Personal information

Emails & domains

Verified email domains

Websites & social links

University Medicine Greifswald, Institute of Physiology

Other IDs

Loop profile: 304211

Keywords

Hypoxia, Oxygen sensing, Hydroxylase, HIF, Signalling, Ubiquitin System, Metabolism, Inflammation, Fibrosis

Countries

Germany

Activities

Collapse all

Works (40)

Thermomechanical properties of bat and human red blood cells—Implications for hibernation

Proceedings of the National Academy of Sciences
2024-10-22 | Journal article
DOI: 10.1073/pnas.2405169121
Contributors: Bob Fregin; Mohammed Faruq Hossain; Doreen Biedenweg; Virginia Friedrichs; Anne Balkema-Buschmann; Marcel Bokelmann; Kristin Lehnert; Dominic Mokbel; Sebastian Aland; Carsten C. Scholz et al.
Source: check_circle
Crossref

PHD1-3 oxygen sensors in vivo—lessons learned from gene deletions

Pflügers Archiv - European Journal of Physiology
2024-09 | Journal article
DOI: 10.1007/s00424-024-02944-x
Contributors: Agnieszka E. Jucht; Carsten C. Scholz
Source: check_circle
Crossref

Oxomer- and Reporter Gene-Based Analysis of FIH Activity in Cells.

Methods in molecular biology (Clifton, N.J.)
2024-01-01 | Journal article
DOI: 10.1007/978-1-0716-3633-6_18
PMID: 38319583
Contributors: Volkova YL; Agnieszka Jucht; Scholz CC
Source: Self-asserted source
Carsten C Scholz

Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase regulation in chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2023-09-01 | Journal article
DOI: 10.1093/ndt/gfad075
PMID: 37096392
PMC: PMC10539236
Contributors: Anna Faivre; Dissard R; Kuo W; Thomas Verissimo; Legouis D; Arnoux G; Heckenmeyer C; Fernandez M; Tihy M; Rajaram RD et al.
Source: Self-asserted source
Carsten C Scholz

Fount, fate, features, and function of renal erythropoietin-producing cells.

Pflugers Archiv : European journal of physiology
2022-06-24 | Journal article
DOI: 10.1007/s00424-022-02714-7
PMID: 35750861
Source: Self-asserted source
Carsten C Scholz
grade
Preferred source (of 2)‎

The effect of HIF on metabolism and immunity.

Nature reviews. Nephrology
2022-06-20 | Journal article
DOI: 10.1038/s41581-022-00587-8
PMID: 35726016
PMC: PMC9208707
Source: Self-asserted source
Carsten C Scholz
grade
Preferred source (of 2)‎

The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor.

Antioxidants & redox signaling
2022-04-29 | Journal article
DOI: 10.1089/ars.2022.0003
PMID: 35166119
Source: Self-asserted source
Carsten C Scholz
grade
Preferred source (of 2)‎

The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism

International Journal of Molecular Sciences
2022-01 | Journal article | Author
DOI: 10.3390/ijms23031536
Contributors: Amalia Ruiz-Serrano; Christina N Boyle; Josep Maria Monne Rodriguez; Julia Günter; Agnieszka Jucht; Svende Pfundstein; Andreas M. Bapst; Thomas Lutz; Roland H. Wenger; Carsten C Scholz
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Fate-mapping of erythropoietin-producing cells in mouse models of hypoxaemia and renal tissue remodelling reveals repeated recruitment and persistent functionality.

Acta physiologica (Oxford, England)
2022-01-04 | Journal article
DOI: 10.1111/apha.13768
PMID: 34982511
Source: Self-asserted source
Carsten C Scholz
grade
Preferred source (of 2)‎

OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control

The FASEB Journal
2021-12 | Journal article
DOI: 10.1096/fj.202100346r
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
Carsten C Scholz

Inhibition of firefly luciferase activity by a HIF prolyl hydroxylase inhibitor.

Journal of photochemistry and photobiology. B, Biology
2020-07-27 | Journal article
DOI: 10.1016/j.jphotobiol.2020.111980
PMID: 32745950
Source: Self-asserted source
Carsten C Scholz

Hypoxia in chronic kidney disease: towards a paradigm shift?

Nephrology Dialysis Transplantation
2020-07-10 | Journal article
DOI: 10.1093/ndt/gfaa091
Part of ISSN: 0931-0509
Part of ISSN: 1460-2385
Source: Self-asserted source
Carsten C Scholz

HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2019-12-19 | Journal article
DOI: 10.1096/fj.201902240r
PMID: 31908020
Source: Self-asserted source
Carsten C Scholz

Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1.

Redox biology
2019-07-02 | Journal article
DOI: 10.1016/j.redox.2019.101265
PMID: 31299612
PMC: PMC6624438
Source: Self-asserted source
Carsten C Scholz

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes.

Journal of immunology (Baltimore, Md. : 1950)
2019-01-30 | Journal article
DOI: 10.4049/jimmunol.1800912
PMID: 30700584
Source: Self-asserted source
Carsten C Scholz
grade
Preferred source (of 2)‎

Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation, and a telocyte phenotype.

Kidney international
2018-11-27 | Journal article
DOI: 10.1016/j.kint.2018.08.043
PMID: 30502050
Source: Self-asserted source
Carsten C Scholz

Genetic Knockdown and Pharmacologic Inhibition of Hypoxia-Inducible Factor (HIF) Hydroxylases.

Methods in molecular biology (Clifton, N.J.)
2018-01 | Journal article
DOI: 10.1007/978-1-4939-7665-2_1
PMID: 29330785
Contributors: Pickel C; Taylor CT; Scholz CC
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.

The Journal of biological chemistry
2017-05 | Journal article
DOI: 10.1074/jbc.M116.755090
PMID: 28507099
PMC: PMC5500817
Contributors: Keogh CE; Scholz CC; Rodriguez J; Selfridge AC; von Kriegsheim A; Cummins EP
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central
grade
Preferred source (of 2)‎

The functional interplay between the HIF pathway and the ubiquitin system - more than a one-way road.

Experimental cell research
2017-03 | Journal article
DOI: 10.1016/j.yexcr.2017.03.027
PMID: 28315321
Contributors: Günter J; Ruiz-Serrano A; Pickel C; Wenger RH; Scholz CC
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells.

Free radical biology & medicine
2016-10 | Journal article
DOI: 10.1016/j.freeradbiomed.2016.10.002
PMID: 27717868
Contributors: Gutsche K; Randi EB; Blank V; Fink D; Wenger RH; Leo C; Scholz CC
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

REST is a hypoxia-responsive transcriptional repressor.

Scientific reports
2016-08 | Journal article
DOI: 10.1038/srep31355
PMID: 27531581
PMC: PMC4987654
Contributors: Cavadas MA; Mesnieres M; Crifo B; Manresa MC; Selfridge AC; Keogh CE; Fabian Z; Scholz CC; Nolan KA; Rocha LM et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.

The Journal of biological chemistry
2016-04 | Journal article
DOI: 10.1074/jbc.M116.713941
PMID: 27044749
PMC: PMC4882447
Contributors: Selfridge AC; Cavadas MA; Scholz CC; Campbell EL; Welch LC; Lecuona E; Colgan SP; Barrett KE; Sporn PH; Sznajder JI et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

PLoS biology
2016-01 | Journal article
DOI: 10.1371/journal.pbio.1002347
PMID: 26752685
PMC: PMC4709136
Contributors: Scholz CC; Rodriguez J; Pickel C; Burr S; Fabrizio JA; Nolan KA; Spielmann P; Cavadas MA; Crifo B; Halligan DN et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.

Scientific reports
2015-12 | Journal article
DOI: 10.1038/srep17851
PMID: 26647819
PMC: PMC4673454
Contributors: Cavadas MA; Mesnieres M; Crifo B; Manresa MC; Selfridge AC; Scholz CC; Cummins EP; Cheong A; Taylor CT
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Hypoxia: from basic mechanisms to therapeutics - a meeting report on the Keystone and HypoxiaNet Symposium.

Hypoxia (Auckland, N.Z.)
2015-10 | Journal article
DOI: 10.2147/HP.S83240
PMID: 27774483
PMC: PMC5045090
Contributors: Nolan KA; Scholz CC
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Frequently asked questions in hypoxia research.

Hypoxia (Auckland, N.Z.)
2015-09 | Journal article
DOI: 10.2147/HP.S92198
PMID: 27774480
PMC: PMC5045069
Contributors: Wenger RH; Kurtcuoglu V; Scholz CC; Marti HH; Hoogewijs D
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function.

2015-05 | Journal article
DOI: 10.1016/j.chom.2015.03.005
PMID: 25865369
Contributors: Kelly CJ; Zheng L; Campbell EL; Saeedi B; Scholz CC; Bayless AJ; Wilson KE; Glover LE; Kominsky DJ; Magnuson A et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network.

2015-01 | Journal article
DOI: 10.1242/jcs.167304
PMID: 25589793
Contributors: Nguyen LK; Cavadas MA; Scholz CC; Fitzpatrick SF; Bruning U; Cummins EP; Tambuwala MM; Manresa MC; Kholodenko BN; Taylor CT et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Paricalcitol protects against TGF-β1-induced fibrotic responses in hypoxia and stabilises HIF-α in renal epithelia.

2015-01 | Journal article
DOI: 10.1016/j.yexcr.2014.07.034
PMID: 25107382
Contributors: Nolan KA; Brennan EP; Scholz CC; Cullen C; Ryan A; Taylor CT; Godson C
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Editorial: a PHD in macrophage survival.

2014-09 | Journal article
DOI: 10.1189/jlb.3CE0314-157R
PMID: 25183793
Contributors: Taylor CT; Scholz CC
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

2013-11 | Journal article
DOI: 10.1073/pnas.1309718110
PMID: 24145445
PMC: PMC3832034
Contributors: Scholz CC; Cavadas MA; Tambuwala MM; Hams E; Rodríguez J; von Kriegsheim A; Cotter P; Bruning U; Fallon PG; Cheong A et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Targeting the HIF pathway in inflammation and immunity.

2013-08 | Journal article
DOI: 10.1016/j.coph.2013.04.009
PMID: 23660374
Contributors: Scholz CC; Taylor CT
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Hydroxylase-dependent regulation of the NF-κB pathway.

2013-04 | Journal article
DOI: 10.1515/hsz-2012-0338
PMID: 23362195
Contributors: Scholz CC; Taylor CT
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network.

2013-03 | Journal article
DOI: 10.1242/jcs.119974
PMID: 23390316
Contributors: Nguyen LK; Cavadas MA; Scholz CC; Fitzpatrick SF; Bruning U; Cummins EP; Tambuwala MM; Manresa MC; Kholodenko BN; Taylor CT et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia.

2011-10 | Journal article
DOI: 10.1128/MCB.01276-10
PMID: 21807897
PMC: PMC3187364
Contributors: Bruning U; Cerone L; Neufeld Z; Fitzpatrick SF; Cheong A; Scholz CC; Simpson DA; Leonard MO; Tambuwala MM; Cummins EP et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia.

2011-02 | Journal article
DOI: 10.1074/jbc.M110.115931
PMID: 21123177
PMC: PMC3039330
Contributors: Agbor TA; Cheong A; Comerford KM; Scholz CC; Bruning U; Clarke A; Cummins EP; Cagney G; Taylor CT
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia.

2011-01 | Journal article
DOI: 10.4049/jimmunol.1002256
PMID: 21149600
Contributors: Fitzpatrick SF; Tambuwala MM; Bruning U; Schaible B; Scholz CC; Byrne A; O'Connor A; Gallagher WM; Lenihan CR; Garvey JF et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.

2010-12 | Journal article
DOI: 10.1053/j.gastro.2010.06.068
PMID: 20600011
Contributors: Tambuwala MM; Cummins EP; Lenihan CR; Kiss J; Stauch M; Scholz CC; Fraisl P; Lasitschka F; Mollenhauer M; Saunders SP et al.
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells.

2010-10 | Journal article
DOI: 10.4049/jimmunol.1000701
PMID: 20817876
Contributors: Cummins EP; Oliver KM; Lenihan CR; Fitzpatrick SF; Bruning U; Scholz CC; Slattery C; Leonard MO; McLoughlin P; Taylor CT
Source: Self-asserted source
Carsten C Scholz via Europe PubMed Central

Hypoxic regulation of NF-kappaB signaling.

Methods in enzymology
2007-01-01 | Journal article
DOI: 10.1016/s0076-6879(07)35025-8
PMID: 17998070
Source: Self-asserted source
Carsten C Scholz

Peer review (2 reviews for 2 publications/grants)

Review activity for Communications biology. (1)
Review activity for Nature immunology. (1)
How many people are using ORCID?