Personal information

Emails & domains

Verified email domains

Websites & social links

Microbial adaptation, Chromatin Remodeling and DNA repair lab

Other IDs

Loop profile: 966936

Keywords

M. tuberculosis, B.subtilis,Biofilm, DNA repair, SOS Response, SWR1 CRC, Arp8,

Countries

India

Biography

Dr. Saravanan Matheshwaran is an Associate Professor at the Department of Biological Sciences and Bioengineering, IIT Kanpur, where he leads a dynamic research group focused on microbial adaptation and chromatin dynamics, to understand the emergence and mitigation of Antimicrobial Resistance (AMR). His groundbreaking doctoral research at IISc Bangalore on Klebsiella pneumoniae nuclease (KpnI) identified the HNH motif in restriction enzymes (REases), leading to the development of a high-fidelity version of KpnI, now widely distributed by New England Biolabs (NEB) and protected by a U.S. patent. This work has had a significant impact on molecular cloning and genetic research. Dr. Matheshwaran’s postdoctoral work at Cancer Research UK and EMBL Heidelberg, supported by prestigious EMBO and Marie Curie fellowships, expanded his expertise in chromatin biology, structural biochemistry, and chromosome dynamics. His research at IIT Kanpur focuses on stress biology, antimicrobial resistance, and the bacterial SOS response—a DNA repair mechanism that contributes to drug resistance. His lab aims to uncover novel therapeutic targets for pathogens like Mycobacterium tuberculosis and Acinetobacter baumannii. Dr. Matheshwaran’s interdisciplinary collaborations with chemists and physicists have led to patented small molecules for disease treatment. His teaching spans a broad array of subjects, including Microbiology, Immunology, and Molecular Biology, integrating cutting-edge research with core concepts to provide students with a comprehensive understanding of biological sciences. His work has earned him numerous awards, including the INSA Young Scientist Award and the DBT-Innovative Young Biotechnologist Award.

Activities

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Employment (6)

Indian Institute of Technology Kanpur: Kanpur, Uttar Pradesh, IN

2023-01-01 to present | Associate Professor (Biological Sciences and Bioengineering)
Employment
Source: Self-asserted source
Saravanan Matheshwaran

Indian Institute of Technology Kanpur: Kanpur, Uttar Pradesh, IN

2013-05-01 to 2022-12-31 | Assistant Professor Grade I (Biological Sciences and Bioengineering)
Employment
Source: Self-asserted source
Saravanan Matheshwaran

Indian Institute of Science: Bangalore, Karnataka, IN

2012-10 to 2013-04 | Research Associate (Microbiology and Cell Biology)
Employment
Source: Self-asserted source
Saravanan Matheshwaran

European Molecular Biology Laboratory: Heidelberg, Baden-Württemberg, DE

2012-04 to 2012-10 | EIPOD-Marie Curie Actions Fellow (Cell Biology and Structural biology Units)
Employment
Source: Self-asserted source
Saravanan Matheshwaran

Institute of Cancer Research: London, London, GB

2010-10 to 2012-02 | EMBO Fellow (Structural Biology)
Employment
Source: Self-asserted source
Saravanan Matheshwaran

London Research Institute Clare Hall Laboratories: South Mimms, Hertfordshire, GB

2008-04-24 to 2010-09-30 | CR UK Postdoctoral Fellow (Molecular Enzymology)
Employment
Source: Self-asserted source
Saravanan Matheshwaran

Education and qualifications (3)

Indian Institute of Science: Bangalore, Karnataka, IN

2001-08 to 2008-04 | PhD (M Sreenivasaya Medal for Best PhD Thesis) (Microbiology and Cell Biology)
Education
Source: Self-asserted source
Saravanan Matheshwaran

Madurai Kamaraj University: Madurai, Tamil Nadu, IN

1999-07 to 2001-05 | M.Sc (Microbial Technology)
Education
Source: Self-asserted source
Saravanan Matheshwaran

Muthayammal College of Arts and Science: Rasipuram, Tamilnadu, IN

1996-06 to 1999-05 | B.Sc (Microbiology) (Microbiology)
Education
Source: Self-asserted source
Saravanan Matheshwaran

Professional activities (13)

Society of Biological Chemists, India: Kanpur, IN

Convener , Local Chapter
Invited position
Source: Self-asserted source
Saravanan Matheshwaran

Society of Biological Chemists, India: Bangalore, IN

Membership
Source: Self-asserted source
Saravanan Matheshwaran

Biochemical Society: London, GB

Membership
Source: Self-asserted source
Saravanan Matheshwaran

Asian Federation of Biotechnology, RBO, INDIA: New Delhi, IN

2024-10 to present | Steering Committee Member
Membership
Source: Self-asserted source
Saravanan Matheshwaran

UK Research and Innovation: London, GB

2018-03-14 to 2021-03-30 | Peer Review College Member
Service
Source: Self-asserted source
Saravanan Matheshwaran

Department of Biotechnology, Ministry of Science and Technology, India: New Delhi, IN

2017 | DBT-Innovative Young Biotechnologist Award (IYBA)
Distinction
Source: Self-asserted source
Saravanan Matheshwaran

European Molecular Biology Laboratory: Heidelberg, Baden-Württemberg, DE

2012 | EIPOD-Marie Curie fellowship European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
Distinction
Source: Self-asserted source
Saravanan Matheshwaran

Indian National Science Academy: New Delhi, IN

2010 | INSA YOUNG SCIENTIST MEDAL
Distinction
Source: Self-asserted source
Saravanan Matheshwaran

Indian Institute of Science: Bangalore, Karnataka, IN

2009 | M SREENIVASAYA MEDAL FOR BEST PHD THESIS (Microbiology and Cell Biology)
Distinction
Source: Self-asserted source
Saravanan Matheshwaran

EMBO: Heidelberg, DE

2009 | EMBO Long term fellowship
Distinction
Source: Self-asserted source
Saravanan Matheshwaran

Cancer Research UK: London, GB

2008 | CR UK Postdoctoral Fellowship
Distinction
Source: Self-asserted source
Saravanan Matheshwaran

CSIR: New Delhi, IN

2002 | CSIR JRF
Distinction
Source: Self-asserted source
Saravanan Matheshwaran

MHRD: New Delhi, IN

2001 | GATE
Distinction
Source: Self-asserted source
Saravanan Matheshwaran

Funding (19)

“Deciphering the role of Ustilago maydis SWR1 chromatin remodeler in melanin biosynthesis, morphogenesis, and virulence mechanism"

2024-09 to 2027-09 | Grant
DBT (New Delhi, IN)
GRANT_NUMBER:

BT/PR53645/BSA/33/125/2024
Source: Self-asserted source
Saravanan Matheshwaran

Deciphering The Role Of "Lexa Family Transcriptional Regulator" In SOS Induced Mutagenesis And Antimicrobial Resitance (AMR) Of Multi-Drug Resistant Acinetobacter baumannii

2024-02 to 2027-02 | Grant
Science and Engineering Research Board (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Small Molecule Inhibitors To Cripple Mycobacterial "SOS" Response Mutagenic Axis And Combat Antimicrobial Resistance (AMR)

2024-02 to 2027-02 | Grant
Indian Council of Medical Research (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Centre of Excellence (CoE) on Antimicrobial Resistance (AMR)

2024 to present | Grant
Department of Science and Technology (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Treatment Of Organics-Laden Industrial Wastewater Effluent Under Flow Conditions Using Photobioreactor-Integrated Microbial Fuel Cell

2023-09 to 2025-03 | Grant
Department of Biotechnology (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Deciphering The Role Of Nuclear Actin Related Protein8 (Arp8) In Rrna Recognition - A Role Beyond Chromatin Remodeling

2023-07 to 2026-07 | Grant
Science and Engineering Research Board (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Understanding The Role Of Putative Antibiotic Methyltransferase Rv1377c Antibiotic Resistance And Persisters Formation

2022-03 to 2025-03 | Grant
Indian Council of Medical Research (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Nanoscale Zeolite-Sinc-Carbo-Mycolyzers (Zinccarbolyzers) To Improve Productivity Of Rice

2022-01 to 2025-01 | Grant
Department of Biotechnology, Ministry of Science and Technology, India (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Understanding The Mechanism Of Mg2+ Mediated Sos Induction In Mycobacterium Tuberculosis To Declipher Its Role In Antibiotic Resistance And Survival In Macrophage

2020-02 to 2023-02 | Grant
MHRD, STARS (Bangalore, IN)
Source: Self-asserted source
Saravanan Matheshwaran

DECIPHERING THE ROLES OF MYCOBACTERIAL "SOS" RESPONSE REGULATED TOXIN-ANTITOXIN (VAPBC40) MODULE IN PERSISTENCE AND ANTIBIOTIC RESISTANCE

2017-07 to 2020-06 | Award
Department of Biotechnology , Ministry of Science and Technology (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

ROLE OF SWRI CHROMATIN REMODELING COMPLEX IN RADIATION RESISTANCE FUNGUS "USTILAGO MAYDIS"

2017-04 to 2020-03 | Grant
Science and Engineering Research Board (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Membrane Curvature Sensing And Generation By Proteins In Lipid Bilayer Membrane

2015-04 to 2018-03 | Grant
Department of Science and Technology, Ministry of Science and Technology, India (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Molecular And Biochemical Characterization Of Lexa Regulated Proteins From Mycobacterium Tuberculosis And Proteins Involved In Chromatin Transactions Under The Centre Of Excellence In Chemical Biology

2014-08 to present | Grant
MHRD (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Molecular And Biochemical Characterization Of Lexa Regulated Proteins From Mycobacterium Tuberculosis And Proteins Involved In Chromatin Transactions Under The Centre Of Excellence In Chemical Biology

2014-08 to present | Grant
MHRD (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Molecular And Biochemical Characterization Of Nuclear Actin Related Proteins (Arps) From Ustilago Maydis

2014-04 to 2017-03 | Award
Indian National Science Academy (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Understanding The Role Of SOS-Regulated HNH Nucleases Of Mycobacterium Tuberculosis In Latency And Reactivation

Grant
SERB (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

A Smart Phone Based Dark Field Microscope For Point Of Care (Poc) Diagnosis Of Blood Cell Disorder In Lethal Diseases

Grant
IMPRINT, MHRD (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Genome Wide Identification And Functional Characterization Of The Effector Genes Of Phytophthora Drechleri Tucker F.Sp. Cajani Causing Phytophthora Blight In Pigeonpea

Grant
SERB (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Molecular & Biochemical Characterixation Of Sachharomyces Cerevisiae Actin Related Protein 8 (Arp8)

Grant
SERB (New Delhi, IN)
Source: Self-asserted source
Saravanan Matheshwaran

Works (45)

Analytical methods for evaluating and characterizing recombinant proteins

Fundamentals of Recombinant Protein Production, Purification and Characterization
2025 | Book chapter
Contributors: Saravanan Matheshwaran
Source: Self-asserted source
Saravanan Matheshwaran

A NANOFORMULATION FOR INHIBITION OF MYCOBACTERIAL SOS RESPONSE AND A PROCESS OF PREPARATION THEREOF

Indian Patent Office
2025-01-14 | Patent
Contributors: Saravanan Matheshwaran
Source: Self-asserted source
Saravanan Matheshwaran

Biochemical and steady-state kinetic analyses of arsenate reductases from an arsenic-tolerant strain of Citrobacter youngae IITK SM2

Biochemical and Biophysical Research Communications
2024-12 | Journal article
DOI: 10.1016/j.bbrc.2024.150936
Contributors: Akshat Verma; Hariharan Vedi Chinnasamy; Bhumika Biswas; Abhas Singh; Saravanan Matheshwaran
Source: check_circle
Crossref

Asymmetric Janus Nanofibrous Agar-Based Wound Dressing Infused with Enhanced Antioxidant and Antibacterial Properties

ACS Applied Bio Materials
2024-11-18 | Journal article
DOI: 10.1021/acsabm.4c01184
Contributors: Kalpana Rathore; Dheeraj Upadhyay; Noopur Verma; Ajay Kumar Gupta; Saravanan Matheshwaran; Sandeep Sharma; Vivek Verma
Source: check_circle
Crossref

COPPER(II) BASED ANTIMICROBIAL AGENTS FOR ATTENUATION OF IN-VIVO DENTAL BIOFILM FORMATION

Indian Patent Office
2024-11-13 | Patent | Investigation
Contributors: Saravanan Matheshwaran
Source: Self-asserted source
Saravanan Matheshwaran

Zinc(II) based antimicrobical agents for attenuation of Staphylococcus aureus infection

Indian Patent Office
2024-11-13 | Patent | Supervision
Contributors: Saravanan Matheshwaran; Ritika Gautam; Santosh K Misra
Source: Self-asserted source
Saravanan Matheshwaran

Anti-mutagenic agent targeting LexA to combat antimicrobial resistance in mycobacteria

Journal of Biological Chemistry
2024-09 | Journal article
DOI: 10.1016/j.jbc.2024.107650
Contributors: Chitral Chatterjee; Gokul Raj Mohan; Hariharan V. Chinnasamy; Bhumika Biswas; Vidya Sundaram; Ashutosh Srivastava; Saravanan Matheshwaran
Source: check_circle
Crossref

Deciphering the influence of NaCl on social behaviour of Bacillus subtilis

Royal Society Open Science
2024-09 | Journal article
DOI: 10.1098/rsos.240822
Contributors: Prem Anand Murugan; Muktesh Kumar Sahu; Manish Kumar Gupta; T. Sabari Sankar; Sivasurender Chandran; Saravanan Matheshwaran
Source: check_circle
Crossref

Harnessing density to control the duration of intermittent Lévy walks in bacterial turbulence

Physical Review E
2024-07-02 | Journal article
DOI: 10.1103/PhysRevE.110.L012601
Contributors: Dhananjay Gautam; Hemlata Meena; Saravanan Matheshwaran; Sivasurender Chandran
Source: check_circle
Crossref

Pyridine‐2,6‐Dicarboxamide Proligands and their Cu(II)/Zn(II) Complexes Targeting <i>Staphylococcus Aureus</i> for the Attenuation of In Vivo Dental Biofilm

Advanced Healthcare Materials
2024-04-23 | Journal article
DOI: 10.1002/adhm.202400378
Part of ISSN: 2192-2640
Part of ISSN: 2192-2659
Contributors: Kajal Chaudhary; Bhumika Agrahari; Bhumika Biswas; Niranjan Chatterjee; Ayushi Chaudhary; Ashwini Kumar; Himanshu Sonker; Sayari Dewan; Deepanshi Saxena; Abdul Akhir et al.
Source: Self-asserted source
Saravanan Matheshwaran

Antimicrobial efficacy of a hemilabile Pt(<scp>ii</scp>)–NHC compound against drug-resistant <i>S. aureus</i> and <i>Enterococcus</i>

Dalton Transactions
2023 | Journal article
DOI: 10.1039/d2dt03365h
Part of ISSN: 1477-9226
Part of ISSN: 1477-9234
Contributors: Mandeep Kaur; Ritesh Thakare; Arindom Bhattacherya; Prem Anand Murugan; Grace Kaul; Manjulika Shukla; Alok Kr. Singh; Saravanan Matheshwaran; Sidharth Chopra; Jitendra Kumar Bera
Source: Self-asserted source
Saravanan Matheshwaran

ANTIBACTERIAL PLATINUM-N-HETEROCYCLIC CARBENECOMPOUNDS AND PROCESS OF PREPARATION THEREOF

Indian Patent Office
2023-11-20 | Patent | Supervision, Investigation, Funding acquisition, Conceptualization, Data curation
Contributors: Saravanan Matheshwaran
Source: Self-asserted source
Saravanan Matheshwaran

Boronic acid derivative inhibits LexA mediated SOS response in Mycobacteria

2023-11-15 | Preprint
DOI: 10.1101/2023.11.15.567215
Contributors: Chitral Chatterjee; Gokul Raj Mohan; V.C Hariharan; Bhumika Biswas; Vidya Sundaram; Ashutosh Srivastava; Saravanan Matheshwaran
Source: check_circle
Crossref

A FORMULATION FOR INHIBITION OF SARS-COV-2 INFECTION AND PROCESS FOR PREPARATION THEREOF

Indian Patent Office
2023-10-18 | Patent | Investigation, Conceptualization, Validation
Contributors: Saravanan Matheshwaran
Source: Self-asserted source
Saravanan Matheshwaran

Spin-dependent electrified protein interfaces for probing the CISS effect

The Journal of Chemical Physics
2023-07-14 | Journal article
DOI: 10.1063/5.0156479
Contributors: Ritu Gupta; Hariharan V. Chinnasamy; Dipak Sahu; Saravanan Matheshwaran; Chanchal Sow; Prakash Chandra Mondal
Source: check_circle
Crossref

Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus, targets peptidoglycan biosynthesis

Chemical Communications
2022 | Journal article
DOI: 10.1039/D2CC04102B
Contributors: Viral Rawat; Sona Tiwari; Shweta Khanna; Umang Gupta; Sridhar S. N. C.; Dharmendra K. Yadav; Grace Kaul; Abdul Akhir; Deepanshi Saxena; Saravanan Matheshwaran et al.
Source: check_circle
Crossref

Zn2+-Induced Conformational Change Affects the SAM Binding in a Mycobacterial SAM-Dependent Methyltransferase

ACS Omega
2022-10-11 | Journal article
DOI: 10.1021/acsomega.2c04555
Contributors: Soneya Majumdar; Umang Gupta; Hariharan V. Chinnasamy; Sathishkumar Laxmipathy; Saravanan Matheshwaran
Source: check_circle
Crossref

Anti-bacterial and arsenic remediation insights in aqueous systems onto heterogeneous metal oxide (Cu0.52Al0.1Fe0.47O4)/rGO hybrid: an approach towards airborne microbial degradation

Environmental Science and Pollution Research
2022-07-29 | Journal article
DOI: 10.1007/s11356-022-22169-8
Part of ISSN: 0944-1344
Part of ISSN: 1614-7499
Contributors: Saravanan Matheshwaran
Source: Self-asserted source
Saravanan Matheshwaran

NaCl Triggers the Sessile-to-Motile Transition of Bacillus subtilis

2022-02-15 | Preprint
DOI: 10.1101/2022.02.15.480532
Contributors: Prem Anand Murugan; Manish Kumar Gupta; T. Sabari Sankar; Sivasurender Chandran; Saravanan Matheshwaran
Source: check_circle
Crossref

Identification and Genome Analysis of an Arsenic‐Metabolizing Strain of Citrobacter youngae IITK SM2 in Middle Indo‐Gangetic Plain Groundwater

BioMed Research International
2022-01 | Journal article
DOI: 10.1155/2022/6384742
Contributors: Akshat Verma; Prem Anand Murugan; Hariharan Vedi Chinnasamy; Abhas Singh; Saravanan Matheshwaran; Swaran J. S. Flora
Source: check_circle
Crossref

Real-time kinetic studies of Mycobacterium tuberculosis LexA–DNA interaction

Bioscience Reports
2021-11-26 | Journal article
DOI: 10.1042/BSR20211419
Contributors: Chitral Chatterjee; Soneya Majumdar; Sachin Deshpande; Deepak Pant; Saravanan Matheshwaran
Source: check_circle
Crossref

A biphasic nanohydroxyapatite/calcium sulphate carrier containing Rifampicin and Isoniazid for local delivery gives sustained and effective antibiotic release and prevents biofilm formation

Scientific Reports
2020-12 | Journal article
DOI: 10.1038/s41598-020-70726-3
Part of ISSN: 2045-2322
Source: Self-asserted source
Saravanan Matheshwaran

Effect of Zn and Co doping on antibacterial efficacy and cytocompatibility of spark plasma sintered hydroxyapatite

Journal of the American Ceramic Society
2020-08 | Journal article
DOI: 10.1111/jace.17077
Part of ISSN: 0002-7820
Part of ISSN: 1551-2916
Contributors: Arjak Bhattacharjee; Rubia Hassan; Anshul Gupta; Madhu Verma; Prem Anand Murugan; Pradyut Sengupta; Matheshwaran Saravanan; Indranil Manna; Kantesh Balani
Source: Self-asserted source
Saravanan Matheshwaran

Antibacterial and magnetic response of site-specific cobalt incorporated hydroxyapatite

Ceramics International
2019-09 | Journal article
DOI: 10.1016/j.ceramint.2019.08.291
Part of ISSN: 0272-8842
Source: Self-asserted source
Saravanan Matheshwaran

Site-specific antibacterial efficacy and cyto/hemo-compatibility of zinc substituted hydroxyapatite

Ceramics International
2019-06 | Journal article
DOI: 10.1016/j.ceramint.2019.03.132
Part of ISSN: 0272-8842
Source: Self-asserted source
Saravanan Matheshwaran

Exocyst Subcomplex Functions in Autophagosome Biogenesis by Regulating Atg9 Trafficking.

Journal of molecular biology
2019-05-17 | Journal article
DOI: 10.1016/j.jmb.2019.04.048
PMID: 31103773
Source: Self-asserted source
Saravanan Matheshwaran

Unveiling the Modulating Role of Extracellular pH in Permeation and Accumulation of Small Molecules in Subcellular Compartments of Gram-negative Escherichia coli using Nonlinear Spectroscopy.

Analytical chemistry
2019-04-24 | Journal article
DOI: 10.1021/acs.analchem.9b00574
PMID: 30986344
Source: Self-asserted source
Saravanan Matheshwaran

Genome Sequence of Bacillus subtilis subsp. subtilis Strain IITK SM1, Isolated from Kitchen Waste Compost

Microbiology Resource Announcements
2019-02-07 | Journal article
DOI: 10.1128/MRA.01330-18
Source: Self-asserted source
Saravanan Matheshwaran
grade
Preferred source (of 2)‎

3'-UTR SNP rs2229611 in G6PC1 affects mRNA stability, expression and Glycogen Storage Disease type-Ia risk.

Clinica chimica acta; international journal of clinical chemistry
2017-05-11 | Journal article
DOI: 10.1016/j.cca.2017.05.016
PMID: 28502559
Source: Self-asserted source
Saravanan Matheshwaran

Hemocompatible glutaminase free l-asparaginase from marine Bacillus tequilensis PV9W with anticancer potential modulating p53 expression

RSC Advances
2016 | Journal article
DOI: 10.1039/c6ra00727a
Part of ISSN: 2046-2069
Source: Self-asserted source
Saravanan Matheshwaran

Functional expression and purification of Anabaena PCC 7120 XisA protein.

Protein expression and purification
2015-10-03 | Journal article
DOI: 10.1016/j.pep.2015.09.027
PMID: 26434536
Source: Self-asserted source
Saravanan Matheshwaran

Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex.

Proceedings of the National Academy of Sciences of the United States of America
2012-12-03 | Journal article
DOI: 10.1073/pnas.1214735109
PMID: 23213201
PMC: PMC3529010
Source: Self-asserted source
Saravanan Matheshwaran

Variant of KpnI restriction endonuclease.

United States
2012-02-21 | Patent
Contributors: Saravanan Matheshwaran
Source: Self-asserted source
Saravanan Matheshwaran

Endonuclease active site plasticity allows DNA cleavage with diverse alkaline Earth and transition metal ions.

ACS chemical biology
2011-07-07 | Journal article
DOI: 10.1021/cb200107y
PMID: 21736285
Source: Self-asserted source
Saravanan Matheshwaran

Generation of a manganese specific restriction endonuclease with nicking activity.

Biochemistry
2010-09-01 | Journal article
DOI: 10.1021/bi101035k
PMID: 20734974
Source: Self-asserted source
Saravanan Matheshwaran

Conformational changes triggered by Mg2+ mediate transactivator function.

Biochemistry
2009-03-01 | Journal article
DOI: 10.1021/bi8022448
PMID: 19170593
Source: Self-asserted source
Saravanan Matheshwaran

KpnI Restriction Endonucleases with Reduced Star Activity

2008-09-18 | Patent
Source: Self-asserted source
Saravanan Matheshwaran

Evolution of sequence specificity in a restriction endonuclease by a point mutation.

Proceedings of the National Academy of Sciences of the United States of America
2008-07-22 | Journal article
DOI: 10.1073/pnas.0804974105
PMID: 18647833
PMC: PMC2492507
Source: Self-asserted source
Saravanan Matheshwaran

Structural integrity of the beta beta alpha-Metal finger motif is required for DNA binding and stable protein-DNA complex formation in R.KpnI.

Biochimica et biophysica acta
2008-02-01 | Journal article
DOI: 10.1016/j.bbapap.2007.07.011
PMID: 18329982
Source: Self-asserted source
Saravanan Matheshwaran

Dual role for Zn2+ in maintaining structural integrity and inducing DNA sequence specificity in a promiscuous endonuclease.

The Journal of biological chemistry
2007-09-04 | Journal article
DOI: 10.1074/jbc.m705927200
PMID: 17785455
Source: Self-asserted source
Saravanan Matheshwaran

R.KpnI, an HNH superfamily REase, exhibits differential discrimination at non-canonical sequences in the presence of Ca2+ and Mg2+.

Nucleic acids research
2007-04-11 | Journal article
DOI: 10.1093/nar/gkm114
PMID: 17430971
PMC: PMC1885652
Source: Self-asserted source
Saravanan Matheshwaran

Type II restriction endonuclease R.KpnI is a member of the HNH nuclease superfamily.

Nucleic acids research
2004-11-23 | Journal article
DOI: 10.1093/nar/gkh951
PMID: 15562004
PMC: PMC534630
Source: Self-asserted source
Saravanan Matheshwaran

Ca(2+)-mediated site-specific DNA cleavage and suppression of promiscuous activity of KpnI restriction endonuclease.

The Journal of biological chemistry
2004-09-16 | Journal article
DOI: 10.1074/jbc.m409483200
PMID: 15375161
Source: Self-asserted source
Saravanan Matheshwaran

A new type II restriction endonuclease, OfoI from nonheterocystous cyanobacterium Oscillatoria foreaui

Journal article
Source: Self-asserted source
Saravanan Matheshwaran

Variant of KpnI restriction endonuclease

Patent
Source: Self-asserted source
Saravanan Matheshwaran

Peer review (7 reviews for 5 publications/grants)

Review activity for ACS omega. (3)
Review activity for Advanced science. (1)
Review activity for Biochimica et biophysica acta. (1)
Review activity for Biofilm. (1)
Review activity for JoVE. (1)
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