Personal information

Activities

Employment (1)

Genentech, Inc.: South San Francisco, CA, US

1996 to present | Principal Scientist (Early Discovery Biochemistry)
Employment
Source: Self-asserted source
Andrea G. Cochran

Education and qualifications (3)

Whitehead Institute for Biomedical Research: Cambridge, MA, US

1991-01 to 1996-06 | postdoctoral fellow
Education
Source: Self-asserted source
Andrea G. Cochran

University of California Berkeley: Berkeley, CA, US

1986-09 to 1991-12 | PhD (Chemistry)
Education
Source: Self-asserted source
Andrea G. Cochran

Massachusetts Institute of Technology: Cambridge, MA, US

1982-09 to 1986-06 | B. S. (Chemistry)
Education
Source: Self-asserted source
Andrea G. Cochran

Works (50 of 53)

Items per page:
Page 1 of 2

Bromodomains: a new target class for drug development

Nature Reviews Drug Discovery
2019-08-04 | Journal article
Contributors: Andrea G. Cochran; Andrew R. Conery; Robert J. Sims, III
Source: check_circle
Crossref

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like

2018-10-06 | Journal article
Source: Self-asserted source
Andrea G. Cochran

Structure and Biochemistry of the Polycomb Repressive Complex 1 Ubiquitin Ligase Module

Polycomb Group Proteins
2017 | Book chapter
Part of ISBN: 9780128097373
Source: Self-asserted source
Andrea G. Cochran

Expansion of the ISWI chromatin remodeler family with new active complexes

EMBO reports
2017-10 | Journal article
Contributors: Mariano Oppikofer; Tianyi Bai; Yutian Gan; Benjamin Haley; Peter Liu; Wendy Sandoval; Claudio Ciferri; Andrea G Cochran
Source: check_circle
Crossref

Non-canonical reader modules of BAZ1A promote recovery from DNA damage

Nature Communications
2017-10-11 | Journal article
Source: Self-asserted source
Andrea G. Cochran

Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance

Bioorganic & Medicinal Chemistry Letters
2017-08 | Journal article
Part of ISSN: 0960-894X
Source: Self-asserted source
Andrea G. Cochran

GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2)

ACS Medicinal Chemistry Letters
2017-07-13 | Journal article
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Source: Self-asserted source
Andrea G. Cochran

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

Journal of Medicinal Chemistry
2016-12-08 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Andrea G. Cochran

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

Nature Chemical Biology
2016-07 | Journal article
Part of ISSN: 1552-4450
Part of ISSN: 1552-4469
Source: Self-asserted source
Andrea G. Cochran

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

Journal of Biological Chemistry
2016-06-17 | Journal article
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Andrea G. Cochran

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains

Journal of Medicinal Chemistry
2016-06-09 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Andrea G. Cochran

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

ACS Medicinal Chemistry Letters
2016-05-12 | Journal article
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Source: Self-asserted source
Andrea G. Cochran

A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications

Structure
2015 | Journal article
EID:

2-s2.0-84943659553

Contributors: Flynn, E.M.; Huang, O.W.; Poy, F.; Oppikofer, M.; Bellon, S.F.; Tang, Y.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase

Nature Communications
2015 | Journal article
EID:

2-s2.0-84936742306

Contributors: Taherbhoy, A.M.; Huang, O.W.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

Nature
2015 | Journal article
EID:

2-s2.0-84925232279

Contributors: Rutz, S.; Kayagaki, N.; Phung, Q.T.; Eidenschenk, C.; Noubade, R.; Wang, X.; Lesch, J.; Lu, R.; Newton, K.; Huang, O.W. et al.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Regulation of deubiquitinase proteolytic activity

Current Opinion in Structural Biology
2013 | Journal article
EID:

2-s2.0-84888437178

Contributors: Huang, O.W.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Phosphorylation-dependent activity of the deubiquitinase DUBA

Nature Structural and Molecular Biology
2012 | Journal article
EID:

2-s2.0-84856708042

Contributors: Huang, O.W.; Ma, X.; Yin, J.; Flinders, J.; Maurer, T.; Kayagaki, N.; Phung, Q.; Bosanac, I.; Arnott, D.; Dixit, V.M. et al.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

EMBO Journal
2011 | Journal article
EID:

2-s2.0-80155198826

Contributors: Bentley, M.L.; Corn, J.E.; Dong, K.C.; Phung, Q.; Cheung, T.K.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

Structure
2011 | Journal article
EID:

2-s2.0-80054083830

Contributors: Bourhis, E.; Wang, W.; Tam, C.; Hwang, J.; Zhang, Y.; Spittler, D.; Huang, O.W.; Gong, Y.; Estevez, A.; Zilberleyb, I. et al.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Reconstitution of a Frizzled8·Wnt3a·LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

Journal of Biological Chemistry
2010 | Journal article
EID:

2-s2.0-77950592184

Contributors: Bourhis, E.; Tam, C.; Franke, Y.; Bazan, J.F.; Ernst, J.; Hwang, J.; Costa, M.; Cochran, A.G.; Hannoush, R.N.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B

Journal of Medicinal Chemistry
2009 | Journal article
EID:

2-s2.0-66249097356

Contributors: Aliagas-Martin, I.; Burdick, D.; Corson, L.; Dotson, J.; Drummond, J.; Fields, C.; Huang, O.W.; Hunsaker, T.; Kleinheinz, T.; Krueger, E. et al.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation

Biochemistry
2009 | Journal article
EID:

2-s2.0-67651204572

Contributors: Bourhis, E.; Lingel, A.; Phung, Q.; Fairbrother, W.J.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability

Journal of Medicinal Chemistry
2008 | Journal article
EID:

2-s2.0-49449091410

Contributors: Rawson, T.E.; Rüth, M.; Blackwood, E.; Burdick, D.; Corson, L.; Dotson, J.; Drummond, J.; Fields, C.; Georges, G.J.; Goller, B. et al.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Aurora A: Target Invalidated?

Chemistry and Biology
2008 | Journal article
EID:

2-s2.0-44949248282

Contributors: Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

The mitotic regulator survivin binds as a monomer to its functional interactor borealin

Journal of Biological Chemistry
2007 | Journal article
EID:

2-s2.0-36849085294

Contributors: Bourhis, E.; Hymowitz, S.G.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists

Journal of Molecular Biology
2006 | Journal article
EID:

2-s2.0-33746694185

Contributors: Li, B.; Russell, S.J.; Compaan, D.M.; Totpal, K.; Marsters, S.A.; Ashkenazi, A.; Cochran, A.G.; Hymowitz, S.G.; Sidhu, S.S.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Phage-display as a tool for quantifying protein stability determinants

European Journal of Biochemistry
2004 | Journal article
EID:

2-s2.0-2342627978

Contributors: Kotz, J.D.; Bond, C.J.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site

Biochemistry
2003 | Journal article
EID:

2-s2.0-0037846097

Contributors: Gordon, N.C.; Pan, B.; Hymowitz, S.G.; Yin, J.; Kelley, R.F.; Cochran, A.G.; Yan, M.; Dixit, V.M.; Fairbrother, W.J.; Starovasnik, M.A.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Stability of cyclic β-hairpins: Asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair

Journal of the American Chemical Society
2003 | Journal article
EID:

2-s2.0-0037438384

Contributors: Russell, S.J.; Blandl, T.; Skelton, N.J.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Turn stability in β-hairpin peptides: Investigation of peptides containing 3:5 type I G1 bulge turns

Protein Science
2003 | Journal article
EID:

2-s2.0-0037304420

Contributors: Blandl, T.; Cochran, A.G.; Skelton, N.J.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

β-hairpin polypeptides by design and selection

Spectroscopy
2003 | Journal article
EID:

2-s2.0-0038219827

Contributors: Skelton, N.J.; Blandl, T.; Russell, S.J.; Starovasnik, M.A.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Amino acid determinants of β-hairpin conformation in erythropoeitin receptor agonist peptides derived from a phage display library

Journal of Molecular Biology
2002 | Journal article
EID:

2-s2.0-0036300793

Contributors: Skelton, N.J.; Russell, S.; De Sauvage, F.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-κB2

Immunity
2002 | Journal article
EID:

2-s2.0-18644369740

Contributors: Kayagaki, N.; Yan, M.; Seshasayee, D.; Wang, H.; Lee, W.; French, D.M.; Grewal, I.S.; Cochran, A.G.; Gordon, N.C.; Yin, J. et al.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Erratum: Tryptophan zippers: Stable, monomeric β-hairpins (Proceedings of the National Academy of Sciences of the United State of America (May 8, 2001) 98:10 (5578-5583))

Proceedings of the National Academy of Sciences of the United States of America
2002 | Journal article
EID:

2-s2.0-0037173098

Contributors: Cochran, A.G.; Skelton, N.J.; Starovasnik, M.A.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Quantifying β-sheet stability by phage display

Journal of Molecular Biology
2002 | Journal article
EID:

2-s2.0-0036970470

Contributors: Distefano, M.D.; Zhong, A.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Short constrained peptides that inhibit HIV-1 entry

Proceedings of the National Academy of Sciences of the United States of America
2002 | Journal article
EID:

2-s2.0-0037069386

Contributors: Sia, S.K.; Carr, P.A.; Cochran, A.G.; Malashkevich, V.N.; Kim, P.S.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor

Journal of Molecular Biology
2002 | Journal article
EID:

2-s2.0-0036300518

Contributors: Pan, B.; Li, B.; Russell, S.J.; Tom, J.Y.K.; Cochran, A.G.; Fairbrother, W.J.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

A minimal peptide scaffold for β-turn display: Optimizing a strand position in disulfide-cyclized β-hairpins

Journal of the American Chemical Society
2001 | Journal article
EID:

2-s2.0-0035977632

Contributors: Cochran, A.G.; Tong, R.T.; Starovasnik, M.A.; Park, E.J.; McDowell, R.S.; Theaker, J.E.; Skelton, N.J.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Protein-protein interfaces: Mimics and inhibitors

Current Opinion in Chemical Biology
2001 | Journal article
EID:

2-s2.0-0035630691

Contributors: Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Structure - Function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1

Biochemistry
2001 | Journal article
EID:

2-s2.0-0035943101

Contributors: Skelton, N.J.; Chen, Y.M.; Dubree, N.; Quan, C.; Jackson, D.Y.; Cochran, A.; Zobel, K.; Deshayes, K.; Baca, M.; Pisabarro, M.T. et al.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Tryptophan zippers: Stable, monomeric β-hairpins

Proceedings of the National Academy of Sciences of the United States of America
2001 | Journal article
EID:

2-s2.0-0035826776

Contributors: Cochran, A.G.; Skelton, N.J.; Starovasnik, M.A.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Antagonists of protein-protein interactions

Chemistry and Biology
2000 | Journal article
EID:

2-s2.0-0034177264

Contributors: Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Designing stable β-hairpins: Energetic contributions from cross-strand residues

Journal of the American Chemical Society
2000 | Journal article
EID:

2-s2.0-0034694688

Contributors: Russell, S.J.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Computational learning reveals coiled coil-like motifs in histidine kinase linker domains

Proceedings of the National Academy of Sciences of the United States of America
1998 | Journal article
EID:

2-s2.0-0032539854

Contributors: Singh, M.; Berger, B.; Kim, P.S.; Berger, J.M.; Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Crystal structure of the complex between VEGF and a receptor-blocking peptide

Biochemistry
1998 | Journal article
EID:

2-s2.0-0032559020

Contributors: Wiesmann, C.; Christinger, H.W.; Cochran, A.G.; Cunningham, B.C.; Fairbrother, W.J.; Keenan, C.J.; Meng, G.; De Vos, A.M.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site

Biochemistry
1998 | Journal article
EID:

2-s2.0-0032559040

Contributors: Fairbrother, W.J.; Christinger, H.W.; Cochran, A.G.; Fuh, G.; Keenan, C.J.; Quan, C.; Shriver, S.K.; Tom, J.Y.K.; Wells, J.A.; Cunningham, B.C.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Engineered receptor cytoplasmic domains with fixed signal output: Probing mechanism with design

FASEB Journal
1997 | Journal article
EID:

2-s2.0-33750230540

Contributors: Cochran, A.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Imitation of Escherichia coli aspartate receptor signaling in engineered dimers of the cytoplasmic domain

Science
1996 | Journal article
EID:

2-s2.0-0029915153

Contributors: Cochran, A.G.; Kim, P.S.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Mechanistic studies of antibody-catalyzed pyrimidine dimer photocleavage

Journal of the American Chemical Society
1995 | Journal article
EID:

2-s2.0-0029009433

Contributors: Jacobsen, J.R.; Cochran, A.G.; Stephans, J.C.; King, D.S.; Schultz, P.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier

Antibody-catalyzed biomolecular imine formation

Journal of the American Chemical Society
1991 | Journal article
EID:

2-s2.0-0000515139

Contributors: Cochran, A.G.; Pham, T.; Sugasawara, R.; Schultz, P.G.
Source: Self-asserted source
Andrea G. Cochran via Scopus - Elsevier
Items per page:
Page 1 of 2