Personal information

Keywords

Organic synthesis, novel chemical methods, medicinal chemistry

Countries

New Zealand

Activities

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Employment (2)

The University of Auckland: Auckland, NZ

2013-02-01 to present | Associate Professor (Chemical Sciences)
Employment
Source: check_circle
The University of Auckland

University of Auckland: Auckland, NZ

2010-01 to present | Associate Professor (School of Chemical Sciences)
Employment
Source: Self-asserted source
Daniel Furkert

Education and qualifications (5)

University of Bath: Bath, Bath and North East Somer, GB

2006-01 to 2009-12 | Postdoc (Pharmacy & Phamacology)
Education
Source: Self-asserted source
Daniel Furkert

The University of Auckland: Auckland, NZ

2004-10-17 | Doctor of Philosophy
Education
Source: check_circle
The University of Auckland

Oregon State University: Corvallis, OR, US

2003-02 to 2004-09 | Postdoc (Chemistry)
Education
Source: Self-asserted source
Daniel Furkert

University of Auckland: Auckland, Auckland, NZ

1999-01-11 to 2003-02-08 | PhD (School of Chemical Sciences)
Education
Source: Self-asserted source
Daniel Furkert

The University of Auckland: Auckland, NZ

1998-05-07 | Bachelor of Science (Honours)
Education
Source: check_circle
The University of Auckland

Funding (3)

Unlocking the therapeutic potential of the human cannabinoid CB1 receptor: Rational design of novel allosteric modulators.

2023 to 2026 | Contract
Marsden Fund (Wellington, NZ)
PROPOSAL_ID:

MFP-22-UOO-205

GRANT_NUMBER:

MFP-UOO2202
Source: check_circle
Royal Society Te Apārangi

Unravelling the unprecedented architecture of the NZ natural product portimine using molecular chess

2015 to 2018 | Contract
Marsden Fund (Wellington, NZ)
PROPOSAL_ID:

MFP-14-UOA-190

GRANT_NUMBER:

MFP-UOA1422
Source: check_circle
Royal Society Te Apārangi

A novel route to restricting G-protein coupled receptor signalling

2012 to 2015 | Contract
Marsden Fund (Wellington, NZ)
PROPOSAL_ID:

MFP-11-UOA-201

GRANT_NUMBER:

MFP-UOA1102
Source: check_circle
Royal Society Te Apārangi

Works (48)

Total Synthesis of (−)‐Cordycicadin D and 3,4‐trans‐Cordycicadins A and B: Entry to the 3,4‐trans‐Fused Cordycicadin Framework

Angewandte Chemie International Edition
2025-02-10 | Journal article
DOI: 10.1002/anie.202419989
Contributors: Liam R. Hunt; Phillip S. Grant; Grace K. Shimokura; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Total Synthesis of (−)‐Cordycicadin D and 3,4‐trans‐Cordycicadins A and B: Entry to the 3,4‐trans‐Fused Cordycicadin Framework

Angewandte Chemie
2025-02-10 | Journal article
DOI: 10.1002/ange.202419989
Contributors: Liam R. Hunt; Phillip S. Grant; Grace K. Shimokura; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Synthesis of the bicyclic butenolide core of pallamolide A: a biomimetic approach

Organic & Biomolecular Chemistry
2024 | Journal article
DOI: 10.1039/D4OB01380H
Contributors: Grace J. Drummond; Phillip S. Grant; Alisha M. Geurts; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Total Synthesis of (–)-Cordycicadin D and 3,4-trans-Cordycicadins A and B: Entry to the 3,4-trans-Fused Cordycicadin Framework

2024-11-15 | Preprint
DOI: 10.26434/chemrxiv-2024-swzp7
Contributors: Liam Hunt; Phillip Grant; Grace Shimokura; Daniel Furkert; Margaret Brimble
Source: check_circle
Crossref

Synthesis and α-Functionalisation of Cyclic Imines

Synlett
2024-09 | Journal article
DOI: 10.1055/a-2251-4145
Contributors: Margaret A. Brimble; Ze Kuang; Xiao-Bo Ding; Daniel P. Furkert
Source: check_circle
Crossref

Essential Dynamics of CB1Receptor-Agonist Complexes: Implications for Signalling Bias

2024-03-29 | Preprint
DOI: 10.1101/2024.03.25.586709
Contributors: Daniel M. J. Fellner; Michelle Glass; Daniel P. Furkert
Source: check_circle
Crossref

Determination of the Cannabinoid CB1 Receptor’s Positive Allosteric Modulator Binding Site through Mutagenesis Studies

Pharmaceuticals
2024-01-24 | Journal article
DOI: 10.3390/ph17020154
Contributors: Hayley M. Green; Daniel M. J. Fellner; David B. Finlay; Daniel P. Furkert; Michelle Glass
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

P1 Glutamine isosteres in the design of inhibitors of 3C/3CL protease of human viruses of the Pisoniviricetes class

RSC Chemical Biology
2023 | Journal article
DOI: 10.1039/D3CB00075C
Contributors: Louise A. Stubbing; Jonathan G. Hubert; Joseph Bell-Tyrer; Yann O. Hermant; Sung Hyun Yang; Alice M. McSweeney; Geena M. McKenzie-Goldsmith; Vernon K. Ward; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Stereoselective synthesis of the spirocyclic core of 13-desmethyl spirolide C using an aza-Claisen rearrangement and an exo-selective Diels–Alder cycloaddition

Organic & Biomolecular Chemistry
2023 | Journal article
DOI: 10.1039/D2OB01992B
Contributors: Andrew D. W. Earl; Freda F. Li; Chao Ma; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Synthesis of the spiroimine fragment of portimines A and B

Organic & Biomolecular Chemistry
2023 | Journal article
DOI: 10.1039/D3OB00998J
Contributors: Xiao-Bo Ding; Alexander Wung; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Azide–Enolate Cycloaddition‐Rearrangement Enables Direct α‐Amination of Amides and Enelactam Synthesis from Esters

Chemistry – A European Journal
2023-06-02 | Journal article
DOI: 10.1002/chem.202301235
Contributors: Joseph J. Bell‐Tyrer; Paul A. Hume; Phillip S. Grant; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Azide–Enolate Cycloaddition‐Rearrangement Enables Direct α‐Amination of Amides and Enelactam Synthesis from Esters**

Chemistry – A European Journal
2023-06-02 | Journal article
DOI: 10.1002/chem.202300261
Contributors: Joseph J. Bell‐Tyrer; Paul A. Hume; Phillip S. Grant; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Front Cover: Azide–Enolate Cycloaddition‐Rearrangement Enables Direct α‐Amination of Amides and Enelactam Synthesis from Esters (Chem. Eur. J. 31/2023)

Chemistry – A European Journal
2023-06-02 | Journal article
DOI: 10.1002/chem.202301234
Contributors: Joseph J. Bell‐Tyrer; Paul A. Hume; Phillip S. Grant; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Total Synthesis of Spiroketal Alkaloids Lycibarbarines A–C

Organic Letters
2023-04-28 | Journal article
DOI: 10.1021/acs.orglett.3c00902
Contributors: Eilidh G. Young; Phillip S. Grant; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Total Synthesis of Spiroketal Alkaloids Lycibarbarines A–C

2023-03-22 | Preprint
DOI: 10.26434/chemrxiv-2023-hsgb9
Contributors: Eilidh Young; Phillip Grant; Daniel Furkert; Margaret Brimble
Source: check_circle
Crossref

Direct alpha-Amination of Amides and Lactams Enabled by the (3+2) Vinyl Azide-Enolate Cycloaddition Manifold

2022-05-30 | Preprint
DOI: 10.26434/chemrxiv-2022-cf0c3-v2
Contributors: Joseph Bell-Tyrer; Paul Hume; Phillip Grant; Margaret Brimble; Daniel Furkert
Source: check_circle
Crossref

Ene-gamma-lactam synthesis via (3+2) vinyl azide-enolate cycloaddition: Enolate addition to vinyl triazolinone intermediates

2022-05-30 | Preprint
DOI: 10.26434/chemrxiv-2022-dhhj9
Contributors: Joseph Bell-Tyrer; Paul Hume; Margaret Brimble; Daniel Furkert
Source: check_circle
Crossref

Direct alpha-Amination of Amides and Lactams Enabled by the (3+2) Vinyl Azide-Enolate Cycloaddition Manifold

2022-05-27 | Preprint
DOI: 10.26434/chemrxiv-2022-cf0c3
Contributors: Joseph Bell-Tyrer; Paul Hume; Phillip Grant; Margaret Brimble; Daniel Furkert
Source: check_circle
Crossref

Synthetic studies toward inducamide C

Organic & Biomolecular Chemistry
2021 | Journal article
DOI: 10.1039/D0OB01995J
Contributors: Ardalan A. Nabi; Lydia M. Scott; Daniel P. Furkert; Jonathan Sperry
Source: check_circle
Crossref

Synthesis of the C4–C16 Polyketide Fragment of Portimines A and B

The Journal of Organic Chemistry
2021-09-17 | Journal article
DOI: 10.1021/acs.joc.1c01463
Contributors: Xiao-Bo Ding; Harry R. M. Aitken; Esperanza S. Pearl; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

A Ring Closing Metathesis Approach to the Formal Synthesis of (+)‐Callyspongiolide

ChemCatChem
2020-11-19 | Journal article
DOI: 10.1002/cctc.202001139
Contributors: Kwang‐Yoon Ko; Zoe E. Wilson; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Total Synthesis of (±)-Leonuketal

Organic Letters
2020-11-06 | Journal article
DOI: 10.1021/acs.orglett.0c03364
Contributors: Phillip S. Grant; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Total Synthesis of (±)-Leonuketal

2020-07-20 | Other
DOI: 10.26434/chemrxiv.12673757.v1
Contributors: Phillip Grant; Dan Furkert; Margaret Brimble
Source: check_circle
Crossref

Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin

Organic Letters
2020-07-17 | Journal article
DOI: 10.1021/acs.orglett.0c01913
Contributors: Emma K. Davison; Jared L. Freeman; Wanli Zhang; William M. Wuest; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Synthetic approaches towards bedaquiline and its derivatives

Bioorganic & Medicinal Chemistry Letters
2020-06 | Journal article
DOI: 10.1016/j.bmcl.2020.127172
Contributors: Matthew B. Calvert; Daniel P. Furkert; Christopher B. Cooper; Margaret A. Brimble
Source: check_circle
Crossref

Utility of the Leptospermum scoparium Compound Lepteridine as a Chemical Marker for Manuka Honey Authenticity

ACS Omega
2020-04-21 | Journal article
DOI: 10.1021/acsomega.0c00486
Contributors: Bin Lin; Benjamin J. Daniels; Martin J. Middleditch; Daniel P. Furkert; Margaret A. Brimble; Jessie Bong; Jonathan M. Stephens; Kerry M. Loomes
Source: check_circle
Crossref

A Catalytic Asymmetric Ene Reaction for Direct Preparation of α-Hydroxy 1,4-Diketones as Intermediates in Natural Product Synthesis

Synlett
2020-04-19 | Journal article
DOI: 10.1055/s-0037-1610748
Contributors: Harry R. M. Aitken; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Synthetic Studies Towards Spirocyclic Imine Marine Toxins Using N-Acyl Iminium Ions as Dienophiles in Diels–Alder Reactions

Synlett
2020-04-13 | Journal article
DOI: 10.1055/s-0039-1691593
Contributors: Jared L. Freeman; Freda F. Li; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Intermolecular Diels–Alder Cycloaddition/Cross-Coupling Sequences of 2-Bromo-1,3-butadienes

Organic Letters
2020-02-07 | Journal article
DOI: 10.1021/acs.orglett.9b04567
Contributors: Hans Choi; Harry J. Shirley; Harry R. M. Aitken; Tim Schulte; Tilo Söhnel; Paul A. Hume; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis

Natural Product Reports
2019 | Journal article
DOI: 10.1039/C8NP00051D
Contributors: James M. Wood; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

A chiral auxiliary-based synthesis of the C5–C17 trans-decalin framework of anthracimycin

Organic Chemistry Frontiers
2019 | Journal article
DOI: 10.1039/C9QO00769E
Contributors: Jared L. Freeman; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Convenient access to 5-membered cyclic iminium ions: evidence for a stepwise [4 + 2] cycloaddition mechanism

Organic & Biomolecular Chemistry
2019 | Journal article
DOI: 10.1039/C9OB00262F
Contributors: Jared L. Freeman; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Divalent Cannabinoid-1 Receptor Ligands: A Linker Attachment Point Survey of SR141716A for Development of High-Affinity CB1R Molecular Probes

Bioorganic & Medicinal Chemistry Letters
2019-08 | Journal article
DOI: 10.1016/j.bmcl.2019.126644
Contributors: Phillip S. Grant; Nils Kahlcke; Karan Govindpani; Morag Hunter; Christa MacDonald; Margaret A. Brimble; Michelle Glass; Daniel P. Furkert
Source: check_circle
Crossref

Highly Diastereoselective Synthesis of Syn‐1,3‐Dihydroxyketone Motifs from Propargylic Alcohols via Spiroepoxide Intermediates

Angewandte Chemie
2019-08-19 | Journal article
DOI: 10.1002/ange.201905736
Contributors: Xiao‐Bo Ding; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Highly Diastereoselective Synthesis of Syn‐1,3‐Dihydroxyketone Motifs from Propargylic Alcohols via Spiroepoxide Intermediates

Angewandte Chemie International Edition
2019-08-19 | Journal article
DOI: 10.1002/anie.201905736
Contributors: Xiao‐Bo Ding; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Naturally Occurring Lumazines

Journal of Natural Products
2019-07-26 | Journal article
DOI: 10.1021/acs.jnatprod.9b00351
Contributors: Benjamin J. Daniels; Freda F. Li; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Synthesis of the Bicyclic Lactone Core of Leonuketal, Enabled by a Telescoped Diels–Alder Reaction Sequence

Chemistry – An Asian Journal
2019-04-15 | Journal article
DOI: 10.1002/asia.201800903
Contributors: Phillip S. Grant; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Reactivity of 2-Nitropyrrole Systems: Development of Improved Synthetic Approaches to Nitropyrrole Natural Products

The Journal of Organic Chemistry
2018-10-19 | Journal article
DOI: 10.1021/acs.joc.8b01692
Contributors: Xiao-Bo Ding; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Total Synthesis of (−)-Peniphenone A

The Journal of Organic Chemistry
2018-07-06 | Journal article
DOI: 10.1021/acs.joc.7b03231
Contributors: Mathilde Pantin; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Total Synthesis of the Highly N-Methylated Acetylene-Containing Anticancer Peptide Jahanyne

Organic Letters
2018-02-02 | Journal article
DOI: 10.1021/acs.orglett.7b03925
Contributors: Andrew Siow; George Opiyo; Iman Kavianinia; Freda F. Li; Daniel P. Furkert; Paul W. R. Harris; Margaret A. Brimble
Source: check_circle
Crossref

Gold catalysis: synthesis of spiro, bridged, and fused ketal natural products

Organic & Biomolecular Chemistry
2017 | Journal article
DOI: 10.1039/C7OB00496F
Contributors: Rachelle Quach; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Synthesis and biological evaluation of novel teixobactin analogues

Org. Biomol. Chem.
2017 | Journal article
DOI: 10.1039/C7OB02169K
Contributors: Christian E. Schumacher; Paul W. R. Harris; Xiao-Bo Ding; Bernard Krause; Tom H. Wright; Gregory M. Cook; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Stereochemical Characterization of Polyketide Stereotriads Synthesized via Hydrogen-Mediated Asymmetric syn-Crotylation

The Journal of Organic Chemistry
2017-10-20 | Journal article
DOI: 10.1021/acs.joc.7b01820
Contributors: Mathilde Pantin; Jonathan G. Hubert; Tilo Söhnel; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

General Synthesis of the Nitropyrrolin Family of Natural Products via Regioselective CO2-Mediated Alkyne Hydration

Organic Letters
2017-10-06 | Journal article
DOI: 10.1021/acs.orglett.7b02687
Contributors: Xiao-Bo Ding; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Total Synthesis and Stereochemical Revision of the 2-Formylpyrrole Alkaloid Hemerocallisamine I

Journal of Natural Products
2017-06-23 | Journal article
DOI: 10.1021/acs.jnatprod.7b00314
Contributors: James M. Wood; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Unexpected Direct Synthesis of N‐Vinyl Amides through Vinyl Azide–Enolate [3+2] Cycloaddition

Angewandte Chemie International Edition
2017-06-19 | Journal article
DOI: 10.1002/anie.201702727
Contributors: Hans Choi; Harry J. Shirley; Paul A. Hume; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

Unexpected Direct Synthesis of N‐Vinyl Amides through Vinyl Azide–Enolate [3+2] Cycloaddition

Angewandte Chemie
2017-06-19 | Journal article
DOI: 10.1002/ange.201702727
Contributors: Hans Choi; Harry J. Shirley; Paul A. Hume; Margaret A. Brimble; Daniel P. Furkert
Source: check_circle
Crossref

2-Nitropyrrole cross-coupling enables a second generation synthesis of the heronapyrrole antibiotic natural product family

Chemical Communications
2016 | Journal article
DOI: 10.1039/C6CC07532K
Contributors: Xiao-Bo Ding; Daniel P. Furkert; Margaret A. Brimble
Source: check_circle
Crossref

Peer review (69 reviews for 13 publications/grants)

Review activity for ACS omega. (1)
Review activity for Angewandte Chemie. (2)
Review activity for Bioconjugate chemistry. (1)
Review activity for Chemistry - an Asian journal. (4)
Review activity for Chemistry. (2)
Review activity for Communications chemistry. (1)
Review activity for European journal of organic chemistry. (5)
Review activity for Journal of chemical education. (2)
Review activity for Journal of medicinal chemistry. (1)
Review activity for Journal of organic chemistry. (21)
Review activity for Nature synthesis. (1)
Review activity for Organic letters. (26)
Review activity for Tetrahedron letters. (2)
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