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Scopus Author ID: 56664523800

Keywords

Protein biophysics, Mass Spectrometry, Antigen-antibody mapping

Countries

Singapore

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Employment (2)

MSD (Singapore): Singapore, SG

2023-04-01 to present | Senior Scientist (Quantitative Biosciences)
Employment
Source: Self-asserted source
Tulsian NK

National University of Singapore: Singapore, SG

2018-04-16 to 2023-03-31 | Postdoctoral Research Fellow (Biochemistry)
Employment
Source: Self-asserted source
Tulsian NK

Education and qualifications (1)

National University of Singapore: Singapore, SG

2012-07-24 to 2017-02-01 | Doctor of Philosophy (Biological Sciences)
Education
Source: Self-asserted source
Tulsian NK

Works (27)

Insights into the regulation of CHIP E3 ligase-mediated ubiquitination of neuronal protein BNIP-H

PNAS Nexus
2024-11-28 | Journal article
DOI: 10.1093/pnasnexus/pgae536
Contributors: Srihari Shankar; Yaochen Liu; Nikhil Kumar Tulsian; Boon C Low; Qingsong Lin; J Sivaraman; Nancy Bonini
Source: check_circle
Crossref

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1

Proceedings of the National Academy of Sciences
2024-10-08 | Journal article
DOI: 10.1073/pnas.2415567121
Contributors: Rachel L. Harold; Nikhil K. Tulsian; Rajesh Narasimamurthy; Noelle Yaitanes; Maria G. Ayala Hernandez; Hsiau-Wei Lee; Priya Crosby; Sarvind M. Tripathi; David M. Virshup; Carrie L. Partch
Source: check_circle
Crossref

Nutrient conditions influence allelopathic capabilities of Ludwigia adscendens and other tropical macrophytes against Microcystis aeruginosa

Freshwater Biology
2024-04 | Journal article
DOI: 10.1111/fwb.14227
Contributors: Darren Z. H. Sim; Maxine A. D. Mowe; Simon M. Mitrovic; Nikhil K. Tulsian; Ganesh S. Anand; Darren C. J. Yeo
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Crossref

Defining neutralization and allostery by antibodies against COVID-19 variants

Nature Communications
2023-11-01 | Journal article
DOI: 10.1038/s41467-023-42408-x
Contributors: Nikhil Kumar Tulsian; Raghuvamsi Venkata Palur; Xinlei Qian; Yue Gu; Bhuvaneshwari D/O Shunmuganathan; Firdaus Samsudin; Yee Hwa Wong; Jianqing Lin; Kiren Purushotorman; Mary McQueen Kozma et al.
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Crossref

Structural and functional characterization of Aedes aegypti pupal cuticle protein that controls dengue virus infection

Protein Science
2023-10 | Journal article
DOI: 10.1002/pro.4761
Contributors: Qingqing Huang; Edem Gavor; Nikhil Kumar Tulsian; Jingsong Fan; Qingsong Lin; Yu Keung Mok; R. Manjunatha Kini; J. Sivaraman
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Crossref

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein Kinase 1

2023-04-24 | Preprint
DOI: 10.1101/2023.04.24.538174
Contributors: Rachel L. Harold; Nikhil K. Tulsian; Rajesh Narasimamurthy; Noelle Yaitanes; Maria G. Ayala Hernandez; Hsiau-Wei Lee; Priya Crosby; Sarvind M. Tripathi; David M. Virshup; Carrie L. Partch
Source: check_circle
Crossref

Defining neutralization and allostery by antibodies against COVID-19 variants

2023-01-23 | Preprint
DOI: 10.21203/rs.3.rs-2465199/v1
Contributors: Nikhil Tulsian; Palur Raghuvamsi; Xinlei Qian; Yue Gu; Bhuvaneshwari D/O Shunmuganathan; Firdaus Samsudin; Yee Hwa Wong; Jianqing Lin; Kiren Purushotorman; Mary Kozma et al.
Source: check_circle
Crossref

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

Structure
2022-08 | Journal article
DOI: 10.1016/j.str.2022.05.006
Contributors: Lorena Zuzic; Firdaus Samsudin; Aishwary T. Shivgan; Palur V. Raghuvamsi; Jan K. Marzinek; Alister Boags; Conrado Pedebos; Nikhil K. Tulsian; Jim Warwicker; Paul MacAry et al.
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Crossref

Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen–deuterium exchange mass spectrometry

Cellular and Molecular Life Sciences
2022-05 | Journal article
DOI: 10.1007/s00018-022-04245-x
Contributors: Tanaya Bagga; Nikhil Kumar Tulsian; Yu Keung Mok; R. Manjunatha Kini; J. Sivaraman
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Crossref

Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner

Journal for ImmunoTherapy of Cancer
2022-02 | Journal article
DOI: 10.1136/jitc-2021-003382
Part of ISSN: 2051-1426
Source: Self-asserted source
Tulsian NK

Binding specificity of type three secretion system effector NleH2 to multi‐cargo chaperone CesT and their phosphorylation

Protein Science
2021-12 | Journal article
DOI: 10.1002/pro.4210
Part of ISSN: 0961-8368
Part of ISSN: 1469-896X
Source: Self-asserted source
Tulsian NK

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

2021-12-28 | Preprint
DOI: 10.1101/2021.12.27.474251
Contributors: Nikhil K. Tulsian; Palur V. Raghuvamsi; Xinlei Qian; Gu Yue; Bhuvaneshwari D/O Shunmuganathan; Firdaus Samsudin; Wong Yee Hwa; Lin Jianqing; Kiren Purushotorman; Mary M. Kozma et al.
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Crossref

Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection

Life Science Alliance
2021-11-08 | Journal article
DOI: 10.26508/lsa.202101211
Part of ISSN: 2575-1077
Source: Self-asserted source
Tulsian NK

The novel conserved NAD+-binding micropeptide SGHRT regulates mitochondrial function and metabolism in human cardiomyocytes

2021-10-26 | Other
DOI: 10.1101/2021.10.24.465637
Contributors: Vinh Dang Do; Nikhil Kumar Tulsian; Warren KY Tan; Zhe Li; Liyi Cheng; Matias I. Autio; Wilson LW Tan; Zenia Tiang; Arnaud Perrin; Jianhong Ching et al.
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Crossref

Development of Phosphodiesterase–Protein-Kinase Complexes as Novel Targets for Discovery of Inhibitors with Enhanced Specificity

International Journal of Molecular Sciences
2021-05-15 | Journal article
DOI: 10.3390/ijms22105242
Part of ISSN: 1422-0067
Source: Self-asserted source
Tulsian NK
grade
Preferred source (of 3)‎

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

[]
2021-05-05 | Preprint
DOI: 10.1101/2021.05.05.442536
Source: Self-asserted source
Tulsian NK

SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

eLife
2021-02-08 | Journal article
DOI: 10.7554/eLife.63646
Contributors: Palur V Raghuvamsi; Nikhil K Tulsian; Firdaus Samsudin; Xinlei Qian; Kiren Purushotorman; Gu Yue; Mary M Kozma; Wong Y Hwa; Julien Lescar; Peter J Bond et al.
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Crossref

Adenylate control in cAMP signaling: implications for adaptation in signalosomes

Biochemical Journal
2020-08-28 | Journal article
DOI: 10.1042/BCJ20200435
Contributors: Nikhil K. Tulsian; Abhijeet Ghode; Ganesh S. Anand
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Crossref

Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices.

Structure (London, England : 1993)
2018-11-29 | Journal article
DOI: 10.1016/j.str.2018.10.012
PMID: 30503779
PMC: PMC6377431
Source: Self-asserted source
Tulsian NK

Dissecting Orthosteric Contacts for a Reverse-Fragment-Based Ligand Design.

Analytical chemistry
2017-07-14 | Journal article
DOI: 10.1021/acs.analchem.7b00587
PMID: 28628309
Source: Self-asserted source
Tulsian NK

Channeling of cAMP in PDE-PKA Complexes Promotes Signal Adaptation.

Biophysical journal
2017-06-01 | Journal article
DOI: 10.1016/j.bpj.2017.04.045
PMID: 28636912
PMC: PMC5479052
Source: Self-asserted source
Tulsian NK

Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions.

Scientific reports
2016-11-15 | Journal article
DOI: 10.1038/srep37061
PMID: 27845431
PMC: PMC5109232
Source: Self-asserted source
Tulsian NK

Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling.

Biophysical journal
2015-08-11 | Journal article
DOI: 10.1016/j.bpj.2015.06.067
PMID: 26276689
PMC: PMC4576172
Source: Self-asserted source
Tulsian NK

Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.

Biophysical journal
2014-09-01 | Journal article
DOI: 10.1016/j.bpj.2014.07.050
PMID: 25229150
PMC: PMC4167538
Source: Self-asserted source
Tulsian NK

Mycobacterial Hsp65 potentially cross-reacts with autoantibodies of diabetes sera and also induces (in vitro) cytokine responses relevant to diabetes mellitus.

Molecular bioSystems
2013-11-01 | Journal article
DOI: 10.1039/c3mb70307j
PMID: 24056978
Source: Self-asserted source
Tulsian NK

In vitro cytokine profiles and viability of different human cells treated with whole cell lysate of Mycobacterium avium subsp. paratuberculosis.

Gut pathogens
2012-09-24 | Journal article
DOI: 10.1186/1757-4749-4-10
PMID: 23006537
PMC: PMC3495707
Source: Self-asserted source
Tulsian NK

Development of Phosphodiesterase-Protein Kinase Complexes as Novel Targets for Discovery of Inhibitors with Enhanced Specificity
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Peer review (1 review for 1 publication/grant)

Review activity for Cellular and molecular life sciences (1)
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