Samuel C Grant (0000-0001-7738-168X)

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Our research emphasis over the last ten years has been the application of high field magnetic resonance imaging (MRI) and spectroscopy (MRS) to biomedical problems. The utilization of high magnetic fields beyond 11 T provides the sensitivity and specificity to interrogate a range of specimens, from biological solutions to single cells and bioengineered constructs to in vivo animals. Furthermore, high magnetic fields open new areas of study involving non-proton nuclei, novel contrast agents and unique contrast mechanisms that can be brought to bear upon biomedical applications. Since establishment of the laboratory group at The Florida State University in 2006, this emphasis has been focused along two intersecting lines of research:
1) the fabrication and optimization of tools for high field MRI application & 2) the utilization of those tools for the evaluation of biological tissues and cellular engineered constructs in the study of neurological and muscular degeneration.

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Florida State University: Tallahassee, FL, US

2021-08-01 to present | Professor (Chemical & Biomedical Engineering)

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Samuel C Grant

https://orcid.org/0000-0001-7738-168X

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Employment (4)

Florida State University: Tallahassee, FL, US

Florida State University: Tallahassee, FL, US

Florida State University: Tallahassee, FL, US

University of Florida: Gainesville, FL, US

Education and qualifications (3)

University of Illinois at Chicago: Chicago, IL, US

University of Illinois at Urbana-Champaign: Urbana, IL, US

University of Illinois at Urbana-Champaign: Urbana, IL, US

Professional activities (3)

International Society for Magnetic Resonance in Medicine: Concord, CA, US

Institute of Electrical and Electronics Engineers: Piscataway, NJ, US

Biomedical Engineering Society: Landover, Maryland, US

Funding (4)

MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke Therapy

Dysfunction of Sodium Homeostasis in Migraine

MRI: Development of an NMR Console for the 36 T Series Hybrid

Collaborative Research: Are Muscle Fibers Just the Right Size?

Works (50 of 138)

Nuclear magnetic resonance study of monoclonal antibodies near an oil-water interface

Superparamagnetic Iron Oxide Nanoparticle-Labeled Extracellular Vesicles for Magnetic Resonance Imaging of Ischemic Stroke

Profiling biomanufactured extracellular vesicles of human forebrain spheroids in a Vertical‐Wheel Bioreactor

Probing Self-assembled Micellar Topologies via Micro-scale Diffusive Dynamics of Surfactants

Human Forebrain Organoid-Derived Extracellular Vesicle Labeling with Iron Oxides for In Vitro Magnetic Resonance Imaging

Nonparametric 5D D-R2 distribution imaging with single-shot EPI at 21.1 T: Initial results for in vivo rat brain

Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke

Department Profile: The Department of Chemical and Biomedical Engineering at the FAMU-FSU College of Engineering

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

A Multifunctional Contrast Agent for 19F-Based Magnetic Resonance Imaging

Extended Ischemic Recovery After Implantation of Human Mesenchymal Stem Cell Aggregates Indicated by Sodium MRI at 21.1 T.

NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment

Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model.

Olfactory bulb‐targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice

Nuclear Magnetic Resonance Diffusometry of Linear and Branched Wormlike Micelles.

Biogenesis of Extracellular Vesicles Produced from Human-Stem-Cell-Derived Cortical Spheroids Exposed to Iron Oxides.

Cyclical aggregation extends in vitro expansion potential of human mesenchymal stem cells.

Aggregation-induced integrated stress response rejuvenates culture-expanded human mesenchymal stem cells.

Multiparametric classification of sub‐acute ischemic stroke recovery with ultrafast diffusion, 23Na, and MPIO‐labeled stem cell MRI at 21.1 T

Regulation of CSF and Brain Tissue Sodium Levels by the Blood-CSF and Blood-Brain Barriers During Migraine.

Magnetic resonance electrical property mapping at 21.1 T: a study of conductivity and permittivity in phantoms, ex vivo tissue and in vivo ischemia

Aggregation of human mesenchymal stem cells enhances survival and efficacy in stroke treatment

Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation

Intraventricular Implantation of Human Mesenchymal Stem Cell 3D Aggregates as Regeneration Center for Ischemic Stroke Treatment

Brain investigations of rodent disease models by chemical exchange saturation transfer at 21.1 T

Cationic carrier peptide enhances cerebrovascular targeting of nanoparticles in Alzheimer's disease brain.

Cellular and molecular responses to acute cocaine treatment in neuronal-like N2a cells: potential mechanism for its resistance in cell death.

Effects of labeling human mesenchymal stem cells with superparamagnetic iron oxides on cellular functions and magnetic resonance contrast in hypoxic environments and long-term monitoring.

Dynamic Sodium Imaging at Ultra-High Field Reveals Progression in a Preclinical Migraine Model.

Li Distribution Heterogeneity in Solid Electrolyte Li10GeP2S12 upon Electrochemical Cycling Probed by 7Li MRI.

Identification of biochemical and cytotoxic markers in cocaine treated PC12 cells.

Chronic Methamphetamine Effects on Brain Structure and Function in Rats (vol 11, e0155457, 2016)

Correction: Chronic Methamphetamine Effects on Brain Structure and Function in Rats.

In Vitro 3D Culture of Human Mesenchymal Stem Cells for Ischemic Stroke Treatment

Distinguishing neuronal from astrocytic subcellular microstructures using in vivo Double Diffusion Encoded 1H MRS at 21.1 T.

Metabolic assessment of a migraine model using relaxation-enhanced 1 H spectroscopy at ultrahigh field.

Direct detection of neural activity in vitro using magnetic resonance electrical impedance tomography (MREIT).

Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.

Aerobic and resistance training dependent skeletal muscle plasticity in the colon-26 murine model of cancer cachexia

Chronic Methamphetamine Effects on Brain Structure and Function in Rats

Transplantation of Aggregate-Derived Human Mesenchymal Stem Cells in Stroke Treatment: Mechanism of Functional Enhancement and High Field MRI

Transverse relaxation of selectively excited metabolites in stroke at 21.1 T

Use of human mesenchymal stem cell treatment to prevent anhedonia in a rat model of traumatic brain injury

Structural connectivity within neural ganglia: A default small-world network.

A Decade of Experience With the UltraWide-Bore 900-MHz NMR Magnet

In Vitro Preconditioning of Human Mesenchymal Stem Cells for Stroke Treatment

Labeling pluripotent stem cell-derived neural progenitors with iron oxide particles for magnetic resonance imaging.

Ultrafast in vivo diffusion imaging of stroke at 21.1 T by spatiotemporal encoding.

Cryopreservation of embryonic stem cell-derived multicellular neural aggregates labeled with micron-sized particles of iron oxide for magnetic resonance imaging.

Intracellular labeling of mouse embryonic stem cell-derived neural progenitor aggregates with micron-sized particles of iron oxide.

Peer review (1 review for 1 publication/grant)