journal article
DOI: 10.1038/s42003-021-02594-0
Part of ISSN: 2399-3642
Contributors: Daniel Ho; Denis M. Nyaga; William Schierding; Richard Saffery; Jo K. Perry; John A. Taylor; Mark Vickers; Andreas W. Kempa-Liehr; Justin O'Sullivan
Source: Self-asserted source
Denis M Nyaga

Untangling the genetic link between type 1 and type 2 diabetes using functional genomics

Scientific Reports
2021-07-06 | Journal article
DOI: 10.1038/s41598-021-93346-x
Part of ISSN: 2045-2322
Contributors: Denis M. Nyaga; Mark H. Vickers; Craig Jefferies; Tayaza Fadason; Justin M. O’Sullivan
Source: Self-asserted source
Denis M Nyaga

A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors

2020-04-15 | Preprint
DOI: 10.1101/2020.04.14.042002
Contributors: Tayaza Fadason; Sreemol Gokuladhas; Evgeniia Golovina; Daniel Ho; Sophie Farrow; Denis Nyaga; Hong Pan; Neerja Karnani; Conroy Wong; Antony Cooper et al.
Source: Self-asserted source
Denis M Nyaga

Type 1 Diabetes Mellitus-Associated Genetic Variants Contribute to Overlapping Immune Regulatory Networks

Frontiers in Genetics
2018-11 | Journal article
DOI: 10.3389/fgene.2018.00535
Part of ISSN: 1664-8021
Contributors: Denis M. Nyaga; Mark H. Vickers; Craig Jefferies; Jo K. Perry; Justin M. O’Sullivan
Source: Self-asserted source
Denis M Nyaga via Crossref Metadata Search

The genetic architecture of type 1 diabetes mellitus

Molecular and Cellular Endocrinology
2018-06 | Journal article
DOI: 10.1016/j.mce.2018.06.002
Part of ISSN: 0303-7207
Contributors: Denis M. Nyaga; Mark H. Vickers; Craig Jefferies; Jo K. Perry; Justin M. O'Sullivan
Source: Self-asserted source
Denis M Nyaga via Crossref Metadata Search
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Type 1 diabetes mellitus-associated genetic variants contribute to overlapping immune regulatory networks

2018-05 | Other
DOI: 10.1101/325225
Contributors: Denis M Nyaga; Mark H Vickers; Craig Jefferies; Jo K Perry; Justin Martin O'Sullivan
Source: Self-asserted source
Denis M Nyaga via Crossref Metadata Search
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