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Biography

Dr Chioma Izzi-Engbeaya is a Clinical Academic in the Section of Endocrinology and Investigative Medicine and a Consultant Endocrinologist at Imperial College Healthcare NHS Trust. Her research and clinical interests include assessing the hormonal interactions between metabolic and reproductive systems, as well as investigating the management of obesity and obesity-related co-morbidities.

Dr Izzi-Engbeaya completed her undergraduate medical training at Guy’s Kings and St Thomas’ Medical School in 2004. During this time she also completed an Intercalated BSc in Endocrinology. Her junior doctor training posts were undertaken at various London NHS Trusts including Guy’s and St Thomas’ NHS Trust and Imperial College Healthcare NHS Trust. She became an NIHR Academic Clinical Fellow during her training as a Diabetes and Endocrinology Registrar and was subsequently awarded a 1-year Imperial Health Charity Fellowship, followed by an MRC Clinical Research Training PhD Fellowship in 2014. She completed her PhD (investigating the neuroendocrine control of metabolism and reproduction) with Professor Waljit Dhillo and Dr James Gardiner in 2018. In 2019, she was awarded an Imperial College-BRC funded IPPRF Clinical Research Fellowship, during which she investigated the impact of reproductive hormones on metabolic conditions. In 2024, she was awarded an NIHR Senior Clinical and Practitioner Research Award, and continues to undertake translational and clinical research.

Alongside her research and clinical work, Dr Izzi-Engbeaya is actively involved in education and training. In 2020, she was appointed the Academic Lead for the Implementation of the BMA Charter, and from 2021-2024 she was the Director of Equality, Diversity and Inclusivity in Imperial College School of Medicine. In addition, Dr Izzi-Engbeaya is the Pathway Director of the Pharmacology Intercalated BSc (Imperial College School of Medicine) and the Deputy Director of the Clinical Academic Training Office (Imperial College Academic Health Science Centre).

Activities

Works (50 of 53)

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Commentary: ‘Diversity of invited speakers at endocrinology conferences’

Clinical Endocrinology
2024-01 | Journal article
Contributors: Chioma Izzi‐Engbeaya; Victoria Salem
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Crossref

Brown adipose tissue and regulation of human body weight

Diabetes/Metabolism Research and Reviews
2023-01 | Journal article
Contributors: Elissa Harb; Omar Kheder; Gishani Poopalasingam; Razi Rashid; Akash Srinivasan; Chioma Izzi‐Engbeaya
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Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men.

Frontiers in endocrinology
2022-11 | Journal article
Contributors: Abbara A; Koysombat K; Phylactou M; Eng PC; Clarke S; Comninos AN; Yang L; Izzi-Engbeaya C; Hanassab S; Smith N et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

The acute effect of glucagon on components of energy balance and glucose homoeostasis in adults without diabetes: a systematic review and meta-analysis.

International journal of obesity (2005)
2022-09 | Journal article
Contributors: Frampton J; Izzi-Engbeaya C; Salem V; Murphy KG; Tan TM; Chambers ES
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Gut hormones and reproduction

Annales d'Endocrinologie
2022-08 | Journal article
Contributors: Chioma Izzi-Engbeaya; Waljit S. Dhillo
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Crossref

Letter to the editor of clinical endocrinology: Assessment of adrenal function in patients who survive COVID-19.

Clinical endocrinology
2022-08 | Journal article
Contributors: Clarke SA; Phylactou M; Patel B; Mills EG; Muzi B; Izzi-Engbeaya C; Choudhury S; Khoo B; Meeran K; Comninos AN et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model.

The Journal of clinical investigation
2022-05 | Journal article
Contributors: Guzman S; Dragan M; Kwon H; de Oliveira V; Rao S; Bhatt V; Kalemba KM; Shah A; Rustgi VK; Wang H et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

The benefit of dexamethasone in patients with COVID-19 infection is preserved in patients with diabetes.

Diabetes, obesity & metabolism
2022-04 | Journal article
Contributors: Eng PC; Distaso W; Durreshahwar H; Shaikhali Y; Narendranathan D; Cassin-Scott R; Misra S; Hill NE; Tharakan G; Oliver NS et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Emerging roles for kisspeptin in metabolism

The Journal of Physiology
2022-03 | Journal article
Contributors: Chioma Izzi‐Engbeaya; Waljit S. Dhillo
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Crossref

Preserved C‐peptide in survivors of COVID‐19: Post hoc analysis

Diabetes, Obesity and Metabolism
2022-03 | Journal article
Contributors: Sophie A. Clarke; Maria Phylactou; Bijal Patel; Edouard G. Mills; Beatrice Muzi; Chioma Izzi‐Engbeaya; Bernard Khoo; Karim Meeran; Alexander N. Comninos; Ali Abbara et al.
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Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications

The Journal of Clinical Endocrinology & Metabolism
2022-01-01 | Journal article
Contributors: Ali Abbara; Maya Al-Memar; Maria Phylactou; Elisabeth Daniels; Bijal Patel; Pei C Eng; Rans Nadir; Chioma Izzi-Engbeaya; Sophie A Clarke; Edouard G Mills et al.
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Crossref

Normal Adrenal and Thyroid Function in Patients Who Survive COVID-19 Infection

The Journal of Clinical Endocrinology & Metabolism
2021-07-13 | Journal article
Contributors: Sophie A Clarke; Maria Phylactou; Bijal Patel; Edouard G Mills; Beatrice Muzi; Chioma Izzi-Engbeaya; Sirazum Choudhury; Bernard Khoo; Karim Meeran; Alexander N Comninos et al.
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Crossref

Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester.

Fertility and sterility
2021-05 | Journal article
Contributors: Abbara A; Al-Memar M; Phylactou M; Kyriacou C; Eng PC; Nadir R; Izzi-Engbeaya C; Clarke SA; Mills EG; Daniels E et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Adverse outcomes in COVID-19 and diabetes: a retrospective cohort study from three London teaching hospitals

BMJ Open Diabetes Research & Care
2021-01 | Journal article
Contributors: Chioma Izzi-Engbeaya; Walter Distaso; Anjali Amin; Wei Yang; Oluwagbemiga Idowu; Julia S Kenkre; Ronak J Shah; Evelina Woin; Christine Shi; Nael Alavi et al.
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Representing the Metabolome with High Fidelity: Range and Response as Quality Control Factors in LC-MS-Based Global Profiling.

Analytical chemistry
2021-01 | Journal article
Contributors: Sands CJ; Gómez-Romero M; Correia G; Chekmeneva E; Camuzeaux S; Izzi-Engbeaya C; Dhillo WS; Takats Z; Lewis MR
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour.

Nature reviews. Endocrinology
2020-12 | Journal article
Contributors: Mills EG; Izzi-Engbeaya C; Abbara A; Comninos AN; Dhillo WS
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism.

Neuroendocrinology
2020-11 | Journal article
Contributors: Abbara A; Eng PC; Phylactou M; Clarke SA; Mills E; Chia G; Yang L; Izzi-Engbeaya C; Smith N; Jayasena CN et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders

Journal of Clinical Investigation
2020-11-16 | Journal article
Contributors: Ali Abbara; Pei Chia Eng; Maria Phylactou; Sophie A. Clarke; Rachel Richardson; Charlene M. Sykes; Chayarndorn Phumsatitpong; Edouard Mills; Manish Modi; Chioma Izzi-Engbeaya et al.
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Endocrine Requirements for Oocyte Maturation Following hCG, GnRH Agonist, and Kisspeptin During IVF Treatment.

Frontiers in endocrinology
2020-10 | Journal article
Contributors: Abbara A; Hunjan T; Ho VNA; Clarke SA; Comninos AN; Izzi-Engbeaya C; Ho TM; Trew GH; Hramyka A; Kelsey T et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Using Aptamers as a Novel Method for Determining GnRH/LH Pulsatility

International Journal of Molecular Sciences
2020-10-07 | Journal article
Contributors: Chioma Izzi-Engbeaya; Ali Abbara; Anthony Cass; Waljit Dhillo
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Crossref

Severe COVID-19 and Diabetes - A Retrospective Cohort Study from Three London Teaching Hospitals

2020-08-11 | Other
Contributors: Chioma Izzi-Engbeaya; Walter Distaso; Anjali Amin; Wei Yang; Oluwagbemiga Idowu; Julia S Kenkre; Ronak J Shah; Evelina Woin; Christine Shi; Nael Alavi et al.
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Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men

The Journal of Clinical Endocrinology & Metabolism
2020-06-01 | Journal article
Contributors: Chioma Izzi-Engbeaya; Sophie Jones; Yoshibye Crustna; Pratibha C Machenahalli; Deborah Papadopoulou; Manish Modi; Jessica Starikova; Derek Chan; Pei Chia Eng; Maria Phylactou et al.
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Crossref

OR20-06 Kisspeptin as a Biomarker for Pregnancy Complications

Journal of the Endocrine Society
2020-05 | Journal article
Contributors: Phylactou M; Abbara A; Al-Memar M; Eng P; Comninos A; Izzi-Engbeaya C; Clarke S; Mills E; Nadir R; Sykes M et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Pharmacodynamic Response to Anti-thyroid Drugs in Graves' Hyperthyroidism.

Frontiers in endocrinology
2020-05 | Journal article
Contributors: Abbara A; Clarke SA; Brewster R; Simonnard A; Eng PC; Phylactou M; Papadopoulou D; Izzi-Engbeaya C; Sam AH; Wernig F et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release

JCI Insight
2020-04-23 | Journal article
Contributors: Yue Ma; Risheka Ratnasabapathy; Ivan De Backer; Chioma Izzi-Engbeaya; Marie-Sophie Nguyen-Tu; Joyceline Cuenco; Ben Jones; Christopher D. John; Brian Y.H. Lam; Guy A. Rutter et al.
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Effects of Glucagon-like Peptide-1 on the Reproductive Axis in Healthy Men

The Journal of Clinical Endocrinology & Metabolism
2020-04-01 | Journal article
Contributors: Chioma Izzi-Engbeaya; Sophie Jones; Yoshibye Crustna; Pratibha C Machenahalli; Deborah Papadopoulou; Manish Modi; Christos Panayi; Jessica Starikova; Pei Chia Eng; Maria Phylactou et al.
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Effects of corticosterone within the hypothalamic arcuate nucleus on food intake and body weight in male rats

Molecular Metabolism
2020-03 | Journal article
Contributors: Chioma Izzi-Engbeaya; Yue Ma; Niki W. Buckley; Risheka Ratnasabapathy; Errol Richardson; John R. Counsell; Isabel Fernandes-Freitas; Mariana Norton; Gala Farooq; Zainab Mirza et al.
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Effects of Peptide YY on the Hypothalamic-Pituitary-Gonadal Axis in Healthy Men

The Journal of Clinical Endocrinology & Metabolism
2020-03-01 | Journal article
Contributors: Chioma Izzi-Engbeaya; Sophie Jones; Yoshibye Crustna; Pratibha C Machenahalli; Deborah Papadopoulou; Manish Modi; Christos Panayi; Jessica Starikova; Pei Chia Eng; Maria Phylactou et al.
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Kisspeptin and Glucose Homeostasis.

Seminars in reproductive medicine
2019-05 | Journal article
Contributors: Izzi-Engbeaya C; Hill TG; Bowe JE
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

OR32-3 Kisspeptin- a Novel Clinical Test of Hypothalamic Function in Men with Hypogonadotrophic Hypogonadism

Journal of the Endocrine Society
2019-04 | Journal article
Contributors: Phylactou M; Abbara A; Eng P; Clarke S; Mills E; Koteshwara M; Chia G; Yang L; Machenahalli P; Papadopoulou D et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

OR33-4 A Single Subcutaneous Injection Of The Kisspeptin Analogue, MVT-602, Induces A More Prolonged LH Surge Compared With Kisspeptin-54 In Healthy Women

Journal of the Endocrine Society
2019-04 | Journal article
Contributors: Clarke S; Abbara A; Eng P; Phylactou M; Chia G; Yang L; Prague J; Muralidhara K; Papadopoulou D; Mills E et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

SUN-112 Arcuate 11-Betahydroxysteroid Dehydrogenase Type1 Regulates Energy Homeostasis

Journal of the Endocrine Society
2019-04 | Journal article
Contributors: Izzi-Engbeaya C; Ma Y; Buckley N; Ratnasabapathy R; Richardson E; Counsell J; Fernandes-Freitas I; Norton M; Farooq G; Mirza Z et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

SUN-LB044 Effects of Glucagon-Like Peptide-1 (GLP-1) on the Hypothalamic-Pituitary-Gonadal Axis in Healthy Men

Journal of the Endocrine Society
2019-04 | Journal article
Contributors: Izzi-Engbeaya C; Jones S; Crustna Y; Machenahalli P; Papadopoulou D; Modi M; Panayi C; Starikova J; Eng P; Phylactou M et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans

Diabetes, Obesity and Metabolism
2018-12 | Journal article
Contributors: Chioma Izzi‐Engbeaya; Alexander N. Comninos; Sophie A. Clarke; Anne Jomard; Lisa Yang; Sophie Jones; Ali Abbara; Shakunthala Narayanaswamy; Pei Chia Eng; Deborah Papadopoulou et al.
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Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions

JCI Insight
2018-10-18 | Journal article
Contributors: Alexander N. Comninos; Lysia Demetriou; Matthew B. Wall; Amar J. Shah; Sophie A. Clarke; Shakunthala Narayanaswamy; Alexander Nesbitt; Chioma Izzi-Engbeaya; Julia K. Prague; Ali Abbara et al.
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Crossref

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis

Diabetes, Obesity and Metabolism
2018-09 | Journal article
Contributors: Yue Ma; Risheka Ratnasabapathy; Chioma Izzi‐Engbeaya; Marie‐Sophie Nguyen‐Tu; Errol Richardson; Sufyan Hussain; Ivan De Backer; Christopher Holton; Mariana Norton; Gaelle Carrat et al.
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Crossref

Hypothalamic Response to Kisspeptin-54 and Pituitary Response to Gonadotropin-Releasing Hormone Are Preserved in Healthy Older Men.

Neuroendocrinology
2018-03 | Journal article
Contributors: Abbara A; Narayanaswamy S; Izzi-Engbeaya C; Comninos AN; Clarke SA; Malik Z; Papadopoulou D; Clobentz A; Sarang Z; Bassett P et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Reply: Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.

Human reproduction (Oxford, England)
2018-02 | Journal article
Contributors: Abbara A; Clarke S; Islam R; Prague JK; Comninos A; Narayanaswamy S; Papadopoulou DA; Roberts RE; Izzi-Engbeaya CN; Ratnasabapathy R et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.

Human reproduction (Oxford, England)
2017-09 | Journal article
Contributors: Abbara A; Clarke S; Islam R; Prague JK; Comninos AN; Narayanaswamy S; Papadopoulou D; Roberts R; Izzi-Engbeaya C; Ratnasabapathy R et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2017-09 | Journal article
Contributors: Law J; Morris DE; Izzi-Engbeaya C; Salem V; Coello C; Robinson L; Jayasinghe M; Scott R; Gunn R; Rabiner E et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Kisspeptin modulates sexual and emotional brain processing in humans.

The Journal of clinical investigation
2017-01 | Journal article
Contributors: Comninos AN; Wall MB; Demetriou L; Shah AJ; Clarke SA; Narayanaswamy S; Nesbitt A; Izzi-Engbeaya C; Prague JK; Abbara A et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and association with late miscarriage.

Human reproduction (Oxford, England)
2016-09 | Journal article
Contributors: Jayasena CN; Abbara A; Comninos AN; Narayanaswamy S; Gonzalez Maffe J; Izzi-Engbeaya C; Oldham J; Lee TT; Sarang Z; Malik Z et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans.

Diabetes, obesity & metabolism
2015-11 | Journal article
Contributors: Salem V; Izzi-Engbeaya C; Coello C; Thomas DB; Chambers ES; Comninos AN; Buckley A; Win Z; Al-Nahhas A; Rabiner EA et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy.

The Journal of clinical endocrinology and metabolism
2015-07 | Journal article
Contributors: Abbara A; Jayasena CN; Christopoulos G; Narayanaswamy S; Izzi-Engbeaya C; Nijher GM; Comninos AN; Peters D; Buckley A; Ratnasabapathy R et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Neurokinin B administration induces hot flushes in women.

Scientific reports
2015-02 | Journal article
Contributors: Jayasena CN; Comninos AN; Stefanopoulou E; Buckley A; Narayanaswamy S; Izzi-Engbeaya C; Abbara A; Ratnasabapathy R; Mogford J; Ng N et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Associations of coefficient of variation of serum GH with previous radiotherapy, hypopituitarism and cardiac disease in patients with treated acromegaly.

Clinical endocrinology
2015-01 | Journal article
Contributors: Jayasena CN; Izzi-Engbeaya C; Narayanaswamy S; Modi M; Clarke H; Nijher GM; Meeran K; Dhillo WS
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Reduced levels of plasma kisspeptin during the antenatal booking visit are associated with increased risk of miscarriage.

The Journal of clinical endocrinology and metabolism
2014-12 | Journal article
Contributors: Jayasena CN; Abbara A; Izzi-Engbeaya C; Comninos AN; Harvey RA; Gonzalez Maffe J; Sarang Z; Ganiyu-Dada Z; Padilha AI; Dhanjal M et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Insights into Brown Adipose Tissue Physiology as Revealed by Imaging Studies.

Adipocyte
2014-11 | Journal article
Contributors: Izzi-Engbeaya C; Salem V; Atkar RS; Dhillo WS
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.

The Journal of clinical investigation
2014-07 | Journal article
Contributors: Jayasena CN; Abbara A; Comninos AN; Nijher GM; Christopoulos G; Narayanaswamy S; Izzi-Engbeaya C; Sridharan M; Mason AJ; Warwick J et al.
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central

Kisspeptin is providing new insights into the control of reproduction.

Clinical medicine (London, England)
2013-12 | Journal article
Contributors: Izzi-Engbeaya C; Meeran K; Dhillo WS
Source: Self-asserted source
Chioma Izzi-Engbeaya via Europe PubMed Central
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