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Page 1 of 7

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease

Chembiochem
2017 | Journal article
DOI: 10.1002/cbic.201600561 [doi]
Source: Self-asserted source
Herman Overkleeft

Activity-Based Protein Profiling: From Chemical Novelty to Biomedical Stalwart

Methods Mol Biol
2017 | Journal article
DOI: 10.1007/978-1-4939-6439-0_1 [doi]
Source: Self-asserted source
Herman Overkleeft

Activity-Dependent Photoaffinity Labeling of Metalloproteases

Methods Mol Biol
2017 | Journal article
DOI: 10.1007/978-1-4939-6439-0_8 [doi]
Source: Self-asserted source
Herman Overkleeft

Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors

J Am Chem Soc
2017 | Journal article
DOI: 10.1021/jacs.7b01773 [doi]
Source: Self-asserted source
Herman Overkleeft

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases

ACS Chem Biol
2017 | Journal article
DOI: 10.1021/acschembio.6b01052 [doi]
Source: Self-asserted source
Herman Overkleeft

Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates

Angew. Chem Int Ed Engl
2017 | Journal article
DOI: 10.1002/anie.201611878 [doi]
Source: Self-asserted source
Herman Overkleeft

Conformational Behaviour of Azasugars Based on Mannuronic Acid

Chembiochem
2017 | Journal article
DOI: 10.1002/cbic.201700080 [doi]
Source: Self-asserted source
Herman Overkleeft

Correlative light and electron microscopy reveals discrepancy between gold and fluorescence labelling

J Microsc
2017 | Journal article
DOI: 10.1111/jmi.12567 [doi]
Source: Self-asserted source
Herman Overkleeft

Inhibition of the Proteasome beta2 Site Sensitizes Triple-Negative Breast Cancer Cells to beta5 Inhibitors and Suppresses Nrf1 Activation
Source: Self-asserted source
Herman Overkleeft

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes
Source: Self-asserted source
Herman Overkleeft

Mapping the Reactivity and Selectivity of 2-Azidofucosyl Donors for the Assembly of N-Acetylfucosamine-Containing Bacterial Oligosaccharides

J Org Chem
2017 | Journal article
DOI: 10.1021/acs.joc.6b02593 [doi]
Source: Self-asserted source
Herman Overkleeft

Proteasome Activity Profiling Uncovers Alteration of Catalytic beta2 and beta5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots

Front Plant Sci
2017 | Journal article
DOI: 10.3389/fpls.2017.00107 [doi]
Source: Self-asserted source
Herman Overkleeft

Simultaneous quantitation of sphingoid bases by UPLC-ESI-MS/MS with identical 13C-encoded internal standards

Clin Chim. Acta
2017 | Journal article
DOI: S0009-8981(17)30025-6 [pii];10.1016/j.cca.2017.01.014 [doi]
Source: Self-asserted source
Herman Overkleeft

Stabilization of Glucocerebrosidase by Active Site Occupancy

ACS Chem Biol
2017 | Journal article
DOI: 10.1021/acschembio.7b00276 [doi]
Source: Self-asserted source
Herman Overkleeft

Stereoselectivity of Conformationally Restricted Glucosazide Donors

J Org Chem
2017 | Journal article
DOI: 10.1021/acs.joc.7b00470 [doi]
Source: Self-asserted source
Herman Overkleeft

Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections

Plant J
2017 | Journal article
DOI: 10.1111/tpj.13494 [doi]
Source: Self-asserted source
Herman Overkleeft

Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit

Org Lett
2017 | Journal article
DOI: 10.1021/acs.orglett.7b00747 [doi]
Source: Self-asserted source
Herman Overkleeft

Teichoic acids: synthesis and applications

Chem Soc Rev
2017 | Journal article
DOI: 10.1039/c6cs00270f [doi]
Source: Self-asserted source
Herman Overkleeft

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding

J Med Chem
2017 | Journal article
DOI: 10.1021/acs.jmedchem.6b01482 [doi]
Source: Self-asserted source
Herman Overkleeft

Two-Step Activity-Based Protein Profiling with the Proteasome System as Model of Study

Methods Mol Biol
2017 | Journal article
DOI: 10.1007/978-1-4939-6439-0_15 [doi]
Source: Self-asserted source
Herman Overkleeft

A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta5i

EMBO J
2016 | Journal article
DOI: embj.201695222 [pii];10.15252/embj.201695222 [doi]
Source: Self-asserted source
Herman Overkleeft

A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities

Angew. Chem Int Ed Engl
2016 | Journal article
DOI: 10.1002/anie.201509092 [doi]
Source: Self-asserted source
Herman Overkleeft

Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard

Clin Chim. Acta
2016 | Journal article
DOI: S0009-8981(16)30221-2 [pii];10.1016/j.cca.2016.05.017 [doi]
Source: Self-asserted source
Herman Overkleeft

Association Between Progranulin and Gaucher Disease
Source: Self-asserted source
Herman Overkleeft

Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients

Orphanet J Rare Dis
2016 | Journal article
DOI: 10.1186/s13023-016-0413-3 [doi];10.1186/s13023-016-0413-3 [pii]
Source: Self-asserted source
Herman Overkleeft

Bis-pyridylethenyl benzene as novel backbone for amyloid-beta binding compounds

Bioorg. Med Chem
2016 | Journal article
DOI: S0968-0896(16)30346-7 [pii];10.1016/j.bmc.2016.05.022 [doi]
Source: Self-asserted source
Herman Overkleeft

Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-beta-glucosidases

FEBS Lett
2016 | Journal article
DOI: 10.1002/1873-3468.12059 [doi]
Source: Self-asserted source
Herman Overkleeft

Detection of Active Mammalian GH31 alpha-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

ACS Cent Sci
2016 | Journal article
DOI: 10.1021/acscentsci.6b00057 [doi]
Source: Self-asserted source
Herman Overkleeft

Development of new Malt1 inhibitors and probes

Bioorg. Med Chem
2016 | Journal article
DOI: S0968-0896(16)30191-2 [pii];10.1016/j.bmc.2016.03.035 [doi]
Source: Self-asserted source
Herman Overkleeft

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

Oncotarget
2016 | Journal article
DOI: 7596 [pii];10.18632/oncotarget.7596 [doi]
Source: Self-asserted source
Herman Overkleeft

Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib

Chem Commun (Camb. )
2016 | Journal article
DOI: 10.1039/c6cc01156j [doi]
Source: Self-asserted source
Herman Overkleeft

Endo-beta-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement

Chembiochem
2016 | Journal article
DOI: 10.1002/cbic.201600312 [doi]
Source: Self-asserted source
Herman Overkleeft

Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic alpha-amylase

FEBS Lett
2016 | Journal article
DOI: 10.1002/1873-3468.12143 [doi]
Source: Self-asserted source
Herman Overkleeft

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular beta-glucosidases

J Lipid Res
2016 | Journal article
DOI: jlr.M064923 [pii];10.1194/jlr.M064923 [doi]
Source: Self-asserted source
Herman Overkleeft

Hydrophobic Interactions Contribute to Conformational Stabilization of Endoglycoceramidase II by Mechanism-Based Probes

Biochemistry
2016 | Journal article
DOI: 10.1021/acs.biochem.6b00363 [doi]
Source: Self-asserted source
Herman Overkleeft

Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages

Cell Death Differ
2016 | Journal article
DOI: cdd20163 [pii];10.1038/cdd.2016.3 [doi]
Source: Self-asserted source
Herman Overkleeft

Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease

Am J Respir Crit Care Med
2016 | Journal article
DOI: 10.1164/rccm.201506-1122OC [doi]
Source: Self-asserted source
Herman Overkleeft

Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes
Source: Self-asserted source
Herman Overkleeft

Lipophilic Muramyl Dipeptide-Antigen Conjugates as Immunostimulating Agents

ChemMedChem
2016 | Journal article
DOI: 10.1002/cmdc.201500196 [doi]
Source: Self-asserted source
Herman Overkleeft

Lyso-glycosphingolipid abnormalities in different murine models of lysosomal storage disorders

Mol Genet Metab
2016 | Journal article
DOI: S1096-7192(15)30090-1 [pii];10.1016/j.ymgme.2015.12.006 [doi]
Source: Self-asserted source
Herman Overkleeft

Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases

FEBS Lett
2016 | Journal article
DOI: 10.1002/1873-3468.12104 [doi]
Source: Self-asserted source
Herman Overkleeft

Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes

Mol Biosyst
2016 | Journal article
DOI: 10.1039/c6mb00257a [doi]
Source: Self-asserted source
Herman Overkleeft

Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
Source: Self-asserted source
Herman Overkleeft

Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism

Leukemia
2016 | Journal article
DOI: leu2016102 [pii];10.1038/leu.2016.102 [doi]
Source: Self-asserted source
Herman Overkleeft

Proteasome Subunit Selective Activity-Based Probes Report on Proteasome Core Particle Composition in a Native Polyacrylamide Gel Electrophoresis Fluorescence-Resonance Energy Transfer Assay

J Am Chem Soc
2016 | Journal article
DOI: 10.1021/jacs.6b04207 [doi]
Source: Self-asserted source
Herman Overkleeft

Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

Proc Natl Acad Sci U S A
2016 | Journal article
DOI: 1522364112 [pii];10.1073/pnas.1522364112 [doi]
Source: Self-asserted source
Herman Overkleeft

Structure-Based Design of beta5c Selective Inhibitors of Human Constitutive Proteasomes

J Med Chem
2016 | Journal article
DOI: 10.1021/acs.jmedchem.6b00705 [doi]
Source: Self-asserted source
Herman Overkleeft

Synthesis and evaluation of fluorescent Pam3Cys peptide conjugates

Bioorg. Med Chem Lett
2016 | Journal article
DOI: S0960-894X(16)30604-7 [pii];10.1016/j.bmcl.2016.05.094 [doi]
Source: Self-asserted source
Herman Overkleeft

Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides

Angew. Chem Int Ed Engl
2016 | Journal article
DOI: 10.1002/anie.201604058 [doi]
Source: Self-asserted source
Herman Overkleeft

Synthesis of E. faecium wall teichoic acid fragments

Bioorg. Med Chem
2016 | Journal article
DOI: S0968-0896(16)30168-7 [pii];10.1016/j.bmc.2016.03.019 [doi]
Source: Self-asserted source
Herman Overkleeft
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Page 1 of 7

Peer review (39 reviews for 8 publications/grants)

Review activity for ACS central science. (7)
Review activity for ACS chemical biology. (5)
Review activity for ACS medicinal chemistry letters. (1)
Review activity for Analytical chemistry. (1)
Review activity for Journal of medicinal chemistry. (6)
Review activity for Journal of organic chemistry. (3)
Review activity for Journal of the American Chemical Society. (14)
Review activity for Organic letters. (2)
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