Personal information

Other IDs

Loop profile: 237394

Keywords

Autism, Syngap1, Intellectual Disability, Neurodevelopment, Memory

Countries

United Kingdom

Activities

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Employment (5)

University of Exeter: Exeter, GB

2023-04-17 to present | Senior Research Scientist
Employment
Source: Self-asserted source
James Clement

Jawaharlal Nehru Centre for Advanced Scientific Research: Bengaluru, Karnataka, IN

2019-07-17 to 2023-04-06 | Associate Professor (Neuroscience)
Employment
Source: Self-asserted source
James Clement

Jawaharlal Nehru Centre for Advanced Scientific Research: Bangalore, Karnataka, IN

2013-07-17 to 2019-07-16 | Assistant Profesor (Neuroscience)
Employment
Source: Self-asserted source
James Clement

Scripps Research Insitute. Florida: Jupiter, FL, US

2010-05-18 to 2013-05-31 | Post-doc (Neuroscience)
Employment
Source: Self-asserted source
James Clement

National Centre for Biological Sciences: Bangalore, Karnataka, IN

2003-10 to 2006-07 | Research Assistant (Neuroscience)
Employment
Source: Self-asserted source
James Clement

Education and qualifications (2)

Madurai Kamaraj University: Madurai, Tamil Nadu, IN

2001-07 to 2003-05 | M.Sc (School of Biological Sciences)
Education
Source: Self-asserted source
James Clement

American College: Madurai, Tamil Nadu, IN

1998-07 to 2001-05 | B.Sc (Zoology)
Education
Source: Self-asserted source
James Clement

Professional activities (2)

Society for Neuroscience: Washington, US

2018-05-09 to present | Annual renewal
Membership
Source: Self-asserted source
James Clement

Indian Academy of Neurosciences: Lucknow, IN

2014 to present
Service
Source: Self-asserted source
James Clement

Funding (2)

Role of astrocytes in neuronal formation and maturation in Syngap1 Heterozygous mutation

2018 to 2021 | Grant
Department of Science and Technology (Delhi, IN)
GRANT_NUMBER:

EMR/2016/004795
Source: Self-asserted source
James Clement

Impact of syngap1 heterozygous mutations on the maturation and function of GABAergic interneurons during development

2014 to 2017 | Award
Department of Science and Technology, Ministry of Science and Technology (New Delhi, IN)
GRANT_NUMBER:

SB/YS/LS-215/2013; 2014-2017
Source: Self-asserted source
James Clement

Works (21)

Epilepsy Characteristics in Neurodevelopmental Disorders: Research from Patient Cohorts and Animal Models Focusing on Autism Spectrum Disorder

International Journal of Molecular Sciences
2022-09-16 | Journal article
DOI: 10.3390/ijms231810807
Contributors: Sukanya Chakraborty; Rrejusha Parayil; Shefali Mishra; Upendra Nongthomba; James P. Clement
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder

Experimental Brain Research
2022-09-05 | Journal article
DOI: 10.1007/s00221-022-06448-x
Contributors: Sushmitha S. Purushotham; Neeharika M. N. Reddy; Michelle Ninochka D’Souza; Nilpawan Roy Choudhury; Anusa Ganguly; Niharika Gopalakrishna; Ravi Muddashetty; James P. Clement
Source: check_circle
Crossref

Pharmacological intervention in young adolescents rescues synaptic physiology and behavioural deficits in Syngap1+/− mice

Experimental Brain Research
2022-01 | Journal article
DOI: 10.1007/s00221-021-06254-x
Contributors: Vijaya Verma; M. J. Vijay Kumar; Kavita Sharma; Sridhar Rajaram; Ravi Muddashetty; Ravi Manjithaya; Thomas Behnisch; James P. Clement
Source: check_circle
Crossref

Correction to: Identification of an individual with a SYNGAP1 pathogenic mutation in India

Molecular Biology Reports
2021-09-24 | Journal article
DOI: 10.1007/s11033-021-06649-7
Contributors: Vijaya Verma; Amit Mandora; Abhijeet Botre; James P. Clement
Source: check_circle
Crossref

Spatiotemporal analysis of soluble aggregates and autophagy markers in the R6/2 mouse model

Scientific Reports
2021-01-08 | Journal article
DOI: 10.1038/s41598-020-78850-w
Contributors: M. J. Vijay Kumar; Devanshi Shah; Mridhula Giridharan; Niraj Yadav; Ravi Manjithaya; James P. Clement
Source: check_circle
Crossref

Identification of an individual with a SYNGAP1 pathogenic mutation in India

Molecular Biology Reports
2020-11-22 | Journal article
DOI: 10.1007/s11033-020-05915-4
Contributors: Vijaya Verma; Amit Mandora; Abhijeet Botre; James P. Clement
Source: check_circle
Crossref

Novel de novo heterozygous mutation on SYNGAP1 from the Indian population

2020-01-28 | Other
DOI: 10.21203/rs.2.22020/v1
Contributors: Vijaya Verma; Amit Mandora; Abhijeet Botre; James Premdoss Clement
Source: check_circle
Crossref

Chemogenetic Activation of Excitatory Neurons Alters Hippocampal Neurotransmission in a Dose-Dependent Manner.

eNeuro
2019-11-15 | Journal article
DOI: 10.1523/ENEURO.0124-19.2019
PMID: 31645362
PMC: PMC6860986
Source: Self-asserted source
James Clement

Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration.

EBioMedicine
2019-11-11 | Journal article
Part of DOI: 10.1016/j.ebiom.2019.10.036
PMID: 31727601
PMC: PMC6921191
Source: Self-asserted source
James Clement

Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour

Open Biology
2019-06 | Journal article
DOI: 10.1098/rsob.180265
Contributors: Vijaya Verma; Abhik Paul; Anjali Amrapali Vishwanath; Bhupesh Vaidya; James P. Clement
Source: check_circle
Crossref

Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity.

Frontiers in Molecular Neuroscience
2019-05-09 | Journal article
DOI: 10.3389/fnmol.2019.00097
PMID: 31143100
PMC: PMC6520660
Source: Self-asserted source
James Clement

Neurodegenerative diseases: model organisms, pathology and autophagy.

Journal of genetics
2018-07-01 | Journal article
DOI: 10.1007/s12041-018-0955-3
PMID: 30027903
Source: Self-asserted source
James Clement

Epigenetic modulation by small molecule compounds for neurodegenerative disorders.

Pharmacological research
2018-04-20 | Journal article
DOI: 10.1016/j.phrs.2018.04.014
PMID: 29684672
Source: Self-asserted source
James Clement

Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective.

Frontiers in molecular neuroscience
2018-04-09 | Journal article
DOI: 10.3389/fnmol.2018.00109
PMID: 29686608
PMC: PMC5900053
Source: Self-asserted source
James Clement

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity.

Autophagy
2017-03-28 | Journal article
DOI: 10.1080/15548627.2017.1302045
PMID: 28350199
PMC: PMC5529071
Source: Self-asserted source
James Clement

Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation.

Nature neuroscience
2017-02-13 | Journal article
DOI: 10.1038/nn.4505
PMID: 28192396
Source: Self-asserted source
James Clement

SYNGAP1: Mind the Gap.

Frontiers in Cellular Neuroscience
2016-02-15 | Journal article
DOI: 10.3389/fncel.2016.00032
PMID: 26912996
PMC: PMC4753466
Source: Self-asserted source
James Clement

SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2013-06-01 | Journal article
DOI: 10.1523/JNEUROSCI.0765-13.2013
PMID: 23785156
PMC: PMC3685838
Source: Self-asserted source
James Clement

Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.

Cell
2012-11-01 | Journal article
DOI: 10.1016/j.cell.2012.08.045
PMID: 23141534
PMC: PMC3500766
Source: Self-asserted source
James Clement

Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability.

The European journal of neuroscience
2009-05-29 | Journal article
DOI: 10.1111/j.1460-9568.2009.06780.x
PMID: 19490024
Source: Self-asserted source
James Clement

Rats smell in stereo.

Science (New York, N.Y.)
2006-02-01 | Journal article
DOI: 10.1126/science.1122096
PMID: 16456082
Source: Self-asserted source
James Clement

Peer review (16 reviews for 5 publications/grants)

Review activity for Behavioral and brain functions (1)
Review activity for Experimental brain research. (12)
Review activity for Neurochemistry international. (1)
Review activity for PloS one. (1)
Review activity for Translational psychiatry. (1)
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