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Activities

Employment (9)

AstraZeneca UK Ltd: Cambridge, Cambridgeshire, GB

2015 to 2025 | Principal Scientist (Discovery Sciences)
Employment
Source: Self-asserted source
David M Smith

AstraZeneca: Gothenburg, SE

2012 to 2015 | Senior Principal Scientist (CVRM)
Employment
Source: Self-asserted source
David M Smith

AstraZeneca: Macclesfield, Cheshire, GB

2007 to 2012 | Senior Principal Scientist (CVGI)
Employment
Source: Self-asserted source
David M Smith

AstraZeneca: Macclesfield, Cheshire, GB

2006 to 2007 | Principal Scientist (CVGI)
Employment
Source: Self-asserted source
David M Smith

AstraZeneca: Macclesfield, Cheshire, GB

2001 to 2006 | Team leader (Cardiovascular & Gastrointestinal )
Employment
Source: Self-asserted source
David M Smith

Imperial College London: London, Westminster, GB

1996 to 2001 | Senior Lecturer (Metabolic Medicine)
Employment
Source: Self-asserted source
David M Smith

Royal Postgraduate Medical School: London, Greater London, GB

1989 to 1996 | Lecturer (Medicine)
Employment
Source: Self-asserted source
David M Smith

University of Southampton: Southampton, Hampshire, GB

1986 to 1989 | Postdoctoral fellow (Biochemistry)
Employment
Source: Self-asserted source
David M Smith

Cardiothoracic Institute: London, Greater London, GB

1984 to 1986 | Postdoctoral Research Assistant (Cardiac Medicine)
Employment
Source: Self-asserted source
David M Smith

Education and qualifications (2)

University of London: London, GB

1980 to 1985 | PhD (Biochemistry)
Education
Source: Self-asserted source
David M Smith

University of Bristol: Bristol, GB

1977 to 1980 | BSc (hons) (Biochemistry)
Education
Source: Self-asserted source
David M Smith

Professional activities (5)

British Pharmacological Society: London, GB

1999 to present | Fellow
Membership
Source: Self-asserted source
David M Smith

St Bartholomew's Hospital: London, London, GB

2017-04-01 to 2020-03-31 | Senior Lecturer (William Harvey Research Institute)
Invited position
Source: Self-asserted source
David M Smith

Royal Society of Biology: London, GB

2017-10-01 | Fellow (FRSB)
Distinction
Source: Self-asserted source
David M Smith

British Pharmacological Society: London, GB

2017-09-21 | Fellow (FBPhS)
Distinction
Source: Self-asserted source
David M Smith

Biochemical Society: London, GB

1977 to 2011
Membership
Source: Self-asserted source
David M Smith

Works (50 of 148)

Items per page:
Page 1 of 3

A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target

2022-04 | Preprint
Contributors: Davaapil H; McNamara M; Granata A; Macrae RG; Hirano M; Fitzek M; Aragon-Martin JA; Child A; Smith DM; Sinha S
Source: Self-asserted source
David M Smith via Europe PubMed Central

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase.

Diabetologia
2022-03 | Journal article
Contributors: Nguyen-Tu MS; Harris J; Martinez-Sanchez A; Chabosseau P; Hu M; Georgiadou E; Pollard A; Otero P; Lopez-Noriega L; Leclerc I et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Glucose-dependent miR-125b is a negative regulator of β-cell function

2021-05 | Preprint
Contributors: Cheung R; Pizza G; Chabosseau P; Rolando D; Tomas A; Burgoyne T; Wu Z; Salowka A; Thapa A; Macklin A et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

The long noncoding RNA <i>TUNAR</i> modulates Wnt signaling and regulates human β-cell proliferation.

American journal of physiology. Endocrinology and metabolism
2021-03 | Journal article
Contributors: Zhou AX; Mondal T; Tabish AM; Abadpour S; Ericson E; Smith DM; Knöll R; Scholz H; Kanduri C; Tyrberg B et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation.

International journal of molecular sciences
2020-12 | Journal article
Contributors: Parafati M; Bae SH; Kirby RJ; Fitzek M; Iyer P; Engkvist O; Smith DM; Malany S
Source: Self-asserted source
David M Smith via Europe PubMed Central

A small molecule inhibitor of HER3: a proof-of-concept study.

The Biochemical journal
2020-09 | Journal article
Contributors: Colomba A; Fitzek M; George R; Weitsman G; Roberts S; Zanetti-Domingues L; Hirsch M; Rolfe DJ; Mehmood S; Madin A et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge.

Diabetes, obesity & metabolism
2020-07 | Journal article
Contributors: Ford BE; Chachra SS; Alshawi A; Brennan A; Harnor S; Cano C; Baker DJ; Smith DM; Fairclough RJ; Agius L
Source: Self-asserted source
David M Smith via Europe PubMed Central

Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming.

Nature communications
2020-07 | Journal article
Contributors: Cheung KCP; Fanti S; Mauro C; Wang G; Nair AS; Fu H; Angeletti S; Spoto S; Fogolari M; Romano F et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Inhibition of the prostaglandin D<sub>2</sub>-GPR44/DP2 axis improves human islet survival and function.

Diabetologia
2020-04 | Journal article
Contributors: Abadpour S; Tyrberg B; Schive SW; Huldt CW; Gennemark P; Ryberg E; Rydén-Bergsten T; Smith DM; Korsgren O; Skrtic S et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors.

ACS pharmacology & translational science
2020-03 | Journal article
Contributors: Hendrikse ER; Liew LP; Bower RL; Bonnet M; Jamaluddin MA; Prodan N; Richards KD; Walker CS; Pairaudeau G; Smith DM et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition.

Cell death discovery
2020-02 | Journal article
Contributors: Brito H; Marques V; Afonso MB; Brown DG; Börjesson U; Selmi N; Smith DM; Roberts IO; Fitzek M; Aniceto N et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.

Nature metabolism
2019-02 | Journal article
Contributors: Pollard AE; Martins L; Muckett PJ; Khadayate S; Bornot A; Clausen M; Admyre T; Bjursell M; Fiadeiro R; Wilson L et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Urotensin II in the development and progression of chronic kidney disease following ⅚ nephrectomy in the rat.

Experimental physiology
2019-01 | Journal article
Contributors: Eyre HJ; Speight T; Glazier JD; Smith DM; Ashton N
Source: Self-asserted source
David M Smith via Europe PubMed Central

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Immunity
2018-04 | Journal article
Contributors: Kishore M; Cheung KCP; Fu H; Bonacina F; Wang G; Coe D; Ward EJ; Colamatteo A; Jangani M; Baragetti A et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

MiR-184 expression is regulated by AMPK in pancreatic islets.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2018-01 | Journal article
Contributors: Martinez-Sanchez A; Nguyen-Tu MS; Cebola I; Yavari A; Marchetti P; Piemonti L; de Koning E; Shapiro AMJ; Johnson P; Sakamoto K et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Agonism of free fatty acid receptors 1 and 4 generates peptide YY-mediated inhibitory responses in mouse colon.

British journal of pharmacology
2017-11 | Journal article
Contributors: Moodaley R; Smith DM; Tough IR; Schindler M; Cox HM
Source: Self-asserted source
David M Smith via Europe PubMed Central

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Immunity
2017-11 | Journal article
Contributors: Kishore M; Cheung KCP; Fu H; Bonacina F; Wang G; Coe D; Ward EJ; Colamatteo A; Jangani M; Baragetti A et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Nonclinical and clinical pharmacology evidence for cardiovascular safety of saxagliptin.

Cardiovascular diabetology
2017-09 | Journal article
Contributors: Pollack PS; Chadwick KD; Smith DM; Billger M; Hirshberg B; Iqbal N; Boulton DW
Source: Self-asserted source
David M Smith via Europe PubMed Central

Dapagliflozin slows the progression of the renal and liver fibrosis associated with type 2 diabetes.

American journal of physiology. Endocrinology and metabolism
2017-08 | Journal article
Contributors: Tang L; Wu Y; Tian M; Sjöström CD; Johansson U; Peng XR; Smith DM; Huang Y
Source: Self-asserted source
David M Smith via Europe PubMed Central

Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion.

Scientific reports
2017-07 | Journal article
Contributors: Kristinsson H; Sargsyan E; Manell H; Smith DM; Göpel SO; Bergsten P
Source: Self-asserted source
David M Smith via Europe PubMed Central

Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.

Diabetes
2017-04 | Journal article
Contributors: Trevaskis JL; Sacramento CB; Jouihan H; Ali S; Le Lay J; Oldham S; Bhagroo N; Boland BB; Cann J; Chang Y et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Dapagliflozin-lowered blood glucose reduces respiratory Pseudomonas aeruginosa infection in diabetic mice.

British journal of pharmacology
2017-03 | Journal article
Contributors: Åstrand A; Wingren C; Benjamin A; Tregoning JS; Garnett JP; Groves H; Gill S; Orogo-Wenn M; Lundqvist AJ; Walters D et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for <i>Elovl2</i> in glucose-induced insulin secretion.

Molecular metabolism
2017-01 | Journal article
Contributors: Cruciani-Guglielmacci C; Bellini L; Denom J; Oshima M; Fernandez N; Normandie-Levi P; Berney XP; Kassis N; Rouch C; Dairou J et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.

Cell metabolism
2016-09 | Journal article
Contributors: Segerstolpe Å; Palasantza A; Eliasson P; Andersson EM; Andréasson AC; Sun X; Picelli S; Sabirsh A; Clausen M; Bjursell MK et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells.

Peptides
2015-07 | Journal article
Contributors: Moss CE; Glass LL; Diakogiannaki E; Pais R; Lenaghan C; Smith DM; Wedin M; Bohlooly-Y M; Gribble FM; Reimann F
Source: Self-asserted source
David M Smith via Europe PubMed Central

The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model.

PloS one
2015-03 | Journal article
Contributors: Sahraoui A; Winzell MS; Gorman T; Smith DM; Skrtic S; Hoeyem M; Abadpour S; Johansson L; Korsgren O; Foss A et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120.

PloS one
2014-12 | Journal article
Contributors: Bjursell M; Xu X; Admyre T; Böttcher G; Lundin S; Nilsson R; Stone VM; Morgan NG; Lam YY; Storlien LH et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.

Diabetologia
2014-03 | Journal article
Contributors: Stone VM; Dhayal S; Brocklehurst KJ; Lenaghan C; Sörhede Winzell M; Hammar M; Xu X; Smith DM; Morgan NG
Source: Self-asserted source
David M Smith via Europe PubMed Central

Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis.

International journal of experimental pathology
2014-02 | Journal article
Contributors: Jones HB; Reens J; Brocklehurst SR; Betts CJ; Bickerton S; Bigley AL; Jenkins RP; Whalley NM; Morgan D; Smith DM
Source: Self-asserted source
David M Smith via Europe PubMed Central

Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response.

Experimental physiology
2013-12 | Journal article
Contributors: Mullooly N; Vernon W; Smith DM; Newsholme P
Source: Self-asserted source
David M Smith via Europe PubMed Central

ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes.

Nutrition & diabetes
2013-10 | Journal article
Contributors: Omikorede O; Qi C; Gorman T; Chapman P; Yu A; Smith DM; Herbert TP
Source: Self-asserted source
David M Smith via Europe PubMed Central

FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion.

Endocrinology
2013-09 | Journal article
Contributors: Kristinsson H; Smith DM; Bergsten P; Sargsyan E
Source: Self-asserted source
David M Smith via Europe PubMed Central

Regulation of lipid metabolism by glucocorticoids and 11β-HSD1 in skeletal muscle.

Endocrinology
2013-04 | Journal article
Contributors: Morgan SA; Gathercole LL; Simonet C; Hassan-Smith ZK; Bujalska I; Guest P; Abrahams L; Smith DM; Stewart PM; Lavery GG et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.

The British journal of nutrition
2012-10 | Journal article
Contributors: Bellahcene M; O'Dowd JF; Wargent ET; Zaibi MS; Hislop DC; Ngala RA; Smith DM; Cawthorne MA; Stocker CJ; Arch JR
Source: Self-asserted source
David M Smith via Europe PubMed Central

Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets.

Endocrinology
2012-07 | Journal article
Contributors: Welters HJ; El Ouaamari A; Kawamori D; Meyer J; Hu J; Smith DM; Kulkarni RN
Source: Self-asserted source
David M Smith via Europe PubMed Central

The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.

British journal of pharmacology
2012-04 | Journal article
Contributors: Stone VM; Dhayal S; Smith DM; Lenaghan C; Brocklehurst KJ; Morgan NG
Source: Self-asserted source
David M Smith via Europe PubMed Central

Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?

The Journal of endocrinology
2011-07 | Journal article
Contributors: Whalley NM; Pritchard LE; Smith DM; White A
Source: Self-asserted source
David M Smith via Europe PubMed Central

Upregulation of β-cell genes and improved function in rodent islets following chronic glucokinase activation.

Journal of molecular endocrinology
2011-07 | Journal article
Contributors: Gill D; Brocklehurst KJ; Brown HW; Smith DM
Source: Self-asserted source
David M Smith via Europe PubMed Central

Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice.

European journal of pharmacology
2011-05 | Journal article
Contributors: Winzell MS; Coghlan M; Leighton B; Frangioudakis G; Smith DM; Storlien LH; Ahrén B
Source: Self-asserted source
David M Smith via Europe PubMed Central

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet.

American journal of physiology. Endocrinology and metabolism
2010-10 | Journal article
Contributors: Bjursell M; Admyre T; Göransson M; Marley AE; Smith DM; Oscarsson J; Bohlooly-Y M
Source: Self-asserted source
David M Smith via Europe PubMed Central

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.

FEBS letters
2010-04 | Journal article
Contributors: Zaibi MS; Stocker CJ; O'Dowd J; Davies A; Bellahcene M; Cawthorne MA; Brown AJ; Smith DM; Arch JR
Source: Self-asserted source
David M Smith via Europe PubMed Central

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

Diabetes
2009-08 | Journal article
Contributors: Morgan SA; Sherlock M; Gathercole LL; Lavery GG; Lenaghan C; Bujalska IJ; Laber D; Yu A; Convey G; Mayers R et al.
Source: Self-asserted source
David M Smith via Europe PubMed Central

The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice.

Biochemical Society transactions
2008-10 | Journal article
Contributors: Brownlie R; Mayers RM; Pierce JA; Marley AE; Smith DM
Source: Self-asserted source
David M Smith via Europe PubMed Central

A review of islet of Langerhans degeneration in rodent models of type 2 diabetes.

Toxicologic pathology
2008-05 | Journal article
Contributors: Nugent DA; Smith DM; Jones HB
Source: Self-asserted source
David M Smith via Europe PubMed Central

Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice.

Diabetes, obesity & metabolism
2007-11 | Journal article
Contributors: Gorman T; Hope DC; Brownlie R; Yu A; Gill D; Löfvenmark J; Wedin M; Mayers RM; Snaith MR; Smith DM
Source: Self-asserted source
David M Smith via Europe PubMed Central

Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells.

Biochemical Society transactions
2007-11 | Journal article
Contributors: Johnson D; Shepherd RM; Gill D; Gorman T; Smith DM; Dunne MJ
Source: Self-asserted source
David M Smith via Europe PubMed Central

Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator.

Diabetes
2007-03 | Journal article
Contributors: Johnson D; Shepherd RM; Gill D; Gorman T; Smith DM; Dunne MJ
Source: Self-asserted source
David M Smith via Europe PubMed Central

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.

Journal of molecular endocrinology
2006-10 | Journal article
Contributors: Bujalska IJ; Quinkler M; Tomlinson JW; Montague CT; Smith DM; Stewart PM
Source: Self-asserted source
David M Smith via Europe PubMed Central

Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis.

Gene
2006-06 | Journal article
Contributors: Quinkler M; Bujalska IJ; Tomlinson JW; Smith DM; Stewart PM
Source: Self-asserted source
David M Smith via Europe PubMed Central

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice.

Diabetologia
2006-04 | Journal article
Contributors: Wang SJ; Birtles S; de Schoolmeester J; Swales J; Moody G; Hislop D; O'Dowd J; Smith DM; Turnbull AV; Arch JR
Source: Self-asserted source
David M Smith via Europe PubMed Central
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