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Employment (3)

UiT - The Arctic University of Norway: Tromsø, NO

2020-01-13 to present | Associate Professor in Infection Biology (Department of Medical Biology)
Employment
Source: Self-asserted source
Christian Lentz

Helmholtz-Zentrum für Infektionsforschung GmbH: Braunschweig, Niedersachsen, DE

2018-09-15 to 2019-12-31 (Chemical Biology)
Employment
Source: Self-asserted source
Christian Lentz

Stanford University: Stanford, CA, US

2014-03-01 to 2018-09-30 | Postdoctoral Researcher (School of Medicine, Department of Pathology)
Employment
Source: Self-asserted source
Christian Lentz

Education and qualifications (2)

University of Bonn: Bonn, DE

2009-05-01 to 2013-05-29 | Dr. rer. nat. (PhD) (Institute for Medical Microbiology, Immunology and Parasitoloty)
Education
Source: Self-asserted source
Christian Lentz

University of Bonn: Bonn, DE

2004-10-01 to 2009-03-13 | Dipl. Mol. Biomed. (Molecular Biomedicine Division/ Diploma Thesis at Institute of Medical Microbiology, Immunology and Parasitology)
Education
Source: Self-asserted source
Christian Lentz

Funding (1)

Targeting newly discovered biofilm-associated virulence factors of Staphylococcus aureus to treat chronic bacterial infection

2023 to 2026 | Contract
Marsden Fund (Wellington, NZ)
PROPOSAL_ID:

MFP-22-UOO-128

GRANT_NUMBER:

MFP-UOO2201
Source: check_circle
Royal Society Te Apārangi

Works (27)

Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus

ACS Infectious Diseases
2025-03-14 | Journal article
DOI: 10.1021/acsinfecdis.4c00638
Contributors: Md Jalal Uddin; Kjersti Julin; Herman S. Overkleeft; Mona Johannessen; Christian S. Lentz
Source: check_circle
Crossref

A programmable, selection-free CRISPR interference system inStaphylococcus aureus

2024-11-27 | Preprint
DOI: 10.1101/2024.11.27.625599
Contributors: Roni Miah; Mona Johannessen; Morten Kjos; Christian S. Lentz
Source: check_circle
Crossref

Development of an inducer-free, virulence gene promoter-controlled, and fluorescent reporter-labeled CRISPR interference system in Staphylococcus aureus

Microbiology Spectrum
2024-10-03 | Journal article
DOI: 10.1128/spectrum.00602-24
Contributors: Roni Miah; Mona Johannessen; Morten Kjos; Christian S. Lentz; Rebecca S. Shapiro
Source: check_circle
Crossref

Single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities

Communications Biology
2024-10-01 | Journal article
DOI: 10.1038/s42003-024-06894-z
Contributors: Jonathan Hira; Bhupender Singh; Tirthankar Halder; Anel Mahmutovic; Clement Ajayi; Arif Ahmed Sekh; Kristin Hegstad; Mona Johannessen; Christian S. Lentz
Source: check_circle
Crossref

Deciphering Staphylococcus aureus– host dynamics using dual activity-based protein profiling of ATP-interacting proteins

mSystems
2024-05-16 | Journal article
DOI: 10.1128/msystems.00179-24
Contributors: Stephen Dela Ahator; Kristin Hegstad; Christian S. Lentz; Mona Johannessen; Kathryn C. Milligan-McClellan
Source: check_circle
Crossref

Activity-based protein profiling of serine hydrolases and penicillin-binding proteins in Enterococcus faecium

FEMS Microbes
2024-01-10 | Journal article
DOI: 10.1093/femsmc/xtae015
Contributors: Jeanette S Grunnvåg; Kristin Hegstad; Christian S Lentz
Source: check_circle
Crossref

Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response

ACS Infectious Diseases
2023-11-10 | Journal article
DOI: 10.1021/acsinfecdis.3c00246
Contributors: Matthias Fellner; Annabel Walsh; Stephen Dela Ahator; Nadia Aftab; Ben Sutherland; Eng W. Tan; Alexander T. Bakker; Nathaniel I. Martin; Mario van der Stelt; Christian S. Lentz
Source: check_circle
Crossref

Activity‐Based Protein Profiling in Methicillin‐Resistant Staphylococcus aureus Reveals the Broad Reactivity of a Carmofur‐Derived Probe

ChemBioChem
2023-11-02 | Journal article
DOI: 10.1002/cbic.202300473
Contributors: Md Jalal Uddin; Hermen S. Overkleeft; Christian S. Lentz
Source: check_circle
Crossref

High-throughput single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenicStaphylococcus aureuscommunities

2023-11-02 | Preprint
DOI: 10.1101/2023.11.02.562170
Contributors: Jonathan Hira; Bhupender Singh; Tirthankar Halder; Anel Mahmutovic; Clement Ajayi; Arif Ahmed Sekh; Kristin Hegstad; Mona Johannessen; Christian S. Lentz
Source: check_circle
Crossref

From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology.

Molecules (Basel, Switzerland)
2020-10-26 | Journal article
DOI: 10.3390/molecules25214949
PMID: 33114655
Source: Self-asserted source
Christian Lentz

Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus.

ACS infectious diseases
2020-09-15 | Journal article
DOI: 10.1021/acsinfecdis.0c00503
PMID: 32865965
Source: Self-asserted source
Christian Lentz

Characterization of Serine Hydrolases Across Clinical Isolates of Commensal Skin Bacteria Staphylococcus epidermidis Using Activity-Based Protein Profiling.

ACS infectious diseases
2020-04-27 | Journal article
DOI: 10.1021/acsinfecdis.0c00095
PMID: 32298574
Source: Self-asserted source
Christian Lentz

Structural basis for active-site probes targetingStaphylococcus aureusserine hydrolase virulence factors

2020-04-23 | Preprint
DOI: 10.1101/2020.04.21.054437
Contributors: Matthias Fellner; Christian S. Lentz; Sam A. Jamieson; Jodi L. Brewster; Linhai Chen; Matthew Bogyo; Peter D. Mace
Source: check_circle
Crossref

What you see is what you get: activity-based probes in single-cell analysis of enzymatic activities

Biological Chemistry
2020-02-25 | Journal article
DOI: 10.1515/hsz-2019-0262
Contributors: Christian S. Lentz
Source: check_circle
Crossref

Fluorescent Triazole Urea Activity‐Based Probes for the Single‐Cell Phenotypic Characterization of Staphylococcus aureus

Angewandte Chemie
2019-04-16 | Journal article
DOI: 10.1002/ange.201900511
Contributors: Linhai Chen; Laura J. Keller; Edward Cordasco; Matthew Bogyo; Christian S. Lentz
Source: check_circle
Crossref

Fluorescent Triazole Urea Activity‐Based Probes for the Single‐Cell Phenotypic Characterization of Staphylococcus aureus

Angewandte Chemie International Edition
2019-04-16 | Journal article
DOI: 10.1002/anie.201900511
Contributors: Linhai Chen; Laura J. Keller; Edward Cordasco; Matthew Bogyo; Christian S. Lentz
Source: check_circle
Crossref

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

Nat Chem Biol
2018 | Journal article
DOI: 10.1038/s41589-018-0060-1
Contributors: Lentz, C. S.; Sheldon, J. R.; Crawford, L. A.; Cooper, R.; Garland, M.; Amieva, M. R.; Weerapana, E.; Skaar, E. P.; Bogyo, M.
Source: Self-asserted source
Christian Lentz via ResearcherID

An NAD+-dependent novel transcription factor controls stage conversion in Entamoeba

eLife
2018-10-30 | Journal article
DOI: 10.7554/elife.37912
ISSN: 2050-084X
Source: Self-asserted source
Christian Lentz

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity

ACS Cent Sci
2017 | Journal article
DOI: 10.1021/acscentsci.7b00224
Contributors: Tomlin, F. M.; Gerling-Driessen, U. I. M.; Liu, Y. C.; Flynn, R. A.; Vangala, J. R.; Lentz, C. S.; Clauder-Muenster, S.; Jakob, P.; Mueller, W. F.; Ordoñez-Rueda, D. et al.
Source: Self-asserted source
Christian Lentz via ResearcherID

Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis

ACS Infect Dis
2016 | Journal article
DOI: 10.1021/acsinfecdis.6b00092
Contributors: Lentz, C. S.; Ordonez, A. A.; Kasperkiewicz, P.; La Greca, F.; O'Donoghue, A. J.; Schulze, C. J.; Powers, J. C.; Craik, C. S.; Drag, M.; Jain, S. K. et al.
Source: Self-asserted source
Christian Lentz via ResearcherID

In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites

Antimicrob Agents Chemother
2015 | Journal article
DOI: 10.1128/AAC.02383-14
Contributors: Lentz, C. S.; Sattler, J. M.; Fendler, M.; Gottwalt, S.; Halls, V. S.; Strassel, S.; Arriens, S.; Hannam, J. S.; Specht, S.; Famulok, M. et al.
Source: Self-asserted source
Christian Lentz via ResearcherID

Eotaxin-1 is involved in parasite clearance during chronic filarial infection

Parasite Immunol
2014 | Journal article
DOI: 10.1111/pim.12079
Contributors: Gentil, K.; Lentz, C. S.; Rai, R.; Muhsin, M.; Kamath, A. D.; Mutluer, O.; Specht, S.; Hübner, M. P.; Hoerauf, A.
Source: Self-asserted source
Christian Lentz via ResearcherID

wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs

J Med Chem
2014 | Journal article
DOI: 10.1021/jm401785n
Contributors: Lentz, C. S.; Halls, V. S.; Hannam, J. S.; Strassel, S.; Lawrence, S. H.; Jaffe, E. K.; Famulok, M.; Hoerauf, A.; Pfarr, K. M.
Source: Self-asserted source
Christian Lentz via ResearcherID

A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro

Chem Biol
2013 | Journal article
DOI: 10.1016/j.chembiol.2012.11.009
Contributors: Lentz, C. S.; Halls, V.; Hannam, J. S.; Niebel, B.; Strübing, U.; Mayer, G.; Hoerauf, A.; Famulok, M.; Pfarr, K. M.
Source: Self-asserted source
Christian Lentz via ResearcherID

New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria

Bioorg Med Chem Lett
2013 | Journal article
DOI: 10.1016/j.bmcl.2013.08.052
Contributors: Lentz, C. S.; Stumpfe, D.; Bajorath, J.; Famulok, M.; Hoerauf, A.; Pfarr, K. M.
Source: Self-asserted source
Christian Lentz via ResearcherID

The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections

J Antimicrob Chemother
2013 | Journal article
DOI: 10.1093/jac/dkt105
Contributors: Schiefer, A.; Vollmer, J.; Lämmer, C.; Specht, S.; Lentz, C.; Ruebsamen-Schaeff, H.; Brötz-Oesterhelt, H.; Hoerauf, A.; Pfarr, K.
Source: Self-asserted source
Christian Lentz via ResearcherID

ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling

Chemistry
2010 | Journal article
DOI: 10.1002/chem.201001192
Contributors: Niebel, B.; Lentz, C.; Pofahl, M.; Mayer, G.; Hoerauf, A.; Pfarr, K. M.; Famulok, M.
Source: Self-asserted source
Christian Lentz via ResearcherID

Peer review (5 reviews for 4 publications/grants)

Review activity for ACS chemical biology. (1)
Review activity for Angewandte Chemie. (2)
Review activity for Communications biology. (1)
Review activity for Israel journal of chemistry. (1)
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