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HERV, HBV, HCC, schizophernia, neuropsychiatric disorder
China

Activities

Employment (1)

Wuhan University: Wuhan, Hubei, CN

2007-12-01 to present | director/professor (Department of medical microbiology)
Employment
Source: Self-asserted source
fan zhu

Education and qualifications (2)

Stanford University: Palo Alto, US

2005-04-15 to 2007-01-31 | Postdoctor (Department of Surgery)
Qualification
Source: Self-asserted source
fan zhu

Wuhan University: Wuhan, Hubei, CN

1998-09-01 to 2002-05-31 | Ph.D (school of life science)
Education
Source: Self-asserted source
fan zhu

Professional activities (2)

Harbin Medical University: Harbin, Heilongjiang, CN

2018-01-01 to present | visiting Professor
Invited position
Source: Self-asserted source
fan zhu

Wuhan University: Wuhan, Hubei, CN

2013-01-01 | Luojia Distinguished Professor
Distinction
Source: Self-asserted source
fan zhu

Funding (6)

精神分裂症中HERV-W家族包膜基因(ERVWE1)过表达致神经细胞线粒体异常的研究

2020-01-01 to 2023-12-01 | Grant
National Natural Science Foundation of China (Beijing, CN)
GRANT_NUMBER:

81971943

Source: Self-asserted source
fan zhu via DimensionsWizard

精神分裂症中HERV-W家族包膜(ERVWE1)基因过表达致突触异常的分子机制研究

2018-01-01 to 2021-12-31 | Grant
National Natural Science Foundation of China (Beijing, CN)
GRANT_NUMBER: 81772196
Source: Self-asserted source
fan zhu via DimensionsWizard

人内源性逆转录病毒W家族env基因高表达导致神经细胞中胞内钙离子浓度升高的机制及作用研究

2015-01-01 to 2018-12-31 | Grant
National Natural Science Foundation of China (Beijing, CN)
GRANT_NUMBER: 31470264
Source: Self-asserted source
fan zhu via DimensionsWizard

人内源性逆转录病毒W家族包膜蛋白致神经炎症反应机制

2013-01-01 to 2016-12-31 | Grant
National Natural Science Foundation of China (Beijing, CN)
GRANT_NUMBER: 81271820
Source: Self-asserted source
fan zhu via DimensionsWizard

Study lead to acute schizophrenia molecular neurobiology mechanism HERV env gene abnormal expression

Source: Self-asserted source
fan zhu via DimensionsWizard
grade
Preferred source (of 2)‎

Epidemiological studies of schizophrenia and activation of HERV-w family molecule

Source: Self-asserted source
fan zhu via DimensionsWizard
grade
Preferred source (of 2)‎

Works (50 of 78)

Items per page:
Page 1 of 2

HERV-W Env Induces Neuron Pyroptosis via the NLRP3–CASP1–GSDMD Pathway in Recent-Onset Schizophrenia

International Journal of Molecular Sciences
2025-01-09 | Journal article
Contributors: Chen Jia; Mengqi Zhang; Xiulin Wu; Xu Zhang; Zhao Lv; Kexin Zhao; Jiahang Zhang; Yaru Su; Fan Zhu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Additional file 1 of Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

figshare
2024 | Other
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; fan zhu
Source: check_circle
DataCite
grade
Preferred source (of 2)‎

Additional file 1 of Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

figshare
2024 | Other
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; fan zhu
Source: check_circle
DataCite
grade
Preferred source (of 2)‎

Additional file 1 of Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

figshare
2024 | Other
Contributors: Xiulin Wu; Lianzhong Liu; Xing Xue; Xuhang Li; Kexin Zhao; Jiahang Zhang; Wenshi Li; Wei Yao; Shuang Ding; Chen Jia et al.
Source: check_circle
DataCite

Additional file 1 of Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

figshare
2024 | Other
Contributors: Xiulin Wu; Lianzhong Liu; Xing Xue; Xuhang Li; Kexin Zhao; Jiahang Zhang; Wenshi Li; Wei Yao; Shuang Ding; Chen Jia et al.
Source: check_circle
DataCite

Additional file 2 of Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

figshare
2024 | Other
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; fan zhu
Source: check_circle
DataCite

Additional file 2 of Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

figshare
2024 | Other
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; fan zhu
Source: check_circle
DataCite

Additional file 3 of Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

figshare
2024 | Dataset
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; fan zhu
Source: check_circle
DataCite

Additional file 3 of Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

figshare
2024 | Dataset
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; fan zhu
Source: check_circle
DataCite

Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

figshare
2024 | Other
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; fan zhu
Source: check_circle
DataCite

Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

figshare
2024 | Other
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; fan zhu
Source: check_circle
DataCite

Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

figshare
2024 | Other
Contributors: Xiulin Wu; Lianzhong Liu; Xing Xue; Xuhang Li; Kexin Zhao; Jiahang Zhang; Wenshi Li; Wei Yao; Shuang Ding; Chen Jia et al.
Source: check_circle
DataCite

Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

figshare
2024 | Other
Contributors: Xiulin Wu; Lianzhong Liu; Xing Xue; Xuhang Li; Kexin Zhao; Jiahang Zhang; Wenshi Li; Wei Yao; Shuang Ding; Chen Jia et al.
Source: check_circle
DataCite

Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2

Cell & Bioscience
2024-11-14 | Journal article
Contributors: Wenshi Li; Xing Xue; Xuhang Li; Xiulin Wu; Ping Zhou; Yaru Xia; Jiahang Zhang; Mengqi Zhang; Fan Zhu
Source: check_circle
Crossref

Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia

Virologica Sinica
2024-02 | Journal article
Contributors: Dongyan Zhang; Xiulin Wu; Xing Xue; Wenshi Li; Ping Zhou; Zhao Lv; Kexin Zhao; Fan Zhu
Source: check_circle
Crossref

Granular architecture of lotus seed starch and its impact on physicochemical properties

OpenAlex
2023-12-01 | Other
Contributors: Chuanjie Chen; Guantian Li; Yacine Hémar; Harold Corke; fan zhu
Source: check_circle
DataCite

Granular architecture of lotus seed starch and its impact on physicochemical properties

OpenAlex
2023-12-01 | Other
Contributors: Chuanjie Chen; Guantian Li; Yacine Hémar; Harold Corke; fan zhu
Source: check_circle
DataCite

Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

Cell & Bioscience
2023-11-21 | Journal article | Author
Part of ISSN: 2045-3701
Contributors: Xiulin Wu; Lianzhong Liu; Xing Xue; Xuhang Li; Kexin Zhao; Jiahang Zhang; Wenshi Li; Wei Yao; Shuang Ding; Chen Jia et al.
Source: Self-asserted source
fan zhu

Impact of long-term ultrasound treatment on structural and physicochemical properties of starches differing in granule size

OpenAlex
2023-11-01 | Other
Contributors: Wei Yuan; Guantian Li; fan zhu
Source: check_circle
DataCite

Impact of long-term ultrasound treatment on structural and physicochemical properties of starches differing in granule size

OpenAlex
2023-11-01 | Other
Contributors: Wei Yuan; Guantian Li; fan zhu
Source: check_circle
DataCite

Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma

World Journal of Gastroenterology
2023-08-21 | Journal article
Part of ISSN: 1007-9327
Contributors: Ming-He Zhang; Yu-Feng Yuan; Li-Juan Liu; Yu-Xin Wei; Wan-Yue Yin; Lan-Zhuo-Yin Zheng; Ying-Ying Tang; Zhao Lv; Fan Zhu
Source: Self-asserted source
fan zhu

ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia

Viruses
2023-05-31 | Journal article
Contributors: Xing Xue; Xiulin Wu; Lijuan Liu; Lianzhong Liu; Fan Zhu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Domesticated HERV-W env contributes to the activation of the small conductance Ca2+-activated K+ type 2 channels via decreased 5-HT4 receptor in recent-onset schizophrenia

Virologica Sinica
2023-02 | Journal article | Author
Part of ISSN: 1995-820X
Contributors: Xiulin Wu; Qiujin Yan; Lianzhong Liu; Xing Xue; Wei Yao; Xuhang Li; Wenshi Li; Shuang Ding; Yaru Xia; Dongyan Zhang et al.
Source: Self-asserted source
fan zhu
grade
Preferred source (of 2)‎

HBV Enhances Sorafenib Resistance in Hepatocellular Carcinoma by Reducing Ferroptosis via SRSF2-Mediated Abnormal PCLAF Splicing

International Journal of Molecular Sciences
2023-02-07 | Journal article
Contributors: Lijuan Liu; Zhao Lv; Miao Wang; Dongyan Zhang; Dongying Liu; Fan Zhu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia

International Journal of Molecular Sciences
2023-02-03 | Journal article
Contributors: Xuhang Li; Xiulin Wu; Wenshi Li; Qiujin Yan; Ping Zhou; Yaru Xia; Wei Yao; Fan Zhu
Source: check_circle
Crossref

ERVWE1 Reduces Hippocampal Neuron Density and Impairs Dendritic Spine Morphology through Inhibiting Wnt/JNK Non-Canonical Pathway via miR-141-3p in Schizophrenia

Viruses
2023-01-05 | Journal article
Contributors: Wei Yao; Ping Zhou; Qiujin Yan; Xiulin Wu; Yaru Xia; Wenshi Li; Xuhang Li; Fan Zhu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Canonical WNT Signaling Activated by WNT7B Contributes to L-HBs-Mediated Sorafenib Resistance in Hepatocellular Carcinoma by Inhibiting Mitophagy

Cancers
2022-11-24 | Journal article
Contributors: Li-Juan Liu; Zhao Lv; Xing Xue; Zhong-Yuan Xing; Fan Zhu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Abnormal synaptic plasticity and impaired cognition in schizophrenia.

World journal of psychiatry
2022-04 | Journal article
Contributors: Wu XL; Yan QJ; Zhu F
Source: Self-asserted source
fan zhu via Europe PubMed Central

Correction to: Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance

Cell Death Discovery
2022-04-01 | Journal article
Contributors: Yan Zhou; Lijuan Liu; Youyi Liu; Ping Zhou; Qiujin Yan; Honglian Yu; Xiaobei Chen; Fan Zhu
Source: check_circle
Crossref

HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk

Viruses
2022-01-14 | Journal article
Contributors: Qiujin Yan; Xiulin Wu; Ping Zhou; Yan Zhou; Xuhang Li; Zhongchun Liu; Huawei Tan; Wei Yao; Yaru Xia; Fan Zhu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Exosomes as potential diagnosis and treatment for liver cancer.

World journal of gastrointestinal oncology
2022-01-01 | Journal article
Contributors: fan zhu; Wei XC; Liu LJ; Zhu F
Source: Self-asserted source
fan zhu

Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma.

World journal of gastroenterology
2021-12-01 | Journal article
Contributors: fan zhu; Wei XC; Xia YR; Zhou P; Xue X; Ding S; Liu LJ; Zhu F
Source: Self-asserted source
fan zhu

CPEB1, a novel risk gene in recent-onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1.

World journal of psychiatry
2021-11 | Journal article
Contributors: Xia YR; Wei XC; Li WS; Yan QJ; Wu XL; Yao W; Li XH; Zhu F
Source: Self-asserted source
fan zhu via Europe PubMed Central

Proliferating cell nuclear antigen clamp associated factor, a potential proto-oncogene with increased expression in malignant gastrointestinal tumors

World Journal of Gastrointestinal Oncology
2021-10-15 | Journal article
Part of ISSN: 1948-5204
Source: Self-asserted source
fan zhu
grade
Preferred source (of 2)‎

Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance

Cell Death Discovery
2021-07-08 | Journal article
Contributors: Yan Zhou; Lijuan Liu; Youyi Liu; Ping Zhou; Qiujin Yan; Honglian Yu; Xiaobei Chen; Fan Zhu
Source: check_circle
Crossref

Human endogenous retrovirus W family envelope protein (HERV-W env) facilitates the production of TNF-α and IL-10 by inhibiting MyD88s in glial cells

Archives of Virology
2021-01-12 | Journal article
Part of ISSN: 0304-8608
Part of ISSN: 1432-8798
Source: Self-asserted source
fan zhu
grade
Preferred source (of 2)‎

CKLF1 Enhances Inflammation-Mediated Carcinogenesis and Prevents Doxorubicin-Induced Apoptosis via IL6/STAT3 Signaling in HCC

Clinical Cancer Research
2019-07-01 | Journal article
Part of ISSN: 1078-0432
Part of ISSN: 1557-3265
Source: Self-asserted source
fan zhu

DNA methylation of the Tacr2 gene in a CUMS model of depression

Behavioural Brain Research
2019-06 | Journal article
Part of ISSN: 0166-4328
Source: Self-asserted source
fan zhu

HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells

Journal of NeuroVirology
2019-02-05 | Journal article
Contributors: Yatang Chen; Qiujin Yan; Ping Zhou; Shan Li; Fan Zhu
Source: check_circle
Crossref

Human endogenous retroviral envelope protein Syncytin-1 and inflammatory abnormalities in neuropsychological diseases

Frontiers in Psychiatry
2018 | Journal article
EID:

2-s2.0-85053147941

Contributors: Wang, X.; Huang, J.; Zhu, F.
Source: Self-asserted source
fan zhu via Scopus - Elsevier

Increased Asics Expression via the Camkii-CREB Pathway in a Novel Mouse Model of Trigeminal Pain

Cellular Physiology and Biochemistry
2018 | Journal article
Part of ISSN: 1015-8987
Part of ISSN: 1421-9778
Source: Self-asserted source
fan zhu

Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function

Neurochemical Research
2018-06 | Journal article
Part of ISSN: 0364-3190
Part of ISSN: 1573-6903
Source: Self-asserted source
fan zhu

Syncytin-1, an endogenous retroviral protein, triggers the activation of CRP via TLR3 signal cascade in glial cells.

Brain, behavior, and immunity
2018-01 | Journal article
Contributors: Wang X; Liu Z; Wang P; Li S; Zeng J; Tu X; Yan Q; Xiao Z; Pan M; Zhu F
Source: Self-asserted source
fan zhu via Europe PubMed Central
grade
Preferred source (of 2)‎

HBV X Protein induces overexpression of HERV-W env through NF-κB in HepG2 cells.

Virus genes
2017-12 | Journal article
Contributors: Liu C; Liu L; Wang X; Liu Y; Wang M; Zhu F
Source: Self-asserted source
fan zhu via Europe PubMed Central

Human leukemia antigen-A*0201-restricted epitopes of human endogenous retrovirus W family envelope (HERV-W env) induce strong cytotoxic T lymphocyte responses

Virologica Sinica
2017-08 | Journal article
Contributors: Xiaoning Tu; Shan Li; Lijuan Zhao; Ran Xiao; Xiuling Wang; Fan Zhu
Source: check_circle
Crossref

Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase

Virologica Sinica
2017-06 | Journal article
Contributors: Ran Xiao; Shan Li; Qian Cao; Xiuling Wang; Qiujin Yan; Xiaoning Tu; Ying Zhu; Fan Zhu
Source: check_circle
Crossref

Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.

2017-03 | Journal article
Contributors: Liu L; Liu Y; Chen X; Wang M; Zhou Y; Zhou P; Li W; Zhu F
Source: Self-asserted source
fan zhu via Europe PubMed Central

Aberrant regulation of Wnt signaling in hepatocellular carcinoma.

2016-09 | Journal article
Contributors: Liu LJ; Xie SX; Chen YT; Xue JL; Zhang CJ; Zhu F
Source: Self-asserted source
fan zhu via Europe PubMed Central

Elevation of Ser9 phosphorylation of GSK3β is required for HERV-W env-mediated BDNF signaling in human U251 cells.

2016-08 | Journal article
Contributors: Qin C; Li S; Yan Q; Wang X; Chen Y; Zhou P; Lu M; Zhu F
Source: Self-asserted source
fan zhu via Europe PubMed Central

Hypothalamic gastrin-releasing peptide receptor mediates an antidepressant-like effect in a mouse model of stress.

American journal of translational research
2016-07-15 | Journal article
Source: Self-asserted source
fan zhu
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 2

Peer review (3 reviews for 3 publications/grants)

Review activity for Advanced science. (1)
Review activity for Current medical science. (1)
Review activity for Current microbiology. (1)