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Boddey Lab

Other IDs

Loop profile: 269560

Keywords

Malaria, Plasmodium falciparum, functional genomics, ookinete, mosquito, sporozoite, liver, blood, v

Countries

Australia

Activities

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Employment (2)

Walter and Eliza Hall Institute of Medical Research: Melbourne, VIC, AU

2006-02 to present | Laboratory Head/Associate Professor (Division of Infection and Immunity)
Employment
Source: Self-asserted source
Justin Boddey

University of Melbourne: Melbourne, VIC, AU

2006-02 to present | Associate Professor (Department of Medical Biology)
Employment
Source: Self-asserted source
Justin Boddey

Education and qualifications (3)

Griffith University - Gold Coast Campus: Southport, QLD, AU

2006-03-14 | PhD
Education
Source: Self-asserted source
Justin Boddey

Griffith University - Gold Coast Campus: Southport, QLD, AU

2001-11-31 | BBiomedSc(Hons)
Education
Source: Self-asserted source
Justin Boddey

Griffith University - Gold Coast Campus: Southport, QLD, AU

2000-11-31 | BBiomedSc
Education
Source: Self-asserted source
Justin Boddey

Funding (7)

Functional genomics of malaria liver infection and transmission

2017-01-01 to 2020-12-31 | Grant
National Health and Medical Research Council (Canberra, AU)
URL: https://grants.uberresearch.com/501100000925/1123727/Functional-genomics-of-malaria-liver-infection-and-transmission
GRANT_NUMBER: 1123727
Source: Self-asserted source
Justin Boddey via DimensionsWizard

Effector export in P. falciparum infected human erythrocytes

2017-01-01 to 2020-01-01 | Grant
National Health and Medical Research Council (Canberra, AU)
URL: https://grants.uberresearch.com/501100000925/1121178/Effector-export-in-P-falciparum-infected-human-erythrocytes
GRANT_NUMBER: 1121178
Source: Self-asserted source
Justin Boddey via DimensionsWizard

Role of exported proteins in the intracellular dynamics of liver-stage falciparum malaria

2012-05-01 to 2015-04-30 | Grant
International Human Frontier Science Program Organization (Strasbourg, FR)
URL: https://grants.uberresearch.com/100004412/e4816856/Role-of-exported-proteins-in-the-intracellular-dynamics-of-liver-stage-falciparum-malaria
GRANT_NUMBER:

e4816856
Source: Self-asserted source
Justin Boddey via DimensionsWizard

Understanding how Plasmepsin V directs export of malaria virulence proteins to the host cell

Source: Self-asserted source
Justin Boddey via DimensionsWizard

Function and inhibition of Plasmepsin V in targeting malaria virulence proteins into human erythrocytes

Source: Self-asserted source
Justin Boddey via DimensionsWizard

Identification of the Plasmodium falciparum translocon that exports parasite proteins into their erythocytic hosts.

Source: Self-asserted source
Justin Boddey via DimensionsWizard

characterisation of P. Flaciparum erythrocyte-targeted proteins

2007-01-01 to 2010-01-01 | Grant
National Health and Medical Research Council (Canberra, AU)
URL: https://grants.uberresearch.com/501100000925/461281/characterisation-of-P-Flaciparum-erythrocyte-targeted-proteins
GRANT_NUMBER: 461281
Source: Self-asserted source
Justin Boddey via DimensionsWizard

Works (50 of 51)

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Page 1 of 2

Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice

Nature Microbiology
2025-01-31 | Journal article
DOI: 10.1038/s41564-024-01905-5
Contributors: Gigliola Zanghí; Hardik Patel; Jenny L. Smith; Nelly Camargo; Yeji Bae; Eva Hesping; Justin A. Boddey; Kannan Venugopal; Matthias Marti; Erika L. Flannery et al.
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Crossref

BioMalPar XX: looking back on, and forward from, 20 years of malaria research

Trends in Parasitology
2024-08 | Journal article
DOI: 10.1016/j.pt.2024.06.012
Contributors: Nedal-Djamil Darif; Markus Ganter; Jerzy Michal Dziekan; Nicole Kilian; Nicolas Brancucci; Caroline Ng; Laura E. de Vries; David Guttery; Nisha Philip; Justin A. Boddey et al.
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Crossref

Flp/ FRT -mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver-stage development

Proceedings of the National Academy of Sciences
2024-07-09 | Journal article
DOI: 10.1073/pnas.2403442121
Contributors: Robyn McConville; Jelte M. M. Krol; Ryan W. J. Steel; Matthew T. O’Neill; Bethany K. Davey; Anthony N. Hodder; Thomas Nebl; Alan F. Cowman; Norman Kneteman; Justin A. Boddey
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Crossref

Whole‐genome CRISPR screens to understand Apicomplexan–host interactions

Molecular Microbiology
2024-04 | Journal article
DOI: 10.1111/mmi.15221
Contributors: Eva Hesping; Justin A. Boddey
Source: check_circle
Crossref

Malaria parasite resistance to azithromycin is not readily transmitted by mosquitoes

2024-04-02 | Preprint
DOI: 10.7554/eLife.96433.1
Contributors: Hayley D. Buchanan; Robyn McConville; Lee M. Yeoh; Michael F. Duffy; Justin A. Boddey; Geoffrey I. McFadden; Christopher D. Goodman
Source: check_circle
Crossref

Malaria parasite resistance to azithromycin is not readily transmitted by mosquitoes

2024-04-02 | Preprint
DOI: 10.7554/eLife.96433
Contributors: Hayley D. Buchanan; Robyn McConville; Lee M. Yeoh; Michael F. Duffy; Justin A. Boddey; Geoffrey I. McFadden; Christopher D. Goodman
Source: check_circle
Crossref

Genome-wide gene expression profiles throughout human malaria parasite liver stage development

2023-12-13 | Preprint
DOI: 10.21203/rs.3.rs-3689897/v1
Contributors: Stefan Kappe; Gigliola Zanghi; Hardik Patel; Nelly Camargo; Jenny Smith; Yeji Bae; Eva Hesping; Justin Boddey; Erika Flannery; Vorada Chuenchob et al.
Source: check_circle
Crossref

Malaria parasite resistance to azithromycin is not readily transmitted by mosquitoes

2023-11-11 | Preprint
DOI: 10.1101/2023.11.10.566666
Contributors: Hayley D. Buchanan; Robyn McConville; Lee M. Yeoh; Michael F. Duffy; Justin A. Boddey; Geoffrey I. McFadden; Christopher D. Goodman
Source: check_circle
Crossref

Plasmodium falciparum exoerythrocytic forms require the PTEX translocon for development in human hepatocytes

2023-03-01 | Preprint
DOI: 10.21203/rs.3.rs-2632356/v1
Contributors: Robyn McConville; Jelte Krol; Ryan Steel; Matthew O'Neill; Bethany Davey; Anthony Hodder; Tom Nebl; Alan Cowman; N. M. Kneteman; Justin Boddey
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Crossref

Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites

npj Vaccines
2021-11-29 | Journal article
DOI: 10.1038/s41541-021-00408-2
Contributors: Benjamin J. Evert; Shuxiong Chen; Robyn McConville; Ryan W. J. Steel; Julie Healer; Justin A. Boddey; Lucas Huntimer; Bernd H. A. Rehm
Source: check_circle
Crossref

Molecular approaches to Malaria 2020

Cellular Microbiology
2021-03-16 | Journal article
DOI: 10.1111/cmi.13289
Contributors: Tania F. Koning‐Ward; Justin A. Boddey; Freya J.I. Fowkes
Source: check_circle
Crossref

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes

Cell Reports
2019-12-17 | Journal article
DOI: 10.1016/j.celrep.2019.11.073
Part of ISSN: 2211-1247
Source: Self-asserted source
Justin Boddey

Organoids for Liver Stage Malaria Research

Trends in Parasitology
2019-12-14 | Journal article
DOI: 10.1016/j.pt.2019.12.003
Part of ISSN: 1471-4922
Source: Self-asserted source
Justin Boddey

Malaria surveillance from both ends: concurrent detection of Plasmodium falciparum in saliva and excreta harvested from Anopheles mosquitoes.

Parasites & vectors
2019-07-18 | Journal article
DOI: 10.1186/s13071-019-3610-9
PMID: 31319880
Source: Self-asserted source
Justin Boddey

Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte

Nature Microbiology
2018-08 | Journal article
DOI: 10.1038/s41564-018-0219-2
Part of ISSN: 2058-5276
Contributors: Danushka S. Marapana; Laura F. Dagley; Jarrod J. Sandow; Thomas Nebl; Tony Triglia; Michał Pasternak; Benjamin K. Dickerman; Brendan S. Crabb; Paul R. Gilson; Andrew I. Webb et al.
Source: Self-asserted source
Justin Boddey via Crossref Metadata Search

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P 2 position of PEXEL peptidomimetics

European Journal of Medicinal Chemistry
2018-06 | Journal article
DOI: 10.1016/j.ejmech.2018.05.022
Part of ISSN: 0223-5234
Contributors: William Nguyen; Anthony N. Hodder; Richard Bestel de Lezongard; Peter E. Czabotar; Kate E. Jarman; Matthew T. O'Neill; Jennifer K. Thompson; Helene Jousset Sabroux; Alan F. Cowman; Justin A. Boddey et al.
Source: Self-asserted source
Justin Boddey via Crossref Metadata Search

Plasmodium falciparum subtilisin‐like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut

Molecular Microbiology
2018-06-05 | Journal article
DOI: 10.1111/mmi.13993
Source: Self-asserted source
Justin Boddey

Implications of Plasmodium glycosylation on vaccine efficacy and design

Future Microbiology
2018-04-06 | Journal article
DOI: 10.2217/fmb-2017-0284
Part of ISSN: 1746-0913
Contributors: Ethan D Goddard-Borger; Justin A Boddey
Source: Self-asserted source
Justin Boddey via Crossref Metadata Search

Aspartyl Protease 5 matures virulence factors found at the host-parasite interface in Toxoplasma gondii

2018-02-26 | Other
DOI: 10.1101/271676
Contributors: Michael J Coffey; Laura F Dagley; Eugene A Kapp; Giuseppe Infusini; Justin A Boddey; Andrew I Webb; Christopher J Tonkin
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Crossref

Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries

mSphere
2018-01-03 | Journal article
DOI: 10.1128/msphere.00551-17
Part of ISSN: 2379-5042
Contributors: Stéphanie Hallée; Justin A. Boddey; Alan F. Cowman; Dave Richard; Photini Sinnis
Source: Self-asserted source
Justin Boddey via Crossref Metadata Search

Plasmepsins on the antimalarial hit list

Science
2017-10 | Journal article
DOI: 10.1126/science.aaq0002
Part of ISSN: 0036-8075
Contributors: Justin A. Boddey
Source: Self-asserted source
Justin Boddey via Crossref Metadata Search

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

Nature Communications
2017-09 | Journal article
DOI: 10.1038/s41467-017-00571-y
Part of ISSN: 2041-1723
Contributors: Sash Lopaticki; Annie S. P. Yang; Alan John; Nichollas E. Scott; James P. Lingford; Matthew T. O’Neill; Sara M. Erickson; Nicole C. McKenzie; Charlie Jennison; Lachlan W. Whitehead et al.
Source: Self-asserted source
Justin Boddey via Crossref Metadata Search

AMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liver

Cellular Microbiology
2017-09-18 | Journal article
DOI: 10.1111/cmi.12745
Contributors: Annie S. P. Yang; Sash Lopaticki; Matthew T. O'Neill; Sara M. Erickson; Donna N. Douglas; Norman M. Kneteman; Justin A. Boddey
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Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice.

2017-03 | Journal article
DOI: 10.1016/j.celrep.2017.03.017
PMID: 28355563
Contributors: Yang AS; O'Neill MT; Jennison C; Lopaticki S; Allison CC; Armistead JS; Erickson SM; Rogers KL; Ellisdon AM; Whisstock JC et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Molecular mechanisms of host cell traversal by malaria sporozoites.

2017-02 | Journal article
DOI: 10.1016/j.ijpara.2016.09.002
PMID: 27825827
Contributors: Yang AS; Boddey JA
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Role of the ER and Golgi in protein export by Apicomplexa

Current Opinion in Cell Biology
2016-08 | Journal article
DOI: 10.1016/j.ceb.2016.03.007
Contributors: Michael J Coffey; Charlie Jennison; Christopher J Tonkin; Justin A Boddey
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Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.

2016-05 | Journal article
DOI: 10.1016/j.bmc.2016.03.027
PMID: 27021426
Contributors: Gazdik M; Jarman KE; O'Neill MT; Hodder AN; Lowes KN; Jousset Sabroux H; Cowman AF; Boddey JA; Sleebs BE
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.

2016-02 | Journal article
DOI: 10.1038/ncomms10470
PMID: 26832821
PMC: PMC4740378
Contributors: Boddey JA; O'Neill MT; Lopaticki S; Carvalho TG; Hodder AN; Nebl T; Wawra S; van West P; Ebrahimzadeh Z; Richard D et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V

MedChemComm
2015 | Journal article
DOI: 10.1039/c4md00409d
Part of ISSN: 2040-2503
Contributors: Michelle Gazdik; Matthew T. O'Neill; Sash Lopaticki; Kym N. Lowes; Brian J. Smith; Alan F. Cowman; Justin A. Boddey; Brad E. Sleebs
Source: Self-asserted source
Justin Boddey via Crossref Metadata Search

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell.

2015-11 | Journal article
DOI: 10.7554/elife.10809
PMID: 26576949
PMC: PMC4764566
Contributors: Coffey MJ; Sleebs BE; Uboldi AD; Garnham A; Franco M; Marino ND; Panas MW; Ferguson DJ; Enciso M; O'Neill MT et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central
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Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

2015-08 | Journal article
DOI: 10.1038/nsmb.3061
PMID: 26214367
Contributors: Hodder AN; Sleebs BE; Czabotar PE; Gazdik M; Xu Y; O'Neill MT; Lopaticki S; Nebl T; Triglia T; Smith BJ et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

2015-04 | Journal article
PMID: 25834186
PMC: PMC4381531
Contributors: Nandi T; Holden MT; Didelot X; Mehershahi K; Boddey JA; Beacham I; Peak I; Harting J; Baybayan P; Guo Y et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

2015-01 | Journal article
DOI: 10.1101/gr.177543.114
PMID: 25236617
PMC: PMC4317168
Contributors: Nandi T; Holden MT; Didelot X; Mehershahi K; Boddey JA; Beacham I; Peak I; Harting J; Baybayan P; Guo Y et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.

2014-09 | Journal article
DOI: 10.1021/jm500797g
PMID: 25167370
Contributors: Sleebs BE; Gazdik M; O'Neill MT; Rajasekaran P; Lopaticki S; Lackovic K; Lowes K; Smith BJ; Cowman AF; Boddey JA
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

2014-07 | Journal article
DOI: 10.1371/journal.pbio.1001897
PMID: 24983235
PMC: PMC4077696
Contributors: Sleebs BE; Lopaticki S; Marapana DS; O'Neill MT; Rajasekaran P; Gazdik M; Günther S; Whitehead LW; Lowes KN; Barfod L et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

The acute transcriptomic and proteomic response of HC-04 hepatoma cells to hepatocyte growth factor and its implications for Plasmodium falciparum sporozoite invasion.

2014-05 | Journal article
DOI: 10.1074/mcp.m113.035584
PMID: 24532842
PMC: PMC4014276
Contributors: Tao D; King JG; Tweedell RE; Jost PJ; Boddey JA; Dinglasan RR; Dinglasan RR
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Plasmodium nesting: remaking the erythrocyte from the inside out.

2013 | Journal article
DOI: 10.1146/annurev-micro-092412-155730
PMID: 23808341
Contributors: Boddey JA; Cowman AF
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.

2013-05 | Journal article
DOI: 10.1111/tra.12053
PMID: 23387285
Contributors: Boddey JA; Carvalho TG; Hodder AN; Sargeant TJ; Sleebs BE; Marapana D; Lopaticki S; Nebl T; Cowman AF
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids.

2012-11 | Journal article
DOI: 10.1074/jbc.m112.395129
PMID: 22977236
PMC: PMC3488080
Contributors: Wawra S; Agacan M; Boddey JA; Davidson I; Gachon CM; Zanda M; Grouffaud S; Whisson SC; Birch PR; Porter AJ et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

A common protein export pathway in malaria parasites.

2010 | Journal article
DOI: 10.1186/1475-2875-9-s2-i3
PMC: PMC2963209
Contributors: Crabb B; Bullen H; Charnaud S; Haase S; Boddey J; Cowman A; de Koning-Ward T; Gilson P
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

That was then but this is now: malaria research in the time of an eradication agenda.

2010-05 | Journal article
DOI: 10.1126/science.1184785
PMID: 20466924
Contributors: Kappe SH; Vaughan AM; Boddey JA; Cowman AF
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence.

2010-04 | Journal article
DOI: 10.1371/journal.ppat.1000845
PMID: 20368977
PMC: PMC2848565
Contributors: Nandi T; Ong C; Singh AP; Boddey J; Atkins T; Sarkar-Tyson M; Essex-Lopresti AE; Chua HH; Pearson T; Kreisberg JF et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

An aspartyl protease directs malaria effector proteins to the host cell.

2010-02 | Journal article
DOI: 10.1038/nature08728
PMID: 20130643
PMC: PMC2818761
Contributors: Boddey JA; Hodder AN; Günther S; Gilson PR; Patsiouras H; Kapp EA; Pearce JA; de Koning-Ward TF; Simpson RJ; Crabb BS et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

A newly discovered protein export machine in malaria parasites.

2009-06 | Journal article
DOI: 10.1038/nature08104
PMID: 19536257
PMC: PMC2725363
Contributors: de Koning-Ward TF; Gilson PR; Boddey JA; Rug M; Smith BJ; Papenfuss AT; Sanders PR; Lundie RJ; Maier AG; Cowman AF et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum.

2009-03 | Journal article
DOI: 10.1371/journal.ppat.1000328
PMID: 19266084
PMC: PMC2648313
Contributors: Richard D; Kats LM; Langer C; Black CG; Mitri K; Boddey JA; Cowman AF; Coppel RL
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte.

2009-03 | Journal article
DOI: 10.1111/j.1600-0854.2008.00864.x
PMID: 19055692
PMC: PMC2682620
Contributors: Boddey JA; Moritz RL; Simpson RJ; Cowman AF
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

The bacterial gene lfpA influences the potent induction of calcitonin receptor and osteoclast-related genes in Burkholderia pseudomallei-induced TRAP-positive multinucleated giant cells.

2007-02 | Journal article
DOI: 10.1111/j.1462-5822.2006.00807.x
PMID: 16987331
Contributors: Boddey JA; Day CJ; Flegg CP; Ulrich RL; Stephens SR; Beacham IR; Morrison NA; Peak IR
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Temperature-regulated microcolony formation by Burkholderia pseudomallei requires pilA and enhances association with cultured human cells.

2006-09 | Journal article
DOI: 10.1128/iai.00569-06
PMID: 16926432
PMC: PMC1594825
Contributors: Boddey JA; Flegg CP; Day CJ; Beacham IR; Peak IR
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.

2005-02 | Journal article
DOI: 10.1128/iai.73.2.1260-1264.2005
PMID: 15664977
PMC: PMC547011
Contributors: Essex-Lopresti AE; Boddey JA; Thomas R; Smith MP; Hartley MG; Atkins T; Brown NF; Tsang CH; Peak IR; Hill J et al.
Source: Self-asserted source
Justin Boddey via Europe PubMed Central

Identification of a novel two-partner secretion system from Burkholderia pseudomallei.

2004-09 | Journal article
DOI: 10.1007/s00438-004-1039-z
PMID: 15316770
Contributors: Brown NF; Logue CA; Boddey JA; Scott R; Hirst RG; Beacham IR
Source: Self-asserted source
Justin Boddey via Europe PubMed Central
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Page 1 of 2

Peer review (6 reviews for 5 publications/grants)

Review activity for Cell. (1)
Review activity for EMBO reports. (1)
Review activity for Nature (1)
Review activity for Nature communications (2)
Review activity for PLoS biology. (1)
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