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Other IDs

Scopus Author ID: 7003392559

Keywords

Computational biology, structural bioinformatics, protein structure prediction

Countries

United States

Activities

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Employment (1)

Fox Chase Cancer Center: Philadelphia, PA, US

1997-10-05 to present | Professor (Institute for Cancer Research)
Employment
Source: Self-asserted source
Roland Dunbrack

Education and qualifications (2)

Harvard University: Cambridge, MA, US

1987-09-10 to 1993-06-10 | Ph.D. (Biophysics)
Education
Source: Self-asserted source
Roland Dunbrack

Harvard College: Cambridge, MA, US

1981-09-12 to 1985-06-08 | A.B. (Chemistry)
Education
Source: Self-asserted source
Roland Dunbrack

Funding (7)

Structural bioinformatics of proteins and protein complexes and applications to cancer biology

2017-04-01 to 2022-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.6618517
GRANT_NUMBER: R35GM122517
Source: Self-asserted source
Roland Dunbrack via DimensionsWizard

Development of methods for antibody computational design

2015-08-01 to 2019-07-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: 1R01GM111819-01A1
GRANT_NUMBER: 1R01GM111819-01A1
Source: Self-asserted source
Roland Dunbrack via DimensionsWizard

Bayesian Statistics and Algorithms for Homology Modeling

2008-05-15 to 2017-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: 5R01GM084453-12
GRANT_NUMBER: 5R01GM084453-12
Source: Self-asserted source
Roland Dunbrack via DimensionsWizard

New Methods for High-Resolution Comparative Modeling

2006-04-01 to 2011-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: 3P20GM076222-03S1
GRANT_NUMBER: 3P20GM076222-03S1
Source: Self-asserted source
Roland Dunbrack via DimensionsWizard

Modeling of Protein Complexes and Missense Mutations

2006-03-01 to 2011-02-28 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: 5R01GM073784-04
GRANT_NUMBER: 5R01GM073784-04
Source: Self-asserted source
Roland Dunbrack via DimensionsWizard

Bayesian Statistics and Algorithms for Homology Modeling

2001-12-14 to 2008-03-31 | Grant
National Human Genome Research Institute (Bethesda, US)
GRANT_NUMBER: 5R01HG002302-05
GRANT_NUMBER: 5R01HG002302-05
Source: Self-asserted source
Roland Dunbrack via DimensionsWizard

COMPUTER SIMULATIONS OF PROTEIN FOLDING

1995-11-01 to present | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: 5F32GM016279-03
GRANT_NUMBER: 5F32GM016279-03
Source: Self-asserted source
Roland Dunbrack via DimensionsWizard

Works (50 of 158)

Items per page:
Page 1 of 4

Rēs ipSAE loquunt: What’s wrong with AlphaFold’sipTMscore and how to fix it

2025-02-14 | Preprint
DOI: 10.1101/2025.02.10.637595
Contributors: Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Queer voices in computational biology: the first ISCB LGBTQI+ Symposium

Bioinformatics Advances
2024-12-26 | Journal article
DOI: 10.1093/bioadv/vbae204
Contributors: R Gonzalo Parra; Mark N Wass; Seth Munholland; Mallory L Wiper; Diane Kovats; Lorena Pantano; Roland L Dunbrack, Jr; Alex Bateman
Source: check_circle
Crossref

E proteins control the development of NKγδT cells through their invariant T cell receptor

Nature Communications
2024-06-13 | Journal article
DOI: 10.1038/s41467-024-49496-3
Contributors: Ariana Mihai; Sang-Yun Lee; Susan Shinton; Mitchell I. Parker; Alejandra V. Contreras; Baojun Zhang; Michele Rhodes; Roland L. Dunbrack; Juan-Carlos Zúñiga-Pflücker; Maria Ciofani et al.
Source: check_circle
Crossref

PAK2 is necessary for myelination in the peripheral nervous system

Brain
2024-05-03 | Journal article
DOI: 10.1093/brain/awad413
Contributors: Bo Hu; Daniel Moiseev; Isabella Schena; Bulat Faezov; Roland Dunbrack; Jonathan Chernoff; Jun Li
Source: check_circle
Crossref

Data from Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

2024-02-01 | Preprint
DOI: 10.1158/1535-7163.c.7054219
Contributors: Favour Achimba; Bulat Faezov; Brandon Cohen; Roland Dunbrack; Mandë Holford
Source: check_circle
Crossref

Data from Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

2024-02-01 | Preprint
DOI: 10.1158/1535-7163.c.7054219.v1
Contributors: Favour Achimba; Bulat Faezov; Brandon Cohen; Roland Dunbrack; Mandë Holford
Source: check_circle
Crossref

Figure S1 from Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

2024-02-01 | Preprint
DOI: 10.1158/1535-7163.25125205
Contributors: Favour Achimba; Bulat Faezov; Brandon Cohen; Roland Dunbrack; Mandë Holford
Source: check_circle
Crossref

Figure S1 from Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

2024-02-01 | Preprint
DOI: 10.1158/1535-7163.25125205.v1
Contributors: Favour Achimba; Bulat Faezov; Brandon Cohen; Roland Dunbrack; Mandë Holford
Source: check_circle
Crossref

Table S1 from Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

2024-02-01 | Preprint
DOI: 10.1158/1535-7163.25125202.v1
Contributors: Favour Achimba; Bulat Faezov; Brandon Cohen; Roland Dunbrack; Mandë Holford
Source: check_circle
Crossref

Table S1 from Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

2024-02-01 | Preprint
DOI: 10.1158/1535-7163.25125202
Contributors: Favour Achimba; Bulat Faezov; Brandon Cohen; Roland Dunbrack; Mandë Holford
Source: check_circle
Crossref

Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

Molecular Cancer Therapeutics
2024-02-01 | Journal article
DOI: 10.1158/1535-7163.MCT-23-0256
Contributors: Favour Achimba; Bulat Faezov; Brandon Cohen; Roland Dunbrack; Mandë Holford
Source: check_circle
Crossref

AlphaFold2 models of the active form of all 437 catalytically competent human protein kinase domains

2023-07-25 | Preprint
DOI: 10.1101/2023.07.21.550125
Contributors: Bulat Faezov; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Data from Delineating the RAS Conformational Landscape

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.c.6513960
Contributors: Mitchell I. Parker; Joshua E. Meyer; Erica A. Golemis; Roland L. Dunbrack,
Source: check_circle
Crossref

Data from Delineating the RAS Conformational Landscape

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.c.6513960.v1
Contributors: Mitchell I. Parker; Joshua E. Meyer; Erica A. Golemis; Roland L. Dunbrack,
Source: check_circle
Crossref

Supplementary Data from Delineating the RAS Conformational Landscape

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22431714
Contributors: Mitchell I. Parker; Joshua E. Meyer; Erica A. Golemis; Roland L. Dunbrack,
Source: check_circle
Crossref

Supplementary Data from Delineating the RAS Conformational Landscape

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22431714.v1
Contributors: Mitchell I. Parker; Joshua E. Meyer; Erica A. Golemis; Roland L. Dunbrack,
Source: check_circle
Crossref

Supplementary Data from Delineating the RAS Conformational Landscape

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22431711
Contributors: Mitchell I. Parker; Joshua E. Meyer; Erica A. Golemis; Roland L. Dunbrack,
Source: check_circle
Crossref

Supplementary Data from Delineating the RAS Conformational Landscape

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22431711.v1
Contributors: Mitchell I. Parker; Joshua E. Meyer; Erica A. Golemis; Roland L. Dunbrack,
Source: check_circle
Crossref

The protein common assembly database (ProtCAD)—a comprehensive structural resource of protein complexes

Nucleic Acids Research
2023-01-06 | Journal article
DOI: 10.1093/nar/gkac937
Contributors: Qifang Xu; Roland L Dunbrack, Jr.
Source: check_circle
Crossref

Development and Utility of a PAK1-Selective Degrader

Journal of Medicinal Chemistry
2022-12-08 | Journal article
DOI: 10.1021/acs.jmedchem.2c00756
Contributors: Hoi-Yee Chow; Sofiia Karchugina; Brian J. Groendyke; Sean Toenjes; John Hatcher; Katherine A. Donovan; Eric S. Fischer; Gleb Abalakov; Bulat Faezov; Roland Dunbrack et al.
Source: check_circle
Crossref

A penultimate classification of canonical antibody CDR conformations

2022-10-16 | Preprint
DOI: 10.1101/2022.10.12.511988
Contributors: Simon Kelow; Bulat Faezov; Qifang Xu; Mitchell Parker; Jared Adolf-Bryfogle; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

The Protein Common Assembly Database (ProtCAD) – A comprehensive structural resource of protein complexes

2022-08-15 | Preprint
DOI: 10.1101/2022.08.15.503938
Contributors: Qifang Xu; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Delineating the RAS Conformational Landscape

Cancer Research
2022-07-05 | Journal article
DOI: 10.1158/0008-5472.CAN-22-0804
Contributors: Mitchell I. Parker; Joshua E. Meyer; Erica A. Golemis; Roland L. Dunbrack,, Jr.
Source: check_circle
Crossref

Signatures of defective DNA repair and replication in early-onset renal cancer patients referred for germline genetic testing

2022-05-25 | Preprint
DOI: 10.1101/2022.05.23.22275227
Contributors: Elena V. Demidova; Ilya G. Serebriiskii; Ramilia Vlasenkova; Simon Kelow; Mark D. Andrake; Tiffiney R. Hartman; Tatiana Kent; Richard T. Pomerantz; Roland L. Dunbrack, Jr.; Erica A. Golemis et al.
Source: check_circle
Crossref

Development and utility of a PAK1-selective degrader

2022-05-13 | Preprint
DOI: 10.1101/2022.05.12.491715
Contributors: Hoi-Yee Chow; Sofiia Karchugina; Brian J. Groendyke; Sean Toenjes; John Hatcher; Katherine A. Donovan; Eric S. Fischer; Gleb Abalakov; Bulat Faezov; Roland Dunbrack et al.
Source: check_circle
Crossref

The ERK2 DBP domain opposes pathogenesis of a JAK2V617F-driven myeloproliferative neoplasm

Blood
2022-04-18 | Journal article
DOI: 10.1182/blood.2021013068
Contributors: Yong Zhang; Billy Truong; Shawn P Fahl; Esteban Martinez; Kathy Cai; Essel Dulaimi; Yulan Gong; Dan A. Liebermann; Jonathan Soboloff; Roland Dunbrack et al.
Source: check_circle
Crossref

Defining An Expanded RAS Conformational Landscape Based on Over 700 Experimentally Determined Structures of KRAS, NRAS, and HRAS

2022-02-05 | Preprint
DOI: 10.1101/2022.02.02.478568
Contributors: Mitchell I. Parker; Joshua E. Meyer; Erica A. Golemis; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Kincore: a web resource for structural classification of protein kinases and their inhibitors

Nucleic Acids Research
2022-01-07 | Journal article
DOI: 10.1093/nar/gkab920
Contributors: Vivek Modi; Roland L Dunbrack, Jr
Source: check_circle
Crossref

PDBrenum: A webserver and program providing Protein Data Bank files renumbered according to their UniProt sequences

PLOS ONE
2021-07-06 | Journal article
DOI: 10.1371/journal.pone.0253411
Contributors: Bulat Faezov; Yang Zhang; Roland L. Dunbrack
Source: check_circle
Crossref

Structure of TFIIK for phosphorylation of CTD of RNA polymerase II

Science Advances
2021-04-09 | Journal article
DOI: 10.1126/sciadv.abd4420
Contributors: Trevor van Eeuwen; Tao Li; Hee Jong Kim; Jose J. Gorbea Colón; Mitchell I. Parker; Roland L. Dunbrack; Benjamin A. Garcia; Kuang-Lei Tsai; Kenji Murakami
Source: check_circle
Crossref

PDBrenum: a webserver and program providing Protein Data Bank files renumbered according to their UniProt sequences

2021-02-14 | Preprint
DOI: 10.1101/2021.02.14.431128
Contributors: Bulat Faezov; Roland L. Dunbrack, Jr
Source: check_circle
Crossref

Kincore: a web resource for structural classification of protein kinases and their inhibitors

2021-02-13 | Preprint
DOI: 10.1101/2021.02.12.430923
Contributors: Vivek Modi; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Multifaceted analysis of training and testing convolutional neural networks for protein secondary structure prediction

PLOS ONE
2020-05-06 | Journal article
DOI: 10.1371/journal.pone.0232528
Contributors: Maxim Shapovalov; Björn Wallner; Roland L. Dunbrack; Slobodan Vucetic
Source: check_circle
Crossref

Protein domain-based structural interfaces help interpret biologically-relevant interactions in the human interaction network

2020-03-16 | Preprint
DOI: 10.1101/2020.03.14.992149
Contributors: Krishna Praneeth Kilambi; Qifang Xu; Guruharsha Kuthethur Gururaj; Kejie Li; Spyros Artavanis-Tsakonas; Roland L. Dunbrack, Jr.; Andreas Lehmann
Source: check_circle
Crossref

Hiding in plain sight: structure and sequence analysis reveals the importance of the antibody DE loop for antibody-antigen binding

2020-02-13 | Preprint
DOI: 10.1101/2020.02.12.946350
Contributors: Simon P. Kelow; Jared Adolf-Bryfogle; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

ProtCID: a data resource for structural information on protein interactions

Nature Communications
2020-02-05 | Journal article
DOI: 10.1038/s41467-020-14301-4
Contributors: Qifang Xu; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Multifaceted analysis of training and testing convolutional neural networks for protein secondary structure prediction

2020-01-18 | Preprint
DOI: 10.1101/2020.01.17.911065
Contributors: Maxim Shapovalov; Roland L. Dunbrack, Jr.; Slobodan Vucetic
Source: check_circle
Crossref

Assessment of predicted enzymatic activity of α‐ N ‐acetylglucosaminidase variants of unknown significance for CAGI 2016

Human Mutation
2019-09-24 | Journal article
DOI: 10.1002/humu.23875
Contributors: Wyatt T. Clark; Laura Kasak; Constantina Bakolitsa; Zhiqiang Hu; Gaia Andreoletti; Giulia Babbi; Yana Bromberg; Rita Casadio; Roland Dunbrack; Lukas Folkman et al.
Source: check_circle
Crossref

A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains

2019-09-20 | Other
DOI: 10.1101/776740
Contributors: Vivek Modi; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Defining a new nomenclature for the structures of active and inactive kinases

Proceedings of the National Academy of Sciences
2019-04-02 | Journal article
DOI: 10.1073/pnas.1814279116
Contributors: Vivek Modi; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Interaction of germline variants in a family with a history of early‐onset clear cell renal cell carcinoma

Molecular Genetics & Genomic Medicine
2019-03 | Journal article
DOI: 10.1002/mgg3.556
Contributors: Emmanuelle Nicolas; Elena V. Demidova; Waleed Iqbal; Ilya G. Serebriiskii; Ramilia Vlasenkova; Pooja Ghatalia; Yan Zhou; Kim Rainey; Andrea F. Forman; Roland L. Dunbrack, Jr et al.
Source: check_circle
Crossref

ProtCID: A data resource for structural information on protein interactions

2019-03-16 | Other
DOI: 10.1101/579862
Contributors: Qifang Xu; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

A new clustering and nomenclature for beta turns derived from high-resolution protein structures

PLOS Computational Biology
2019-03-07 | Journal article
DOI: 10.1371/journal.pcbi.1006844
Contributors: Maxim Shapovalov; Charlotte M. Deane; Slobodan Vucetic; Roland L. Dunbrack
Source: check_circle
Crossref

Principles and characteristics of biological assemblies in experimentally determined protein structures

2019-03-01 | Other
DOI: 10.1101/564385
Contributors: Qifang Xu; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

A New Clustering and Nomenclature for Beta Turns Derived from High-Resolution Protein Structures

2018-08-13 | Other
DOI: 10.1101/390211
Contributors: Maxim Shapovalov; Slobodan Vucetic; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design

PLOS Computational Biology
2018-04-27 | Journal article
DOI: 10.1371/journal.pcbi.1006112
Contributors: Jared Adolf-Bryfogle; Nir Ben-Tal; Oleks Kalyuzhniy; Michael Kubitz; Brian D. Weitzner; Xiaozhen Hu; Yumiko Adachi; William R. Schief; Roland L. Dunbrack
Source: check_circle
Crossref

Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI

Human Mutation
2017-09 | Journal article
DOI: 10.1002/humu.23235
Contributors: Marco Carraro; Giovanni Minervini; Manuel Giollo; Yana Bromberg; Emidio Capriotti; Rita Casadio; Roland Dunbrack; Lisa Elefanti; Pietro Fariselli; Carlo Ferrari et al.
Source: check_circle
Crossref

RosettaAntibodyDesign (RAbD): A General Framework for Computational Antibody Design

2017-08-31 | Preprint
DOI: 10.1101/183350
Contributors: Jared Adolf-Bryfogle; Oleks Kalyuzhniy; Michael Kubitz; Brian D. Weitzner; Xiaozhen Hu; Yumiko Adachi; William R. Schief; Roland L. Dunbrack, Jr.
Source: check_circle
Crossref

Cancer signature investigation: ERBB2 (HER2)-activating mutation and amplification-positive breast carcinoma mimicking lung primary

JNCCN Journal of the National Comprehensive Cancer Network
2015 | Journal article
EID:

2-s2.0-84940118656
Contributors: Shih, J.; Bashir, B.; Gustafson, K.S.; Andrake, M.; Dunbrack, R.L.; Goldstein, L.J.; Boumber, Y.
Source: Self-asserted source
Roland Dunbrack via Scopus - Elsevier

Characteristics of clinical trials that require participants to be fluent in English

Clinical Trials
2015 | Journal article
DOI: 10.1177/1740774515592881
EID:

2-s2.0-84947068462
Contributors: Egleston, B.L.; Pedraza, O.; Wong, Y.-N.; Dunbrack, R.L.; Griffin, C.L.; Ross, E.A.; Beck, J.R.
Source: Self-asserted source
Roland Dunbrack via Scopus - Elsevier
Items per page:
Page 1 of 4

Peer review (13 reviews for 11 publications/grants)

Review activity for ACS chemical biology. (1)
Review activity for ACS omega. (1)
Review activity for Biochemistry. (1)
Review activity for Communications biology. (1)
Review activity for F1000Research. (1)
Review activity for Journal of chemical information and modeling. (1)
Review activity for Journal of chemical theory and computation : (1)
Review activity for Nature (1)
Review activity for Nature communications (2)
Review activity for PLoS biology. (1)
Review activity for PLoS computational biology. (2)
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