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Works (50)

Short term stability of the sputum microbiota in bronchiectasis and cystic fibrosis

ERJ Open Research
2024-11-19 | Journal article
DOI: 10.1183/23120541.00247-2024
Contributors: Hollian Richardson; Holly R. Keir; Sandrine Nitza; Christopher J. Fong; Megan L. Crichton; Alison J. Dicker; James D. Chalmers
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Crossref

Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection

European Respiratory Journal
2024-03 | Journal article
DOI: 10.1183/13993003.00787-2023
Contributors: Merete B. Long; Andrew J.M. Howden; Holly R. Keir; Christina M. Rollings; Yan Hui Giam; Thomas Pembridge; Lilia Delgado; Hani Abo-Leyah; Amy F. Lloyd; Gabriel Sollberger et al.
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Crossref

SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial

ERJ Open Research
2024-03 | Journal article
DOI: 10.1183/23120541.00917-2023
Contributors: Merete B. Long; Hani Abo-Leyah; Yan Hui Giam; Thenmalar Vadiveloo; Rebecca C. Hull; Holly R. Keir; Thomas Pembridge; Daniela Alferes De Lima; Lilia Delgado; Sarah K. Inglis et al.
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Crossref

Inflammatory Molecular Endotypes in Bronchiectasis: A European Multicenter Cohort Study.

American journal of respiratory and critical care medicine
2023-09-28 | Journal article
DOI: 10.1164/rccm.202303-0499oc
PMID: 37769155
Contributors: Hayoung Choi; Ryu S; Keir HR; Giam YH; Alison Dicker; Perea L; Richardson H; Huang JTJ; Cant E; Blasi F et al.
Source: Self-asserted source
Holly Rachael Keir

ERS International Congress 2022: highlights from the Respiratory Infections Assembly.

ERJ open research
2023-05-22 | Journal article | Author
DOI: 10.1183/23120541.00628-2022
PMID: 37228292
PMC: PMC10204818
Contributors: Banka R; Kiarina Myroniuk-Konstantynovych; Katie Horton; Tetyana Konstantynovych; Long MB; Melissa McDonnell; Meldrum OW; Mirae Park; Perea L; Oksana Viltsaniuk et al.
Source: Self-asserted source
Holly Rachael Keir

Endotypes in bronchiectasis: moving towards precision medicine. A narrative review.

Pulmonology
2023-04-06 | Journal article
DOI: 10.1016/j.pulmoe.2023.03.004
PMID: 37030997
Contributors: Mariana Martins; Keir HR; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

Highlights of the ERS Lung Science Conference 2022

Breathe
2022-12 | Journal article
DOI: 10.1183/20734735.0212-2022
Contributors: Helen G. Hanstock; Theodore S. Kapellos; Holly R. Keir; P. Padmini S.J. Khedoe; Merete B. Long; Elza Evren; Niki D. Ubags; Joana Cruz
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Crossref

COUNTERPOINT: Is Chronic Bacterial Infection Clinically Relevant in COPD? No.

Chest
2022-11-01 | Journal article
DOI: 10.1016/j.chest.2022.07.009
PMID: 36344128
Contributors: Keir HR; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

Rebuttal From Dr Keir and Prof Chalmers.

Chest
2022-11-01 | Journal article
DOI: 10.1016/j.chest.2022.07.012
PMID: 36344130
Contributors: Keir HR; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial.

The Lancet. Respiratory medicine
2022-09-05 | Journal article
DOI: 10.1016/s2213-2600(22)00261-2
PMID: 36075243
PMC: PMC9442496
Contributors: Keir HR; Long MB; Abo-Leyah H; Giam YH; Vadiveloo T; Pembridge T; Hull RC; Delgado L; Band M; McLaren-Neil F et al.
Source: Self-asserted source
Holly Rachael Keir

Neisseria species as pathobionts in bronchiectasis.

Cell host & microbe
2022-09-01 | Journal article
DOI: 10.1016/j.chom.2022.08.005
PMID: 36108613
Contributors: Li L; Mac Aogáin M; Xu T; Jaggi TK; Chan LLY; Qu J; Lan Wei; Liao S; Cheng HS; Keir HR et al.
Source: Self-asserted source
Holly Rachael Keir

Endotyping Chronic Obstructive Pulmonary Disease, Bronchiectasis, and the "Chronic Obstructive Pulmonary Disease-Bronchiectasis Association".

American journal of respiratory and critical care medicine
2022-08-01 | Journal article
DOI: 10.1164/rccm.202108-1943oc
PMID: 35436182
Contributors: Jeffrey Huang; Cant E; Keir HR; Barton AK; Kuzmanova E; Shuttleworth M; Pollock J; Finch S; Polverino E; Mathieu Bottier et al.
Source: Self-asserted source
Holly Rachael Keir

Bronchiectasis enters the inflammation era.

Respirology (Carlton, Vic.)
2022-04-13 | Journal article | Author
DOI: 10.1111/resp.14263
PMID: 35417069
Contributors: Holly Rachael Keir; James Chalmers
Source: Self-asserted source
Holly Rachael Keir
grade
Preferred source (of 2)‎

Characterization of Eosinophilic Bronchiectasis: A European Multicohort Study.

American journal of respiratory and critical care medicine
2022-04-01 | Journal article
DOI: 10.1164/rccm.202108-1889oc
PMID: 35050830
Contributors: Amelia Shoemark; Shteinberg M; anthony de soyza; Haworth CS; Richardson H; Yonghua Gao; Perea L; Alison Dicker; Goeminne PC; Cant E et al.
Source: Self-asserted source
Holly Rachael Keir

ERS International Congress 2021: highlights from the Respiratory Infections Assembly.

ERJ open research
2022-04-01 | Journal article | Author
DOI: 10.1183/23120541.00642-2021
PMID: 35615420
PMC: PMC9124871
Contributors: Oliver Meldrum; Belchamber KBR; Kiarina Myroniuk-Konstantynovych; Katie Horton; Tetyana Konstantynovych; Long MB; Melissa McDonnell; Perea L; Garcia-Basteiro AL; Loebinger MR et al.
Source: Self-asserted source
Holly Rachael Keir

Non-COVID-19 respiratory viral infection

Breathe
2022-03 | Journal article
DOI: 10.1183/20734735.0151-2021
Contributors: Cláudio Nunes-Silva; Ana Teresa Vilares; Valentijn Schweitzer; Susana Castanhinha; António Martins; Maria João Lopes; Tommaso Ascoli-Bartoli; Gabriela Canelas; Holly R. Keir; Flávia Cunha et al.
Source: check_circle
Crossref

Neutrophil extracellular traps in chronic lung disease: implications for pathogenesis and therapy.

European respiratory review : an official journal of the European Respiratory Society
2022-02-22 | Journal article | Author
DOI: 10.1183/16000617.0241-2021
PMID: 35197267
PMC: PMC9488971
Contributors: Holly Rachael Keir; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir
grade
Preferred source (of 2)‎

Less is more? Antibiotic treatment duration for exacerbations of bronchiectasis

European Respiratory Journal
2021-12 | Journal article
DOI: 10.1183/13993003.01416-2021
Contributors: James D. Chalmers; Holly R. Keir
Source: check_circle
Crossref

ERS ECM Awardee 2021, a preview of LSC 2022 and a brief overview of the Respiratory Channel.

Breathe (Sheffield, England)
2021-12-01 | Journal article
DOI: 10.1183/20734735.0121-2021
PMID: 35035574
PMC: PMC8753634
Contributors: Costa JC; Mitchelmore P; Niki Ubags; Cristina Calarasu; Keir HR; Joana Cruz
Source: Self-asserted source
Holly Rachael Keir

Sputum Proteomics in Nontuberculous Mycobacterial Lung Disease.

Chest
2021-11-25 | Journal article
DOI: 10.1016/j.chest.2021.11.014
PMID: 34838525
Contributors: Hull RC; Jeffrey Huang; Barton AK; Keir HR; Ellis H; Cookson WOC; Moffatt MF; Loebinger MR; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

SPLUNC1 is a novel marker of disease severity and airway infection in bronchiectasis.

The European respiratory journal
2021-11-11 | Journal article
DOI: 10.1183/13993003.01840-2021
PMID: 34413156
Contributors: Keir HR; Amelia Shoemark; Jeffrey Huang; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

IL-6 trans-signalling: how Haemophilus surfs the NET to amplify inflammation in COPD.

The European respiratory journal
2021-10-14 | Journal article
DOI: 10.1183/13993003.02143-2021
PMID: 34649972
Contributors: Keir HR; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

Exhaled volatile organic compounds and lung microbiome in COPD: a pilot randomised controlled trial.

ERJ open research
2021-10-04 | Journal article
DOI: 10.1183/23120541.00253-2021
PMID: 34616836
PMC: PMC8488227
Contributors: Divya Mohan; Keir HR; Richardson H; Mayhew D; Boyer J; van der Schee MP; Allsworth MD; Bruce Miller; Ruth Tal-Singer; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

Inhaled Corticosteroids and the Lung Microbiome in COPD.

Biomedicines
2021-09-24 | Journal article
DOI: 10.3390/biomedicines9101312
PMID: 34680429
PMC: PMC8533282
Contributors: Keir HR; Marco Contoli; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

Highlights of the ERS Lung Science Conference and Sleep and Breathing Conference 2021 and the new ECMC members.

Breathe (Sheffield, England)
2021-09-01 | Journal article
DOI: 10.1183/20734735.0080-2021
PMID: 35035550
PMC: PMC8753630
Contributors: Amanda Goodwin; Karadoğan D; Martina De Santis; Hani N Alsafadi; Hawthorne I; Bradicich M; Siciliano M; Şahin Duyar S; Adriano Targa; Meszaros M et al.
Source: Self-asserted source
Holly Rachael Keir

High Frequency of Allergic Bronchopulmonary Aspergillosis in Bronchiectasis-COPD Overlap.

Chest
2021-08-05 | Journal article
DOI: 10.1016/j.chest.2021.07.2165
PMID: 34364870
Contributors: pei yee tiew; Lim AYH; Keir HR; Alison Dicker; Mac Aogáin M; Pang SL; Low TB; Hassan TM; MAU-ERN POH; Xu H et al.
Source: Self-asserted source
Holly Rachael Keir

Pathophysiology of Bronchiectasis.

Seminars in respiratory and critical care medicine
2021-07-14 | Journal article
DOI: 10.1055/s-0041-1730891
PMID: 34261175
Contributors: Keir HR; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study.

The Lancet. Respiratory medicine
2021-05-04 | Journal article
DOI: 10.1016/s2213-2600(20)30557-9
PMID: 33961805
Contributors: Alison Dicker; Lonergan M; Keir HR; Smith AH; Pollock J; Finch S; Cassidy AJ; Jeffrey Huang; Chalmers JD
Source: Self-asserted source
Holly Rachael Keir

ERS International Congress 2020: highlights from the Respiratory Infections assembly.

ERJ open research
2021-04-19 | Journal article
DOI: 10.1183/23120541.00091-2021
PMID: 33898612
PMC: PMC8053904
Contributors: Frent S; Cristina Calarasu; Suska K; Gashynova K; Keir H
Source: Self-asserted source
Holly Rachael Keir

Integrative microbiomics in bronchiectasis exacerbations.

Nature medicine
2021-04-05 | Journal article | Author
DOI: 10.1038/s41591-021-01289-7
PMID: 33820995
Contributors: Micheál Mac Aogáin; Jayanth Kumar Narayana; pei yee tiew; Ali NABM; Valerie Fei Lee Yong; Tavleen Kaur Jaggi; yick hou lim; Holly Rachael Keir; Alison Dicker; Thng KX et al.
Source: Self-asserted source
Holly Rachael Keir
grade
Preferred source (of 2)‎

A high-risk airway mycobiome is associated with frequent exacerbation and mortality in COPD.

The European respiratory journal
2021-03-11 | Journal article
DOI: 10.1183/13993003.02050-2020
PMID: 32972986
Contributors: pei yee tiew; Alison Dicker; Keir HR; MAU-ERN POH; Sze Lei Pang; Mac Aogáin M; Chua BQY; Tan JL; Xu H; Mariko S Koh et al.
Source: Self-asserted source
Holly Rachael Keir

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study.

The Lancet. Respiratory medicine
2021-02-17 | Journal article
DOI: 10.1016/s2213-2600(20)30504-x
PMID: 33609487
Contributors: Keir HR; Amelia Shoemark; Alison Dicker; Lídia Perea; Pollock J; Giam YH; Guillermo Suarez-Cuartin; Crichton ML; Lonergan M; Oriano M et al.
Source: Self-asserted source
Holly Rachael Keir

Clinical endotypes of exacerbation are associated with differences in microbial composition and diversity in COPD.

The European respiratory journal
2020-10-29 | Journal article
DOI: 10.1183/13993003.00391-2020
PMID: 32444406
Contributors: Keir HR; Alison Dicker; Lonergan M; Crichton M; Miller BE; Ruth Tal-Singer; James Chalmers
Source: Self-asserted source
Holly Rachael Keir

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin.

ERJ open research
2020-10-01 | Journal article
DOI: 10.1183/23120541.00583-2020
PMID: 33263062
PMC: PMC7682717
Contributors: Keir HR; Richardson H; Fillmore C; Amelia Shoemark; Lazaar AL; Miller BE; Ruth Tal-Singer; Chalmers JD; Mohan D
Source: Self-asserted source
Holly Rachael Keir

Serum Desmosine Is Associated with Long-Term All-Cause and Cardiovascular Mortality in Bronchiectasis.

American journal of respiratory and critical care medicine
2020-09-01 | Journal article
DOI: 10.1164/rccm.202002-0434le
PMID: 32402210
Contributors: Jeffrey Huang; Kuzmanova E; Alison Dicker; Keir HR; Finch S; Aliberti S; Fardon TC; James Chalmers
Source: Self-asserted source
Holly Rachael Keir

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD.

Respiratory research
2020-07-01 | Journal article
DOI: 10.1186/s12931-020-01436-7
PMID: 32611352
PMC: PMC7329438
Contributors: Lonergan M; Alison Dicker; Crichton ML; Keir HR; Van Dyke MK; Mullerova H; Miller BE; Tal-Singer R; James Chalmers
Source: Self-asserted source
Holly Rachael Keir

The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease.

The Journal of allergy and clinical immunology
2020-04-28 | Journal article
DOI: 10.1016/j.jaci.2020.02.040
PMID: 32353489
Contributors: Alison Dicker; Jeffrey Huang; Lonergan M; Keir HR; Fong CJ; Tan B; Cassidy AJ; Finch S; Mullerova H; Miller BE et al.
Source: Self-asserted source
Holly Rachael Keir

Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis.

Chest
2020-03-14 | Journal article
DOI: 10.1016/j.chest.2020.02.048
PMID: 32184111
Contributors: Poh TY; pei yee tiew; yick hou lim; Thng KX; Binte Mohamed Ali NA; Jayanth Kumar Narayana; Micheál Mac Aogáin; Tien Z; Chew WM; Wai Chan AK et al.
Source: Self-asserted source
Holly Rachael Keir

Pregnancy Zone Protein Is Associated with Airway Infection, Neutrophil Extracellular Trap Formation, and Disease Severity in Bronchiectasis.

American journal of respiratory and critical care medicine
2019-10-01 | Journal article
DOI: 10.1164/rccm.201812-2351oc
PMID: 31264895
PMC: PMC6794104
Contributors: Finch S; Amelia Shoemark; Alison Dicker; Keir HR; Smith A; Ong S; Tan B; Choi JY; Fardon TC; Cassidy D et al.
Source: Self-asserted source
Holly Rachael Keir

Early Career Members at the Lung Science Conference and the Sleep and Breathing Conference 2019.

Breathe (Sheffield, England)
2019-09-01 | Journal article
DOI: 10.1183/20734735.0203-2019
PMID: 31508161
PMC: PMC6717613
Contributors: Isaac Almendros; Natalia El-Merhie; Akhilesh Jha; Keir HR; Lykouras D; Irma Mahmutovic Persson; Ubags ND; Sabine Bartel
Source: Self-asserted source
Holly Rachael Keir

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis.

Thorax
2019-07-05 | Journal article
DOI: 10.1136/thoraxjnl-2018-212895
PMID: 31278172
Contributors: Oriol Sibila; Lídia Perea; ELISABET CANTO; Amelia Shoemark; Cassidy D; Smith AH; Guillermo Suarez-Cuartin; Rodrigo-Troyano A; Keir HR; Martina Oriano et al.
Source: Self-asserted source
Holly Rachael Keir

Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis.

American journal of respiratory and critical care medicine
2019-07-01 | Journal article
DOI: 10.1164/rccm.201809-1651oc
PMID: 31109172
Contributors: Oriol Sibila; Laserna E; Amelia Shoemark; Keir HR; Finch S; Rodrigo-Troyano A; Lídia Perea; Lonergan M; Goeminne PC; James Chalmers
Source: Self-asserted source
Holly Rachael Keir

A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation.

The European respiratory journal
2019-06-13 | Journal article
DOI: 10.1183/13993003.00303-2019
PMID: 31151955
Contributors: Amelia Shoemark; Cant E; Carreto L; Smith A; Oriano M; Keir HR; Lídia Perea; ELISABET CANTO; Terranova L; Silvia Vidal et al.
Source: Self-asserted source
Holly Rachael Keir

Distinct "Immunoallertypes" of Disease and High Frequencies of Sensitization in Non-Cystic Fibrosis Bronchiectasis.

American journal of respiratory and critical care medicine
2019-04-01 | Journal article
DOI: 10.1164/rccm.201807-1355oc
PMID: 30265843
Contributors: Micheál Mac Aogáin; Tiew PY; yick hou lim; Low TB; Tan GL; Hassan T; Ong TH; Pang SL; Lee ZY; Gwee XW et al.
Source: Self-asserted source
Holly Rachael Keir

Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition.

ERJ open research
2019-02-01 | Journal article
DOI: 10.1183/23120541.00252-2018
PMID: 30918898
PMC: PMC6431753
Contributors: Keir HR; Christopher John Fong; Crichton ML; Barth P; Chevalier E; Brady G; Gwen Kennedy; Zimmermann J; Bruijnzeel PLB; Alison Dicker et al.
Source: Self-asserted source
Holly Rachael Keir

Circulating desmosine as a biomarker of azithromycin treatment response: a post hoc analysis of the COLUMBUS randomised controlled trial.

ERJ open research
2018-10-01 | Journal article
DOI: 10.1183/23120541.00136-2018
PMID: 30443554
PMC: PMC6230815
Contributors: Chalmers JD; Djamin RS; Schouten M; Keir HR; Tan B; Aerts JGJV; Jeffrey Huang; van der Eerden M
Source: Self-asserted source
Holly Rachael Keir

Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study.

The European respiratory journal
2018-07-27 | Journal article
DOI: 10.1183/13993003.00766-2018
PMID: 29880655
PMC: PMC6092680
Contributors: Micheál Mac Aogáin; Chandrasekaran R; yick hou lim; Low TB; Tan GL; Hassan T; Ong TH; Hui Qi Ng A; Bertrand D; Koh JY et al.
Source: Self-asserted source
Holly Rachael Keir

10 years since TORCH: shining a new light on the risks of inhaled corticosteroids in COPD.

The European respiratory journal
2017-09-20 | Journal article
DOI: 10.1183/13993003.01582-2017
PMID: 28931673
Contributors: James Chalmers; Keir HR
Source: Self-asserted source
Holly Rachael Keir

Profile of the ProAxsis active neutrophil elastase immunoassay for precision medicine in chronic respiratory disease.

Expert review of molecular diagnostics
2017-09-07 | Journal article
DOI: 10.1080/14737159.2017.1374174
PMID: 28854829
Contributors: Keir HR; Fong CJ; Alison Dicker; James Chalmers
Source: Self-asserted source
Holly Rachael Keir

The past decade in bench research into pulmonary infectious diseases: What do clinicians need to know?

Respirology (Carlton, Vic.)
2017-06-28 | Journal article
DOI: 10.1111/resp.13106
PMID: 28657170
Contributors: Finch S; Keir HR; Alison Dicker; James Chalmers
Source: Self-asserted source
Holly Rachael Keir

Peer review (2 reviews for 1 publication/grant)

Review activity for Respiratory research. (2)
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