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Employment (5)

National Science Foundation: Alexandria, Virginia, US

2024-09-09 to present | AD (Lead) - Mathematical & Phys Sci Directorate
Employment
Source: Self-asserted source
David B. Berkowitz

University of Nebraska–Lincoln: Lincoln, US

2024-08-19 to present | Elmer H. & Ruby M. Cordes Professor (Department of Chemistry)
Employment
Source: Self-asserted source
David B. Berkowitz

University of Nebraska-Lincoln: Lincoln, NE, US

2024-08-18 | Willa Cather Professor (Chemistry)
Employment
Source: Self-asserted source
David B. Berkowitz

National Science Foundation: Alexandria, Virginia, US

2020-05-28 to 2024-05-22 | Director (Division of Chemistry)
Employment
Source: Self-asserted source
David B. Berkowitz

Yale University: New Haven, CT, US

1990 to 1991 | Merck Postdoctoral Fellow (Chemistry)
Employment
Source: Self-asserted source
David B. Berkowitz

Education and qualifications (3)

University of Chicago: Chicago, IL, US

BS (Chemistry)
Education
Source: Self-asserted source
David B. Berkowitz

Harvard University: Cambridge, MA, US

PhD (Chemistry)
Education
Source: Self-asserted source
David B. Berkowitz

Eidgenössische Technische Hochschule Zürich: Zurich, ZH, CH

Visiting Scholar (Organische Chemie/Chemische Biologie)
Education
Source: Self-asserted source
David B. Berkowitz

Professional activities (5)

Alfred P. Sloan Foundation: NY, NY, US

Alfred P. Sloan Fellow
Distinction
Source: Self-asserted source
David B. Berkowitz

Université Paris Descartes: Paris, FR

2016 to 2016 | Visiting Professor
Invited position
Source: Self-asserted source
David B. Berkowitz

American Association For The Advancement of Science: Washington D.C., District of Columbia, US

2015 | AAAS Fellow (Chemistry)
Distinction
Source: Self-asserted source
David B. Berkowitz

Japan Society for the Promotion of Science: Tokyo, JP

2008 | JSPS Fellow
Distinction
Source: Self-asserted source
David B. Berkowitz

Max-Planck-Institut für molekulare Physiologie: Dortmund, Nordrhein-Westfalen, DE

2006 to 2006 | Visiting Professor
Invited position
Source: Self-asserted source
David B. Berkowitz

Works (50 of 84)

Items per page:
Page 1 of 2

Exploiting Archaeal/Thermostable Enzymes in Synthetic Chemistry: Back to the Future?

ChemCatChem
2024-07-08 | Journal article
DOI: 10.1002/cctc.202400835
Part of ISSN: 1867-3880
Part of ISSN: 1867-3899
Contributors: David B. Berkowitz; Gaurav P. Kudalkar; Virendra Tiwari
Source: Self-asserted source
David B. Berkowitz

Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography

Science Advances
2024-03-29 | Journal article
DOI: 10.1126/sciadv.adk7201
Part of ISSN: 2375-2548
Contributors: Nathan; Medhanjali Dasgupta; David C. Wych; Cole Dolamore; Raymond G. Sierra; Stella Lisova; Darya Marchany-Rivera; Aina Cohen; Sebastien Boutet; Mark S. Hunter et al.
Source: Self-asserted source
David B. Berkowitz

Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography

2023-08-16 | Preprint | Author
DOI: 10.1101/2023.08.15.553460
Contributors: Nathan; Dr. Medhanjali Dasgupta; David Wych; Coleman Dolamore; Raymond G. Sierra; Stella Lisova; Darya Marchany-Rivera; Aina Cohen; Sebastien Boutet; Mark Hunter et al.
Source: Self-asserted source
David B. Berkowitz

Information-Rich, Dual-Function <sup>13</sup>C/<sup>2</sup>H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme “Partitioning Fingerprint” and Reveals Disparate Chemotypes for hSR Inhibition

Journal of the American Chemical Society
2023-01-25 | Journal article | Author
DOI: 10.1021/jacs.2c12774
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Contributors: Stephany Ramos De Dios; Jared Hass; Danielle Graham; Nivesh Kumar; Aina Antony; Martha D. Morton; David B. Berkowitz
Source: Self-asserted source
David B. Berkowitz

A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures

Radiation Research
2022-11-11 | Journal article
DOI: 10.1667/rade-21-00187.1
Part of ISSN: 0033-7587
Contributors: Sushil K. Shakyawar; Nitish K. Mishra; Neetha N. Vellichirammal; Lynnette Cary; Tomáš Helikar; Robert Powers; Rebecca E. Oberley-Deegan; David B. Berkowitz; Kenneth W. Bayles; Vijay K. Singh et al.
Source: Self-asserted source
David B. Berkowitz

Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization

Chemical Reviews
2022-08-24 | Journal article
DOI: 10.1021/acs.chemrev.2c00213
Part of ISSN: 0009-2665
Part of ISSN: 1520-6890
Contributors: David B. Berkowitz
Source: Self-asserted source
David B. Berkowitz

Rapid Enantioselective and Diastereoconvergent Hybrid Organic/Biocatalytic Entry into the Oseltamivir Core.

The Journal of organic chemistry
2021-04-15 | Journal article
DOI: 10.1021/acs.joc.1c00326
PMID: 33857378
Source: Self-asserted source
David B. Berkowitz

Author Correction: Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome.

Scientific reports
2021-03-23 | Journal article
DOI: 10.1038/s41598-021-86614-3
PMID: 33758302
PMC: PMC7988132
Source: Self-asserted source
David B. Berkowitz

Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome.

Scientific reports
2021-03-10 | Journal article
DOI: 10.1038/s41598-021-85044-5
PMID: 33692493
PMC: PMC7946886
Source: Self-asserted source
David B. Berkowitz

A Hammett Study of Clostridium acetobutylicum Alcohol Dehydrogenase (CaADH): An Enzyme with Remarkable Substrate Promiscuity and Utility for Organic Synthesis

Synlett
2020-02 | Journal article
DOI: 10.1055/s-0039-1691576
Part of ISSN: 0936-5214
Part of ISSN: 1437-2096
Contributors: Gaurav P. Kudalkar; Virendra K. Tiwari; Joshua D. Lee; David B. Berkowitz
Source: Self-asserted source
David B. Berkowitz

Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis.

Proceedings of the National Academy of Sciences of the United States of America
2019-12-04 | Journal article
DOI: 10.1073/pnas.1901864116
PMID: 31801874
PMC: PMC6926069
Source: Self-asserted source
David B. Berkowitz

Rapid Entry into Biologically Relevant α,α-Difluoroalkylphosphonates Bearing Allyl Protection-Deblocking under Ru(II)/(IV)-Catalysis.

Organic letters
2019-12-02 | Journal article
DOI: 10.1021/acs.orglett.9b03707
PMID: 31789041
Source: Self-asserted source
David B. Berkowitz

Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.

Frontiers in molecular biosciences
2019-03-13 | Journal article
DOI: 10.3389/fmolb.2019.00008
PMID: 30918891
PMC: PMC6424897
Source: Self-asserted source
David B. Berkowitz

Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.

Biochemistry
2018-04-13 | Journal article
DOI: 10.1021/acs.biochem.8b00092
PMID: 29630349
PMC: PMC6496941
Source: Self-asserted source
David B. Berkowitz
grade
Preferred source (of 2)‎

The In Situ Enzymatic Screening (ISES) Approach to Reaction Discovery and Catalyst Identification.

Current protocols in chemical biology
2017-12-14 | Journal article
DOI: 10.1002/cpch.30
PMID: 29241292
PMC: PMC5734113
Source: Self-asserted source
David B. Berkowitz

A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C-SCN and C-C bond formation.

Chemical science
2017-10-03 | Journal article
DOI: 10.1039/c7sc04083k
PMID: 29568453
PMC: PMC5855125
Source: Self-asserted source
David B. Berkowitz

Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.

Journal of the American Chemical Society
2017-09-28 | Journal article
DOI: 10.1021/jacs.7b04690
PMID: 28906111
PMC: PMC6052324
Source: Self-asserted source
David B. Berkowitz

General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor.

Organic letters
2017-07-28 | Journal article
DOI: 10.1021/acs.orglett.7b01914
PMID: 28753028
PMC: PMC6208139
Source: Self-asserted source
David B. Berkowitz

Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.

The Journal of biological chemistry
2017-07-10 | Journal article
DOI: 10.1074/jbc.m117.777904
PMID: 28696262
PMC: PMC5572919
Source: Self-asserted source
David B. Berkowitz

"Zipped Synthesis" by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model.

ACS central science
2016-03-09 | Journal article
DOI: 10.1021/acscentsci.6b00019
PMID: 27163055
PMC: PMC4850510
Source: Self-asserted source
David B. Berkowitz

Mini-ISES identifies promising carbafructopyranose-based salens for asymmetric catalysis: Tuning ligand shape via the anomeric effect.

Science advances
2015-07-10 | Journal article
DOI: 10.1126/sciadv.1500066
PMID: 26501130
PMC: PMC4613784
Source: Self-asserted source
David B. Berkowitz

A useful methoxyvinyl cation equivalent: α-t-butyldimethylsilyl-α-methoxyacetaldehyde.

Tetrahedron letters
2015-06-01 | Journal article
DOI: 10.1016/j.tetlet.2015.02.122
PMID: 26028786
PMC: PMC4445900
Source: Self-asserted source
David B. Berkowitz

Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.

Advanced synthesis & catalysis
2015-05-12 | Journal article
DOI: 10.1002/adsc.201500316
PMID: 26622223
PMC: PMC4662550
Source: Self-asserted source
David B. Berkowitz

Combining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biology.

Journal of the American Chemical Society
2015-03-05 | Journal article
DOI: 10.1021/jacs.5b00022
PMID: 25719907
PMC: PMC4883101
Source: Self-asserted source
David B. Berkowitz

Phosphatase-inert glucosamine 6-phosphate mimics serve as actuators of the glmS riboswitch.

ACS chemical biology
2014-10-27 | Journal article
DOI: 10.1021/cb500458f
PMID: 25254431
PMC: PMC4273988
Source: Self-asserted source
David B. Berkowitz

Unleashing a "true" pSer-mimic in the cell.

Chemistry & biology
2012-06-01 | Journal article
DOI: 10.1016/j.chembiol.2012.06.005
PMID: 22726679
PMC: PMC4688326
Source: Self-asserted source
David B. Berkowitz

Halocarbocyclization entry into the oxabicyclo[4.3.1]decyl exomethylene-δ-lactone cores of linearifolin and zaluzanin A: exploiting combinatorial catalysis.

Organic letters
2012-02-08 | Journal article
DOI: 10.1021/ol203088g
PMID: 22316136
PMC: PMC3289138
Source: Self-asserted source
David B. Berkowitz
grade
Preferred source (of 2)‎

Combinatorial catalysis employing a visible enzymatic beacon in real time: synthetically versatile (pseudo)halometalation/carbocyclizations.

Angewandte Chemie (International ed. in English)
2011-08-16 | Journal article
DOI: 10.1002/anie.201103365
PMID: 21905180
PMC: PMC3517167
Source: Self-asserted source
David B. Berkowitz

A new dehydrogenase from Clostridium acetobutylicum for asymmetric synthesis: dynamic reductive kinetic resolution entry into the Taxotère side chain.

Chemical communications (Cambridge, England)
2010-12-20 | Journal article
DOI: 10.1039/c0cc04585c
PMID: 21173953
PMC: PMC4882475
Source: Self-asserted source
David B. Berkowitz

Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (S)-profens.

Journal of the American Chemical Society
2010-05-01 | Journal article
DOI: 10.1021/ja910778p
PMID: 20377222
PMC: PMC2869291
Source: Self-asserted source
David B. Berkowitz

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes.

Proceedings of the National Academy of Sciences of the United States of America
2010-02-17 | Journal article
DOI: 10.1073/pnas.0910333106
PMID: 20164409
PMC: PMC2842025
Source: Self-asserted source
David B. Berkowitz

The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.

Chemistry & biology
2009-09-01 | Journal article
DOI: 10.1016/j.chembiol.2009.08.008
PMID: 19778720
PMC: PMC2766077
Source: Self-asserted source
David B. Berkowitz

Enantioselective, ketoreductase-based entry into pharmaceutical building blocks: ethanol as tunable nicotinamide reductant.

Organic letters
2009-01-01 | Journal article
DOI: 10.1021/ol802464g
PMID: 19128188
PMC: PMC6027600
Source: Self-asserted source
David B. Berkowitz

Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical Advantages.

Journal of fluorine chemistry
2008-09-01 | Journal article
DOI: 10.1016/j.jfluchem.2008.05.016
PMID: 19727327
PMC: PMC2598403
Source: Self-asserted source
David B. Berkowitz

A set of phosphatase-inert "molecular rulers" to probe for bivalent mannose 6-phosphate ligand-receptor interactions.

Bioorganic & medicinal chemistry letters
2007-11-28 | Journal article
DOI: 10.1016/j.bmcl.2007.11.094
PMID: 18068981
PMC: PMC2862223
Source: Self-asserted source
David B. Berkowitz

Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

Biochemistry
2007-06-20 | Journal article
DOI: 10.1021/bi700272u
PMID: 17580961
PMC: PMC2888091
Source: Self-asserted source
David B. Berkowitz

"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides.

Angewandte Chemie (International ed. in English)
2007-01-01 | Journal article
DOI: 10.1002/anie.200701280
PMID: 17702083
PMC: PMC6112158
Source: Self-asserted source
David B. Berkowitz

Examination of the new alpha-(2'Z-fluoro)vinyl trigger with lysine decarboxylase: the absolute stereochemistry dictates the reaction course.

Journal of the American Chemical Society
2007-01-01 | Journal article
DOI: 10.1021/ja067240k
PMID: 17212389
PMC: PMC2562574
Source: Self-asserted source
David B. Berkowitz

Protein structure similarity clustering: dynamic treatment of PDB structures facilitates clustering.

Angewandte Chemie (International ed. in English)
2006-11-01 | Journal article
DOI: 10.1002/anie.200602125
PMID: 17075950
Source: Self-asserted source
David B. Berkowitz

Insulin-like growth factor type 1 receptor activity promotes survival and inhibits glutamate-induced excitotoxicity of cortical neurons

Brain, Behavior, and Immunity
2006-05 | Journal article
DOI: 10.1016/j.bbi.2006.04.091
Part of ISSN: 0889-1591
Contributors: Robert H. McCusker; Klemen Strle; Robert Dantzer; Samantha M. Zunich; Suzanne R. Broussard; Sungjo Choi; David B. Berkowitz; Keith W. Kelley
Source: Self-asserted source
David B. Berkowitz

A formal [3,3]-sigmatropic rearrangement route to quaternary alpha-vinyl amino acids: use of allylic N-PMP trifluoroacetimidates.

Organic letters
2006-03-01 | Journal article
DOI: 10.1021/ol060019s
PMID: 16494487
PMC: PMC2504469
Source: Self-asserted source
David B. Berkowitz

α-Vinylic Amino Acids: Occurrence, Asymmetric Synthesis and Biochemical Mechanisms.

Tetrahedron, asymmetry
2006-03-01 | Journal article
DOI: 10.1016/j.tetasy.2006.02.026
PMID: 29977107
PMC: PMC6029878
Source: Self-asserted source
David B. Berkowitz

A continuous spectrophotometric assay for human cystathionine beta-synthase.

Analytical biochemistry
2005-07-01 | Journal article
DOI: 10.1016/j.ab.2005.03.051
PMID: 15958186
PMC: PMC6064648
Source: Self-asserted source
David B. Berkowitz

Double-cuvette ISES: in situ estimation of enantioselectivity and relative rate for catalyst screening.

Journal of the American Chemical Society
2005-06-01 | Journal article
DOI: 10.1021/ja052010b
PMID: 15954763
Source: Self-asserted source
David B. Berkowitz

Mono- and bivalent ligands bearing mannose 6-phosphate (M6P) surrogates: targeting the M6P/insulin-like growth factor II receptor.

Organic letters
2004-12-01 | Journal article
DOI: 10.1021/ol0479444
PMID: 15606100
Source: Self-asserted source
David B. Berkowitz

In situ enzymatic screening (ISES) of P,N-ligands for Ni(0)-mediated asymmetric intramolecular allylic amination.

Tetrahedron, asymmetry
2004-09-13 | Journal article
DOI: 10.1016/j.tetasy.2004.06.052
PMID: 30147246
PMC: PMC6107308
Source: Self-asserted source
David B. Berkowitz

Following an ISES lead: the first examples of asymmetric Ni(0)-mediated allylic amination.

Organic letters
2004-08-01 | Journal article
DOI: 10.1021/ol049159x
PMID: 15281738
PMC: PMC6080629
Source: Self-asserted source
David B. Berkowitz

Synthesis of quaternary amino acids bearing a (2'Z)-fluorovinyl alpha-branch: potential PLP enzyme inactivators.

Organic letters
2004-05-01 | Journal article
DOI: 10.1021/ol049422u
PMID: 15151423
PMC: PMC5575781
Source: Self-asserted source
David B. Berkowitz

Structure-activity analysis of guanidine group in agmatine for brain agmatinase.

Annals of the New York Academy of Sciences
2003-12-01 | Journal article
DOI: 10.1196/annals.1304.006
PMID: 15028570
Source: Self-asserted source
David B. Berkowitz

In situ enzymatic screening (ISES): a tool for catalyst discovery and reaction development.

Angewandte Chemie (International ed. in English)
2002-05-01 | Journal article
DOI: 10.1002/1521-3773(20020503)41:9<1603::aid-anie1603>3.0.co;2-d
PMID: 19750680
PMC: PMC6076430
Source: Self-asserted source
David B. Berkowitz
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