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Works (45)

Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord

Neuroscience Bulletin
2023-01 | Journal article
Contributors: Jing Yang; Shulan Xie; Shengmei Zhu; Zhen-Zhong Xu
Source: check_circle
Crossref

Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia

Nature Communications
2023-01-03 | Journal article
Contributors: Heng Zhang; Jia-Jia Lin; Ya-Kai Xie; Xiu-Zu Song; Jia-Yi Sun; Bei-Lei Zhang; Yun-Kun Qi; Zhen-Zhong Xu; Fan Yang
Source: check_circle
Crossref

GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation

Science translational medicine
2022 | Journal article
EID:

2-s2.0-85127661658

Part of ISSN: 19466242
Contributors: Xie, Y.-K.; Luo, H.; Zhang, S.-X.; Chen, X.-Y.; Guo, R.; Qiu, X.-Y.; Liu, S.; Wu, H.; Chen, W.-B.; Zhen, X.-H. et al.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

mTOR–neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain

JCI Insight
2022-11-22 | Journal article
Contributors: Lunhao Chen; Yaling Hu; Siyuan Wang; Kelei Cao; Weihao Mai; Weilin Sha; Huan Ma; Ling-Hui Zeng; Zhen-Zhong Xu; Yong-Jing Gao et al.
Source: check_circle
Crossref

Rational Design of a Modality-Specific Inhibitor of TRPM8 Channel against Oxaliplatin-Induced Cold Allodynia

Advanced Science
2021 | Journal article
EID:

2-s2.0-85117592368

Part of ISSN: 21983844
Contributors: Aierken, A.; Xie, Y.-K.; Dong, W.; Apaer, A.; Lin, J.-J.; Zhao, Z.; Yang, S.; Xu, Z.-Z.; Yang, F.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

GPR151 in nociceptors modulates neuropathic pain via regulating P2X3 function and microglial activation

Brain
2021-12-16 | Journal article
Contributors: Li-Ping Xia; Hao Luo; Qiang Ma; Ya-Kai Xie; Wei Li; Hailan Hu; Zhen-Zhong Xu
Source: check_circle
Crossref
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Preferred source (of 2)‎

Resolution of Inflammatory Pain by Endogenous Chemerin and G Protein-Coupled Receptor ChemR23

Neuroscience Bulletin
2021-09-27 | Journal article
Contributors: Ya-Kai Xie; Hao Luo; Xiao-Yun Qiu; Zhen-Zhong Xu
Source: check_circle
Crossref
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Preferred source (of 2)‎

The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain

Neuroscience Bulletin
2021-07 | Journal article
Contributors: Zilong Wang; Zhen-Zhong Xu
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Crossref
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Preferred source (of 2)‎

Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons

Proceedings of the National Academy of Sciences
2021-02-16 | Journal article
Contributors: Jun Wang; Jie Li; Qian Yang; Ya-Kai Xie; Ya-Lan Wen; Zhen-Zhong Xu; Yulong Li; Tianle Xu; Zhi-Ying Wu; Shumin Duan et al.
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Crossref
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Preferred source (of 2)‎

Interleukin-17 Regulates Neuron-Glial Communications, Synaptic Transmission, and Neuropathic Pain after Chemotherapy

Cell Reports
2019 | Journal article
EID:

2-s2.0-85074997647

Part of ISBN:

22111247

Contributors: Luo, H.; Liu, H.-Z.; Zhang, W.-W.; Matsuda, M.; Lv, N.; Chen, G.; Xu, Z.-Z.; Zhang, Y.-Q.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Distinct analgesic actions of DHA and DHA-derived specialized pro-resolving mediators on post-operative pain after bone fracture in mice

Frontiers in Pharmacology
2018 | Journal article
EID:

2-s2.0-85046653847

Part of ISBN:

16639812

Contributors: Zhang, L.; Terrando, N.; Xu, Z.-Z.; Bang, S.; Jordt, S.-E.; Maixner, W.; Serhan, C.N.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

Journal of Clinical Investigation
2018 | Journal article
EID:

2-s2.0-85051243514

Part of ISBN:

15588238 00219738

Contributors: Bang, S.; Xie, Y.-K.; Zhang, Z.-J.; Wang, Z.; Xu, Z.-Z.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions

Scientific Reports
2016 | Journal article
EID:

2-s2.0-84989211088

Part of ISBN:

20452322

Contributors: Liu, C.-C.; Gao, Y.-J.; Luo, H.; Berta, T.; Xu, Z.-Z.; Ji, R.-R.; Tan, P.-H.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

β-Arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

Nature Communications
2016 | Journal article
EID:

2-s2.0-84983315657

Part of ISBN:

20411723

Contributors: Chen, G.; Xie, R.-G.; Gao, Y.-J.; Xu, Z.-Z.; Zhao, L.-X.; Bang, S.; Berta, T.; Park, C.-K.; Lay, M.; Chen, W. et al.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

Nature Medicine
2015 | Journal article
EID:

2-s2.0-84946225615

Part of ISBN:

1546170X 10788956

Contributors: Xu, Z.-Z.; Kim, Y.H.; Bang, S.; Zhang, Y.; Berta, T.; Wang, F.; Oh, S.B.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Development of a membrane-Anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain

Journal of Biological Chemistry
2014 | Journal article
EID:

2-s2.0-84900440321

Part of ISBN:

1083351X 00219258

Contributors: Doyle, J.R.; Krishnaji, S.T.; Zhu, G.; Xu, Z.-Z.; Heller, D.; Ji, R.-R.; Levy, B.D.; Kumar, K.; Kopin, A.S.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Emerging targets in neuroinflammation-driven chronic pain

Nature Reviews Drug Discovery
2014 | Journal article
EID:

2-s2.0-84903814786

Part of ISBN:

14741784 14741776

Contributors: Ji, R.-R.; Xu, Z.-Z.; Gao, Y.-J.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

Journal of Clinical Investigation
2014 | Journal article
EID:

2-s2.0-84896801592

Part of ISBN:

00219738 15588238

Contributors: Berta, T.; Park, C.-K.; Xu, Z.-Z.; Xie, R.-G.; Liu, T.; Lü, N.; Liu, Y.-C.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Extracellular microRNAs Activate nociceptor neurons to elicit pain via TLR7 and TRPA1

Neuron
2014 | Journal article
EID:

2-s2.0-84897467553

Part of ISBN:

10974199 08966273

Contributors: Park, C.-K.; Xu, Z.-Z.; Berta, T.; Han, Q.; Chen, G.; Liu, X.-J.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter

Cell Research
2014 | Journal article
EID:

2-s2.0-84908594575

Part of ISBN:

17487838 10010602

Contributors: Liu, X.-J.; Zhang, Y.; Liu, T.; Xu, Z.-Z.; Park, C.-K.; Berta, T.; Jiang, D.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: Involvement of Ca<sup>2+</sup>-activated small conductance potassium channels

Journal of Neuroscience
2013 | Journal article
EID:

2-s2.0-84881538791

Part of ISBN:

02706474 15292401

Contributors: Pagadala, P.; Park, C.-K.; Bang, S.; Xu, Z.-Z.; Xie, R.-G.; Liu, T.; Han, B.-X.; Daniel Tracey, W.; Wang, F.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.

Annals of neurology
2013 | Journal article
EID:

2-s2.0-84890265022

Part of ISBN:

15318249

Contributors: Xu, Z.Z.; Liu, X.J.; Berta, T.; Park, C.K.; Lü, N.; Serhan, C.N.; Ji, R.R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury

Journal of Neuroimmune Pharmacology
2013 | Journal article
EID:

2-s2.0-84874645504

Part of ISBN:

15571890 15571904

Contributors: Xu, Z.-Z.; Berta, T.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice

Neuroscience
2013 | Journal article
EID:

2-s2.0-84880623225

Part of ISBN:

03064522 18737544

Contributors: Berta, T.; Liu, Y.-C.; Xu, Z.-Z.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals

Journal of Neuroscience
2012 | Journal article
EID:

2-s2.0-84860318535

Part of ISBN:

02706474 15292401

Contributors: Sisignano, M.; Park, C.-K.; Angioni, C.; Zhang, D.D.; von Hehn, C.; Cobos, E.J.; Ghasemlou, N.; Xu, Z.-Z.; Kumaran, V.; Lu, R. et al.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9

Molecular Pain
2012 | Journal article
EID:

2-s2.0-84862826216

Part of ISBN:

17448069

Contributors: Berta, T.; Liu, T.; Liu, Y.-C.; Xu, Z.-Z.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

FASEB Journal
2012 | Journal article
EID:

2-s2.0-84860899033

Part of ISBN:

08926638 15306860

Contributors: Serhan, C.N.; Dalli, J.; Karamnov, S.; Choi, A.; Park, C.-K.; Xu, Z.-Z.; Ji, R.-R.; Zhu, M.; Petasi, N.A.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Short small-interfering RNAs produce interferon-α-mediated analgesia

British Journal of Anaesthesia
2012 | Journal article
EID:

2-s2.0-84863346635

Part of ISBN:

14716771 00070912

Contributors: Tan, P.H.; Gao, Y.J.; Berta, T.; Xu, Z.Z.; Ji, R.R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

Journal of Clinical Investigation
2012 | Journal article
EID:

2-s2.0-84861794417

Part of ISBN:

00219738 15588238

Contributors: Liu, T.; Berta, T.; Xu, Z.-Z.; Park, C.-K.; Zhang, L.; Lü, N.; Liu, Q.; Liu, Y.; Gao, Y.-J.; Liu, Y.-C. et al.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Emerging roles of resolvins in the resolution of inflammation and pain

Trends in Neurosciences
2011 | Journal article
EID:

2-s2.0-82455192824

Part of ISBN:

01662236 1878108X

Contributors: Ji, R.-R.; Xu, Z.-Z.; Strichartz, G.; Serhan, C.N.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: Distinct roles of resolvin D1, D2, and E1

Journal of Neuroscience
2011 | Journal article
EID:

2-s2.0-83455177641

Part of ISBN:

02706474 15292401

Contributors: Park, C.-K.; Xu, Z.-Z.; Liu, T.; Lü, N.; Serhan, C.N.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1

Journal of Neuroscience
2011 | Journal article
EID:

2-s2.0-80054749697

Part of ISBN:

02706474 15292401

Contributors: Park, C.-K.; Lü, N.; Xu, Z.-Z.; Liu, T.; Serhan, C.N.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Resolvins are potent analgesics for arthritic pain

British Journal of Pharmacology
2011 | Journal article
EID:

2-s2.0-80052001049

Part of ISBN:

00071188 14765381

Contributors: Xu, Z.-Z.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: Distinct role of TNF receptor subtypes 1 and 2

Pain
2011 | Journal article
EID:

2-s2.0-78651498932

Part of ISBN:

03043959

Contributors: Zhang, L.; Berta, T.; Xu, Z.-Z.; Liu, T.; Park, J.Y.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

Nature Medicine
2010 | Journal article
EID:

2-s2.0-77952237425

Part of ISBN:

10788956 1546170X

Contributors: Xu, Z.-Z.; Zhang, L.; Liu, T.; Park, J.Y.; Berta, T.; Yang, R.; Serhan, C.N.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition

Pain
2010 | Journal article
EID:

2-s2.0-74849124570

Part of ISBN:

03043959

Contributors: Gao, Y.-J.; Xu, Z.-Z.; Liu, Y.-C.; Wen, Y.-R.; Decosterd, I.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Toll-like receptor 7 mediates pruritus

Nature Neuroscience
2010 | Journal article
EID:

2-s2.0-78650205054

Part of ISBN:

10976256

Contributors: Liu, T.; Xu, Z.-Z.; Park, C.-K.; Berta, T.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain

Journal of Neuroscience
2009 | Journal article
EID:

2-s2.0-65249114367

Part of ISBN:

02706474 15292401

Contributors: Gao, Y.-J.; Zhang, L.; Samad, O.A.; Suter, M.R.; Yasuhiko, K.; Xu, Z.-Z.; Park, J.-Y.; Lind, A.-L.; Ma, Q.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Matrix metalloprotease regulation of neuropathic pain

Trends in Pharmacological Sciences
2009 | Journal article
EID:

2-s2.0-67649394340

Part of ISBN:

01656147

Contributors: Ji, R.-R.; Xu, Z.-Z.; Wang, X.; Lo, E.H.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model

Experimental Neurology
2009 | Journal article
EID:

2-s2.0-68549125155

Part of ISBN:

00144886 10902430

Contributors: Gao, Y.-J.; Cheng, J.-K.; Zeng, Q.; Xu, Z.-Z.; Decosterd, I.; Xu, X.; Ji, R.-R.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

Nature Medicine
2008 | Journal article
EID:

2-s2.0-40449126196

Part of ISBN:

10788956 1546170X

Contributors: Kawasaki, Y.; Xu, Z.-Z.; Wang, X.; Park, J.Y.; Zhuang, Z.-Y.; Tan, P.-H.; Gao, Y.-J.; Roy, K.; Corfas, G.; Lo, E.H. et al.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Endogenous tumor necrosis factor α (TNFα) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model

Journal of Neuroscience
2008 | Journal article
EID:

2-s2.0-44949251781

Part of ISBN:

02706474 02706474

Contributors: Constantin, C.E.; Mair, N.; Sailer, C.A.; Andratsch, M.; Xu, Z.-Z.; Blumer, M.J.F.; Scherbakov, N.; Davis, J.B.; Bluethmann, H.; Ji, R.-R. et al.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Use of bulleyaconitine a as an adjuvant for prolonged cutaneous analgesia in the rat

Anesthesia and Analgesia
2008 | Journal article
EID:

2-s2.0-53449094576

Part of ISBN:

00032999

Contributors: Wang, C.-F.; Gerner, P.; Schmidt, B.; Xu, Z.Z.; Nau, C.; Wang, S.-Y.; Ji, R.-R.; Wang, G.K.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia

Cell
2005 | Journal article
EID:

2-s2.0-23944455412

Part of ISBN:

00928674

Contributors: Guan, J.-S.; Xu, Z.-Z.; Gao, H.; He, S.-Q.; Ma, G.-Q.; Sun, T.; Wang, L.-H.; Zhang, Z.-N.; Lena, I.; Kitchen, I. et al.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier

Activation of Delta Opioid Receptors Induces Receptor Insertion and Neuropeptide Secretion

Neuron
2003 | Journal article
EID:

2-s2.0-0037426950

Part of ISBN:

08966273

Contributors: Bao, L.; Jin, S.-X.; Zhang, C.; Wang, L.-H.; Xu, Z.-Z.; Zhang, F.-X.; Wang, L.-C.; Ning, F.-S.; Cai, H.-J.; Guan, J.-S. et al.
Source: Self-asserted source
Zhen-Zhong Xu via Scopus - Elsevier