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pancreas, liver, organogenesis, stem cell, lineage reprogramming, regenerative medicine, diabetes
United Kingdom

Biography

After graduating from Medical School, I did my Ph.D. in Genetics at the Pasteur Institute and UPMC in Paris, France. Subsequently, I did my postdoc at The Rockefeller University, New York, USA, in the Brivanlou lab. In 2008, I established my research group at the Max Delbrück Center in Berlin, Germany, where I have initiated new lines of investigation on the control of pancreatic cell identity and lineage reprogramming strategies. Subsequently, in 2018 the Spagnoli lab. moved to join the Centre for Gene Therapy & Regenerative Medicine at King’s. My lab also devises strategies for engineering pancreatic cells for cell replacement therapies for diabetes. I have been the recipient of multiple prestigious awards, including an ERC Starting grant and ERC Proof-of-Concept grant, Wellcome Trust Investigator award. I am the coordinator of a FET Open European Consortium, called 'Pan3DP', on bioengineering pancreatic tissue. I am the Director of the Wellcome Trust PhD programme ‘Advanced Therapies for Regenerative Medicine”.

Activities

Employment (5)

King's College London - Guy's Campus: London, London, GB

2018-03-01 to present | Professor of Regenerative Medicine (Centre for Gene Therapy and Regenerative Medicine)
Employment
Source: Self-asserted source
Francesca M Spagnoli

Max Delbrück Centrum für Molekulare Medizin Berlin Buch: Berlin-Buch, Berlin, DE

2008 to 2018-02 | Junior Group Leader
Employment
Source: Self-asserted source
Francesca M Spagnoli

The Rockefeller University: New York, NY, US

2006 to 2008 | Research Associate
Employment
Source: Self-asserted source
Francesca M Spagnoli

The Rockefeller University: New York, NY, US

2002 to 2006 | Postdoctoral Fellow
Employment
Source: Self-asserted source
Francesca M Spagnoli

Institut Pasteur: Paris, Île-de-France, FR

2001 | PhD student
Employment
Source: Self-asserted source
Francesca M Spagnoli

Education and qualifications (2)

Institut Pasteur: Paris, Île-de-France, FR

2001 | Ph.D. Degree
Education
Source: Self-asserted source
Francesca M Spagnoli

Università degli Studi di Roma La Sapienza: Roma, Lazio, IT

1996 | M.D. (Medical School)
Education
Source: Self-asserted source
Francesca M Spagnoli

Professional activities (4)

British Society for Developmental Biology: London, GB

Membership
Source: Self-asserted source
Francesca M Spagnoli

European Association for the Study of Diabetes: Dusseldorf, Nordrhein-Westfalen, DE

2013-01-01 to present
Membership
Source: Self-asserted source
Francesca M Spagnoli

Rockefeller University: New York, NY, US

2008-06-01 to present | Adjunct Faculty Member
Invited position
Source: Self-asserted source
Francesca M Spagnoli

Society For Developmental Biology: Bethesda, Maryland, US

2003-01-01 to present
Membership
Source: Self-asserted source
Francesca M Spagnoli

Funding (10)

Probing cellular heterogeneity in the pancreatic microenvironment

2021-10 to 2026-09 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
Francesca M Spagnoli

Elucidating the mechanisms underlying lineage reprogramming for future diabetes therapies

2020-02 to present | Grant
European Foundation for the Study of Diabetes (Dusseldorf, DE)
Source: Self-asserted source
Francesca M Spagnoli

3D bioprinting of pancreatic tissue for biomedical research

2018-10 to 2022-10 | Grant
H2020 Leadership in Enabling and Industrial Technologies (Brussels, BE)
GRANT_NUMBER:

FETOPEN-01-2016-2017 PAN3DP

Source: Self-asserted source
Francesca M Spagnoli

Generating novel sources of functional human insulin-secreting cells

2018-08 to 2019-07 | Grant
Juvenile Diabetes Research Foundation International (NY, NY, US)
GRANT_NUMBER:

1-INO-2018-634-A-N

Source: Self-asserted source
Francesca M Spagnoli

Molecular dissection of the epithelial-mesenchymal cross-talk in establishing final pancreas shape

2016-01 to 2018-12 | Grant
German-Israeli Foundation for Scientific Research and Development (Jerusalem, IL)
GRANT_NUMBER:

I-1308-203.13/2015

Source: Self-asserted source
Francesca M Spagnoli

Genetic and molecular dissection of the roles of TGIF2 homeodomain protein in pancreatic cell identity

2015-07 to 2017-03 | Grant
European Foundation for the Study of Diabetes (Dusseldorf, DE)
Source: Self-asserted source
Francesca M Spagnoli

Exploring the Potential for Therapeutic Lineage Reprogramming of Diabetes (TheLiRep)

2015-05 to 2016-11 | Grant
H2020 European Research Council (Brussels, BE)
GRANT_NUMBER:

641036

Source: Self-asserted source
Francesca M Spagnoli

MECHANISMS UNDERLYING CELL FATE DECISION BETWEEN PANCREAS AND LIVER

2009-11-01 to 2014-10-31 | Grant
European Research Council (Saint-Josse-ten-Noode, BE)
GRANT_NUMBER: grant.243045
Source: Self-asserted source
Francesca M Spagnoli via DimensionsWizard

ENDOPANC

2009-08 to 2013-07 | Award
FP7 People: Marie-Curie Actions (Brussels, BE)
GRANT_NUMBER:

IRG239534

Source: Self-asserted source
Francesca M Spagnoli

Molecular characterization of the pancreatic differentiation program in Xenopus embryos and ES cells

2003-08-01 to 2005-07-31 | Grant
Juvenile Diabetes Research Foundation (New York City, US)
GRANT_NUMBER:

grant.3-2003-549

Source: Self-asserted source
Francesca M Spagnoli via DimensionsWizard

Peer review (26 reviews for 12 publications/grants)

Review activity for Cell stem cell. (2)
Review activity for Cell. (1)
Review activity for Developmental biology. (2)
Review activity for Developmental cell. (2)
Review activity for EMBO journal. (3)
Review activity for Gene expression patterns. (1)
Review activity for iScience. (1)
Review activity for Nature (4)
Review activity for Nature biotechnology. (2)
Review activity for Nature cell biology (3)
Review activity for Nature communications (4)
Review activity for PLoS biology. (1)