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Washington University in Saint Louis: Saint Louis, MO, US

2018-08-15 to present | Assistant Professor of Surgery (Surgery)
Employment
Source: Self-asserted source
Kiran Mahajan

Works (41)

SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis

Nature Communications
2024-07-04 | Journal article
DOI: 10.1038/s41467-024-49978-4
Part of ISSN: 2041-1723
Contributors: Surbhi Chouhan; Dhivya Sridaran; Cody Weimholt; jingqin luo; Tiandao Li; Myles C. Hodgson; Luana N. Santos; Samantha Le Sommer; bin fang; John Koomen et al.
Source: Self-asserted source
Kiran Mahajan

Prostate-Specific Membrane Antigen–Targeted Imaging and Its Correlation with HOXB13 Expression

Journal of Nuclear Medicine
2024-06-27 | Journal article
DOI: 10.2967/jnumed.123.267301
Part of ISSN: 0161-5505
Part of ISSN: 2159-662X
Contributors: Duminduni Hewa Angappulige; Nimrod S. Barashi; Nicholas Pickersgill; Cody Weimholt; Jingqin Luo; Ghazal Shadmani; Ziad Tarcha; Sampanna Rayamajhi; Nupam P. Mahajan; Gerald L. Andriole et al.
Source: Self-asserted source
Kiran Mahajan

Amino Terminal Acetylation of HOXB13 Regulates the DNA Damage Response in Prostate Cancer

Cancers
2024-04-23 | Journal article | Author
DOI: 10.3390/cancers16091622
Part of ISSN: 2072-6694
Contributors: Duy Nguyen; Urvashi Mahajan; Duminduni Hewa Angappulige; Aashna Doshi; Nupam P. Mahajan; Kiran Mahajan
Source: Self-asserted source
Kiran Mahajan

Epigenetic underpinnings of tumor-immune dynamics in prostate cancer immune suppression

Trends in Cancer
2024-02 | Journal article | Author
DOI: 10.1016/j.trecan.2024.01.004
Part of ISSN: 2405-8033
Contributors: Duminduni Hewa Angappulige; Nupam P. Mahajan; Kiran Mahajan
Source: Self-asserted source
Kiran Mahajan

Symptomatic Benign Prostatic Hyperplasia with Suppressed Epigenetic Regulator HOXB13 Shows a Lower Incidence of Prostate Cancer Development

Cancers
2024-01 | Journal article | Author
DOI: 10.3390/cancers16010213
Contributors: Nimrod S. Barashi; Tiandao Li; Duminduni H. Angappulige; Bo Zhang; Harry O’Gorman; Charles Nottingham; Anup S. Shetty; Joseph Ippolito; Gerald L. Andriole; Nupam P. Mahajan et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Prostate cancer immunotherapy: Improving clinical outcomes with a multi-pronged approach.

Cell reports. Medicine
2023-09-21 | Journal article
DOI: 10.1016/j.xcrm.2023.101199
PMID: 37738978
PMC: PMC10591038
Contributors: Dhivya Sridaran; Bradshaw E; DeSelm C; Pachynski R; Mahajan K; Mahajan NP
Source: Self-asserted source
Kiran Mahajan

Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor

Oncogene
2023-06-17 | Journal article | Author
DOI: 10.1038/s41388-023-02747-x
Part of ISSN: 0950-9232
Part of ISSN: 1476-5594
Contributors: Mithila Sawant; Audrey Wilson; Dhivya Sridaran; Kiran Mahajan; Christopher J. O’Conor; Ian Hagemann; jingqin luo; Cody Weimholt; Tiandao Li; Juan Carlos Roa et al.
Source: Self-asserted source
Kiran Mahajan

Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer

Nature Communications
2023-06-09 | Journal article
DOI: 10.1038/s41467-023-38887-7
Part of ISSN: 2041-1723
Contributors: Thanh Nguyen; Dhivya Sridaran; Surbhi Chouhan; Cody Weimholt; Audrey Wilson; jingqin luo; Tiandao Li; John Koomen; bin fang; Nagireddy Putluri et al.
Source: Self-asserted source
Kiran Mahajan

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance.

Nature communications
2022-11-14 | Journal article
DOI: 10.1038/s41467-022-34724-5
PMID: 36376335
PMC: PMC9663509
Contributors: Kiran Mahajan; Sridaran D; Chouhan S; Mahajan K; Arun Renganathan; Weimholt C; Bhagwat S; Reimers M; Kim EH; Thakur MK et al.
Source: Self-asserted source
Kiran Mahajan

Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research
2022-07-18 | Journal article
DOI: 10.1158/1078-0432.ccr-21-3603
PMID: 35849143
Contributors: Kiran Mahajan
Source: Self-asserted source
Kiran Mahajan

Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting

Science Translational Medicine
2022-06-15 | Journal article
DOI: 10.1126/scitranslmed.abg4132
Part of ISSN: 1946-6234
Part of ISSN: 1946-6242
Source: Self-asserted source
Kiran Mahajan

Loss of long non-coding RNA NXTAR in prostate cancer augments androgen receptor expression and enzalutamide resistance.

Cancer research
2021-11-05 | Journal article
DOI: 10.1158/0008-5472.can-20-3845
PMID: 34740892
Source: Self-asserted source
Kiran Mahajan

ACK1-AR and AR-HOXB13 signaling axes: epigenetic regulation of lethal prostate cancers.

NAR cancer
2020-08-27 | Journal article
DOI: 10.1093/narcan/zcaa018
PMID: 32885168
PMC: PMC7454006
Source: Self-asserted source
Kiran Mahajan

The Homeobox gene, HOXB13, Regulates a Mitotic Protein-Kinase Interaction Network in Metastatic Prostate Cancers.

Scientific reports
2019-07-04 | Journal article
DOI: 10.1038/s41598-019-46064-4
PMID: 31273254
PMC: PMC6609629
Source: Self-asserted source
Kiran Mahajan

Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer.

Molecular cancer therapeutics
2018-09-21 | Journal article
DOI: 10.1158/1535-7163.mct-18-0602
PMID: 30242092
PMC: PMC6528782
Source: Self-asserted source
Kiran Mahajan

Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells

Scientific Reports
2018-01 | Journal article
DOI: 10.1038/s41598-018-20172-z
Part of ISSN: 2045-2322
Contributors: Nupam P. Mahajan; Domenico Coppola; Jongphil Kim; Harshani R. Lawrence; Nicholas J. Lawrence; Kiran Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

WEE1 epigenetically modulates 5-hmC levels by pY37-H2B dependent regulation of IDH2 gene expression.

Oncotarget
2017-11-10 | Journal article
DOI: 10.18632/oncotarget.22374
PMID: 29290954
PMC: PMC5739739
Source: Self-asserted source
Kiran Mahajan
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ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer

Cancer Cell
2017-06 | Journal article
DOI: 10.1016/j.ccell.2017.05.003
Part of ISSN: 1535-6108
Contributors: Kiran Mahajan; Pavani Malla; Harshani R. Lawrence; Zhihua Chen; Chandan Kumar-Sinha; Rohit Malik; Sudhanshu Shukla; Jongphil Kim; Domenico Coppola; Nicholas J. Lawrence et al.
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties.

Oncogene
2016-01-25 | Journal article
DOI: 10.1038/onc.2015.498
PMID: 26804168
PMC: PMC5116559
Source: Self-asserted source
Kiran Mahajan

Cross talk of tyrosine kinases with the DNA damage signaling pathways

Nucleic Acids Research
2015-11-05 | Journal article
DOI: 10.1093/nar/gkv1166
Part of ISSN: 0305-1048
Contributors: Kiran Mahajan; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes.

Oncogene
2015-09-14 | Journal article
DOI: 10.1038/onc.2015.321
PMID: 26364595
Source: Self-asserted source
Kiran Mahajan

Development of novel ACK1/TNK2 inhibitors using a fragment-based approach.

Journal of medicinal chemistry
2015-03-17 | Journal article
DOI: 10.1021/jm501929n
PMID: 25699576
PMC: PMC4605435
Source: Self-asserted source
Kiran Mahajan
grade
Preferred source (of 2)‎

ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.

Oncogene
2014-10-27 | Journal article
DOI: 10.1038/onc.2014.350
PMID: 25347744
PMC: PMC4411206
Source: Self-asserted source
Kiran Mahajan

ACK1 Tyrosine Kinase Interacts with Histone Demethylase KDM3A to Regulate the Mammary Tumor OncogeneHOXA1

Journal of Biological Chemistry
2014-08 | Journal article
DOI: 10.1074/jbc.m114.584425
Part of ISSN: 0021-9258
Contributors: Kiran Mahajan; Harshani R. Lawrence; Nicholas J. Lawrence; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

Akt Goes Cycling

Cancer Control
2014-07 | Journal article
DOI: 10.1177/107327481402100310
Part of ISSN: 1073-2748
Contributors: Kiran N. Mahajan; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

ACK1 tyrosine kinase: Targeted inhibition to block cancer cell proliferation

Cancer Letters
2013-09 | Journal article
DOI: 10.1016/j.canlet.2013.04.004
Part of ISSN: 0304-3835
Contributors: Kiran Mahajan; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

WEE1 tyrosine kinase, a novel epigenetic modifier

Trends in Genetics
2013-07 | Journal article
DOI: 10.1016/j.tig.2013.02.003
Part of ISSN: 0168-9525
Contributors: Kiran Mahajan; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes

Nature Structural & Molecular Biology
2012-08 | Journal article
DOI: 10.1038/nsmb.2356
Part of ISSN: 1545-9993
Contributors: Kiran Mahajan; Bin Fang; John M Koomen; Nupam P Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

PI3K-independent AKT activation in cancers: A treasure trove for novel therapeutics

Journal of Cellular Physiology
2012-05 | Journal article
DOI: 10.1002/jcp.24065
Part of ISSN: 0021-9541
Contributors: Kiran Mahajan; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer

Journal of Biological Chemistry
2012-05-07 | Journal article
DOI: 10.1074/jbc.m112.357384
Part of ISSN: 0021-9258
Contributors: Kiran Mahajan; Domenico Coppola; Bhupendra Rawal; Y. Ann Chen; Harshani R. Lawrence; Robert W. Engelman; Nicholas J. Lawrence; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer Progression

The American Journal of Pathology
2012-04 | Journal article
DOI: 10.1016/j.ajpath.2011.12.028
Part of ISSN: 0002-9440
Contributors: Kiran Mahajan; Domenico Coppola; Y. Ann Chen; Weiwei Zhu; Harshani R. Lawrence; Nicholas J. Lawrence; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity

The Prostate
2010 | Journal article
DOI: 10.1002/pros.21163
Part of ISSN: 0270-4137
Contributors: Kiran Mahajan; Sridevi Challa; Domenico Coppola; Harshani Lawrence; Yunting Luo; Harsukh Gevariya; Weiwei Zhu; Y. Ann Chen; Nicholas J. Lawrence; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

Shepherding AKT and androgen receptor by Ack1 tyrosine kinase

Journal of Cellular Physiology
2010-04 | Journal article
DOI: 10.1002/jcp.22162
Part of ISSN: 0021-9541
Contributors: Kiran Mahajan; Nupam P. Mahajan
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

PLoS ONE
2010-03 | Journal article
DOI: 10.1371/journal.pone.0009646
Part of ISSN: 1932-6203
Contributors: Kiran Mahajan; Domenico Coppola; Sridevi Challa; Bin Fang; Y. Ann Chen; Weiwei Zhu; Alexis S. Lopez; John Koomen; Robert W. Engelman; Charlene Rivera et al.
Source: Self-asserted source
Kiran Mahajan via Crossref Metadata Search

Meiosis-specific yeast Hop1 protein promotes pairing of double-stranded DNA helices via G/C isochores.

Biochemical and biophysical research communications
2005-10-01 | Journal article
DOI: 10.1016/j.bbrc.2005.08.196
PMID: 16154534
Source: Self-asserted source
Kiran Mahajan

Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase.

Proceedings of the National Academy of Sciences of the United States of America
2003-09-05 | Journal article
DOI: 10.1073/pnas.1631060100
PMID: 12960389
PMC: PMC196874
Source: Self-asserted source
Kiran Mahajan

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.

Molecular and cellular biology
2002-07-01 | Journal article
DOI: 10.1128/mcb.22.14.5194-5202.2002
PMID: 12077346
PMC: PMC139779
Source: Self-asserted source
Kiran Mahajan

Association of terminal deoxynucleotidyl transferase with Ku.

Proceedings of the National Academy of Sciences of the United States of America
1999-11-01 | Journal article
DOI: 10.1073/pnas.96.24.13926
PMID: 10570175
PMC: PMC24167
Source: Self-asserted source
Kiran Mahajan

DNA-binding activities of Hop1 protein, a synaptonemal complex component from Saccharomyces cerevisiae.

Molecular and cellular biology
1998-03-01 | Journal article
DOI: 10.1128/mcb.18.3.1424
PMID: 9488458
PMC: PMC108856
Source: Self-asserted source
Kiran Mahajan

Telomere structure, replication and length maintenance.

Critical reviews in biochemistry and molecular biology
1998-01-01 | Journal article
DOI: 10.1080/10409239891204242
PMID: 9747671
Source: Self-asserted source
Kiran Mahajan

Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae.

Genes to cells : devoted to molecular & cellular mechanisms
1997-07-01 | Journal article
DOI: 10.1046/j.1365-2443.1997.1330331.x
PMID: 9366550
Source: Self-asserted source
Kiran Mahajan
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