Bhupesh Prusty (0000-0001-7051-4670)

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Although HHV-6/HHV-7 research is an underestimated, grossly overlooked topic, the significance of these viruses has come to spotlight in the last few years. I, as an independent researcher, have made significant discoveries to understand molecular mechanisms of HHV-6/HHV-7 latency and reactivation during past 12 years that challenge conventional wisdom with creative new approaches. My major achievements include molecular characterization of HHV-6 reactivation by telomeric-circle formation, the finding of HHV-6A infection in neuronal Purkinje cells of bipolar patients, and the characterization of role of viral miRNAs in mitochondrial dysfunction in ME/CFS and other diseases. My unconventional thinking has earned me several highly competitive grants/awards that reflect my capacity to go significantly beyond the conventional knowledge. The international recognition of my work is reflected in numerous collaborations with clinicians all over the world. I have a unique expertise of working with viral as well as bacterial (Chlamydial) pathogens that contributes to a better understanding of co-infection as natural triggers in disease development. My current research interest involves studying molecular biology of HHV-6/HHV-7 encoded small non-coding RNAs and their potential role in human diseases at single cell level.

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Riga Stradiņš University: Riga, Latvia, LV

2024-04-01 to present | Professor of Science (Institute of Microbiology and Virology)

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Bhupesh Prusty

https://orcid.org/0000-0001-7051-4670

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Employment (4)

Riga Stradiņš University: Riga, Latvia, LV

Julius-Maximilians-Universität Würzburg Medizinische Fakultät: Wurzburg, Bayern, DE

Julius-Maximilians-Universitat Wurzburg: Wurzburg, Bayern, DE

German Cancer Research Institute (DKFZ): Heidelberg, DE

Education and qualifications (3)

Julius-Maximilians-Universität Würzburg: Würzburg, Germany, DE

Julius-Maximilians-Universität Würzburg: Würzburg, Bayern, DE

Jamia Millia Islamia: New Delhi, Delhi, IN

Professional activities (7)

RNA Society: Bethesda, Maryland, US

Indian Association for Cancer Research: Mumbai, IN

Solve ME/CFS Initiative: Los Angeles, California, US

HHV-6 Foundation: Santa Barbara, California, US

HHV-6 Foundation: Santa Barbara, CA, US

Indian Council of Medical Research: New Delhi, IN

EMBO: Heidelberg, DE

Funding (10)

Molecular mechanisms governing HHV-6 reactivation in advanced experimental models

Linking serum antibodies to exercise intolerance and muscle/neuronal fatigue in ME/CFS

Mitochondrial dysfunction and metabolic alterations in ME/CFS

SARS-CoV-2 and Infectious Origin of Chronic Fatigue Syndrome

Understanding potential infectious triggers behind mitochondrial dysfunction in ME/CFS

Infection and ME/CFS

Regulation of human miRNA processing by HHV-6A encoded small non-coding RNAs

HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS

Developing a novel and cost effective cell culture based system for high throughput screening of drugs for their potential to reactivate latent, chromosomally integrated HHV-6

Latent Human Herpes Virus-6: functionally dormant but not extinct - a hidden 'transposon' awaiting the ideal trigger?

Works (50 of 60)

Correcting 4sU induced quantification bias in nucleotide conversion RNA-seq data.

Identification of novel canonical and cryptic HCMV-specific T-cell epitopes for HLA-A*03 and HLA-B*15 via peptide-PRISM.

Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome - State of the art: Report of the 2nd international meeting at the Charité Fatigue Center.

Retrospective study on the association of human herpesvirus reactivation with severe DRESS: A description of blood and skin reactivations.

Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID

Decoding murine cytomegalovirus.

Correcting 4sU induced quantification bias in nucleotide conversion RNA-seq data

Tissue specific signature of HHV-6 infection in ME/CFS.

Decoding murine cytomegalovirus

Time-resolved single-cell RNA-seq using metabolic RNA labelling

Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA.

Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth.

The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity.

Multi-omics reveals principles of gene regulation and pervasive non-productive transcription in the human cytomegalovirus genome

Human Herpesvirus 6 Infection in Pediatric Liver Transplantation: Single-Center Study of Incidence, Outcomes, and Management

Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn’s‐like colitis: Case report

Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA Level.

Cytomegalovirus infection and allograft rejection among pediatric heart transplant recipients in the era of valganciclovir prophylaxis

Joining European Scientific Forces to Face Pandemics.

Detection of parvovirus B19 and human herpesvirus 6 in pediatric dilated cardiomyopathy: Impact after heart transplantation.

Donor-to-recipient transmission and reactivation in a kidney transplant recipient of an inherited chromosomally integrated HHV-6A: Evidence and outcomes.

Integrative functional genomics decodes herpes simplex virus 1

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Revisiting the genomes of herpesviruses

Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

Evaluation of liver failure in a pediatric transplant recipient of a liver allograft with inherited chromosomally integrated HHV-6B.

K21 Compound, a Potent Antifungal Agent: Implications for the Treatment of Fluconazole-Resistant HIV-Associated Candida Species.

Does infection of cerebellar Purkinje neurons with human herpes virus 6A or 6B (HHV-6) increase the risk of developing mood disorders?

Peptidase Inhibitor 15 (PI15) Regulates Chlamydial CPAF Activity.

Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Chlamydia trachomatis impairs host base excision repair by downregulating polymerase β.

HHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation.

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.

Chlamydia trachomatis paralyses neutrophils to evade the host innate immune response.

Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21.

Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation

Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission

Chromosomal integration of HHV-6A during non-productive viral infection.

Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

Possible Chromosomal and Germline Integration of Human Herpesvirus 7 (HHV-7).

Identification of novel canonical and cryptic HCMV-specific T-cell epitopes for HLA-A03 and HLA-B15 via peptide-PRISM.