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Scopus Author ID: 8527763600

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Education and qualifications (1)

東海大学: 平塚市北金目４−１ー１, 神奈川県, JP

准教授 (工学部生命化学科)
Qualification
Source: Self-asserted source
Hiroaki Mitsuhashi

Funding (6)

顔面肩甲上腕型筋ジストロフィー病態に関与する内在性レトロウイルスの探索

2018-04-01 to 2021-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.7534341
GRANT_NUMBER: 18K07511
Source: Self-asserted source
Hiroaki Mitsuhashi via DimensionsWizard

Functional analysis of DUX4 and its effect on development.

2015-04-01 to 2018-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.5881500
GRANT_NUMBER: 15K19477
Source: Self-asserted source
Hiroaki Mitsuhashi via DimensionsWizard

顔面肩甲上腕型筋ジストロフィーにおける新規エピジェネティック制御因子の探索

2015-04-01 to 2017-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.5875882
GRANT_NUMBER: 15K09346
Source: Self-asserted source
Hiroaki Mitsuhashi via DimensionsWizard

Screening of a cofactor of DUX4, a candidate causative gene for facioscapulohumeral muscular dystrophy

2013-08-30 to 2015-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.6129159
GRANT_NUMBER: 25893046
Source: Self-asserted source
Hiroaki Mitsuhashi via DimensionsWizard

エメリー・ドレイフス型筋ジストロフィーにおけるリン酸化ラミンの意義

2009-01-01 to 2011-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.6024834
GRANT_NUMBER: 21591104
Source: Self-asserted source
Hiroaki Mitsuhashi via DimensionsWizard

メダカを用いた筋原線維性ミオパチーの病原・病態解明

2008-01-01 to 2009-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.5998008
GRANT_NUMBER: 20659142
Source: Self-asserted source
Hiroaki Mitsuhashi via DimensionsWizard

Works (26)

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

EBioMedicine
2019 | Journal article
DOI: 10.1016/j.ebiom.2019.06.013
EID:

2-s2.0-85068076632
Contributors: Akiyama, T.; Suzuki, N.; Ishikawa, M.; Fujimori, K.; Sone, T.; Kawada, J.; Funayama, R.; Fujishima, F.; Mitsuzawa, S.; Ikeda, K. et al.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers

Scientific Reports
2019 | Journal article
DOI: 10.1038/s41598-018-36684-7
EID:

2-s2.0-85061779023
Contributors: Mitsuhashi, H.; Homma, S.; Beermann, M.L.; Ishimaru, S.; Takeda, H.; Yu, B.K.; Liu, K.; Duraiswamy, S.; Boyce, F.M.; Miller, J.B.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Structural instability of lamin A tail domain modulates its assembly and higher order function in Emery–Dreifuss muscular dystrophy

Biochemical and Biophysical Research Communications
2019 | Journal article
DOI: 10.1016/j.bbrc.2019.02.138
EID:

2-s2.0-85063608253
Contributors: Mio, M.; Sugiki, T.; Matsuda, C.; Mitsuhashi, H.; Kojima, C.; Chan, S.Y.; Hayashi, Y.K.; Mio, K.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Tandem-genotypes: robust detection of tandem repeat expansions from long DNA reads

Genome Biology
2019 | Journal article
DOI: 10.1186/s13059-019-1667-6
EID:

2-s2.0-85063157537
Contributors: Mitsuhashi, S.; Frith, M.C.; Mizuguchi, T.; Miyatake, S.; Toyota, T.; Adachi, H.; Oma, Y.; Kino, Y.; Mitsuhashi, H.; Matsumoto, N.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Transgenic zebrafish model of DUX4 misexpression reveals a developmental role in FSHD pathogenesis

Human Molecular Genetics
2019 | Journal article
DOI: 10.1093/hmg/ddy348
EID:

2-s2.0-85059497208
Contributors: Pakula, A.; Lek, A.; Widrick, J.; Mitsuhashi, H.; Bugda Gwilt, K.M.; Gupta, V.A.; Rahimov, F.; Criscione, J.; Zhang, Y.; Gibbs, D. et al.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Functional domains of the FSHD-associated DUX4 protein

Biology Open
2018 | Journal article
DOI: 10.1242/bio.033977
EID:

2-s2.0-85057143570
Contributors: Mitsuhashi, H.; Ishimaru, S.; Homma, S.; Yu, B.; Honma, Y.; Beermann, M.L.; Miller, J.B.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Nanopore-based single molecule sequencing of the D4Z4 array responsible for facioscapulohumeral muscular dystrophy

Scientific Reports
2017 | Journal article
DOI: 10.1038/s41598-017-13712-6
EID:

2-s2.0-85032789338
Contributors: Mitsuhashi, S.; Nakagawa, S.; Takahashi Ueda, M.; Imanishi, T.; Frith, M.C.; Mitsuhashi, H.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Data describing the effect of DRD4 promoter polymorphisms on promoter activity

Data in Brief
2016 | Journal article
DOI: 10.1016/j.dib.2016.03.084
EID:

2-s2.0-84962427828
Contributors: Tei, S.; Mitsuhashi, H.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Splicing of human chloride channel 1

Biochemistry and Biophysics Reports
2016 | Journal article
DOI: 10.1016/j.bbrep.2015.11.006
EID:

2-s2.0-84948651060
Contributors: Nakamura, T.; Ohsawa-Yoshida, N.; Zhao, Y.; Koebis, M.; Oana, K.; Mitsuhashi, H.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1

Genes to Cells
2015 | Journal article
DOI: 10.1111/gtc.12201
EID:

2-s2.0-84922561371
Contributors: Ohsawa, N.; Koebis, M.; Mitsuhashi, H.; Nishino, I.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Antisense oligonucleotide-mediated exon skipping of CHRNA1 pre-mRNA as potential therapy for Congenital Myasthenic Syndromes

Biochemical and Biophysical Research Communications
2015 | Journal article
DOI: 10.1016/j.bbrc.2015.04.035
EID:

2-s2.0-84937764176
Contributors: Tei, S.; Ishii, H.T.; Mitsuhashi, H.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Aβ induces oxidative stress in senescence-accelerated (SAMP8) mice

Bioscience, Biotechnology and Biochemistry
2015 | Journal article
DOI: 10.1080/09168451.2014.1002449
EID:

2-s2.0-84940051452
Contributors: Takagane, K.; Nojima, J.; Mitsuhashi, H.; Suo, S.; Yanagihara, D.; Takaiwa, F.; Urano, Y.; Noguchi, N.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle

Biochimica et Biophysica Acta - Molecular Basis of Disease
2015 | Journal article
DOI: 10.1016/j.bbadis.2015.07.006
EID:

2-s2.0-84938152594
Contributors: Zhao, Y.; Ogawa, H.; Yonekura, S.-I.; Mitsuhashi, H.; Mitsuhashi, S.; Nishino, I.; Toyoshima, C.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

A high-salinity solution with calcium chloride enables RNase-free, easy plasmid isolation within 55 minutes

BioScience Trends
2013 | Journal article
DOI: 10.5582/bst.2013.v7.6.270
EID:

2-s2.0-84892774435
Contributors: Sasagawa, N.; Koebis, M.; Yonemura, Y.; Mitsuhashi, H.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy

FEBS Letters
2013 | Journal article
DOI: 10.1016/j.febslet.2013.08.002
EID:

2-s2.0-84883489558
Contributors: Mitsuhashi, S.; Mitsuhashi, H.; Alexander, M.S.; Sugimoto, H.; Kang, P.B.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Expression of DUX4 in zebrafish development recapitulates facioscapulohumeral muscular dystrophy

Human Molecular Genetics
2013 | Journal article
DOI: 10.1093/hmg/dds467
EID:

2-s2.0-84872415036
Contributors: Mitsuhashi, H.; Mitsuhashi, S.; Lynn-jones, T.; Kawahara, G.; Kunkel, L.M.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Filamin C plays an essential role in the maintenance of the structural integrity of cardiac and skeletal muscles, revealed by the medaka mutant zacro

Developmental Biology
2012 | Journal article
DOI: 10.1016/j.ydbio.2011.10.008
EID:

2-s2.0-83055180637
Contributors: Fujita, M.; Mitsuhashi, H.; Isogai, S.; Nakata, T.; Kawakami, A.; Nonaka, I.; Noguchi, S.; Hayashi, Y.K.; Nishino, I.; Kudo, A.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

In vivo characterization of mutant myotilins

American Journal of Pathology
2012 | Journal article
DOI: 10.1016/j.ajpath.2011.12.040
EID:

2-s2.0-84859070497
Contributors: Keduka, E.; Hayashi, Y.K.; Shalaby, S.; Mitsuhashi, H.; Noguchi, S.; Nonaka, I.; Nishino, I.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis

American Journal of Human Genetics
2011 | Journal article
DOI: 10.1016/j.ajhg.2011.05.010
EID:

2-s2.0-79958850438
Contributors: Mitsuhashi, S.; Ohkuma, A.; Talim, B.; Karahashi, M.; Koumura, T.; Aoyama, C.; Kurihara, M.; Quinlivan, R.; Sewry, C.; Mitsuhashi, H. et al.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

TMEM43 mutations in emery-dreifuss muscular dystrophy-related myopathy

Annals of Neurology
2011 | Journal article
DOI: 10.1002/ana.22338
EID:

2-s2.0-79959413828
Contributors: Liang, W.-C.; Mitsuhashi, H.; Keduka, E.; Nonaka, I.; Noguchi, S.; Nishino, I.; Hayashi, Y.K.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Specific phosphorylation of Ser458 of A-type lamins in LMNA-associated myopathy patients

Journal of Cell Science
2010 | Journal article
DOI: 10.1242/jcs.072157
EID:

2-s2.0-78649748592
Contributors: Mitsuhashi, H.; Hayashi, Y.K.; Matsuda, C.; Noguchi, S.; Wakatsuki, S.; Araki, T.; Nishino, I.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Defective myotilin homodimerization caused by a novel mutation in MYOT exon 9 in the first Japanese limb girdle muscular dystrophy 1A patient

Journal of Neuropathology and Experimental Neurology
2009 | Journal article
DOI: 10.1097/NEN.0b013e3181a7f703
EID:

2-s2.0-67649413408
Contributors: Shalaby, S.; Mitsuhashi, H.; Matsuda, C.; Minami, N.; Noguchi, S.; Nonaka, I.; Nishino, I.; Hayashi, Y.K.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells

Journal of Neurochemistry
2008 | Journal article
DOI: 10.1111/j.1471-4159.2007.05121.x
EID:

2-s2.0-41149180888
Contributors: Mitsuhashi, H.; Futai, E.; Sasagawa, N.; Hayashi, Y.; Nishino, I.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Neuroligins 3 and 4X interact with syntrophin-γ2, and the interactions are affected by autism-related mutations

Biochemical and Biophysical Research Communications
2007 | Journal article
DOI: 10.1016/j.bbrc.2007.01.127
EID:

2-s2.0-33847082467
Contributors: Yamakawa, H.; Oyama, S.; Mitsuhashi, H.; Sasagawa, N.; Uchino, S.; Kohsaka, S.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Denervation enhances the expression of SHPS-1 in rat skeletal muscle

Journal of Biochemistry
2005 | Journal article
DOI: 10.1093/jb/mvi058
EID:

2-s2.0-20444412336
Contributors: Mitsuhashi, H.; Yoshikawa, A.; Sasagawa, N.; Hayashi, Y.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Expression of ARPP-16/19 in rat denervated skeletal muscle

Journal of Biochemistry
2003 | Journal article
DOI: 10.1093/jb/mvg113
EID:

2-s2.0-0041318960
Contributors: Yoshikawa, A.; Mitsuhashi, H.; Sasagawa, N.; Tsukahara, T.; Hayashi, Y.; Nishino, I.; Goto, Y.-I.; Ishiura, S.
Source: Self-asserted source
Hiroaki Mitsuhashi via Scopus - Elsevier

Peer review (1 review for 1 publication/grant)

Review activity for Forensic toxicology. (1)
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