Personal information

Other IDs

SciProfiles: 1158690
ResearcherID: L-7411-2015

Keywords

Hematopoietic Stem Cells, Niche, Bone marrow transplant, Leukemia

Countries

Spain

Activities

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Employment (5)

Center for Applied Medical Research: Pamplona, Navarra, ES

2016-05-13 to present | Researcher (Hematology-Oncology)
Employment
Source: Self-asserted source
Borja Saez

Massachusetts General Hospital Cancer Center: Boston, MA, US

2015-01-01 to 2016-03-31 | Staff Scientist/Instructor in Medicine
Employment
Source: Self-asserted source
Borja Saez

Harvard Medical School: Boston, MA, US

2011-08-11 to 2016-03-31 | Instructor in Medicine (Medicine)
Employment
Source: Self-asserted source
Borja Saez

Massachusetts General Hospital: Boston, MA, US

2011-01-08 to 2014-12-31 | Assistant in Biology (Center For Regenerative Medicine)
Employment
Source: Self-asserted source
Borja Saez

Harvard University Department of Stem Cell and Regenerative Biology: Cambridge, MA, US

2011-01-01 to 2014-12-31 | Postdoc Fellow
Employment
Source: Self-asserted source
Borja Saez

Education and qualifications (2)

University of Navarra: Pamplona, Navarra, ES

2001-09-01 to 2006-07-28 | PhD (Genetics)
Education
Source: Self-asserted source
Borja Saez

University of Navarra: Pamplona, ES

1997-09-01 to 2001-08-31 | Bachelor in Science
Education
Source: Self-asserted source
Borja Saez

Professional activities (2)

American Society of Hematology: Washington, DC, US

2012-07-01 to 2014-06-30 | ASH Scholar Award
Distinction
Source: Self-asserted source
Borja Saez

University of Navarra: Pamplona, ES

2001-07-28 | European Doctor Honorary Title
Distinction
Source: Self-asserted source
Borja Saez

Funding (3)

Development of non-genotoxic conditioning regimens for hematopoietic stem cell transplantation in Ataxia Telangiectasia.

2018-04 to 2021-03 | Grant
AEFAT (Madrid, ES)
Source: Self-asserted source
Borja Saez

Non-genotoxic preparative regimens for hematopoietic stem cell transplantation in hemoglobinopathies and autoimmune diseases.

2018-01 to 2020-12 | Grant
Instituto de Salud Carlos III (Madrid, ES)
GRANT_NUMBER:

PI17/01346
Source: Self-asserted source
Borja Saez

Understanding the interactions between Acute Myeloid Leukemia and their bone marrow niche cells

2016-09 to 2019-08 | Salary award
AECC (Madrid, ES)
Source: Self-asserted source
Borja Saez

Works (40)

In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis

Nature Genetics
2023-08-14 | Journal article
DOI: 10.1038/s41588-023-01471-2
Part of ISSN: 1061-4036
Part of ISSN: 1546-1718
Contributors: David Lara-Astiaso; Ainhoa Goñi-Salaverri; Julen Mendieta-Esteban; Nisha Narayan; Cynthia Del Valle; Torsten Gross; George Giotopoulos; Tumas Beinortas; Mar Navarro-Alonso; Laura Pilar Aguado-Alvaro et al.
Source: Self-asserted source
Borja Saez

The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells

Leukemia
2022-08 | Journal article | Author
DOI: 10.1038/s41375-022-01601-5
Part of ISSN: 0887-6924
Part of ISSN: 1476-5551
Contributors: Ana C. Viñado; Calvo IA; Itziar Cenzano Armendáriz; Danel Olaverri-Mendizabal; Miguel Cocera; Patxi San Martin-Uriz; Juan P. Romero; Amaia Vilas-Zornoza; Laura Vera; Nuria Gomez et al.
Source: Self-asserted source
Borja Saez

Promises and Challenges of Cell-Based Therapies to Promote Lung Regeneration in Idiopathic Pulmonary Fibrosis

Cells
2022-08-20 | Journal article | Author
DOI: 10.3390/cells11162595
Part of ISSN: 2073-4409
Contributors: Alejandro Egea Zorrilla; Laura Vera alvarez; Borja Saez; Ana Pardo-Saganta
Source: Self-asserted source
Borja Saez
grade
Preferred source (of 2)‎

Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation

iScience
2022-05 | Journal article
DOI: 10.1016/j.isci.2022.104225
Part of ISSN: 2589-0042
Contributors: Jin Ye; Isabel A. Calvo; Itziar Cenzano; Amaia Vilas; Xabier Martinez-de-Morentin; Miren Lasaga; Diego Alignani; Bruno Paiva; Ana C. Viñado; Patxi San Martin-Uriz et al.
Source: Self-asserted source
Borja Saez

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Cell Stem Cell
2021-12 | Journal article | Author
DOI: 10.1016/j.stem.2021.08.014
Part of ISSN: 1934-5909
Contributors: Youmna S. Kfoury; Fei Ji; Michael Mazzola; David B. Sykes; Allison K. Scherer; Anthony Anselmo; Yasutoshi Akiyama; Francois Mercier; Nicolas Severe; KONSTANTINOS KOKKALIARIS et al.
Source: Self-asserted source
Borja Saez

Molecular and Cellular Mechanisms of Delayed Fracture Healing in <i>Mmp10</i> (Stromelysin 2) Knockout Mice

Journal of Bone and Mineral Research
2021-11 | Journal article
DOI: 10.1002/jbmr.4403
Part of ISSN: 0884-0431
Part of ISSN: 1523-4681
Contributors: José Valdés‐Fernández; Tania López‐Martínez; Purificación Ripalda‐Cemboráin; Isabel A Calvo; Borja Sáez; Juan Antonio Romero‐Torrecilla; Javier Aldazabal; Emma Muiños‐López; Verónica Montiel; Josune Orbe et al.
Source: Self-asserted source
Borja Saez

Notch3 Deficiency Attenuates Pulmonary Fibrosis and Impedes Lung-Function Decline

American Journal of Respiratory Cell and Molecular Biology
2021-04 | Journal article | Author
DOI: 10.1165/rcmb.2020-0516oc
Part of ISSN: 1044-1549
Part of ISSN: 1535-4989
Contributors: Laura Vera; Paula Garcia-Olloqui; Eva Petri; Ana Cristina Viñado; Pablo S. Valera; Zuriñe Blasco-Iturri; Isabel A. Calvo; Itziar Cenzano; Clemens Ruppert; Javier J. Zulueta et al.
Source: Self-asserted source
Borja Saez

Engineering a Humanised Niche to Support Human Haematopoiesis in Mice: Novel Opportunities in Modelling Cancer

Cancers
2020-08-06 | Journal article | Author
DOI: 10.3390/cancers12082205
Part of ISSN: 2072-6694
Contributors: Alvaro Sanchez-Herrero; Calvo IA; Maria Flandes-Iparraguirre; Marietta Landgraf; Christoph A. Lahr; Abbas Shafiee; Froilán Granero-Moltó; Borja Saez; Manuel Maria Mazo; Bruno Paiva et al.
Source: Self-asserted source
Borja Saez

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.

Blood
2020-05-26 | Journal article
DOI: 10.1182/blood.2019001808
PMID: 32458004
Source: Self-asserted source
Borja Saez

Characterization of freshly isolated mesenchymal stromal cells from healthy and multiple myeloma bone marrow: transcriptional modulation of the microenvironment.

Haematologica
2020-01-23 | Journal article
DOI: 10.3324/haematol.2019.235135
PMID: 31974200
Source: Self-asserted source
Borja Saez
grade
Preferred source (of 2)‎

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation.

Nature communications
2019-02-06 | Journal article
DOI: 10.1038/s41467-018-08201-x
PMID: 30728354
PMC: PMC6365495
Source: Self-asserted source
Borja Saez

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

Molecular cell
2017 | Journal article
DOI: 10.1016/j.molcel.2017.01.029
Source: Self-asserted source
Borja Saez

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

Nature communications
2017 | Journal article
DOI: 10.1038/ncomms14060
Source: Self-asserted source
Borja Saez

Splicing factor gene mutations in hematologic malignancies

Blood
2017 | Journal article
DOI: 10.1182/blood-2016-10-692400
Source: Self-asserted source
Borja Saez

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells

Cell
2016 | Journal article
DOI: 10.1016/j.cell.2016.10.045
Source: Self-asserted source
Borja Saez

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

Nature biotechnology
2016 | Journal article
DOI: 10.1038/nbt.3584
Source: Self-asserted source
Borja Saez

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway

Proceedings of the National Academy of Sciences of the United States of America
2016 | Journal article
DOI: 10.1073/pnas.1511380113
Source: Self-asserted source
Borja Saez

Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations

Cell stem cell
2015 | Journal article
DOI: 10.1016/j.stem.2015.01.002
Source: Self-asserted source
Borja Saez

Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells

Cell stem cell
2015 | Journal article
DOI: 10.1016/j.stem.2015.04.008
Source: Self-asserted source
Borja Saez

Parent stem cells can serve as niches for their daughter cells

Nature
2015 | Journal article
DOI: 10.1038/nature14553
Source: Self-asserted source
Borja Saez

Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow

The Journal of experimental medicine
2015 | Journal article
DOI: 10.1084/jem.20141843
Source: Self-asserted source
Borja Saez

D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL

Developmental cell
2014 | Journal article
DOI: 10.1016/j.devcel.2014.06.015
Source: Self-asserted source
Borja Saez

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

Blood
2014 | Journal article
DOI: 10.1182/blood-2014-08-593426
Source: Self-asserted source
Borja Saez

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

EMBO molecular medicine
2013 | Journal article
DOI: 10.1002/emmm.201390004
Source: Self-asserted source
Borja Saez

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

EMBO molecular medicine
2013 | Journal article
DOI: 10.1002/emmm.201201606
Source: Self-asserted source
Borja Saez

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

Cancer cell
2013 | Journal article
DOI: 10.1016/j.ccr.2013.09.018
Source: Self-asserted source
Borja Saez

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

Cell
2011 | Journal article
DOI: 10.1016/j.cell.2011.07.032
Source: Self-asserted source
Borja Saez

Diabetes impairs hematopoietic stem cell mobilization by altering niche function

Science translational medicine
2011 | Journal article
DOI: 10.1126/scitranslmed.3002191
Source: Self-asserted source
Borja Saez

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

Blood
2011 | Journal article
DOI: 10.1182/blood-2010-10-313064
Source: Self-asserted source
Borja Saez

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

Nature
2010 | Journal article
DOI: 10.1038/nature09572
Source: Self-asserted source
Borja Saez

Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth

Molecular cancer research : MCR
2008 | Journal article
DOI: 10.1158/1541-7786.mcr-08-0167
Source: Self-asserted source
Borja Saez

Multicolor interphase cytogenetics for the study of plasma cell dyscrasias

Oncology reports
2007 | Journal article
Source: Self-asserted source
Borja Saez

Multiple myeloma primary cells show a highly rearranged unbalanced genome with amplifications and homozygous deletions irrespective of the presence of immunoglobulin-related chromosome translocations

Haematologica
2007 | Journal article
DOI: 10.3324/haematol.11052
Source: Self-asserted source
Borja Saez

Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes

Cancer genetics and cytogenetics
2007 | Journal article
DOI: 10.1016/j.cancergencyto.2006.12.009
Source: Self-asserted source
Borja Saez

Identification of overexpressed genes in frequently gained/amplified chromosome regions in multiple myeloma

Haematologica
2006 | Journal article
Source: Self-asserted source
Borja Saez

Identification of recurrent chromosomal breakpoints in multiple myeloma with complex karyotypes by combined G-banding, spectral karyotyping, and fluorescence in situ hybridization analyses

Cancer genetics and cytogenetics
2006 | Journal article
DOI: 10.1016/j.cancergencyto.2006.04.008
Source: Self-asserted source
Borja Saez

Interphase FISH for the detection of breakpoints in IG loci and chromosomal changes with adverse prognostic impact in multiple myeloma with normal karyotypes

Cancer genetics and cytogenetics
2006 | Journal article
DOI: 10.1016/j.cancergencyto.2005.12.008
Source: Self-asserted source
Borja Saez

Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas

Genes, chromosomes & cancer
2005 | Journal article
DOI: 10.1002/gcc.20187
Source: Self-asserted source
Borja Saez

NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2

Cancer genetics and cytogenetics
2005 | Journal article
DOI: 10.1016/j.cancergencyto.2004.08.001
Source: Self-asserted source
Borja Saez

Chromosomal abnormalities clustering in multiple myeloma reveals cytogenetic subgroups with nonrandom acquisition of chromosomal changes

Leukemia
2004 | Journal article
DOI: 10.1038/sj.leu.2403256
Source: Self-asserted source
Borja Saez

Peer review (1 review for 1 publication/grant)

Review activity for Cells. (1)
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