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Adrenocortical Carcinomas: Molecular Pathogenesis, Treatment Options, and Emerging Immunotherapy and Targeted Therapy Approaches

The Oncologist
2024 | Journal article
Contributors: Chukkalore, Divya; Macdougall, Kira; Master, Viraj; Bilen, Mehmet Asim; Nazha, Bassel
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Age- and sex-based differences in the genomic profiles of patients with gastrointestinal (GI) and pancreatic neuroendocrine neoplasms (NENs)

Journal of Clinical Oncology
2023 | Journal article
Contributors: Liu, Lisa; Li, Shuning; Gandhi, Nishant; Farrell, Alex Patrick; Lou, Emil; Soares, Heloisa P.; Nazha, Bassel; Swensen, Jeffrey; Oberley, Matthew James; Nabhan, Chadi et al.
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Association of baseline inflammatory biomarkers with outcomes in penile squamous cell carcinoma (pSCC) treated with immune checkpoint inhibitors (ICI)

Journal of Clinical Oncology
2023 | Journal article
Contributors: Zhuang, Tony; Goyal, Subir; Brown, Jacqueline T.; Carthon, Bradley Curtis; Kucuk, Omer; McClintock, Greta Russler; Yantorni, Lauren Beth; Bilen, Mehmet Asim; Master, Viraj A.; Nazha, Bassel
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Combined Programmed Death-Ligand 1 and MET Inhibition: Has Papillary Renal Cell Carcinoma MET Its Match?

Journal of Clinical Oncology
2023 | Journal article
Contributors: Brown, Jacqueline T. T.; Nazha, Bassel; Bilen, Mehmet Asim
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Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune-checkpoint inhibitor-related biomarkers

Cancer
2023 | Journal article
Contributors: Nazha, Bassel; Zhuang, Tony; Wu, Sharon; Brown, Jacqueline T.; Magee, Daniel; Carthon, Bradley C.; Kucuk, Omer; Nabhan, Chadi; Barata, Pedro C.; Heath, Elisabeth I. et al.
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Exploration of immunosuppressive features of the tumor microenvironment within hepatic and non-hepatic tumors of urothelial origin

Journal of Clinical Oncology
2023 | Journal article
Contributors: Brown, Jacqueline T.; Elliott, Andrew; Walker, Phillip; Xiu, Joanne; Nazha, Bassel; Stewart, Tyler F.; Gulati, Shuchi; Nandagopal, Lakshminarayanan; Goldman, Jamie; Kucuk, Omer et al.
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Immune-Related Adverse Events and Clinical Outcomes in Advanced Urothelial Cancer Patients Treated With Immune Checkpoint Inhibitors

The Oncologist
2023 | Journal article
Contributors: Sanda, Gregory E.; Shabto, Julie M.; Goyal, Subir; Liu, Yuan; Martini, Dylan J.; Nazha, Bassel; Brown, Jacqueline T.; Yantorni, Lauren B.; Russler, Greta Anne; Caulfield, Sarah et al.
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Molecular and immune analysis of adrenocortical carcinoma (ACC): Implications for immune checkpoint inhibition (ICI)

Journal of Clinical Oncology
2023 | Journal article
Contributors: Nazha, Bassel; Gandhi, Nishant; Naqash, Abdul Rafeh; Hadfield, Matthew James; Zhuang, Tony; Brown, Jacqueline T.; Carthon, Bradley Curtis; Barata, Pedro C.; Agarwal, Neeraj; Soares, Heloisa P. et al.
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Molecular characterization and clinical outcomes of pancreatic neuroendocrine tumors (pNENs) harboring PAK4-NAMPT alterations

Journal of Clinical Oncology
2023 | Journal article
Contributors: Azar, Ibrahim; Gandhi, Nishant; Nagasaka, Misako; Gong, Jun; Nazha, Bassel; Choucair, Khalil; Khushman, Moh'd M.; Soares, Heloisa P.; El-Deiry, Wafik S.; Philip, Agop Philip et al.
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Neoadjuvant platinum-based chemotherapy for clinically node-positive penile squamous cell carcinoma: An international, multicenter, real-world study

Journal of Clinical Oncology
2023 | Journal article
Contributors: Rose, Kyle M.; Sanchez, Darren; Mustasam, Arfa; Sandstrom, Reagan; Marchetti, Kathryn; Zacharias, Niki Marie; Pagliaro, Lance C.; Alifrangis, Constantine; Moses, Kelvin A.; Albersen, Maarten et al.
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Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors

Journal of the National Cancer Institute
2023 | Journal article
Contributors: El Zarif, Talal; Nassar, Amin H.; Pond, Gregory R.; Zhuang, Tony Zibo; Master, Viraj; Nazha, Bassel; Niglio, Scot; Simon, Nicholas; Hahn, Andrew W.; Pettaway, Curtis A. et al.
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The Genomic Landscape of Urothelial Carcinoma with High and Low <i>ERBB2</i> Expression

Cancers
2023 | Journal article
Contributors: Hadadi, Agreen; Krause, Harris B.; Elliott, Andrew; Brown, Jacqueline T.; Nazha, Bassel; Harik, Lara R.; Carthon, Bradley C.; Miron, Benjamin; Nabhan, Chadi; Barata, Pedro C. et al.
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The genomic landscape of urothelial carcinoma with high and low <i>ERBB2</i>/HER2 expression

Journal of Clinical Oncology
2023 | Journal article
Contributors: Hadadi, Agreen; Krause, Harris; Elliott, Andrew; Farrell, Alex Patrick; Brown, Jacqueline T.; Nazha, Bassel; Harik, Lara; Carthon, Bradley Curtis; Nabhan, Chadi; Barata, Pedro C. et al.
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Advances in Knowledge and Management of Immune-Related Adverse Events in Cancer Immunotherapy

Frontiers in Endocrinology
2022 | Journal article
Contributors: Olsen, T. Anders; Zhuang, Tony Zibo; Caulfield, Sarah; Martini, Dylan J.; Brown, Jacqueline T.; Carthon, Bradley C.; Kucuk, Omer; Harris, Wayne; Bilen, Mehmet Asim; Nazha, Bassel
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Analysis of Toxicity and Clinical Outcomes in Full Versus Reduced Starting Dose Cabozantinib in Metastatic Renal Cell Carcinoma Patients

Clinical Genitourinary Cancer
2022 | Journal article
Contributors: Martini, Dylan J.; Evans, Sean T.; Liu, Yuan; Shabto, Julie M.; Uner, Ogul E.; Olsen, T. Anders; Brown, Jacqueline T.; Russler, Greta Anne; Yantorni, Lauren; Caulfield, Sarah et al.
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Baseline basophil and basophil-to-lymphocyte status is associated with clinical outcomes in metastatic hormone sensitive prostate cancer

Urologic Oncology: Seminars and Original Investigations
2022 | Journal article
Contributors: Hadadi, Agreen; Smith, Katherine E. R.; Wan, Limeng; Brown, Jacqueline R.; Russler, Greta; Yantorni, Lauren; Caulfield, Sarah; Lafollette, Jennifer; Moore, Melvin; Kucuk, Omer et al.
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Baseline Neutrophil-to-Eosinophil Ratio Is Associated with Outcomes in Metastatic Renal Cell Carcinoma Treated with Immune Checkpoint Inhibitors

The Oncologist
2022 | Journal article
Contributors: Zhuang, Tony Z.; Ravindranathan, Deepak; Liu, Yuan; Martini, Dylan J.; Brown, Jacqueline T.; Nazha, Bassel; Russler, Greta; Yantorni, Lauren B.; Caulfield, Sarah; Carthon, Bradley C. et al.
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Blood-Based Next-Generation Sequencing in Adrenocortical Carcinoma

The Oncologist
2022 | Journal article
Contributors: Nazha, Bassel; Zhuang, Tony Z.; Dada, Hiba, I; Drusbosky, Leylah M.; Brown, Jacqueline T.; Ravindranathan, Deepak; Carthon, Bradley C.; Kucuk, Omer; Goldman, Jamie; Master, Viraj A. et al.
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Characteristics, Treatment and Outcomes of Patients with Primary Urethral Cancer: A Multi-Center Review over Two Decades

International Journal of Radiation Oncology Biology Physics
2022 | Journal article
Contributors: Qian, D. C.; Xu, K. M.; Hartsell, L. M.; Cimmino, C. B.; Joshi, S. S.; Filson, C. P.; Master, V.; Sanda, M. G.; Nazha, B.; Carthon, B. et al.
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Clinical outcomes in advanced urothelial cancer (UC) patients who experienced immune-related adverse events (irAEs) after immune checkpoint inhibitor monotherapy (ICI)

Journal of Clinical Oncology
2022 | Journal article
Contributors: Sanda, Gregory E.; Shabto, Julie M.; Goyal, Subir; Liu, Yuan; Martini, Dylan J.; Nazha, Bassel; Brown, Jacqueline T.; Yantorni, Lauren Beth; Russler, Greta; Caulfield, Sarah et al.
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Comprehensive genomic profiling of penile squamous cell carcinoma and impact of HPV status on immune-checkpoint inhibition-related biomarkers

Journal of Clinical Oncology
2022 | Journal article
Contributors: Nazha, Bassel; Wu, Sharon; Brown, Jacqueline T.; Magee, Daniel; Carthon, Bradley Curtis; Kucuk, Omer; Korn, W. Michael; Barata, Pedro C.; Heath, Elisabeth I.; Ryan, Charles J. et al.
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Concurrent Androgen Deprivation Therapy for Prostate Cancer Improves Survival for Synchronous or Metachronous Non-Small Cell Lung Cancer: A SEER-Medicare Database Analysis

Cancers
2022 | Journal article
Contributors: Nazha, Bassel; Zhang, Chao; Chen, Zhengjia; Ragin, Camille; Owonikoko, Taofeek K.
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Durable complete response for oligometastatic renal cell carcinoma with immune checkpoint inhibition and cytoreductive nephrectomy in a Jehovah's witness: A case report

Frontiers in Oncology
2022 | Journal article
Contributors: Zhuang, Tony Zibo; Harik, Lara; Force, Seth; Hadadi, Agreen; Bilen, Mehmet Asim; Brown, Jacqueline T.; Carthon, Bradley C.; Goldman, Jamie; Kucuk, Omer; Master, Viraj A. et al.
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Expression of Nectin-4 and PD-L1 in bladder cancer with variant histology

Journal of Clinical Oncology
2022 | Journal article
Contributors: Case, Katherine; Martini, Dylan J.; Dababneh, Melad; Nazha, Bassel; Brown, Jacqueline T.; Joshi, Shreyas S.; Narayan, Vikram M.; Ogan, Kenneth; Master, Viraj A.; Carthon, Bradley Curtis et al.
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High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells

Nature Communications
2022 | Journal article
Contributors: Boya, Mert; Ozkaya-Ahmadov, Tevhide; Swain, Brandi E.; Chu, Chia-Heng; Asmare, Norh; Civelekoglu, Ozgun; Liu, Ruxiu; Lee, Dohwan; Tobia, Sherry; Biliya, Shweta et al.
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Metastatic Clear-Cell Renal Cell Carcinoma in the Era of Immune Checkpoint Inhibitors: Therapies and Ongoing Trials

Cancers
2022 | Journal article
Contributors: Zhuang, Tony Zibo; Case, Katherine; Olsen, Timothy Anders; Brown, Jacqueline T.; Carthon, Bradley C.; Kucuk, Omer; Goldman, Jamie; Harris, Wayne; Bilen, Mehmet Asim; Nazha, Bassel
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Molecular and immune landscape of <i>FH</i>-mutated cancers

Journal of Clinical Oncology
2022 | Journal article
Contributors: Al-Share, Bayan A.; Wu, Sharon; Alloghbi, Abdurahman; Alkassis, Samer; Guastella, Anthony; Helmstetter, Anthony; Nabhan, Chadi; Nazha, Bassel; Barata, Pedro C.; Ryan, Charles J. et al.
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Molecular and immune landscape of <i>FH</i>-mutated kidney cancer

Journal of Clinical Oncology
2022 | Journal article
Contributors: Al-Share, Bayan A.; Wu, Sharon; Alloghbi, Abdurahman; Alkassis, Samer; Guastella, Anthony; Helmstetter, Anthony; Nabhan, Chadi; Korn, W. Michael; Nazha, Bassel; Barata, Pedro C. et al.
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Neoadjuvant platinum-based chemotherapy (NAPC) for metastatic penile squamous cell carcinoma (PSCC): An international, multicenter, real-world study

Annals of Oncology
2022 | Journal article
Contributors: Chahoud, J.; Mustasam, A.; Rose, K. M.; Spiess, P. E.; Moses, K. L.; Master, V. A.; Nazha, B.; Zhuang, T. Z.; Schneider, A.; Marchetti, K. et al.
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Phase 2 study of neoadjuvant cabozantinib in patients with locally advanced non-metastatic clear cell renal cell carcinoma

Journal of Clinical Oncology
2022 | Journal article
Contributors: Bilen, Mehmet Asim; Liu, Yuan; Nazha, Bassel; Brown, Jacqueline T.; Osunkoya, Adeboya O.; Williams, Sierra; Session, Wilena; Yantorni, Lauren Beth; Russler, Greta; Caulfield, Sarah et al.
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REAL-WORLD OUTCOMES IN PATIENTS WITH PENILE SQUAMOUS CELL CARCINOMA (PSCC) RECEIVING IMMUNE CHECKPOINT INHIBITORS (ICI)

Journal for ImmunoTherapy of Cancer
2022 | Journal article
Contributors: Zhuang, Tony; Goyal, Subir; Brown, Jacqueline; Carthon, Bradley; Kucuk, Omer; McClintock, Greta; Yantorni, Lauren; Bilen, Mehmet; Master, Viraj; Nazha, Bassel
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Sarcopenia as a predictor of perioperative morbidity in metastatic renal cell carcinoma patients undergoing radical nephrectomy and IVC tumor thrombectomy

Journal of Clinical Oncology
2022 | Journal article
Contributors: Midenberg, Eric; Medline, Alexandra; Patil, Dattatraya H.; Nazha, Bassel; Brown, Jacqueline T.; Ogan, Kenneth; Psutka, Sarah P.; Bilen, Mehmet Asim; Master, Viraj A.
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The prognostic role of sarcopenia and albumin in locally advanced renal cell carcinoma with IVC tumor thrombus

Journal of Clinical Oncology
2022 | Journal article
Contributors: Midenberg, Eric; Patil, Dattatraya H.; Medline, Alexandra; Higgins, Michelle; Williams, Milton; Nazha, Bassel; Brown, Jacqueline T.; Ogan, Kenneth; Psutka, Sarah P.; Bilen, Mehmet Asim et al.
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Association of basophil to lymphocyte ratio (BLR) with clinical outcomes in metastatic hormone sensitive prostate cancer

Journal of Clinical Oncology
2021 | Journal article
Contributors: Smith, Katherine Emilie Rhoades; Wan, Limeng; Liu, Yuan; Brown, Jacqueline T.; Russler, Greta; Yantorni, Lauren Beth; Caulfield, Sarah; Carthon, Bradley Curtis; Kucuk, Omer; Nazha, Bassel et al.
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Baseline modified Glasgow prognostic score (mGPS) in patients with metastatic renal cell carcinoma (mRCC) treated with immune checkpoint inhibitors (ICI)

Journal of Clinical Oncology
2021 | Journal article
Contributors: Brown, Jacqueline T.; Liu, Yuan; Martini, Dylan J.; Shabto, Julie M.; Russler, Greta; Caulfield, Sarah; Yantorni, Lauren Beth; Joshi, Shreyas S.; Kissick, Haydn; Ogan, Kenneth et al.
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Baseline neutrophil-to-eosinophil ratio (NER) and its association with clinical outcomes in patients with metastatic renal cell carcinoma (mRCC) treated with immune checkpoint inhibitors (CPI)

Journal of Clinical Oncology
2021 | Journal article
Contributors: Ravindranathan, Deepak; Liu, Yuan; Martini, Dylan J.; Brown, Jacqueline T.; Nazha, Bassel; Russler, Greta; Yantorni, Lauren Beth; Caulfield, Sarah; Carthon, Bradley Curtis; Kucuk, Omer et al.
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Benefits and limitations of real-world evidence: lessons from <i>EGFR</i> mutation-positive non-small-cell lung cancer

Future Oncology
2021 | Journal article
Contributors: Nazha, Bassel; Yang, James C-H; Owonikoko, Taofeek K.
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Body Composition as an Independent Predictive and Prognostic Biomarker in Advanced Urothelial Carcinoma Patients Treated with Immune Checkpoint Inhibitors

The Oncologist
2021 | Journal article
Contributors: Martini, Dylan J.; Shabto, Julie M.; Goyal, Subir; Liu, Yuan; Olsen, T. Anders; Evans, Sean T.; Magod, Benjamin L.; Ravindranathan, Deepak; Brown, Jacqueline T.; Yantorni, Lauren et al.
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Body Composition Variables as Radiographic Biomarkers of Clinical Outcomes in Metastatic Renal Cell Carcinoma Patients Receiving Immune Checkpoint Inhibitors

Frontiers in Oncology
2021 | Journal article
Contributors: Martini, Dylan J.; Olsen, T. Anders; Goyal, Subir; Liu, Yuan; Evans, Sean T.; Magod, Benjamin; Brown, Jacqueline T.; Yantorni, Lauren; Russler, Greta Anne; Caulfield, Sarah et al.
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Circulating Interleukin 6, Androgen Deprivation Therapy, and Fatigue in Prostate Cancer: Is Inflammation the Link?

Cancer
2021 | Journal article
Contributors: Nazha, Bassel; Bilen, Mehmet Asim
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Circulating tumor DNA (ctDNA) in patients with advanced adrenocortical carcinoma

Journal of Clinical Oncology
2021 | Journal article
Contributors: Nazha, Bassel; Dada, Hiba I.; Drusbosky, Leylah; Brown, Jacqueline T.; Ravindranathan, Deepak; Carthon, Bradley Curtis; Kucuk, Omer; Master, Viraj A.; Bilen, Mehmet Asim
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Clinical Outcomes and Racial Disparities in Metastatic Hormone-Sensitive Prostate Cancer in the Era of Novel Treatment Options

The Oncologist
2021 | Journal article
Contributors: Smith, Katherine Emilie Rhoades; Brown, Jacqueline Theresa; Wan, Limeng; Liu, Yuan; Russler, Greta; Yantorni, Lauren; Caulfield, Sarah; Lafollette, Jennifer; Moore, Melvin; Kucuk, Omer et al.
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Clinical outcomes in metastatic renal cell carcinoma (mRCC) treated with combination of nivolumab and cabozantinib (nivo-cabo) in the salvage setting

Journal of Clinical Oncology
2021 | Journal article
Contributors: Ravindranathan, Deepak; Liu, Yuan; Martini, Dylan J.; Nazha, Bassel; Brown, Jacqueline T.; Russler, Greta; Yantorni, Lauren Beth; Caulfield, Sarah; Master, Viraj A.; Carthon, Bradley Curtis et al.
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Immune-Related Adverse Events as Clinical Biomarkers in Patients with Metastatic Renal Cell Carcinoma Treated with Immune Checkpoint Inhibitors

The Oncologist
2021 | Journal article
Contributors: Martini, Dylan J.; Goyal, Subir; Liu, Yuan; Evans, Sean T.; Olsen, T. Anders; Case, Katherine; Magod, Benjamin L.; Brown, Jacqueline T.; Yantorni, Lauren; Russler, Greta Anne et al.
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Modified Glasgow Prognostic Score associated with survival in metastatic renal cell carcinoma treated with immune checkpoint inhibitors

Journal for ImmunoTherapy of Cancer
2021 | Journal article
Contributors: Brown, Jacqueline T.; Liu, Yuan; Shabto, Julie M.; Martini, Dylan; Ravindranathan, Deepak; Hitron, Emilie Elise; Russler, Greta Anne; Caulfield, Sarah; Yantorni, Lauren; Joshi, Shreyas Subhash et al.
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Phase II trial of opaganib in patients with metastatic castration-resistant prostate cancer progressing on abiraterone or enzalutamide (NCT04207255)

Journal of Clinical Oncology
2021 | Journal article
Contributors: Kucuk, Omer; Smith, Charles; Plasse, Terry; Ogretmen, Besim; Mehrotra, Shikhar; Gourdin, Theodore Stewart; Bilen, Mehmet Asim; Carthon, Bradley Curtis; Nazha, Bassel; Goldman, Jamie et al.
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Racial Differences in Clinical Outcomes for Metastatic Renal Cell Carcinoma Patients Treated With Immune-Checkpoint Blockade

Frontiers in Oncology
2021 | Journal article
Contributors: Olsen, T. Anders; Martini, Dylan J.; Goyal, Subir; Liu, Yuan; Evans, Sean T.; Magod, Benjamin; Brown, Jacqueline T.; Yantorni, Lauren; Russler, Greta Anne; Caulfield, Sarah et al.
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BODY COMPOSITION AS A PREDICTIVE AND PROGNOSTIC BIOMARKER IN ADVANCED UROTHELIAL CARCINOMA (UC) PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS (ICI)

Journal for ImmunoTherapy of Cancer
2020 | Journal article
Contributors: Martini, Dylan; Shabto, Julie; Goyal, Subir; Liu, Yuan; Olsen, T. Anders; Evans, Sean; Magod, Benjamin; Ravindranathan, Deepak; Brown, Jacqueline; Yantorni, Lauren et al.
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BODY COMPOSITION MAY BE PROGNOSTIC AND PREDICTIVE OF CLINICAL OUTCOMES IN METASTATIC RENAL CELL CARCINOMA (MRCC) PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS (ICI)

Journal for ImmunoTherapy of Cancer
2020 | Journal article
Contributors: Martini, Dylan; Olsen, T. Anders; Goyal, Subir; Liu, Yuan; Evans, Sean; Magod, Benjamin; Brown, Jacqueline; Yantorni, Lauren; Russler, Greta; Caulfield, Sarah et al.
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Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy

Frontiers in Oncology
2020 | Journal article
Contributors: Nazha, Bassel; Inal, Cengiz; Owonikoko, Taofeek K.
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