Personal information

Emails & domains

Verified email domains

Websites & social links

https://odin.mdacc.tmc.edu/~hliang1/

Keywords

cancer research, bioinformatics, computational biology, systems biology

Countries

United States

Activities

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Works (47)

Developmental-status-aware transcriptional decomposition establishes a cell state panorama of human cancers

Genome Medicine
2024-10-28 | Journal article
DOI: 10.1186/s13073-024-01393-6
Contributors: Yikai Luo; Han Liang
Source: check_circle
Crossref

Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment

Journal for ImmunoTherapy of Cancer
2023-11 | Journal article
DOI: 10.1136/jitc-2023-007402
Contributors: Weiwei Lin; Yikai Luo; Jie Wu; Haowan Zhang; Ge Jin; Chahua Guo; Hang Zhou; Han Liang; Xiaoyan Xu
Source: check_circle
Crossref

Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy

Trends in Genetics
2023-10 | Journal article
DOI: 10.1016/j.tig.2023.07.005
Contributors: Yikai Luo; Han Liang
Source: check_circle
Crossref

A mast cell–thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis

Science Immunology
2023-03-31 | Journal article
DOI: 10.1126/sciimmunol.adc9417
Contributors: Chunjing Bao; Ouyang Chen; Huaxin Sheng; Jeffrey Zhang; Yikai Luo; Byron W. Hayes; Han Liang; Wolfgang Liedtke; Ru-Rong Ji; Soman N. Abraham
Source: check_circle
Crossref

Cancer Cells Employ the Most Prolific RNA Editors: A Closer Look at the Single-Cell Level

Cancer Research
2023-02-03 | Journal article
DOI: 10.1158/0008-5472.CAN-22-3537
Contributors: Yikai Luo; Han Liang
Source: check_circle
Crossref

Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma

Cancer Cell
2022-11 | Journal article
DOI: 10.1016/j.ccell.2022.10.012
Contributors: Zhicheng Zhou; Mei-Ju May Chen; Yikai Luo; Kamalika Mojumdar; Xin Peng; Hu Chen; Shweta V. Kumar; Rehan Akbani; Yiling Lu; Han Liang
Source: check_circle
Crossref

RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells

PLOS Genetics
2022-03-30 | Journal article
DOI: 10.1371/journal.pgen.1010130
Contributors: Xinxin Peng; Silvestro G. Conticello; Yikai Luo; Hongyue Li; Xuejiao Guo; Hu Chen; Xuwo Ji; Han Liang
Source: check_circle
Crossref

Convergent Usage of Amino Acids in Human Cancers as a Reversed Process of Tissue Development

Genomics, Proteomics & Bioinformatics
2022-02-01 | Journal article
DOI: 10.1016/j.gpb.2021.08.004
Contributors: Yikai Luo; Han Liang
Source: check_circle
Crossref

Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance

Nature Communications
2021-06-11 | Journal article
DOI: 10.1038/s41467-021-23681-0
Contributors: Xuan Zong; Ying Zhang; Xinxin Peng; Dongyan Cao; Mei Yu; Jinhui Wang; Hongyue Li; Xuejiao Guo; Han Liang; Jiaxin Yang
Source: check_circle
Crossref

A four-gene signature predicts survival and anti-CTLA4 immunotherapeutic responses based on immune classification of melanoma

Communications Biology
2021-03-22 | Journal article
DOI: 10.1038/s42003-021-01911-x
Contributors: Ying Mei; Mei-Ju May Chen; Han Liang; Li Ma
Source: check_circle
Crossref

Convergent Usage of Amino Acids in Human Cancers as a Reversed Process of Tissue Development

2021-03-20 | Preprint
DOI: 10.1101/2021.03.18.436083
Contributors: Yikai Luo; Han Liang
Source: check_circle
Crossref

Comprehensive assessment of computational algorithms in predicting cancer driver mutations

Genome Biology
2020-12 | Journal article
DOI: 10.1186/s13059-020-01954-z
Contributors: Hu Chen; Jun Li; Yumeng Wang; Patrick Kwok-Shing Ng; Yiu Huen Tsang; Kenna R. Shaw; Gordon B. Mills; Han Liang
Source: check_circle
Crossref

Finding cancer drivers in the UPS system

Nature Cancer
2020-01-13 | Journal article
DOI: 10.1038/s43018-019-0013-y
Contributors: Han Liang
Source: check_circle
Crossref

Sex disparities in cancer

Cancer Letters
2019-12 | Journal article
DOI: 10.1016/j.canlet.2019.08.017
Contributors: Yizhi Zhu; Xiaoyan Shao; Xueyan Wang; Lingxiang Liu; Han Liang
Source: check_circle
Crossref

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

Nature Communications
2019-11-26 | Journal article
DOI: 10.1038/s41467-019-13266-3
Contributors: Sue Haupt; Franco Caramia; Alan Herschtal; Thierry Soussi; Guillermina Lozano; Hu Chen; Han Liang; Terence P. Speed; Ygal Haupt
Source: check_circle
Crossref

NUAK2 is a critical YAP target in liver cancer

Nature Communications
2018-11-16 | Journal article
DOI: 10.1038/s41467-018-07394-5
Contributors: Wei-Chien Yuan; Brian Pepe-Mooney; Giorgio G. Galli; Michael T. Dill; Hai-Tsang Huang; Mingfeng Hao; Yumeng Wang; Han Liang; Raffaele A. Calogero; Fernando D. Camargo
Source: check_circle
Crossref

Biosynthetic energy cost for amino acids decreases in cancer evolution

Nature Communications
2018-10-08 | Journal article
DOI: 10.1038/s41467-018-06461-1
Contributors: Hong Zhang; Yirong Wang; Jun Li; Han Chen; Xionglei He; Huiwen Zhang; Han Liang; Jian Lu
Source: check_circle
Crossref

Personalized Integrated Network Modeling of the Cancer Proteome Atlas

Scientific Reports
2018-10-08 | Journal article
DOI: 10.1038/s41598-018-32682-x
Contributors: Min Jin Ha; Sayantan Banerjee; Rehan Akbani; Han Liang; Gordon B. Mills; Kim-Anh Do; Veerabhadran Baladandayuthapani
Source: check_circle
Crossref

PATHOME: an algorithm for accurately detecting differentially expressed subpathways

Oncogene
2014-10 | Journal article
DOI: 10.1038/onc.2014.80
Contributors: S Nam; H R Chang; K-T Kim; M-C Kook; D Hong; C H Kwon; H R Jung; H S Park; G Powis; H Liang et al.
Source: check_circle
Crossref

Integrated genomic characterization of endometrial carcinoma.

2013-05 | Journal article
DOI:

10.1038/nature12113

PMID:

23636398
Contributors: Akbani R; Benz CC; Cherniack AD; Ding L; Kandoth C; Kucherlapati R; Laird PW; Levine DA; Liu Y; Mardis ER et al.
Source: Self-asserted source
Han Liang via Europe PubMed Central

Comparative analysis of somatic copy-number alterations across different human cancer types reveals two distinct classes of breakpoint hotspots.

2012-11 | Journal article
DOI:

10.1093/hmg/dds340

PMID:

22899649
Contributors: Ball RL; Li J; Li Y; Liang H; Liang X; Lin Z; Zhang L
Source: Self-asserted source
Han Liang via Europe PubMed Central

Identifying molecular drivers of gastric cancer through next-generation sequencing.

2012-11 | Journal article
DOI:

10.1016/j.canlet.2012.11.029

PMID:

23178814
Contributors: Kim YH; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.

2012-11 | Journal article
DOI:

10.1101/gr.137596.112

PMID:

23028188

PMC:

PMC3483541
Contributors: Broaddus RR; Carter H; Cheung LW; Dogruluk T; Dyer MD; Gu C; Guo W; Hennessy BT; Ju Z; Karchin R et al.
Source: Self-asserted source
Han Liang via Europe PubMed Central

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker.

2012-10 | Journal article
DOI:

10.1038/nm.2940

PMID:

23001183

PMC:

PMC3684419
Contributors: Chen D; Gupta S; Hung MC; Liang H; Lin HK; Ma L; Rezaeian AH; Sun Y; Teruya-Feldstein J; Wei Y et al.
Source: Self-asserted source
Han Liang via Europe PubMed Central

SurvNet: a web server for identifying network-based biomarkers that most correlate with patient survival data.

2012-07 | Journal article
DOI:

10.1093/nar/gks386

PMID:

22570412

PMC:

PMC3394266
Contributors: Grünewald S; Li J; Liang H; Roebuck P
Source: Self-asserted source
Han Liang via Europe PubMed Central

AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer.

2012-05 | Journal article
DOI:

10.1158/0008-5472.CAN-11-3870

PMID:

22434430
Contributors: Beasley EM; Cheong JH; Cho JY; Chung HC; Downey TJ; Dyer MD; Kim H; Kim YH; Lee JS; Li M et al.
Source: Self-asserted source
Han Liang via Europe PubMed Central

Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic data.

2012-05 | Journal article
DOI:

10.1093/bioinformatics/bts120

PMID:

22419784

PMC:

PMC3338016
Contributors: Ball RL; Liang H; Xu J; Xu Y; Yuan Y
Source: Self-asserted source
Han Liang via Europe PubMed Central

BM-Map: an efficient software package for accurately allocating multireads of RNA-sequencing data.

2012 | Journal article
DOI:

10.1186/1471-2164-13-S8-S9

PMID:

23281802

PMC:

PMC3535707
Contributors: Ji Y; Liang H; Norris C; Tsui KW; Xu Y; Yuan Y
Source: Self-asserted source
Han Liang via Europe PubMed Central

BM-map: Bayesian mapping of multireads for next-generation sequencing data.

2011-12 | Journal article
DOI:

10.1111/j.1541-0420.2011.01605.x

PMID:

21517792

PMC:

PMC3190637
Contributors: Ji Y; Liang H; Liang S; Norris C Jr; Tsui KW; Xu Y; Yuan Y; Zhang Q
Source: Self-asserted source
Han Liang via Europe PubMed Central

Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.

2011-11 | Journal article
DOI:

10.1038/emboj.2011.312

PMID:

21873975

PMC:

PMC3230370
Contributors: Boelens MC; Cheng N; Eves EM; Frankenberger CA; Ishwaran H; Kuo WL; Li WH; Liang H; Minn AJ; Rosner MR et al.
Source: Self-asserted source
Han Liang via Europe PubMed Central

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.

2011-07 | Journal article
DOI:

10.1158/2159-8290.CD-11-0039

PMID:

21984976

PMC:

PMC3187555
Contributors: Broaddus RR; Cantley LC; Cheung LW; Djordjevic B; Dyer MD; Hennessy BT; Ju Z; Li J; Liang H; Lu KH et al.
Source: Self-asserted source
Han Liang via Europe PubMed Central

Decoding the dual-coding region: key factors influencing the translational potential of a two-ORF-containing transcript.

2010-05 | Journal article
DOI:

10.1038/cr.2010.62

PMID:

20436511
Contributors: Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

Functional compensation by duplicated genes in mouse.

2009-10 | Journal article
DOI:

10.1016/j.tig.2009.08.001

PMID:

19783063

PMC:

PMC2764834
Contributors: Li WH; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

Lowly expressed human microRNA genes evolve rapidly.

2009-06 | Journal article
DOI:

10.1093/molbev/msp053

PMID:

19299536

PMC:

PMC2727378
Contributors: Li WH; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

Fast evolution of core promoters in primate genomes.

2008-06 | Journal article
DOI:

10.1093/molbev/msn072

PMID:

18367463

PMC:

PMC2878000
Contributors: Li WH; Liang H; Lin YS
Source: Self-asserted source
Han Liang via Europe PubMed Central

Protein under-wrapping causes dosage sensitivity and decreases gene duplicability.

2008-01 | Journal article
DOI:

10.1371/journal.pgen.0040011

PMID:

18208334

PMC:

PMC2211539
Contributors: Chen J; Fernández A; Li WH; Liang H; Plazonic KR
Source: Self-asserted source
Han Liang via Europe PubMed Central

Evolutionary constraints imposed by gene dosage balance.

2008 | Journal article
DOI:

10.2741/3010

PMID:

18508516
Contributors: Fernandez A; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

Protein structure protection commits gene expression patterns.

2008 | Journal article
DOI:

10.1186/gb-2008-9-7-r107

PMID:

18606003

PMC:

PMC2530859
Contributors: Chen J; Fernández A; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

MicroRNA regulation of human protein protein interaction network.

2007-09 | Journal article
DOI:

10.1261/rna.634607

PMID:

17652130

PMC:

PMC1950750
Contributors: Li WH; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

Gene essentiality, gene duplicability and protein connectivity in human and mouse.

2007-08 | Journal article
DOI:

10.1016/j.tig.2007.04.005

PMID:

17512629
Contributors: Li WH; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

SWAKK: a web server for detecting positive selection in proteins using a sliding window substitution rate analysis.

2006-07 | Journal article
DOI:

10.1093/nar/gkl272

PMID:

16845032

PMC:

PMC1538794
Contributors: Landweber LF; Liang H; Zhou W
Source: Self-asserted source
Han Liang via Europe PubMed Central

A genome-wide study of dual coding regions in human alternatively spliced genes.

2006-02 | Journal article
DOI:

10.1101/gr.4246506

PMID:

16365380

PMC:

PMC1361714
Contributors: Landweber LF; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

Are stop codons recognized by base triplets in the large ribosomal RNA subunit?

2005-10 | Journal article
DOI:

10.1261/rna.2780505

PMID:

16199759

PMC:

PMC1370831
Contributors: Fresco JR; Landweber LF; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

The evolutionary origin of a complex scrambled gene.

2005-10 | Journal article
DOI:

10.1073/pnas.0507682102

PMID:

16217011

PMC:

PMC1257744
Contributors: Bryson PD; Chang WJ; Landweber LF; Liang H; Shin MK
Source: Self-asserted source
Han Liang via Europe PubMed Central

Molecular mimicry: quantitative methods to study structural similarity between protein and RNA.

2005-08 | Journal article
DOI:

10.1261/rna.7207205

PMID:

16043503

PMC:

PMC1370800
Contributors: Landweber LF; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central

Decoding the decoding region: analysis of eukaryotic release factor (eRF1) stop codon-binding residues.

2005-03 | Journal article
DOI:

10.1007/s00239-004-0211-8

PMID:

15871044
Contributors: Bao Q; Cavalcanti AR; Landweber LF; Liang H; Wong JY
Source: Self-asserted source
Han Liang via Europe PubMed Central

Conservation of tandem stop codons in yeasts.

2005 | Journal article
DOI:

10.1186/gb-2005-6-4-r31

PMID:

15833118

PMC:

PMC1088959
Contributors: Cavalcanti AR; Landweber LF; Liang H
Source: Self-asserted source
Han Liang via Europe PubMed Central
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