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Scopus Author ID: 54784705600

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Employment (5)

Nostrum Biodiscovery: Barcelona, ES

2020-10-01 to present | Research Scientist
Employment
Source: Self-asserted source
Javier Iglesias-Fernandez

Universitat de Girona: Girona, Catalunya, ES

2016-10-01 to present | Postdoctoral Researcher (Institut de Química Computacional i Catàlisi)
Employment
Source: Self-asserted source
Javier Iglesias-Fernandez

Max-Planck-Institut für Kohlenforschung: Mulheim an der Ruhr, Nordrhein-Westfalen, DE

2016-06-16 to 2016-10-15 | Visiting Researcher
Employment
Source: Self-asserted source
Javier Iglesias-Fernandez

Kings College London: London, London, GB

2014-10-01 to 2016-06-14 | Associate Researcher (Chemistry Department)
Employment
Source: Self-asserted source
Javier Iglesias-Fernandez

Universitat de Barcelona: Barcelona, Catalunya, ES

2010-10-01 to 2014-09-15 | PhD student (Organic Chemistry)
Employment
Source: Self-asserted source
Javier Iglesias-Fernandez

Education and qualifications (2)

Institut Quimic de Sarria: Barcelona, Catalunya, ES

2008-09-15 to 2010-07-19 | Master Degree Bioengineering
Education
Source: Self-asserted source
Javier Iglesias-Fernandez

Institut Quimic de Sarria: Barcelona, Catalunya, ES

2003-09-15 to 2008-06-16 | Bachelor Degree Chemistry
Education
Source: Self-asserted source
Javier Iglesias-Fernandez

Works (29)

Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient Esterase

2023-08-24 | Preprint
DOI: 10.1101/2023.08.23.554512
Contributors: Guillem Casadevall; Colin Pierce; Bo Guan; Javier Iglesias-Fernandez; Huey-Yee Lim; Lauren R. Greenberg; Meghan E. Walsh; Ke Shi; Wendy Gordon; Hideki Aihara et al.
Source: check_circle
Crossref

In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase

ACS Catalysis
2021-11-05 | Journal article
DOI: 10.1021/acscatal.1c03950
Contributors: Miguel A. Maria-Solano; Thomas Kinateder; Javier Iglesias-Fernández; Reinhard Sterner; Sílvia Osuna
Source: check_circle
Crossref

Mutational Analysis of Linalool Dehydratase Isomerase Suggests That Alcohol and Alkene Transformations Are Catalyzed Using Noncovalent Mechanisms

ACS Catalysis
2020-10-02 | Journal article
DOI: 10.1021/acscatal.0c02958
Contributors: Anibal Cuetos; Javier Iglesias-Fernández; Hamid-Reza Danesh-Azari; Erna Zukic; Adam Dowle; Sílvia Osuna; Gideon Grogan
Source: check_circle
Crossref

Multivalent Ligands with Tailor‐Made Anion Binding Motif as Stabilizers of Protein–Protein Interactions

ChemBioChem
2019-09-24 | Journal article
DOI: 10.1002/cbic.201900288
Part of ISSN: 1439-4227
Part of ISSN: 1439-7633
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Deciphering the Allosterically Driven Conformational Ensemble in Tryptophan Synthase Evolution

Journal of the American Chemical Society
2019-08-21 | Journal article
DOI: 10.1021/jacs.9b03646
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 3)‎

Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency

Angewandte Chemie International Edition
2019-03-04 | Journal article
DOI: 10.1002/anie.201812532
Part of ISSN: 1433-7851
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Role of conformational dynamics in the evolution of novel enzyme function

Chemical Communications
2018 | Journal article
DOI: 10.1039/c8cc02426j
Part of ISSN: 1359-7345
Part of ISSN: 1364-548X
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 3)‎

Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis

Nature
2018-11 | Journal article
DOI: 10.1038/s41586-018-0644-7
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Exploring the Conversion of a d -Sialic Acid Aldolase into a l -KDO Aldolase

European Journal of Organic Chemistry
2018-06-07 | Journal article
DOI: 10.1002/ejoc.201800103
Part of ISSN: 1434-193X
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 3)‎

A Multiperspective Approach to Solvent Regulation of Enzymatic Activity: HMG-CoA Reductase

ChemBioChem
2018-01-18 | Journal article
DOI: 10.1002/cbic.201700596
Part of ISSN: 1439-4227
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

A front-face 'SNi synthase' engineered from a retaining 'double-SN2' hydrolase

Nature Chemical Biology
2017-06-12 | Journal article
DOI: 10.1038/nchembio.2394
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Membrane Phase-Dependent Occlusion of Intramolecular GLUT1 Cavities Demonstrated by Simulations

Biophysical Journal
2017-03-28 | Journal article
DOI: 10.1016/j.bpj.2017.01.030
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Erratum: Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases - Key enzymes in bacterial and fungal mannoprotein metabolism (Angewandte Chemie - International Edition (2015) 54 (5378-5382) DOI: 10.1002/anie.201410502)

Angewandte Chemie - International Edition
2016 | Journal article
DOI: 10.1002/anie.201511540
EID:

2-s2.0-84957827633
Contributors: Thompson, A.J.; Speciale, G.; Iglesias-Fernández, J.; Hakki, Z.; Belz, T.; Cartmell, A.; Spears, R.J.; Chandler, E.; Temple, M.J.; Stepper, J. et al.
Source: Self-asserted source
Javier Iglesias-Fernandez via Scopus - Elsevier

The reaction mechanism of retaining glycosyltransferases

Biochemical Society Transactions
2016 | Journal article
DOI: 10.1042/BST20150177
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

A single glycosidase harnesses different pyranoside ring transition state conformations for hydrolysis of mannosides and glucosides

ACS Catalysis
2015 | Journal article
DOI: 10.1021/acscatal.5b01547
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Binding of azole drugs to heme: A combined MS/MS and computational approach

Polyhedron
2015 | Journal article
DOI: 10.1016/j.poly.2015.02.011
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.

Nature communications
2015 | Journal article
DOI: 10.1038/ncomms7937
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Enantioselective Preparation of δ‐Valerolactones with Horse Liver Alcohol Dehydrogenase.

ChemCatChem
2015 | Journal article
DOI: 10.1002/cctc.201300640
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Evidence for a Boat Conformation at the Transition State of GH76 α‐1, 6‐Mannanases—Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism

Angewandte Chemie International Edition
2015 | Journal article
DOI: 10.1002/anie.201410502
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Molecular dynamics simulations and neutron reflectivity as an effective approach to characterize biological membranes and related macromolecular assemblies

Journal of chemical theory and computation
2015 | Journal article
DOI: 10.1021/acs.jctc.5b00635
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Privateer: software for the conformational validation of carbohydrate structures

Nature structural & molecular biology
2015 | Journal article
DOI: 10.1038/nsmb.3115
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Surfactin at the Water/Air Interface and in Solution.

Langmuir
2015 | Journal article
DOI: 10.1021/acs.langmuir.5b02305
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

The complete conformational free energy landscape of β-xylose reveals a two-fold catalytic itinerary for β-xylanases.

Chemical Science
2015 | Journal article
DOI: 10.1039/C4SC02240H
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Combined Inhibitor Free‐Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate.

Angewandte Chemie International Edition
2014 | Journal article
DOI: 10.1002/anie.201308334
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2

Angewandte Chemie - International Edition
2014 | Journal article
DOI: 10.1002/anie.201402781
EID:

2-s2.0-84905366680
Contributors: Lira-Navarrete, E.; Iglesias-Fernández, J.; Zandberg, W.F.; Compañón, I.; Kong, Y.; Corzana, F.; Pinto, B.M.; Clausen, H.; Peregrina, J.M.; Vocadlo, D.J. et al.
Source: Self-asserted source
Javier Iglesias-Fernandez via Scopus - Elsevier

Substrate‐Guided Front‐Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N‐Acetylgalactosaminyltransferase 2.

Angewandte Chemie
2014 | Journal article
DOI: 10.1002/ange.201402781
Source: Self-asserted source
Javier Iglesias-Fernandez

Structural analysis and insights into the glycon specificity of the rice GH1 Os7BGlu26 β-D-mannosidase

Acta Crystallographica Section D: Biological Crystallography
2013 | Journal article
DOI: 10.1107/S0907444913020568
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

The Reaction Coordinate of a Bacterial GH47 α‐Mannosidase: A Combined Quantum Mechanical and Structural Approach.

Angewandte Chemie International Edition
2012 | Journal article
DOI: 10.1002/anie.201205338
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Catalytic itinerary in 1, 3-1, 4-β-glucanase unraveled by QM/MM metadynamics. Charge is not yet fully developed at the oxocarbenium ion-like transition state.

Journal of the American Chemical Society
2011 | Journal article
DOI: 10.1021/ja207113e
Source: Self-asserted source
Javier Iglesias-Fernandez
grade
Preferred source (of 2)‎

Peer review (2 reviews for 2 publications/grants)

Review activity for ACS catalysis. (1)
Review activity for The journal of physical chemistry. (1)
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