Personal information

Neuroscience, Biomaterials, Lysosomes, Autophagy, Nanomedicine
United States

Activities

Employment (3)

Syracuse University: Syracuse, US

2025-01-02 to present | Assistant Professor (Biomedical and Chemical Engineering)
Employment
Source: Self-asserted source
Jialiu Zeng

Nanyang Technological University: Singapore, SG

2021-08-06 to 2024-12-31 | Presidential Postdoctoral Fellow (LKC Neuroscience)
Employment
Source: Self-asserted source
Jialiu Zeng

Yale University: New Haven, CT, US

2020-09-15 to 2021-07-15 | Postdoctoral Associate (Neuroscience)
Employment
Source: Self-asserted source
Jialiu Zeng

Education and qualifications (2)

Boston University: Boston, MA, US

2014-09-01 to 2020-09-01 | PhD (Biomedical Engineering)
Education
Source: Self-asserted source
Jialiu Zeng

National University of Singapore: Singapore, SG

2010-08-01 to 2014-07-14 | Bachelor of Engineering (Biomedical Engineering)
Education
Source: Self-asserted source
Jialiu Zeng

Works (31)

Role of metabolic dysfunction and inflammation along the liver–brain axis in animal models with obesity-induced neurodegeneration

Neural Regeneration Research
2025-04 | Journal article
Contributors: Evridiki Asimakidou; Eka Norfaishanty Saipuljumri; Chih Hung Lo; Jialiu Zeng
Source: check_circle
Crossref

Editorial: Lipid metabolism dysregulation in obesity-related diseases and neurodegeneration

Frontiers in Endocrinology
2025-02-11 | Journal article
Part of ISSN: 1664-2392
Contributors: Jialiu Zeng; Chih Hung Lo
Source: Self-asserted source
Jialiu Zeng

Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration

Frontiers in Endocrinology
2025-01-17 | Journal article
Part of ISSN: 1664-2392
Contributors: Jialiu Zeng; Lenny Yi Tong Cheong; Chih Hung Lo
Source: Self-asserted source
Jialiu Zeng

Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions

ACS Nano
2024-06-18 | Journal article
Contributors: Chih Hung Lo; Lance M. O’Connor; Gavin Wen Zhao Loi; Eka Norfaishanty Saipuljumri; Jonathan Indajang; Kaitlynn M. Lopes; Orian S. Shirihai; Mark W. Grinstaff; Jialiu Zeng
Source: check_circle
Crossref

Blood–Brain Barrier-Targeting Nanoparticles: Biomaterial Properties and Biomedical Applications in Translational Neuroscience

Pharmaceuticals
2024-05-10 | Journal article
Contributors: Evridiki Asimakidou; Justin Kok Soon Tan; Jialiu Zeng; Chih Hung Lo
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Lysosome-acidifying nanoparticles rescue A30P α-synuclein induced neuronal death in cellular andDrosophilamodels of Parkinson’s disease

2024-04-25 | Preprint
Contributors: Chih Hung Lo; Mengda Ren; Gavin Wen Zhao Loi; Eka Norfaishanty Saipuljumri; Jonathan Indajang; Kah Leong Lim; Jialiu Zeng
Source: check_circle
Crossref

Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor–ligand signaling complex

Proceedings of the National Academy of Sciences
2024-04-02 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Jialiu Zeng; Gavin Wen Zhao Loi; Eka Norfaishanty Saipuljumri; Marco Antonio Romero Durán; Octavio Silva-García; Jose Manuel Perez-Aguilar; Victor M. Baizabal-Aguirre; Chih Hung Lo
Source: Self-asserted source
Jialiu Zeng

Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer’s disease

2023-10-16 | Preprint
Contributors: Chih Hung Lo; Jialiu Zeng; Gavin Wen Zhao Loi; Eka Norfaishanty Saipuljumri; Lance M. O’Connor; Jonathan Indajang; Richard Reynolds; Anna M. Barron
Source: check_circle
Crossref

Data Mining of Microarray Datasets in Translational Neuroscience

Brain Sciences
2023-09-14 | Journal article
Contributors: Lance M. O’Connor; Blake A. O’Connor; Jialiu Zeng; Chih Hung Lo
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration

Journal of Neuroinflammation
2023-08-05 | Journal article
Part of ISSN: 1742-2094
Contributors: Joseph D. Quick; Cristian Silva; Jia Hui Wong; Kah Leong Lim; Richard Reynolds; Anna M. Barron; Jialiu Zeng; Chih Hung Lo
Source: Self-asserted source
Jialiu Zeng

Acidic nanoparticles restore lysosomal acidification and rescue metabolic dysfunction in pancreatic β-cells under lipotoxic condition

2023-07-12 | Preprint
Contributors: Chih Hung Lo; Lance M. O’Connor; Gavin Wen Zhao Loi; Eka Norfaishanty Saipuljumri; Jonathan Indajang; Kaitlynn M. Lopes; Orian S. Shirihai; Mark W. Grinstaff; Jialiu Zeng
Source: check_circle
Crossref

Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective

Journal of Pharmaceutical Analysis
2023-06-30 | Journal article
Part of ISSN: 2095-1779
Contributors: Lance M. O’Connor; Blake A. O’Connor; Su Bin Lim; Jialiu Zeng; Chih Hung Lo
Source: Self-asserted source
Jialiu Zeng

Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases

Translational Neurodegeneration
2023-06-08 | Journal article
Contributors: Chih Hung Lo; Jialiu Zeng
Source: check_circle
Crossref

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

Nature Communications
2023-05-04 | Journal article | Author
Part of ISSN: 2041-1723
Contributors: Jialiu Zeng; Rebeca Acin-Perez; Essam A. Assali; Andrew Martin; Alexandra J. Brownstein; Anton Petcherski; Lucia Fernandez del Rio; Ruiqing Xiao; Chih Hung Lo; Michaël Shum et al.
Source: Self-asserted source
Jialiu Zeng
grade
Preferred source (of 2)‎

A hand‐targeted auxiliary personal protective equipment for intervention of fomite transmission of viruses

Bioengineering & Translational Medicine
2022-09-29 | Journal article
Part of ISSN: 2380-6761
Part of ISSN: 2380-6761
Contributors: Jialiu Zeng
Source: Self-asserted source
Jialiu Zeng
grade
Preferred source (of 2)‎

Synthesis of bioactive (1→6)-β-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages

Nature Communications
2022-08-09 | Journal article
Part of ISSN: 2041-1723
Contributors: Jialiu Zeng
Source: Self-asserted source
Jialiu Zeng
grade
Preferred source (of 2)‎

Application of polymersomes in membrane protein study and drug discovery: Progress, strategies, and perspectives

Bioengineering & Translational Medicine
2022-06-28 | Journal article
Part of ISSN: 2380-6761
Part of ISSN: 2380-6761
Source: Self-asserted source
Jialiu Zeng
grade
Preferred source (of 2)‎

IRGM1 links mitochondrial quality control to autoimmunity

Nature Immunology
2021-03 | Journal article
Part of ISSN: 1529-2908
Part of ISSN: 1529-2916
Source: Self-asserted source
Jialiu Zeng
grade
Preferred source (of 2)‎

Acidic nanoparticles for restoration of autophagy

2021-02-23 | Patent
Source: Self-asserted source
Jialiu Zeng

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Autophagy
2021-01-02 | Journal article
Part of ISSN: 1554-8627
Part of ISSN: 1554-8635
Source: Self-asserted source
Jialiu Zeng

Modulating lysosomal pH: a molecular and nanoscale materials design perspective

JoLS, Journal of Life Sciences
2020-12-01 | Journal article
Part of ISSN: 2688-1020
Source: Self-asserted source
Jialiu Zeng

Silica-Coated Mn-Doped ZnS Nanocrystals for Cancer Theranostics

ACS Applied Nano Materials
2020-03-27 | Journal article
Part of ISSN: 2574-0970
Part of ISSN: 2574-0970
Source: Self-asserted source
Jialiu Zeng
grade
Preferred source (of 2)‎

Biodegradable PLGA Nanoparticles Restore Lysosomal Acidity and Protect Neural PC-12 Cells against Mitochondrial Toxicity

Industrial & Engineering Chemistry Research
2019-08-07 | Journal article
Part of ISSN: 0888-5885
Part of ISSN: 1520-5045
Source: Self-asserted source
Jialiu Zeng
grade
Preferred source (of 2)‎

Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells.

Advanced healthcare materials
2019-01 | Journal article
Contributors: Zeng J; Shirihai OS; Grinstaff MW
Source: Self-asserted source
Jialiu Zeng via Europe PubMed Central
grade
Preferred source (of 2)‎

Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2018-12 | Journal article
Contributors: Assali EA; Shlomo D; Zeng J; Taddeo EP; Trudeau KM; Erion KA; Colby AH; Grinstaff MW; Liesa M; Las G et al.
Source: Self-asserted source
Jialiu Zeng via Europe PubMed Central

Biologically Active Branched Polysaccharide Mimetics: Synthesis via Ring-Opening Polymerization of a Maltose-Based β-Lactam

ACS Macro Letters
2018-07-17 | Journal article
Part of ISSN: 2161-1653
Part of ISSN: 2161-1653
Source: Self-asserted source
Jialiu Zeng

Synthesis of Altrose Poly-amido-saccharides with β-N-(1→2)-d-amide Linkages: A Right-Handed Helical Conformation Engineered in at the Monomer Level.

Journal of the American Chemical Society
2017-09 | Journal article
Contributors: Xiao R; Dane EL; Zeng J; McKnight CJ; Grinstaff MW
Source: Self-asserted source
Jialiu Zeng via Europe PubMed Central

Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity.

The Journal of cell biology
2016-07 | Journal article
Contributors: Trudeau KM; Colby AH; Zeng J; Las G; Feng JH; Grinstaff MW; Shirihai OS
Source: Self-asserted source
Jialiu Zeng via Europe PubMed Central

Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma.

Biomaterials
2016-06 | Journal article
Contributors: Liu R; Colby AH; Gilmore D; Schulz M; Zeng J; Padera RF; Shirihai O; Grinstaff MW; Colson YL
Source: Self-asserted source
Jialiu Zeng via Europe PubMed Central

Grafting of ZnS:Mn-Doped Nanocrystals and an Anticancer Drug onto Graphene Oxide for Delivery and Cell Labeling.

ChemPlusChem
2015-09 | Journal article
Contributors: Dinda S; Kakran M; Zeng J; Sudhaharan T; Ahmed S; Das D; Selvan ST
Source: Self-asserted source
Jialiu Zeng via Europe PubMed Central

An in vitro method for the prediction of renal proximal tubular toxicity in humans

Toxicology Research
2013 | Journal article
Part of ISSN: 2045-452X
Part of ISSN: 2045-4538
Source: Self-asserted source
Jialiu Zeng

Peer review (5 reviews for 5 publications/grants)

Review activity for Chemico-biological interactions. (1)
Review activity for JoVE. (1)
Review activity for Nature nanotechnology (1)
Review activity for NPJ Parkinson's disease. (1)
Review activity for Signal transduction and targeted therapy. (1)