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Works (43)

Hemophagocytic lymphohistiocytosis and clonally related T‐cell malignancies in a pediatric patient

Pediatric Blood & Cancer
2023-09-13 | Journal article | Author
Part of ISSN: 1545-5009
Part of ISSN: 1545-5017
Contributors: Lauren Meyer; Ingold Huang; Benjamin Huang; Jong Chung; Anjali Pawar; Michelle L. Hermiston; Mignon Loh; Robert S. Ohgami; Roberto Ruiz‐Cordero; Parul Bhargava et al.
Source: Self-asserted source
Benjamin Huang

Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation

JCI Insight
2023-09-08 | Journal article | Author
Part of ISSN: 2379-3708
Contributors: Pan-Yu Chen; Benjamin Huang; Max Harris; Christopher Boone; Weijie Wang; Heidi Carias; Brian Mesiona; Daniela Mavrici; Amanda C. Kohler; Gideon Bollag et al.
Source: Self-asserted source
Benjamin Huang

Opposing effects of <i>KDM6A</i> and <i>JDP2</i> on glucocorticoid sensitivity in T-ALL

Blood Advances
2023-07-25 | Journal article | Author
Part of ISSN: 2473-9529
Part of ISSN: 2473-9537
Contributors: Anya Levinson; Karensa Tjoa; Benjamin Huang; Lauren K. Meyer; Mi-Ok Kim; Samuel W. Brady; Jinghui Zhang; Kevin Shannon; Anica M. Wandler
Source: Self-asserted source
Benjamin Huang

Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK).

Pigment cell & melanoma research
2023-07-20 | Journal article
Contributors: Perkins IU; Tan SY; McCalmont TH; Chou PM; Mully TW; Gerami P; Pomerantz JH; Reyes-Múgica M; Balkin DM; Kruse LL et al.
Source: Self-asserted source
Benjamin Huang

Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia

Journal of Clinical Oncology
2023-06-01 | Journal article | Author
Part of ISSN: 0732-183X
Part of ISSN: 1527-7755
Contributors: Jason E Farrar; Jenny L. Smith; Megan Othus; Benjamin Huang; Yi-Cheng Wang; Rhonda Ries; Tiffany Hylkema; Era L. Pogosova-Agadjanyan; Sneha Challa; Amanda Hiser et al.
Source: Self-asserted source
Benjamin Huang

<i>NFIA-ETO2</i>, <i>TP53</i>, and erythroid leukemogenesis

Blood
2023-05-04 | Journal article | Author
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Benjamin Huang; Kevin Shannon
Source: Self-asserted source
Benjamin Huang

Venetoclax in combination with chemotherapy as treatment for pediatric advanced hematologic malignancies.

Pediatric blood & cancer
2023-04-10 | Journal article | Author
Contributors: Amanda Marinoff; Aaronson K; Anurag Agrawal; Benjamin Huang; Golden C; Huang BJ; Michlitsch J; Southworth E; Thrall A; Kieuhoa Vo et al.
Source: Self-asserted source
Benjamin Huang

Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication

Nature Communications
2023-04-05 | Journal article | Author
Part of ISSN: 2041-1723
Contributors: Yanling Liu; Jonathon Klein; Richa Bajpai; Li Dong; Quang Tran; Pandurang Kolekar; Jenny L. Smith; Rhonda Ries; Benjamin Huang; Yi-Cheng Wang et al.
Source: Self-asserted source
Benjamin Huang

Machine learning classifier approaches for predicting response to RTK-type-III inhibitors demonstrate high accuracy using transcriptomic signatures and <i>ex vivo</i> data

Bioinformatics Advances
2023-01-05 | Journal article
Part of ISSN: 2635-0041
Contributors: Mauricio H. Ferrato; Adam G Marsh; Karl R Franke; Benjamin J Huang; E Anders Kolb; Deborah DeRyckere; Douglas K Grahm; Sunita Chandrasekaran; Erin L Crowgey
Source: Self-asserted source
Benjamin Huang

<i>Opposing Effects of KDM6A and JDP2 on Glucocorticoid Sensitivity in T-ALL</i>

Blood
2022-11-15 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Anya Levinson; Karensa Tjoa; Benjamin J. Huang; Lauren K. Meyer; Samuel W Brady; Jinghui Zhang; Kevin M. Shannon; Anica Wandler
Source: Self-asserted source
Benjamin Huang

A Robust Long Non-Coding RNA Expression Classifier for Risk Stratification in Pediatric AML

Blood
2022-11-15 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Jason E Farrar; Jenny L. Smith; Megan Othus; Benjamin J. Huang; Yi-Cheng Wang; Rhonda E. Ries; Tiffany A. Hylkema; Era L Pogosova-Agadjanyan; Sneha Challa; Amanda R. Leonti et al.
Source: Self-asserted source
Benjamin Huang

A Transcriptional Classifier Identifies Pediatric T-Cell Acute Lymphoblastic Leukemias at High Risk for End of Induction Minimal Residual Disease

Blood
2022-11-15 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Lauren K. Meyer; Ritu P. Roy; Petri Pölönen; Abdelrahman Elsayed; Benjamin J. Huang; Shunsuke Kimura; Cristina Delgado-Martin; Tiffaney L. Vincent; Theresa Ryan; Brent L. Wood et al.
Source: Self-asserted source
Benjamin Huang

CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.

The Journal of clinical investigation
2022-11-15 | Journal article
Contributors: Le Q; Hadland B; Jenny L. Smith; Leonti A; Huang BJ; Ries R; Hylkema TA; Castro S; Tang TT; McKay CN et al.
Source: Self-asserted source
Benjamin Huang

Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia

Blood
2022-11-15 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Adam J. Lamble; Rhonda E. Ries; Todd A. Alonzo; Yi-Cheng Wang; Jason E Farrar; Benjamin J. Huang; Matthew A. Kutny; Jessica A. Pollard; Richard Aplenc; Alan S. Gamis et al.
Source: Self-asserted source
Benjamin Huang

Structural Surfaceomics Reveals an AML-Specific Conformation of Integrin-β2 As an Immunotherapeutic Target

Blood
2022-11-15 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Kamal Mandal; Gianina Wicaksono; Clinton Yu; Jarrett J Adams; Michael R Hoopmann; William C Temple; Bonell Patino Escobar; Maryna Gorelik; Christian Ihling; Matthew A Nix et al.
Source: Self-asserted source
Benjamin Huang

Transcriptome Analysis and Machine Learning Prioritize Therapeutic Strategies for High-Risk Pediatric AML Patients of the KMT2A-Fusion Subgroup

Blood
2022-11-15 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Alyssa Obermayer; Sijie Yao; Jenny L. Smith; Rhonda E. Ries; Yi-Cheng Wang; Jason E Farrar; Scott N Furlan; Tim Triche; Xiaotu Ma; Benjamin J. Huang et al.
Source: Self-asserted source
Benjamin Huang

Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia.

Nature communications
2022-09-19 | Journal article | Author
Contributors: Benjamin Huang; Jenny L. Smith; Jason E Farrar; Wang YC; Umeda M; Rhonda Ries; Leonti AR; Crowgey E; Furlan SN; Tarlock K et al.
Source: Self-asserted source
Benjamin Huang

Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.

Blood cancer discovery
2022-05-01 | Journal article | Author
Contributors: Umeda M; Ma J; Benjamin Huang; Hagiwara K; Westover T; Sherif Abdelhamed; Juan M. Barajas; Melvin Thomas; Walsh MP; Guangchun Song et al.
Source: Self-asserted source
Benjamin Huang

Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.

British journal of haematology
2022-04-17 | Journal article
Contributors: Lauren Meyer; Delgado-Martin C; Sharp PP; Huang BJ; McMinn D; Vincent TL; Ryan T; Horton TM; Wood BL; Teachey DT et al.
Source: Self-asserted source
Benjamin Huang

ETS Family Transcription Factor Fusions in Childhood AML: Distinct Expression Networks and Clinical Implications

Blood
2021-11-05 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Jenny L. Smith; Rhonda E. Ries; Yi-Cheng Wang; Amanda R. Leonti; Todd A. Alonzo; Alan S. Gamis; Richard Aplenc; Anders E. Kolb; Benjamin J. Huang; Xiaotu Ma et al.
Source: Self-asserted source
Benjamin Huang

EZH2-Mediated MHC Class II Silencing Drives Immune Evasion in AML with t(16;21) (<i>FUS-ERG)</i>

Blood
2021-11-05 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Nate J Buteyn; Connor G Burke; Jenny L. Smith; Rhonda E. Ries; Amanda R. Leonti; Timothy I. Shaw; Benjamin J. Huang; Todd A. Alonzo; Scott N. Furlan; Jason E Farrar et al.
Source: Self-asserted source
Benjamin Huang

Targeting FOLR1 in High-Risk CBF2AT3-GLIS2 AML with Stro-002 FOLR1-Directed Antibody-Drug Conjugate

Blood
2021-11-05 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Quy Le; Jenny L. Smith; Thao T. Tang; Sommer Castro; Cynthia Nourigat-Mckay; LaKeisha Perkins; Benjamin J. Huang; Rhonda E. Ries; Amanda R. Leonti; Tiffany A. Hylkema et al.
Source: Self-asserted source
Benjamin Huang

CBFB-MYH11 Fusion Transcripts Distinguish Acute Myeloid Leukemias with Distinct Molecular Landscapes and Outcomes.

Blood advances
2021-09-21 | Journal article
Source: Self-asserted source
Benjamin Huang

Targeted gene expression classifier identifies pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients at high risk for end induction minimal residual disease positivity.

Journal of Clinical Oncology
2021-05-20 | Conference abstract
Part of ISSN: 0732-183X
Part of ISSN: 1527-7755
Source: Self-asserted source
Benjamin Huang

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth.

Nature chemical biology
2021-04-29 | Journal article
Source: Self-asserted source
Benjamin Huang

Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib.

Blood advances
2021-03-01 | Journal article
Source: Self-asserted source
Benjamin Huang

Co-Targeting BET Bromodomain Proteins and Aberrant Signaling in AML

Blood
2020-11-05 | Conference abstract
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Benjamin Huang

Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia

Blood
2020-11-05 | Conference abstract
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Benjamin Huang

Genome and Transcriptome Profiling of Monosomy 7 AML Defines Novel Risk and Therapeutic Cohorts

Blood
2020-11-05 | Conference abstract
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Benjamin Huang

Integrated Stem Cell Signature and Cytomolecular Risk Determination in Pediatric Acute Myeloid Leukemia

Blood
2020-11-05 | Conference abstract
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Benjamin Huang

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.

Blood
2020-03-27 | Journal article
Source: Self-asserted source
Benjamin Huang

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.

Leukemia
2020-02-17 | Journal article
Source: Self-asserted source
Benjamin Huang

Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes.

The Journal of clinical investigation
2020-02-01 | Journal article
Source: Self-asserted source
Benjamin Huang

Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias

PLOS Genetics
2019-06 | Journal article
Part of ISSN: 1553-7404
Source: Self-asserted source
Benjamin Huang
grade
Preferred source (of 2)‎

Gene expression signature associated with in vitro dexamethasone resistance and post-induction minimal residual disease in pediatric T-cell acute lymphoblastic leukemia.

Journal of Clinical Oncology
2019-05 | Conference abstract
Part of ISSN: 0732-183X
Source: Self-asserted source
Benjamin Huang
grade
Preferred source (of 2)‎

Glucocorticoids Paradoxically Induce Intrinsic Steroid Resistance through a STAT5-Mediated Survival Mechanism in T-Cell Acute Lymphoblastic Leukemia

Blood
2018-11-29 | Conference abstract
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Benjamin Huang

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias

Leukemia
2017-05-09 | Journal article
Part of ISSN: 0887-6924
Source: Self-asserted source
Benjamin Huang
grade
Preferred source (of 2)‎

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

Cell
2017-02 | Journal article
Part of ISSN: 0092-8674
Source: Self-asserted source
Benjamin Huang
grade
Preferred source (of 2)‎

Response and Resistance to Bromodomain Inhibition in AML Driven By Hyperactive Ras Signaling

Blood
2016 | Conference abstract
Part of ISSN: 0006-4971
Source: Self-asserted source
Benjamin Huang
grade
Preferred source (of 2)‎

Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression

Blood
2016-12-02 | Conference abstract
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Benjamin Huang

Risk Factors for Graft Failure with Busulfan/Fludarabine-Based Conditioning in Children Undergoing Allogeneic Hematopoietic Cell Transplantation for Nonmalignant Disorders

Blood
2014-12-06 | Conference abstract
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Benjamin Huang

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents

Proceedings of the National Academy of Sciences
2010-03-01 | Journal article
Part of ISSN: 0027-8424
Source: Self-asserted source
Benjamin Huang
grade
Preferred source (of 2)‎

Expressing N-RasG12D from the Endogenous Promoter Induces Myeloproliferative Disease (MPD) and Cooperates with Retroviral Insertional Mutagenesis (RIM) To Generate Acute Myeloid Leukemia (AML).

Blood
2007-11-16 | Conference abstract
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Benjamin Huang

Peer review (1 review for 1 publication/grant)

Review activity for PLOS genetics. (1)