Personal information

Emails & domains

Verified email domains

Websites & social links

Lab website

Other IDs

Scopus Author ID: 56564442000
Scopus Author ID: 56767342700

Keywords

WGS,TB, IBD, complex traits, HLA, admixture

Countries

United Kingdom

Activities

Collapse all

Employment (3)

University of Oxford: Oxford, GB

2022-09-26 to present | Group Leader (The Kennedy Institute of Rheumatology)
Employment
Source: Self-asserted source
Yang Luo

Harvard Medical School: Boston, MA, US

2015-09-01 to 2022-05 | Instructor (Medicine)
Employment
Source: Self-asserted source
Yang Luo

Wellcome Trust Sanger Institute: Cambridge, Cambridgeshire, GB

2011-07-01 to 2015-08-31 | Postdoc (Human Genetics)
Employment
Source: Self-asserted source
Yang Luo

Education and qualifications (1)

University of Cambridge: Cambridge, Cambridgeshire, GB

2007-10-01 to 2011-02 | Ph.D. (Mathematics)
Education
Source: Self-asserted source
Yang Luo

Works (43)

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis

Nature Communications
2024-11-29 | Journal article
DOI: 10.1038/s41467-024-54741-w
Contributors: Yang Luo; Chuan-Chin Huang; Nicole C. Howard; Xin Wang; Qingyun Liu; Xinyi Li; Junhao Zhu; Tiffany Amariuta; Samira Asgari; Kazuyoshi Ishigaki et al.
Source: check_circle
Crossref

Smoking’s lasting effect on the immune system

Nature
2024-02-22 | Journal article
DOI: 10.1038/d41586-024-00232-3
Contributors: Yang Luo; Simon Stent
Source: check_circle
Crossref

Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma

Communications Biology
2024-01-05 | Journal article
DOI: 10.1038/s42003-023-05701-5
Contributors: Zhiwei Liu; Yang Luo; Samuel Kirimunda; Murielle Verboom; Olusegun O. Onabajo; Mateus H. Gouveia; Martin D. Ogwang; Patrick Kerchan; Steven J. Reynolds; Constance N. Tenge et al.
Source: check_circle
Crossref

Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease

Nature Protocols
2023-09 | Journal article
DOI: 10.1038/s41596-023-00853-4
Contributors: Saori Sakaue; Saisriram Gurajala; Michelle Curtis; Yang Luo; Wanson Choi; Kazuyoshi Ishigaki; Joyce B. Kang; Laurie Rumker; Aaron J. Deutsch; Sebastian Schönherr et al.
Source: check_circle
Crossref

Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

Nature Communications
2023-04-29 | Journal article
DOI: 10.1038/s41467-023-37985-w
Contributors: Alexandra Barry; Michelle T. McNulty; Xiaoyuan Jia; Yask Gupta; Hanna Debiec; Yang Luo; China Nagano; Tomoko Horinouchi; Seulgi Jung; Manuela Colucci et al.
Source: check_circle
Crossref

Mapping the dynamic genetic regulatory architecture ofHLAgenes at single-cell resolution

2023-03-20 | Preprint
DOI: 10.1101/2023.03.14.23287257
Contributors: Joyce B. Kang; Amber Z. Shen; Saori Sakaue; Yang Luo; Saisriram Gurajala; Aparna Nathan; Laurie Rumker; Vitor R. C. Aguiar; Cristian Valencia; Kaitlyn Lagattuta et al.
Source: check_circle
Crossref

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Nature Genetics
2022-11 | Journal article
DOI: 10.1038/s41588-022-01213-w
Contributors: Kazuyoshi Ishigaki; Saori Sakaue; Chikashi Terao; Yang Luo; Kyuto Sonehara; Kensuke Yamaguchi; Tiffany Amariuta; Chun Lai Too; Vincent A. Laufer; Ian C. Scott et al.
Source: check_circle
Crossref

Multi-population genome-wide association study implicates both immune and non-immune factors in the etiology of pediatric steroid sensitive nephrotic syndrome

2022-09-14 | Preprint
DOI: 10.1101/2022.09.13.22279644
Contributors: Alexandra Barry; Michelle T. McNulty; Xiaoyuan Jia; Yask Gupta; Hanna Debiec; Yang Luo; China Nagano; Tomoko Horinouchi; Seulgi Jung; Manuela Colucci et al.
Source: check_circle
Crossref

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci

Nature
2022-06-02 | Journal article
DOI: 10.1038/s41586-022-04713-1
Contributors: Aparna Nathan; Samira Asgari; Kazuyoshi Ishigaki; Cristian Valencia; Tiffany Amariuta; Yang Luo; Jessica I. Beynor; Yuriy Baglaenko; Sara Suliman; Alkes L. Price et al.
Source: check_circle
Crossref

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Nature Genetics
2022-04 | Journal article
DOI: 10.1038/s41588-022-01032-z
Contributors: Kazuyoshi Ishigaki; Kaitlyn A. Lagattuta; Yang Luo; Eddie A. James; Jane H. Buckner; Soumya Raychaudhuri
Source: check_circle
Crossref

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis

2022-03-03 | Preprint
DOI: 10.21203/rs.3.rs-1397421/v1
Contributors: Soumya Raychaudhuri; Yang Luo; Chuan-Chin Huang; Qingyun Liu; Nicole Howard; Xinyi Li; Junhao Zhu; Tiffany Amariuta; Samira Asgari; Kazuyoshi Ishigaki et al.
Source: check_circle
Crossref

A FLOT1 host regulatory allele is associated with a recently expanded Mtb clade in patients with tuberculosis

2022-02-08 | Preprint
DOI: 10.1101/2022.02.07.22270622
Contributors: Yang Luo; Chuan-Chin Huang; Qingyun Liu; Nicole Howard; Xinyi Li; Junhao Zhu; Tiffany Amariuta; Samira Asgari; Kazuyoshi Ishigaki; Roger Calderon et al.
Source: check_circle
Crossref

Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Nature Genetics
2021-12 | Journal article
DOI: 10.1038/s41588-021-00979-9
Contributors: Yang Luo; Masahiro Kanai; Wanson Choi; Xinyi Li; Saori Sakaue; Kenichi Yamamoto; Kotaro Ogawa; Maria Gutierrez-Arcelus; Peter K. Gregersen; Philip E. Stuart et al.
Source: check_circle
Crossref

Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis

2021-12-05 | Preprint
DOI: 10.1101/2021.12.01.21267132
Contributors: Kazuyoshi Ishigaki; Saori Sakaue; Chikashi Terao; Yang Luo; Kyuto Sonehara; Kensuke Yamaguchi; Tiffany Amariuta; Chun Lai Too; Vincent A Laufer; Ian C Scott et al.
Source: check_circle
Crossref

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Nature Genetics
2021-10 | Journal article
DOI: 10.1038/s41588-021-00935-7
Contributors: Yang Luo; Masahiro Kanai; Wanson Choi; Xinyi Li; Saori Sakaue; Kenichi Yamamoto; Kotaro Ogawa; Maria Gutierrez-Arcelus; Peter K. Gregersen; Philip E. Stuart et al.
Source: check_circle
Crossref

Modeling memory T cell states at single-cell resolution identifies in vivo state-dependence of eQTLs influencing disease

2021-07-30 | Other
DOI: 10.1101/2021.07.29.454316
Contributors: Aparna Nathan; Samira Asgari; Kazuyoshi Ishigaki; Tiffany Amariuta; Yang Luo; Jessica I. Beynor; Yuriy Baglaenko; Sara Suliman; Alkes Price; Leonid Lecca et al.
Source: check_circle
Crossref

Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease

Nature Immunology
2021-06-24 | Journal article
DOI: 10.1038/s41590-021-00933-1
Contributors: Aparna Nathan; Jessica I. Beynor; Yuriy Baglaenko; Sara Suliman; Kazuyoshi Ishigaki; Samira Asgari; Chuan-Chin Huang; Yang Luo; Zibiao Zhang; Kattya Lopez et al.
Source: check_circle
Crossref

A sex-specific evolutionary interaction between ADCY9 and CETP

2021-05-14 | Other
DOI: 10.1101/2021.05.12.443794
Contributors: Isabel Gamache; Marc-André Legault; Jean-Christophe Grenier; Rocio Sanchez; Eric Rhéaume; Samira Asgari; Amina Barhdadi; Yassamin Feroz Zada; Holly Trochet; Yang Luo et al.
Source: check_circle
Crossref

Accurate imputation of human leukocyte antigens with CookHLA

Nature Communications
2021-02-24 | Journal article
DOI: 10.1038/s41467-021-21541-5
Contributors: Seungho Cook; Wanson Choi; Hyunjoon Lim; Yang Luo; Kunhee Kim; Xiaoming Jia; Soumya Raychaudhuri; Buhm Han
Source: check_circle
Crossref

Population-specific causal disease effect sizes in functionally important regions impacted by selection

Nature Communications
2021-02-17 | Journal article
DOI: 10.1038/s41467-021-21286-1
Contributors: Huwenbo Shi; Steven Gazal; Masahiro Kanai; Evan M. Koch; Armin P. Schoech; Katherine M. Siewert; Samuel S. Kim; Yang Luo; Tiffany Amariuta; Hailiang Huang et al.
Source: check_circle
Crossref

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

2020-11-12 | Other
DOI: 10.1101/2020.11.08.20227983
Contributors: Kazuyoshi Ishigaki; Kaitlyn Lagattuta; Yang Luo; Eddie James; Jane Buckner; Soumya Raychaudhuri
Source: check_circle
Crossref

Higher Native Peruvian ancestry proportion is associated with tuberculosis progression risk

2020-09-11 | Other
DOI: 10.1101/2020.09.09.20191437
Contributors: Samira Asgari; Yang Luo; Kamil Slowikowski; Chuan-Chin Huang; Roger Calderon; Judith Jimenez; Rosa Yataco; Carmen Contreras; Jerome T. Galea; Leonid Lecca et al.
Source: check_circle
Crossref

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

2020-07-18 | Other
DOI: 10.1101/2020.07.16.20155606
Contributors: Yang Luo; Masahiro Kanai; Wanson Choi; Xinyi Li; Kenichi Yamamoto; Kotaro Ogawa; Maria Gutierrez-Arcelus; Peter K. Gregersen; Philip E. Stuart; James T. Elder et al.
Source: check_circle
Crossref

A positively selected FBN1 missense variant reduces height in Peruvian individuals

Nature
2020-06-11 | Journal article
DOI: 10.1038/s41586-020-2302-0
Contributors: Samira Asgari; Yang Luo; Ali Akbari; Gillian M. Belbin; Xinyi Li; Daniel N. Harris; Martin Selig; Eric Bartell; Roger Calderon; Kamil Slowikowski et al.
Source: check_circle
Crossref

Multimodal memory T cell profiling identifies a reduction in a polyfunctional Th17 state associated with tuberculosis progression

2020-04-25 | Preprint
DOI: 10.1101/2020.04.23.057828
Contributors: Aparna Nathan; Jessica I. Beynor; Yuriy Baglaenko; Sara Suliman; Kazuyoshi Ishigaki; Samira Asgari; Chuan-Chin Huang; Yang Luo; Zibiao Zhang; Kattya Lopez Tamara et al.
Source: check_circle
Crossref

Advances in genetics toward identifying pathogenic cell states of rheumatoid arthritis

Immunological Reviews
2020-03 | Journal article
DOI: 10.1111/imr.12827
Contributors: Tiffany Amariuta; Yang Luo; Rachel Knevel; Yukinori Okada; Soumya Raychaudhuri
Source: check_circle
Crossref

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

Nature Genetics
2020-03 | Journal article
DOI: 10.1038/s41588-020-0579-4
Contributors: Maria Gutierrez-Arcelus; Yuriy Baglaenko; Jatin Arora; Susan Hannes; Yang Luo; Tiffany Amariuta; Nikola Teslovich; Deepak A. Rao; Joerg Ermann; A. Helena Jonsson et al.
Source: check_circle
Crossref

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

2020-02-28 | Preprint
DOI: 10.1101/2020.02.27.967497
Contributors: Kristi Krebs; Jonas Bovijn; Maarja Lepamets; Jenny C Censin; Tuuli Jürgenson; Dage Särg; Yang Luo; Line Skotte; Frank Geller; Bjarke Feenstra et al.
Source: check_circle
Crossref

Population-specific causal disease effect sizes in functionally important regions impacted by selection

2019-10-15 | Other
DOI: 10.1101/803452
Contributors: Huwenbo Shi; Steven Gazal; Masahiro Kanai; Evan M. Koch; Armin P. Schoech; Katherine M. Siewert; Samuel S. Kim; Yang Luo; Tiffany Amariuta; Hailiang Huang et al.
Source: check_circle
Crossref

Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians

Nature Communications
2019-08-21 | Journal article
DOI: 10.1038/s41467-019-11664-1
Contributors: Yang Luo; Sara Suliman; Samira Asgari; Tiffany Amariuta; Yuriy Baglaenko; Marta Martínez-Bonet; Kazuyoshi Ishigaki; Maria Gutierrez-Arcelus; Roger Calderon; Leonid Lecca et al.
Source: check_circle
Crossref

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

2019-04-04 | Other
DOI: 10.1101/599449
Contributors: Maria Gutierrez-Arcelus; Yuriy Baglaenko; Jatin Arora; Susan Hannes; Yang Luo; Tiffany Amariuta; Nikola Teslovich; Deepak A. Rao; Joerg Ermann; Helena Jonsson et al.
Source: check_circle
Crossref

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

2018-12-20 | Other
DOI: 10.1101/503144
Contributors: Yang Luo; Xinyi Li; Xin Wang; Steven Gazal; Josep Maria Mercader; Benjamin M. Neale; Jose C. Florez; Adam Auton; Alkes L. Price; Hilary K. Finucane et al.
Source: check_circle
Crossref

Progression of recent Mycobacterium tuberculosis exposure to active tuberculosis is a highly heritable complex trait driven by 3q23 in Peruvians

2018-08-28 | Other
DOI: 10.1101/401984
Contributors: Yang Luo; Sara Suliman; Samira Asgari; Tiffany Amariuta; Roger Calderon; Leonid Lecca; Segundo R. León; Judith Jimenez; Rosa Yataco; Carmen Contreras et al.
Source: check_circle
Crossref

IMPACT: Genomic annotation of cell-state-specific regulatory elements inferred from the epigenome of bound transcription factors

2018-07-10 | Other
DOI: 10.1101/366864
Contributors: Tiffany Amariuta; Yang Luo; Steven Gazal; Emma E. Davenport; Bryce van de Geijn; Harm-Jan Westra; Nikola Teslovich; Yukinori Okada; Kazuhiko Yamamoto; Alkes Price et al.
Source: check_circle
Crossref

Fine-mapping identifies causal variants for RA and T1D in DNASE1L3, SIRPG, MEG3, TNFAIP3 and CD28/CTLA4 loci

2017-06 | Other
DOI: 10.1101/151423
Contributors: Harm-Jan Westra; Marta Martinez Bonet; Suna Onengut; Annette Lee; Yang Luo; Nikola Teslovich; Jane Worthington; Javier Martin; Tom Huizinga; Lars Klareskog et al.
Source: Self-asserted source
Yang Luo via Crossref Metadata Search

OP001 Whole genome sequencing and imputation in inflammatory bowel disease identifies 26 novel loci and offers therapeutically-relevant mechanistic insights

Journal of Crohn's and Colitis
2017-01 | Journal article
DOI: 10.1093/ecco-jcc/jjx002.000
Part of ISSN: 1873-9946
Contributors: L. Moutsianas; K. De Lange; Y. Luo; J. Lee; L. Jostins; C. Lamb; N. Kennedy; J. Mansfield; M. Parkes; J. Barrett et al.
Source: Self-asserted source
Yang Luo via Crossref Metadata Search

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

Nature Genetics
2017-01-09 | Journal article
DOI: 10.1038/ng.3761
Part of ISSN: 1061-4036
Contributors: Yang Luo; Katrina M de Lange; Luke Jostins; Loukas Moutsianas; Joshua Randall; Nicholas A Kennedy; Christopher A Lamb; Shane McCarthy; Tariq Ahmad; Cathryn Edwards et al.
Source: Self-asserted source
Yang Luo via Crossref Metadata Search

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

Nature Genetics
2017-01-09 | Journal article
DOI: 10.1038/ng.3760
Part of ISSN: 1061-4036
Contributors: Katrina M de Lange; Loukas Moutsianas; James C Lee; Christopher A Lamb; Yang Luo; Nicholas A Kennedy; Luke Jostins; Daniel L Rice; Javier Gutierrez-Achury; Sun-Gou Ji et al.
Source: Self-asserted source
Yang Luo via Crossref Metadata Search

Intra-host dynamics of Ebola virus during 2014

Nature Microbiology
2016-09-05 | Journal article
DOI: 10.1038/nmicrobiol.2016.151
Part of ISSN: 2058-5276
Contributors: Ming Ni; Chen Chen; Jun Qian; Hai-Xia Xiao; Wei-Feng Shi; Yang Luo; Hai-Yin Wang; Zhen Li; Jun Wu; Pei-Song Xu et al.
Source: Self-asserted source
Yang Luo via Crossref Metadata Search

A reference panel of 64,976 haplotypes for genotype imputation

Nature Genetics
2016-08 | Journal article
DOI: 10.1038/ng.3643
Part of ISSN: 1061-4036
Contributors: the Haplotype Reference Consortium
Source: Self-asserted source
Yang Luo via Crossref Metadata Search

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

2016-06-10 | Other
DOI: 10.1101/058255
Contributors: Katrina M de Lange; Loukas Moutsianas; James C Lee; Christopher A Lamb; Yang Luo; Nicholas A Kennedy; Luke Jostins; Daniel L Rice; Javier Gutierrez-Achury; Sun-Gou Ji et al.
Source: Self-asserted source
Yang Luo via Crossref Metadata Search

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A Mendelian randomisation analysis

The Lancet Diabetes and Endocrinology
2015 | Journal article
DOI: 10.1016/S2213-8587(15)00034-0
EID:

2-s2.0-84925298675
Contributors: Freitag, D.; Butterworth, A.S.; Willeit, P.; Howson, J.M.M.; Burgess, S.; Kaptoge, S.; Young, R.; Ho, W.K.; Wood, A.M.; Sweeting, M. et al.
Source: Self-asserted source
Yang Luo via Scopus - Elsevier

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

Nature Genetics
2015 | Journal article
DOI: 10.1038/ng.3248
EID:

2-s2.0-84925651848
Contributors: Curtis, J.; Luo, Y.; Zenner, H.L.; Cuchet-Lourenço, D.; Wu, C.; Lo, K.; Maes, M.; Alisaac, A.; Stebbings, E.; Liu, J.Z. et al.
Source: Self-asserted source
Yang Luo via Scopus - Elsevier
How many people are using ORCID?