Personal information

Activities

Employment (3)

University of Colorado Anschutz Medical Campus: Denver, Colorado, US

2014 to present | Professor (Pediatrics)
Employment
Source: Self-asserted source
Patricia Ernst

Dartmouth College Geisel School of Medicine: Hanover, NH, US

2004 to 2014 | Associate Professor (Genetics)
Employment
Source: Self-asserted source
Patricia Ernst

Harvard Medical School: Boston, MA, US

1999 to 2004 | Postdoctoral Fellow (Pathology)
Employment
Source: Self-asserted source
Patricia Ernst

Education and qualifications (2)

University of Washington: Seattle, WA, US

1985 to 2000 | B.S. Biochemistry (Chemistry)
Education
Source: Self-asserted source
Patricia Ernst

David Geffen School of Medicine at UCLA: Los Angeles, California, US

1990 to 1996 | PhD (Microbiology and Immunology)
Education
Source: Self-asserted source
Patricia Ernst

Works (50 of 56)

Items per page:
Page 1 of 2

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.

Nature cell biology
2023-01-12 | Journal article | Author
Contributors: Sparbier CE; Gillespie A; Gomez J; Kumari N; Motazedian A; Kah Lok Chan; Charles Bell; Gilan O; Yih-Chih Chan; Popp S et al.
Source: Self-asserted source
Patricia Ernst

Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation

iScience
2022-01 | Journal article
Part of ISSN: 2589-0042
Source: Self-asserted source
Patricia Ernst

Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia.

Experimental Hematology
2021-07-21 | Journal article
Source: Self-asserted source
Patricia Ernst

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.

Nature communications
2021-05-14 | Journal article
Source: Self-asserted source
Patricia Ernst

Menin is necessary for long term maintenance of meningioma-1 driven leukemia.

Leukemia
2021-02-04 | Journal article
Source: Self-asserted source
Patricia Ernst

Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis.

Stem cell reports
2020-01-16 | Journal article
Source: Self-asserted source
Patricia Ernst

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.

Nature communications
2019-09-18 | Journal article
Source: Self-asserted source
Patricia Ernst

Rationale for targeting BCL6 in <i>MLL</i>-rearranged acute lymphoblastic leukemia.

Genes & development
2019-08-08 | Journal article
Source: Self-asserted source
Patricia Ernst

Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation.

Cell cycle (Georgetown, Tex.)
2019-06-04 | Journal article
Source: Self-asserted source
Patricia Ernst

Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

Experimental hematology
2018-10-10 | Journal article
Source: Self-asserted source
Patricia Ernst

MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)
2018-01-19 | Journal article
Source: Self-asserted source
Patricia Ernst

Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis

Current Opinion in Hematology
2017 | Journal article
EID:

2-s2.0-85017136393

Contributors: Yang, W.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

SET/MLL family proteins in hematopoiesis and leukemia

International Journal of Hematology
2017 | Journal article
EID:

2-s2.0-84992745517

Contributors: Yang, W.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Cancer cell
2017-06-01 | Journal article
Source: Self-asserted source
Patricia Ernst
grade
Preferred source (of 2)‎

Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia

Cancer Cell
2016 | Journal article
EID:

2-s2.0-84979777179

Contributors: Watanabe, T.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets

Cancer Biology and Therapy
2016 | Journal article
EID:

2-s2.0-85002261129

Contributors: Lin, W.; Francis, J.M.; Li, H.; Gao, X.; Pedamallu, C.S.; Ernst, P.; Meyerson, M.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia

Journal of Clinical Investigation
2016 | Journal article
EID:

2-s2.0-84964627111

Contributors: Riedel, S.S.; Haladyna, J.N.; Bezzant, M.; Stevens, B.; Pollyea, D.A.; Sinha, A.U.; Armstrong, S.A.; Wei, Q.; Pollock, R.M.; Daigle, S.R. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety

Neuropsychopharmacology
2016 | Journal article
EID:

2-s2.0-84984838248

Contributors: Shen, E.Y.; Jiang, Y.; Javidfar, B.; Kassim, B.; Loh, Y.-H.E.; Ma, Q.; Mitchell, A.C.; Pothula, V.; Stewart, A.F.; Ernst, P. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis

Cancer Cell
2016 | Journal article
EID:

2-s2.0-85003875987

Contributors: Xu, H.; Valerio, D.G.; Eisold, M.E.; Sinha, A.; Koche, R.P.; Hu, W.; Chen, C.-W.; Chu, S.H.; Brien, G.L.; Park, C.Y. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Harnessing gene repression to inhibit leukemia

Nature Medicine
2015 | Journal article
EID:

2-s2.0-84926671363

Contributors: Harte, P.J.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory

Journal of Neuroscience
2015 | Journal article
EID:

2-s2.0-84929346689

Contributors: Jakovcevski, M.; Ruan, H.; Shen, E.Y.; Dincer, A.; Javidfar, B.; Ma, Q.; Peter, C.J.; Cheung, I.; Mitchell, A.C.; Jiang, Y. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition

Neuron
2014 | Journal article
EID:

2-s2.0-84919423609

Contributors: Bharadwaj, R.; Peter, C.J.; Jiang, Y.; Roussos, P.; Vogel-Ciernia, A.; Shen, E.Y.; Mitchell, A.C.; Mao, W.; Whittle, C.; Dincer, A. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis

Cell Reports
2014 | Journal article
EID:

2-s2.0-84901281295

Contributors: Mishra, B.P.; Zaffuto, K.M.; Artinger, E.L.; Org, T.; Mikkola, H.K.A.; Cheng, C.; Djabali, M.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Two decades of leukemia oncoprotein epistasis: The MLL1 paradigm for epigenetic deregulation in leukemia

Experimental Hematology
2014 | Journal article
EID:

2-s2.0-84919478152

Contributors: Li, B.E.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis

Arteriosclerosis, Thrombosis, and Vascular Biology
2013 | Journal article
EID:

2-s2.0-84883263551

Contributors: Huang, L.-H.; Gui, J.; Artinger, E.; Craig, R.; Berwin, B.L.; Ernst, P.A.; Chang, C.C.Y.; Chang, T.-Y.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

An MLL-dependent network sustains hematopoiesis

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
EID:

2-s2.0-84880376187

Contributors: Artinger, E.L.; Mishra, B.P.; Zaffuto, K.M.; Li, B.E.; Chung, E.K.Y.; Moore, A.W.; Chen, Y.; Cheng, C.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Cell context in the control of self-renewal and proliferation regulated by MLL1

Cell Cycle
2013 | Journal article
EID:

2-s2.0-84884884517

Contributors: Artinger, E.L.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells

Blood
2013 | Journal article
EID:

2-s2.0-84887599883

Contributors: Li, B.E.; Gan, T.; Meyerson, M.; Rabbitts, T.H.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition

Developmental Cell
2012 | Journal article
EID:

2-s2.0-84870798143

Contributors: Stan, R.; Tse, D.; Deharvengt, S.; Smits, N.; Xu, Y.; Luciano, M.; McGarry, C.; Buitendijk, M.; Nemani, K.; Elgueta, R. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

WRAD: Enabler of the SET1-family of H3K4 methyltransferases

Briefings in Functional Genomics
2012 | Journal article
EID:

2-s2.0-84864316059

Contributors: Ernst, P.; Vakoc, C.R.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Runx1 loss minimally impacts long-term hematopoietic stem cells

PLoS ONE
2011 | Journal article
EID:

2-s2.0-82455206264

Contributors: Cai, X.; Gaudet, J.J.; Mangan, J.K.; Chen, M.J.; De Obaldia, M.E.; Oo, Z.; Ernst, P.; Speck, N.A.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis

Leukemia
2010 | Journal article
EID:

2-s2.0-77957990791

Contributors: Gan, T.; Jude, C.D.; Zaffuto, K.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele

Cancer Cell
2010 | Journal article
EID:

2-s2.0-76549105779

Contributors: Thiel, A.T.; Blessington, P.; Zou, T.; Feather, D.; Wu, X.; Yan, J.; Zhang, H.; Liu, Z.; Ernst, P.; Koretzky, G.A. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

Nature
2009 | Journal article
EID:

2-s2.0-63649125648

Contributors: Lim, D.A.; Huang, Y.-C.; Swigut, T.; Mirick, A.L.; Garcia-Verdugo, J.M.; Wysocka, J.; Ernst, P.; Alvarez-Buylla, A.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Hematopoietic stem cells

Molecular Basis of Hematopoiesis
2009 | Book
EID:

2-s2.0-84900279050

Contributors: Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

IFN-α wakes up sleeping hematopoietic stem cells

Nature Medicine
2009 | Journal article
EID:

2-s2.0-67149128178

Contributors: Passegué, E.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Leukemia and hematopoietic stem cells: Balancing proliferation and quiescence

Cell Cycle
2008 | Journal article
EID:

2-s2.0-41949092044

Contributors: Jude, C.D.; Gaudet, J.J.; Speck, N.A.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Unique and Independent Roles for MLL in Adult Hematopoietic Stem Cells and Progenitors

Cell Stem Cell
2007 | Journal article
EID:

2-s2.0-34548462072

Contributors: Jude, C.D.; Climer, L.; Xu, D.; Artinger, E.; Fisher, J.K.; Ernst, P.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model

Proceedings of the National Academy of Sciences of the United States of America
2006 | Journal article
EID:

2-s2.0-33750951686

Contributors: Bansal, D.; Scholl, C.; Fröhling, S.; McDowell, E.; Lee, B.H.; Döhner, K.; Ernst, P.; Davidson, A.J.; Daley, G.Q.; Zon, L.I. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease

EMBO Journal
2005 | Journal article
EID:

2-s2.0-13444311619

Contributors: Wang, J.; Iwasaki, H.; Krivtsov, A.; Febbo, P.G.; Thorner, A.R.; Ernst, P.; Anastasiadou, E.; Kutok, J.L.; Kogan, S.C.; Zinkel, S.S. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Embryonic stem cell-derived hematopoietic stem cells

Proceedings of the National Academy of Sciences of the United States of America
2005 | Journal article
EID:

2-s2.0-30044434743

Contributors: Wang, Y.; Yates, F.; Naveiras, O.; Ernst, P.; Daley, G.Q.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Erratum: An Mll-dependent Hox program drives hematopoietic progenitor expansion (Current Biology 14 (2063-2069))

Current Biology
2005 | Journal article
EID:

2-s2.0-12544255064

Contributors: Ernst, P.; Mabon, M.; Davidson, A.J.; Zon, L.I.; Korsmeyer, S.J.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

An Mll-dependent Hox program drives hematopoietic progenitor expansion

Current Biology
2004 | Journal article
EID:

2-s2.0-9244257908

Contributors: Ernst, P.; Mabon, M.; Davidson, A.J.; Zon, L.I.; Korsmeyer, S.J.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Definitive hematopoiesis requires the mixed-lineage leukemia gene

Developmental Cell
2004 | Journal article
EID:

2-s2.0-1642281239

Contributors: Ernst, P.; Fisher, J.K.; Avery, W.; Wade, S.; Foy, D.; Korsmeyer, S.J.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes

Nature
2003 | Journal article
EID:

2-s2.0-0141605010

Contributors: Davidson, A.J.; Ernst, P.; Wang, Y.; Dekens, M.P.S.; Kingsley, P.D.; Palis, J.; Korsmeyer, S.J.; Daley, G.Q.; Zon, L.I.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

Molecular and Cellular Biology
2003 | Journal article
EID:

2-s2.0-0037215399

Contributors: Hsieh, J.J.-D.; Ernst, P.; Erdjument-Bromage, H.; Tempst, P.; Korsmeyer, S.J.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

The role of MLL in hematopoiesis and leukemia

Current Opinion in Hematology
2002 | Journal article
EID:

2-s2.0-0036014973

Contributors: Ernst, P.; Wang, J.; Korsmeyer, S.J.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Down-regulation of TDT transcription in CD4<sup>+</sup>CD8<sup>+</sup>thymocytes by Ikaros proteins in direct competition with an Ets activator

Genes and Development
2001 | Journal article
EID:

2-s2.0-0035878121

Contributors: Trinh, L.A.; Ferrini, R.; Cobb, B.S.; Weinmann, A.S.; Hahm, K.; Ernst, P.; Garraway, I.P.; Merkenschlager, M.; Smale, S.T.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

Molecular and Cellular Biology
2001 | Journal article
EID:

2-s2.0-0035102477

Contributors: Ernst, P.; Wang, J.; Huang, M.; Goodman, R.H.; Korsmeyer, S.J.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier

Mammalian Trithorax and Polycomb-group homologues are antagonistic regulators of homeotic development

Proceedings of the National Academy of Sciences of the United States of America
1999 | Journal article
EID:

2-s2.0-12944332088

Contributors: Hanson, R.D.; Hess, J.L.; Yu, B.D.; Ernst, P.; Van Lohuizen, M.; Berns, A.; Van Der Lugt, N.M.T.; Shashikant, C.S.; Ruddle, F.H.; Seto, M. et al.
Source: Self-asserted source
Patricia Ernst via Scopus - Elsevier
Items per page:
Page 1 of 2