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Scopus Author ID: 52463561100

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Employment (4)

Dana-Farber Cancer Institute: Boston, US

2022-11 to present | Director (Chemical Biology Program)
Employment
Source: Self-asserted source
Eric S. Fischer

Harvard Medical School: Boston, MA, US

2015-10-01 to present | Professor (BCMP)
Employment
Source: Self-asserted source
Eric S. Fischer

Dana-Farber Cancer Institute: Boston, MA, US

2015-10-01 to present | Professor (Cancer Biology)
Employment
Source: Self-asserted source
Eric S. Fischer

Friedrich Miescher Institute: Basel, CH

2013-02-01 to 2015-06-30 | Postdoc
Employment
Source: Self-asserted source
Eric S. Fischer

Education and qualifications (3)

Friedrich Miescher Institute for Biomedical Research: Basel, Basel-Stadt, CH

2010 to 2013 | PhD
Qualification
Source: Self-asserted source
Eric S. Fischer

University of Basel: Basel, Basel-Stadt, CH

2008-07 to 2010-03 | MSc
Qualification
Source: Self-asserted source
Eric S. Fischer

University of Basel: Basel, CH

2005-10 to 2008-07 | BSc
Education
Source: Self-asserted source
Eric S. Fischer

Works (44)

Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators

RSC Medicinal Chemistry
2024 | Journal article
DOI: 10.1039/D3MD00652B
Contributors: Yingpeng Liu; Radosław P. Nowak; Jianwei Che; Katherine A. Donovan; Fidel Huerta; Hu Liu; Rebecca J. Metivier; Eric S. Fischer; Lyn H. Jones
Source: check_circle
Crossref

Ternary complex formation of VCP, VCPIP1 and p47 facilitates Golgi reassembly

2024-10-02 | Preprint
DOI: 10.1101/2024.10.01.616120
Contributors: Binita Shah; Moritz Hunkeler; Ariana Bratt; Hong Yue; Isabella Jaen Maisonet; Eric S. Fischer; Sara J. Buhrlage
Source: check_circle
Crossref

Targeted protein degradation: from mechanisms to clinic

Nature Reviews Molecular Cell Biology
2024-09 | Journal article
DOI: 10.1038/s41580-024-00729-9
Contributors: Jonathan M. Tsai; Radosław P. Nowak; Benjamin L. Ebert; Eric S. Fischer
Source: check_circle
Crossref

Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates

Nature Chemical Biology
2024-09 | Journal article
DOI: 10.1038/s41589-024-01590-9
Contributors: Hai-Tsang Huang; Ryan J. Lumpkin; Ryan W. Tsai; Shuyao Su; Xu Zhao; Yuan Xiong; James Chen; Nada Mageed; Katherine A. Donovan; Eric S. Fischer et al.
Source: check_circle
Crossref

Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism

Nature Communications
2024-06-19 | Journal article
DOI: 10.1038/s41467-024-49161-9
Contributors: Han-Yuan Liu; Zhengnian Li; Theresia Reindl; Zhixiang He; Xueer Qiu; Ryan P. Golden; Katherine A. Donovan; Adam Bailey; Eric S. Fischer; Tinghu Zhang et al.
Source: check_circle
Crossref

Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead

RSC Chemical Biology
2023 | Journal article
DOI: 10.1039/D3CB00103B
Contributors: Radosław P. Nowak; Leah Ragosta; Fidel Huerta; Hu Liu; Scott B. Ficarro; Justin T. Cruite; Rebecca J. Metivier; Katherine A. Donovan; Jarrod A. Marto; Eric S. Fischer et al.
Source: check_circle
Crossref

Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange

ACS Medicinal Chemistry Letters
2023-11-09 | Journal article
DOI: 10.1021/acsmedchemlett.3c00371
Contributors: Justin T. Cruite; Radosław P. Nowak; Katherine A. Donovan; Scott B. Ficarro; Huang Huang; Hu Liu; Yingpeng Liu; Jarrod A. Marto; Rebecca J. Metivier; Eric S. Fischer et al.
Source: check_circle
Crossref

HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent

2023-08-15 | Preprint
DOI: 10.1101/2023.08.15.553363
Contributors: Longlong Wang; Adeline Unterreiner; Ronan Kapetanovic; Selma Aslani; Yuan Xiong; Katherine A. Donovan; Christopher J. Farady; Eric S. Fischer; Frédéric Bornancin; Patrick Matthias
Source: check_circle
Crossref

Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases

Science
2023-03-17 | Journal article
DOI: 10.1126/science.ade5750
Contributors: Moritz Hunkeler; Cyrus Y. Jin; Eric S. Fischer
Source: check_circle
Crossref

E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance

Journal of the American Chemical Society
2023-01-18 | Journal article
DOI: 10.1021/jacs.2c10784
Contributors: Alexander Hanzl; Eleonora Barone; Sophie Bauer; Hong Yue; Radosław P. Nowak; Elisa Hahn; Eugenia V. Pankevich; Anna Koren; Stefan Kubicek; Eric S. Fischer et al.
Source: check_circle
Crossref

Cereblon covalent modulation through structure-based design of histidine targeting chemical probes

RSC Chemical Biology
2022 | Journal article
DOI: 10.1039/D2CB00078D
Contributors: Justin T. Cruite; Geoffrey P. Dann; Jianwei Che; Katherine A. Donovan; Silas Ferrao; Scott B. Ficarro; Eric S. Fischer; Nathanael S. Gray; Fidel Huerta; Nikki R. Kong et al.
Source: check_circle
Crossref

Small molecule modulation of protein polymerization

Chemical Society Reviews
2022 | Journal article
DOI: 10.1039/D2CS00070A
Contributors: Eric S. Fischer; Lyn H. Jones
Source: check_circle
Crossref

Development and Utility of a PAK1-Selective Degrader

Journal of Medicinal Chemistry
2022-12-08 | Journal article
DOI: 10.1021/acs.jmedchem.2c00756
Contributors: Hoi-Yee Chow; Sofiia Karchugina; Brian J. Groendyke; Sean Toenjes; John Hatcher; Katherine A. Donovan; Eric S. Fischer; Gleb Abalakov; Bulat Faezov; Roland Dunbrack et al.
Source: check_circle
Crossref

Redirecting the Neo-Substrate Specificity of Cereblon-Targeting PROTACs to Helios

ACS Chemical Biology
2022-09-16 | Journal article
DOI: 10.1021/acschembio.2c00439
Contributors: Alyssa L. Verano; Inchul You; Katherine A. Donovan; Nada Mageed; Hong Yue; Radosław P. Nowak; Eric S. Fischer; Eric S. Wang; Nathanael S. Gray
Source: check_circle
Crossref

Structures of BIRC6-Client Complexes Provide Mechanism of Smac-Mediated Release of Caspases

2022-08-20 | Preprint
DOI: 10.1101/2022.08.19.504532
Contributors: Moritz Hunkeler; Cyrus Y. Jin; Eric S. Fischer
Source: check_circle
Crossref

Targeted Degradation of the Oncogenic Phosphatase SHP2

Biochemistry
2021-08-31 | Journal article
DOI: 10.1021/acs.biochem.1c00377
Contributors: Vidyasiri Vemulapalli; Katherine A. Donovan; Tom C. M. Seegar; Julia M. Rogers; Munhyung Bae; Ryan J. Lumpkin; Ruili Cao; Matthew T. Henke; Soumya S. Ray; Eric S. Fischer et al.
Source: check_circle
Crossref

Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development

ACS Medicinal Chemistry Letters
2021-08-12 | Journal article
DOI: 10.1021/acsmedchemlett.1c00285
Contributors: Mingxing Teng; Jie Jiang; Scott B. Ficarro; Hyuk-Soo Seo; Jae Hyun Bae; Katherine A. Donovan; Eric S. Fischer; Tinghu Zhang; Sirano Dhe-Paganon; Jarrod A. Marto et al.
Source: check_circle
Crossref

Structure-Guided Design of a “Bump-and-Hole” Bromodomain-Based Degradation Tag

Journal of Medicinal Chemistry
2021-08-12 | Journal article
DOI: 10.1021/acs.jmedchem.1c00958
Contributors: Radosław P. Nowak; Yuan Xiong; Nadia Kirmani; Joann Kalabathula; Katherine A. Donovan; Nicholas A. Eleuteri; J. Christine Yuan; Eric S. Fischer
Source: check_circle
Crossref

Modular HUWE1 architecture serves as hub for degradation of cell-fate decision factors

2020-08-19 | Preprint
DOI: 10.1101/2020.08.19.257352
Contributors: Moritz Hunkeler; Cyrus Y. Jin; Michelle W. Ma; Daan Overwijn; Julie K. Monda; Eric J. Bennett; Eric S. Fischer
Source: check_circle
Crossref

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

Nature Structural & Molecular Biology
2020-07-15 | Journal article
DOI: 10.1038/s41594-020-0438-0
Contributors: Tao Wu; Hojong Yoon; Yuan Xiong; Sarah E. Dixon-Clarke; Radosław P. Nowak; Eric S. Fischer
Source: check_circle
Crossref

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

Cells
2020-04-27 | Journal article
DOI: 10.3390/cells9051083
Contributors: Ivana Gasic; Brian J. Groendyke; Radosław P. Nowak; J. Christine Yuan; Joann Kalabathula; Eric S. Fischer; Nathanael S. Gray; Timothy J. Mitchison
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

Nature Chemical Biology
2020-01-04 | Journal article
DOI: 10.1038/s41589-019-0378-3
Contributors: Tyler B. Faust; Hojong Yoon; Radosław P. Nowak; Katherine A. Donovan; Zhengnian Li; Quan Cai; Nicholas A. Eleuteri; Tinghu Zhang; Nathanael S. Gray; Eric S. Fischer
Source: check_circle
Crossref

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

2019-08-16 | Other
DOI: 10.1101/738534
Contributors: Tyler Faust; Hojong Yoon; Radosław P. Nowak; Katherine A. Donovan; Zhengnian Li; Quan Cai; Nicholas A. Eleuteri; Tinghu Zhang; Nathanael S. Gray; Eric S. Fischer
Source: check_circle
Crossref

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

Nature Communications
2019-08-01 | Journal article
DOI: 10.1038/s41467-019-11429-w
Contributors: Mélissanne de Wispelaere; Guangyan Du; Katherine A. Donovan; Tinghu Zhang; Nicholas A. Eleuteri; Jingting C. Yuan; Joann Kalabathula; Radosław P. Nowak; Eric S. Fischer; Nathanael S. Gray et al.
Source: check_circle
Crossref

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity

Blood
2018-09-20 | Journal article
DOI: 10.1182/blood-2018-01-821769
Contributors: Quinlan L. Sievers; Jessica A. Gasser; Glenn S. Cowley; Eric S. Fischer; Benjamin L. Ebert
Source: check_circle
Crossref

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

eLife
2018-08-01 | Journal article
DOI: 10.7554/eLife.38430
Contributors: Katherine A Donovan; Jian An; Radosław P Nowak; Jingting C Yuan; Emma C Fink; Bethany C Berry; Benjamin L Ebert; Eric S Fischer
Source: check_circle
Crossref

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).

Journal of medicinal chemistry
2018-05 | Journal article
DOI: 10.1021/acs.jmedchem.7b01655
PMID: 29660984
Contributors: Powell CE; Gao Y; Tan L; Donovan KA; Nowak RP; Loehr A; Bahcall M; Fischer ES; Jänne PA; George RE et al.
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central

ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors.

Cancer research
2018-02 | Journal article
DOI: 10.1158/0008-5472.can-17-1904
PMID: 29259014
Contributors: Terai H; Kitajima S; Potter DS; Matsui Y; Quiceno LG; Chen T; Kim TJ; Rusan M; Thai TC; Piccioni F et al.
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

Nature chemical biology
2018-02 | Journal article
DOI: 10.1038/nchembio.2538
PMID: 29251720
Contributors: Olson CM; Jiang B; Erb MA; Liang Y; Doctor ZM; Zhang Z; Zhang T; Kwiatkowski N; Boukhali M; Green JL et al.
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central

A Chemproteomics Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

2017 | Dataset
OTHER-ID:

PXD007851
Source: check_circle
EMBL-EBI

A Chemproteomics Approach to Query the Degradable Kinome Using a Multi-kinase Degrader, part 2

2017 | Dataset
OTHER-ID:

PXD007861
Source: check_circle
EMBL-EBI

pSILAC mass spectrometry reveals ZFP91 as novel IMiD dependent substrate of the CRL4CRBN ligase - PART 1

2017 | Dataset
OTHER-ID:

PXD005849
Source: check_circle
EMBL-EBI

pSILAC mass spectrometry reveals ZFP91 as novel IMiD dependent substrate of the CRL4CRBN ligase - PART 2

2017 | Dataset
OTHER-ID:

PXD005857
Source: check_circle
EMBL-EBI

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.

Cell chemical biology
2017-11 | Journal article
DOI: 10.1016/j.chembiol.2017.10.005
PMID: 29129717
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.

Cell chemical biology
2017-08 | Journal article
DOI: 10.1016/j.chembiol.2017.06.017
PMID: 28781124
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central

pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

Nature Communications
2017-05-22 | Journal article
DOI: 10.1038/ncomms15398
Contributors: Jian An; Charles M. Ponthier; Ragna Sack; Jan Seebacher; Michael B. Stadler; Katherine A. Donovan; Eric S. Fischer
Source: check_circle
Crossref

SPLINTS: small-molecule protein ligand interface stabilizers

Current Opinion in Structural Biology
2016-04 | Journal article
DOI: 10.1016/j.sbi.2016.01.004
Source: check_circle
Crossref

Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase.

Nature
2016-04 | Journal article
DOI: 10.1038/nature16979
PMID: 26909574
Contributors: Petzold G; Fischer ES; Thomä NH
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central

Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.

Nature
2016-03 | Journal article
DOI: 10.1038/nature17416
PMID: 27029275
Contributors: Cavadini S; Fischer ES; Bunker RD; Potenza A; Lingaraju GM; Goldie KN; Mohamed WI; Faty M; Petzold G; Beckwith RE et al.
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central

Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein

Nucleic Acids Research
2015 | Journal article
DOI: 10.1093/nar/gkv038
EID:

2-s2.0-84930635066
Contributors: Matsumoto, S.; Fischer, E.S.; Yasuda, T.; Dohmae, N.; Iwai, S.; Mori, T.; Nishi, R.; Yoshino, K.-I.; Sakai, W.; Hanaoka, F. et al.
Source: Self-asserted source
Eric S. Fischer via Scopus - Elsevier

Crystal structure of the human COP9 signalosome

Nature
2014 | Journal article
DOI: 10.1038/nature13566
EID:

2-s2.0-84906238422
Contributors: Lingaraju, G.M.; Bunker, R.D.; Cavadini, S.; Hess, D.; Hassiepen, U.; Renatus, M.; Fischer, E.S.; Thomä, N.H.
Source: Self-asserted source
Eric S. Fischer via Scopus - Elsevier

Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

Nature
2014 | Journal article
DOI: 10.1038/nature13527
EID:

2-s2.0-84905568369
Contributors: Fischer, E.S.; Böhm, K.; Lydeard, J.R.; Yang, H.; Stadler, M.B.; Cavadini, S.; Nagel, J.; Serluca, F.; Acker, V.; Lingaraju, G.M. et al.
Source: Self-asserted source
Eric S. Fischer via Scopus - Elsevier

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

2011-11 | Journal article
DOI: 10.1016/j.cell.2011.10.035
PMID: 22118460
Contributors: Fischer ES; Scrima A; Böhm K; Matsumoto S; Lingaraju GM; Faty M; Yasuda T; Cavadini S; Wakasugi M; Hanaoka F et al.
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central
grade
Preferred source (of 2)‎

Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!

2011-09 | Journal article
DOI: 10.1016/j.febslet.2011.04.064
PMID: 21550341
Contributors: Scrima A; Fischer ES; Lingaraju GM; Böhm K; Cavadini S; Thomä NH
Source: Self-asserted source
Eric S. Fischer via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (19 reviews for 9 publications/grants)

Review activity for Cell. (2)
Review activity for ChemBioChem. (1)
Review activity for Nature (6)
Review activity for Nature cancer. (1)
Review activity for Nature chemical biology. (4)
Review activity for Nature communications (1)
Review activity for Nature reviews. (2)
Review activity for PLoS biology. (1)
Review activity for Structure. (1)
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