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Rockefeller University: New York City, US

2017-08-01 to present | Instructor in Clinical Investigation
Employment
Source: Self-asserted source
Franck Rapaport

Works (39)

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin

Science
2022-06-17 | Journal article
DOI: 10.1126/science.abm6380
Contributors: András N. Spaan; Anna-Lena Neehus; Emmanuel Laplantine; Frederik Staels; Masato Ogishi; Yoann Seeleuthner; Franck Rapaport; Keenan A. Lacey; Erika Van Nieuwenhove; Maya Chrabieh et al.
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Crossref

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

Journal of Experimental Medicine
2021-11-01 | Journal article
DOI: 10.1084/jem.20210566
Contributors: Juan Li; Wei-Te Lei; Peng Zhang; Franck Rapaport; Yoann Seeleuthner; Bingnan Lyu; Takaki Asano; Jérémie Rosain; Boualem Hammadi; Yu Zhang et al.
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Crossref

Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents

Journal of Clinical Investigation
2021-09-01 | Journal article
DOI: 10.1172/JCI150143
Contributors: Romain Lévy; David Langlais; Vivien Béziat; Franck Rapaport; Geetha Rao; Tomi Lazarov; Mathieu Bourgey; Yu J. Zhou; Coralie Briand; Kunihiko Moriya et al.
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Crossref

Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance

Journal of Experimental Medicine
2021-08-02 | Journal article
DOI: 10.1084/jem.20202592
Contributors: Takaki Asano; Joëlle Khourieh; Peng Zhang; Franck Rapaport; András N. Spaan; Juan Li; Wei-Te Lei; Simon J. Pelham; David Hum; Maya Chrabieh et al.
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Crossref

Negative selection on human genes causing severe inborn errors depends on disease outcome and both the mode and mechanism of inheritance

2020-02-08 | Preprint
DOI: 10.1101/2020.02.07.938894
Contributors: Franck Rapaport; Bertrand Boisson; Anne Gregor; Vivien Béziat; Stephanie Boisson-Dupuis; Jacinta Bustamante; Emmanuelle Jouanguy; Anne Puel; Jeremie Rosain; Qian Zhang et al.
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Crossref

Impact of High-Molecular-Risk Mutations on Transplantation Outcomes in Patients with Myelofibrosis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
2019-01 | Journal article
DOI: 10.1016/j.bbmt.2019.01.002
PMID: 30625392
Contributors: Tamari R; Rapaport F; Zhang N; McNamara C; Kuykendall A; Sallman DA; Komrokji R; Arruda A; Najfeld V; Sandy L et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis.

Proceedings of the National Academy of Sciences of the United States of America
2018-12 | Journal article
DOI: 10.1073/pnas.1808403116
PMID: 30591557
PMC: PMC6338851
Contributors: Maffucci P; Bigio B; Rapaport F; Cobat A; Borghesi A; Lopez M; Patin E; Bolze A; Shang L; Bendavid M et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23.

Science immunology
2018-12 | Journal article
DOI: 10.1126/sciimmunol.aau6759
PMID: 30578351
PMC: PMC6380365
Contributors: Martínez-Barricarte R; Markle JG; Ma CS; Deenick EK; Ramírez-Alejo N; Mele F; Latorre D; Mahdaviani SA; Aytekin C; Mansouri D et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

PopViz: a webserver for visualizing minor allele frequencies and damage prediction scores of human genetic variations.

Bioinformatics (Oxford, England)
2018-12 | Journal article
DOI: 10.1093/bioinformatics/bty536
PMID: 30535305
Contributors: Zhang P; Bigio B; Rapaport F; Zhang SY; Casanova JL; Abel L; Boisson B; Itan Y
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.

The Journal of clinical investigation
2018-09 | Journal article
DOI: 10.1172/JCI124920
PMID: 30222137
PMC: PMC6159958
Contributors: McKenney AS; Lau AN; Somasundara AVH; Spitzer B; Intlekofer AM; Ahn J; Shank K; Rapaport FT; Patel MA; Papalexi E et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins.

Neurology(R) neuroimmunology & neuroinflammation
2018-09 | Journal article
DOI: 10.1212/NXI.0000000000000500
PMID: 30211253
PMC: PMC6131052
Contributors: Carter-Timofte ME; Hansen AF; Mardahl M; Fribourg S; Rapaport F; Zhang SY; Casanova JL; Paludan SR; Christiansen M; Larsen CS et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer cell
2018-04 | Journal article
DOI: 10.1016/j.ccell.2018.03.024
PMID: 29634952
PMC: PMC5908465
Contributors: Kleppe M; Koche R; Zou L; van Galen P; Hill CE; Dong L; De Groote S; Papalexi E; Hanasoge Somasundara AV; Cordner K et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.

Cell stem cell
2018-02 | Journal article
DOI: 10.1016/j.stem.2017.12.018
PMID: 29395057
PMC: PMC6260818
Contributors: Kleppe M; Spitzer MH; Li S; Hill CE; Dong L; Papalexi E; De Groote S; Bowman RL; Keller M; Koppikar P et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.

The Journal of clinical investigation
2018-01 | Journal article
DOI: 10.1172/JCI94516
PMID: 29355841
PMC: PMC5785272
Contributors: McKenney AS; Lau AN; Somasundara AVH; Spitzer B; Intlekofer AM; Ahn J; Shank K; Rapaport FT; Patel MA; Papalexi E et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

2018-01 | Other
DOI: 10.1101/244848
OTHER-ID:

PPR20058
Contributors: Carter-Timofte ME; Hansen AF; Mardahl M; Fribourg S; Rapaport F; Zhang S; Casanova J; Paludan SR; Christiansen M; Larsen CS et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.

Cancer cell
2017-12 | Journal article
DOI: 10.1016/j.ccell.2017.11.012
PMID: 29275866
PMC: PMC5760367
Contributors: Kunimoto H; Meydan C; Nazir A; Whitfield J; Shank K; Rapaport F; Maher R; Pronier E; Meyer SC; Garrett-Bakelman FE et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer cell
2017-12 | Journal article
DOI: 10.1016/j.ccell.2017.11.009
PMID: 29249691
PMC: PMC5760343
Contributors: Kleppe M; Koche R; Zou L; van Galen P; Hill CE; Dong L; De Groote S; Papalexi E; Hanasoge Somasundara AV; Cordner K et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.

Cell stem cell
2017-09 | Journal article
DOI: 10.1016/j.stem.2017.08.011
PMID: 28965767
PMC: PMC5847260
Contributors: Kleppe M; Spitzer MH; Li S; Hill CE; Dong L; Papalexi E; De Groote S; Bowman RL; Keller M; Koppikar P et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Efficacy of ALK5 inhibition in myelofibrosis.

JCI insight
2017-04 | Journal article
DOI: 10.1172/jci.insight.90932
PMID: 28405618
PMC: PMC5374075
Contributors: Yue L; Bartenstein M; Zhao W; Ho WT; Han Y; Murdun C; Mailloux AW; Zhang L; Wang X; Budhathoki A et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells.

Blood
2017-01 | Journal article
DOI: 10.1182/blood-2016-06-721977
PMID: 28077417
PMC: PMC5374286
Contributors: Kunimoto H; McKenney AS; Meydan C; Shank K; Nazir A; Rapaport F; Durham B; Garrett-Bakelman FE; Pronier E; Shih AH et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Mutational correlates of response to hypomethylating agent therapy in acute myeloid leukemia.

Haematologica
2016-07 | Journal article
DOI: 10.3324/haematol.2016.148999
PMID: 27418649
PMC: PMC5394875
Contributors: Coombs CC; Sallman DA; Devlin SM; Dixit S; Mohanty A; Knapp K; Al Ali NH; Lancet JE; List AF; Komrokji RS et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia.

Leukemia research
2016-07 | Journal article
DOI: 10.1016/j.leukres.2016.07.013
PMID: 27568819
PMC: PMC5526052
Contributors: Watts JM; Dumitriu B; Hilden P; Kishtagari A; Rapaport F; Chen C; Ahn J; Devlin SM; Stein EM; Rampal R et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

Nature medicine
2016-06 | Journal article
DOI: 10.1038/nm.4125
PMID: 27322744
PMC: PMC4938719
Contributors: Li S; Garrett-Bakelman FE; Chung SS; Sanders MA; Hricik T; Rapaport F; Patel J; Dillon R; Vijay P; Brown AL et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.

Science translational medicine
2016-05 | Journal article
DOI: 10.1126/scitranslmed.aaf2311
PMID: 27194729
PMC: PMC4991773
Contributors: Shono Y; Docampo MD; Peled JU; Perobelli SM; Velardi E; Tsai JJ; Slingerland AE; Smith OM; Young LF; Gupta J et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Genetic analysis of five children with essential thrombocytosis identified mutations in cancer-associated genes with roles in transcriptional regulation.

Haematologica
2016-03 | Journal article
DOI: 10.3324/haematol.2016.142935
PMID: 26992943
PMC: PMC5013957
Contributors: Kucine N; Viny AD; Rampal R; Berger M; Socci N; Viale A; Bussel JB; Levine RL; Rapaport F
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.

Leukemia
2015-12 | Journal article
DOI: 10.1038/leu.2015.358
PMID: 26710888
PMC: PMC4856586
Contributors: Guryanova OA; Lieu YK; Garrett-Bakelman FE; Spitzer B; Glass JL; Shank K; Martinez AB; Rivera SA; Durham BH; Rapaport F et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.

The Journal of experimental medicine
2015-12 | Journal article
DOI: 10.1084/jem.20150524
PMID: 26666262
PMC: PMC4710200
Contributors: Hatlen MA; Arora K; Vacic V; Grabowska EA; Liao W; Riley-Gillis B; Oschwald DM; Wang L; Joergens JE; Shih AH et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Erratum to: Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data.

Genome biology
2015-11 | Journal article
DOI: 10.1186/s13059-015-0813-z
PMID: 26597945
PMC: PMC4657289
Contributors: Rapaport F; Khanin R; Liang Y; Pirun M; Krek A; Zumbo P; Mason CE; Socci ND; Betel D
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Response to Zhou and Robinson.

Genome biology
2015-10 | Journal article
DOI: 10.1186/s13059-015-0782-2
PMID: 26450418
PMC: PMC4599774
Contributors: Betel D; Socci ND; Khanin R; Mason CE; Rapaport F
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

Cancer cell
2015-07 | Journal article
DOI: 10.1016/j.ccell.2015.06.006
PMID: 26175413
PMC: PMC4503933
Contributors: Meyer SC; Keller MD; Chiu S; Koppikar P; Guryanova OA; Rapaport F; Xu K; Manova K; Pankov D; O'Reilly RJ et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Somatic mutations in leukocytes infiltrating primary breast cancers.

NPJ Breast Cancer
2015-06 | Journal article
DOI: 10.1038/npjbcancer.2015.5
PMID: 28721364
PMC: PMC5515194
Contributors: Kleppe M; Comen E; Wen HY; Bastian L; Blum B; Rapaport FT; Keller M; Granot Z; Socci N; Viale A et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

Cancer cell
2015-04 | Journal article
DOI: 10.1016/j.ccell.2015.03.009
PMID: 25873173
PMC: PMC4518555
Contributors: Shih AH; Jiang Y; Meydan C; Shank K; Pandey S; Barreyro L; Antony-Debre I; Viale A; Socci N; Sun Y et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.

Proceedings of the National Academy of Sciences of the United States of America
2014-12 | Journal article
DOI: 10.1073/pnas.1407792111
PMID: 25516983
PMC: PMC4273376
Contributors: Rampal R; Ahn J; Abdel-Wahab O; Nahas M; Wang K; Lipson D; Otto GA; Yelensky R; Hricik T; McKenney AS et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.

Nature cell biology
2014-08 | Journal article
DOI: 10.1038/ncb3011
PMID: 25086747
PMC: PMC4249762
Contributors: Sevenich L; Bowman RL; Mason SD; Quail DF; Rapaport F; Elie BT; Brogi E; Brastianos PK; Hahn WC; Holsinger LJ et al.
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: a case series with molecular genetic analysis and review of the literature.

Leukemia & lymphoma
2014-02 | Journal article
DOI: 10.3109/10428194.2013.869327
PMID: 24286261
Contributors: Cull EH; Watts JM; Tallman MS; Kopp P; Frattini M; Rapaport F; Rampal R; Levine R; Altman JK
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data.

Genome biology
2013-01 | Journal article
DOI: 10.1186/gb-2013-14-9-r95
PMID: 24020486
PMC: PMC4054597
Contributors: Rapaport F; Khanin R; Liang Y; Pirun M; Krek A; Zumbo P; Mason CE; Socci ND; Betel D
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Determining frequent patterns of copy number alterations in cancer.

PloS one
2010-08 | Journal article
DOI: 10.1371/journal.pone.0012028
PMID: 20711339
PMC: PMC2920822
Contributors: Rapaport F; Leslie C
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Classification of arrayCGH data using fused SVM.

Bioinformatics (Oxford, England)
2008-07 | Journal article
DOI: 10.1093/bioinformatics/btn188
PMID: 18586737
PMC: PMC2718663
Contributors: Rapaport F; Barillot E; Vert JP
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central

Classification of microarray data using gene networks.

BMC bioinformatics
2007-02 | Journal article
DOI: 10.1186/1471-2105-8-35
PMID: 17270037
PMC: PMC1797191
Contributors: Rapaport F; Zinovyev A; Dutreix M; Barillot E; Vert JP
Source: Self-asserted source
Franck Rapaport via Europe PubMed Central
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