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melanoma, BRAFV600E isoforms, pigmentation, in vivo melanoma modeling, attenuated Listeria monocytogenes
Italy

Biography

In 2000, I graduated in Biological Sciences and in 2004 I got my PhD in Molecular Biotechnology, both at University of Pisa, Italy. In 2006, I moved to the US, where I became a post-doctoral fellow in the laboratory of Prof. Pier Paolo Pandolfi, first at MSKCC in New York and then at BIDMC-HMS in Boston. In 2009, I started a second post-doc in the lab of Prof. Iman Osman at NYU. In 2012, I was appointed as Principal Investigator of the Oncogenomics Unit of ITT (now ISPRO) and in 2016 I became Staff Scientist-Ricercatore at the Institute of Clinical Physiology of the National Research Council in Pisa, Italy, where my lab is located. In 2021, I became Senior Staff Scientist-Primo Ricercatore.
Throughout my scientific career, my research interests have mostly revolved around non-coding RNAs (microRNAs, pseudogenes, ceRNAs) in cancer. Currently, we study the coding and non-coding regulatory networks that revolve around BRAFV600E isoforms in melanoma, with the goal to better understand how this oncogene works, to hamper tolerance mechanisms, and to potentiate the efficacy of BRAF inhibitors. Specifically, we are interested in the regulation of isoform expression; the kinase-(in)dependent and coding-(in)dependent functions of each isoform, as well as its modulators, interactors and effectors. To do so, we take advantage of a wide range of techniques: in silico (omics approaches), in vitro (yeast, melanoma cell lines), in vivo (melanoma modeling in zebrafish and in the mouse), and ex vivo (melanoma specimens).
We are also developing new strategies for selective drug delivery, taking advantage of attenuated Listeria monocytogenes.

Activities

Employment (8)

Institute of Clinical Physiology-CNR: Pisa, IT

2021-01-01 to present | Senior Staff Scientist-Primo Ricercatore
Employment
Source: Self-asserted source
Laura Poliseno

ISPRO: Pisa, IT

2012-02-01 to present | Principal Investigator of the Oncogenomics Unit
Employment
Source: Self-asserted source
Laura Poliseno

Institute of Clinical Physiology-CNR: Pisa, IT

2016-12-30 to 2020-12-31 | Staff Scientist-Ricercatore
Employment
Source: Self-asserted source
Laura Poliseno

Azienda Ospedaliero-Universitaria Pisana: Pisa, IT

2012-02-01 to 2016-12-29 | Dirigente Biologo
Employment
Source: Self-asserted source
Laura Poliseno

New York University: New York, NY, US

2009-06-16 to 2011-10-20 | Post-Doctoral Research Fellow
Employment
Source: Self-asserted source
Laura Poliseno

Harvard Medical School: Boston, MA, US

2007-08-01 to 2009-06-15 | Post-Doctoral Research Fellow
Employment
Source: Self-asserted source
Laura Poliseno

Memorial Sloan Kettering Cancer Center: New York, NY, US

2006-01-02 to 2007-07-31 | Post-Doctoral Research Fellow
Employment
Source: Self-asserted source
Laura Poliseno

Scuola Normale Superiore: Pisa, IT

2004-06-01 to 2005-12-31 | Post-Doctoral Research Fellow
Employment
Source: Self-asserted source
Laura Poliseno

Education and qualifications (2)

University of Pisa: Pisa, IT

2004-03-29 | PhD in Molecular Biotechnologies
Education
Source: Self-asserted source
Laura Poliseno

University of Pisa: Pisa, IT

2000-04-12 | Master Degree in Biological Sciences cum laude
Education
Source: Self-asserted source
Laura Poliseno

Professional activities (9)

Zebrafish Disease Model Society: Clifton Park, New York, US

2022-08-01 to present | Member
Membership
Source: Self-asserted source
Laura Poliseno

European Association For Cancer Research: Nottingham, Nottingham, GB

2020-01-09 to present | Member (and Ambassador since September 14 2020)
Membership
Source: Self-asserted source
Laura Poliseno

CNR: Pisa, IT

2014-01-01 to present | Manager of the Zebrafish Facility (IFC)
Service
Source: Self-asserted source
Laura Poliseno

CNR: Pisa, IT

2013-01-01 to present | Manager of the Flow Cytometry Facility (IFC)
Service
Source: Self-asserted source
Laura Poliseno

Ministero dell'Università: Roma, IT

2023-06-09 | Abilitazione a Professore di Prima Fascia in Biologia Molecolare (05/E2)
Distinction
Source: Self-asserted source
Laura Poliseno

Ministero dell'Università: Roma, IT

2023-06-09 | Abilitazione a Professore di Prima Fascia in Biologia Applicata (05/F1)
Distinction
Source: Self-asserted source
Laura Poliseno

Ministero dell'Università: Roma, IT

2023-06-09 | Abilitazione a Professore di Prima Fascia in Genetica (05/I1)
Distinction
Source: Self-asserted source
Laura Poliseno

Ministero dell'Università: Roma, IT

2017-12-07 | Abilitazione a Professore di Prima Fascia in Biologia Molecolare (05/E2)
Distinction
Source: Self-asserted source
Laura Poliseno

Ministero dell'Università: Roma, IT

2017-08-01 | Abilitazione a Professore di Seconda Fascia in Genetica (05/I1)
Distinction
Source: Self-asserted source
Laura Poliseno

Funding (6)

BRAFV600E isoforms: the unknown unknown in melanoma biology

2024-05 to 2027-05 | Grant
Fondazione Pisa (Pisa, IT)
Source: Self-asserted source
Laura Poliseno

CN3-National Center for Gene Therapy and Drugs based on RNA Technology

2022-11 to 2025-10 | Grant
European Union-Next Generation EU (Brussels, BE)
Source: Self-asserted source
Laura Poliseno

The dark side of BRAFi: hampering pigmentation to boost the efficacy of targeted therapy in melanoma

2022-01 to 2026-12 | Grant
Associazione Italiana per la Ricerca sul Cancro (Milano, IT)
GRANT_NUMBER:

IG 25694

Source: Self-asserted source
Laura Poliseno

miR-204 inhibition and attenuated Listeria monocytogenes: development of a novel therapeutic strategy against melanoma

2016-01 to 2019-12 | Grant
Associazione Italiana per la Ricerca sul Cancro (Milano, IT)
GRANT_NUMBER:

MFAG 17095

Source: Self-asserted source
Laura Poliseno

Dissecting the molecular bases of acquired resistance to BRAF inhibitors in metastatic melanoma: towards a multidrug approach

2014-11 to 2018-11 | Grant
Ministero della Salute (Roma, IT)
GRANT_NUMBER:

GR-2011-02348535

Source: Self-asserted source
Laura Poliseno

Start Up and Institutional Funding

2012-02 to 2024-12 | Grant
ISPRO (Firenze, IT)
Source: Self-asserted source
Laura Poliseno

Peer review (4 reviews for 4 publications/grants)

Review activity for Cancers. (1)
Review activity for Cell chemical biology. (1)
Review activity for Journal of experimental & clinical cancer research. (1)
Review activity for Journal of hematology & oncology. (1)